Homo sapiens

1. Traditional chinese medicine decreases neuronal damage in humans.

   Reviewin Alzheimer's disease models

   Traditional Chinese medicine for Alzheimer's disease: pathological mechanisms and multi-target interventions · 3 Biotech · 27 Sep 2026

2. Traditional chinese medicine decreases tau hyperphosphorylation in humans.

   Reviewin Alzheimer's disease models

   Traditional Chinese medicine for Alzheimer's disease: pathological mechanisms and multi-target interventions · 3 Biotech · 27 Sep 2026

3. Traditional chinese medicine decreases Aβ deposition in humans.

   Reviewin Alzheimer's disease models

   Traditional Chinese medicine for Alzheimer's disease: pathological mechanisms and multi-target interventions · 3 Biotech · 27 Sep 2026

Traditional chinese medicine →

1. Melissic acid decreases mitochondrial dysfunction in human cells.

   Cellsstem cells from human exfoliated deciduous teeth

   Melissic acid reduces senescence in human stem cells via cAMP signaling · Frontiers in pharmacology · 17 Sep 2026

2. Melissic acid activates autophagy in human cells.

   Cellsstem cells from human exfoliated deciduous teeth

   Melissic acid reduces senescence in human stem cells via cAMP signaling · Frontiers in pharmacology · 17 Sep 2026

3. Melissic acid decreases cellular senescence in human cells.

   Cellsin replicative exhaustion and doxorubicin-induced stress modelsstem cells from human exfoliated deciduous teeth5-20 μM

   Melissic acid reduces senescence in human stem cells via cAMP signaling · Frontiers in pharmacology · 17 Sep 2026

Melissic acid →

1. Bifidobacterium animalis subsp. lactis decreases chronic inflammation in human cells.

   “Moreover, BL-G101 suppressed UVB-induced inflammation by significantly decreasing IL-1β and TNF-α levels.”

   Cellsunder UVB exposureBL-G101Hs68

   Bifidobacterium animalis subsp. lactis BL-G101 Protects Against UVB-Induced Photoaging in HS68 Dermal Fibroblasts · Nutrients · 15 Sep 2026

2. Bifidobacterium animalis subsp. lactis protects against oxidative stress and ROS signalling in human cells.

   “BL-G101 treatment also protects against UVB-induced oxidative stress, which was evidenced by significantly decreased MDA levels and enhanced SOD activity.”

   Cellsunder UVB exposureBL-G101Hs68

   Bifidobacterium animalis subsp. lactis BL-G101 Protects Against UVB-Induced Photoaging in HS68 Dermal Fibroblasts · Nutrients · 15 Sep 2026

3. Bifidobacterium animalis subsp. lactis decreases cellular senescence in human cells.

   “SA-β-gal staining revealed a reduction in senescent fibroblasts following BL-G101 treatment.”

   Cellsfollowing UVB exposureBL-G101Hs68

   Bifidobacterium animalis subsp. lactis BL-G101 Protects Against UVB-Induced Photoaging in HS68 Dermal Fibroblasts · Nutrients · 15 Sep 2026

Bifidobacterium animalis subsp. lactis →

1. Hyperglycemia raises the risk of diabetic kidney disease in humans.

   “A hyperglycaemic microenvironment is a critical contributor of proximal tubular epithelial cell injury to disease initiation and progression.”

   Review

   Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression-a narrative review · Frontiers in cell and developmental biology · 10 Sep 2026

2. Hyperglycemia induces cellular senescence in humans.

   “A hyperglycaemic microenvironment could damage the proximal tubular epithelial cells via mechanisms such as dedifferentiation, metabolic reprogramming, cell death and senescence”

   Reviewproximal tubular epithelial cell

   Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression-a narrative review · Frontiers in cell and developmental biology · 10 Sep 2026

3. Hyperglycemia induces mitochondrial dysfunction in humans.

   “Chronic hyperglycaemia activates multiple pathogenic pathways, including the polyol, hexosamine, protein kinase C (PKC), and advanced glycation end-product pathways, resulting in excessive reactive oxygen species generation, mitochondrial dysfunction, inflammation”

   Reviewchronicproximal tubular epithelial cell

   Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression-a narrative review · Frontiers in cell and developmental biology · 10 Sep 2026

Hyperglycemia →

1. Epoxomicin increases phosphatidylserine in human cells.

   “Physiological restoration of proteasome-inhibited RBCs caused accelerated ATP depletion, massive protein aggregation, reduced deformability, hemolysis, and phosphatidylserine exposure”

   Cellsduring physiological restorationerythrocyte

   Proteasome activity maintains red blood cell integrity during storage and restoration · Antioxidants (Basel, Switzerland) · 9 Sep 2026

2. Epoxomicin increases loss of proteostasis in human cells.

   “Physiological restoration of proteasome-inhibited RBCs caused accelerated ATP depletion, massive protein aggregation, reduced deformability, hemolysis, and phosphatidylserine exposure”

   Cellsduring physiological restorationerythrocyte

   Proteasome activity maintains red blood cell integrity during storage and restoration · Antioxidants (Basel, Switzerland) · 9 Sep 2026

3. Epoxomicin decreases ATP in human cells.

   “Proteasome inhibition during storage depleted ATP and altered RBC morphology without immediate oxidative damage.”

   Cellsduring storageerythrocyte

   Proteasome activity maintains red blood cell integrity during storage and restoration · Antioxidants (Basel, Switzerland) · 9 Sep 2026

Epoxomicin →

1. Uqh 1,4-bis-hemi-succinate increases COL1A1 in human cells.

   Cellsesterified derivativedermal fibroblast100 μM48 h

   Enhanced Extracellular Matrix Synthesis-Related Responses Induced by Ubiquinol-10 Derivatives in Human Dermal Fibroblasts · BioFactors (Oxford, England) · 1 Sep 2026

2. Uqh 1,4-bis-hemi-succinate decreases senescence-associated secretory phenotype (SASP) in human cells.

   Cellsesterified derivativedermal fibroblast100 μM48 h

   Enhanced Extracellular Matrix Synthesis-Related Responses Induced by Ubiquinol-10 Derivatives in Human Dermal Fibroblasts · BioFactors (Oxford, England) · 1 Sep 2026

3. Uqh 1,4-bis-hemi-succinate increases adenosine triphosphate in human cells.

   Cellsesterified derivativedermal fibroblast100 μM48 h

   Enhanced Extracellular Matrix Synthesis-Related Responses Induced by Ubiquinol-10 Derivatives in Human Dermal Fibroblasts · BioFactors (Oxford, England) · 1 Sep 2026

Uqh 1,4-bis-hemi-succinate →

1. Farnesylation amino acid targeted editing protects against progeria in human cells.

   CellsmRNA conjugated with lipid nanoparticlesneuromuscular organoid

   Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026

2. Farnesylation amino acid targeted editing activates DNA repair in human cells.

   CellsHGPS NMOsneuromuscular organoid

   Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026

3. Farnesylation amino acid targeted editing improves TP53BP1 in human cells.

   CellsHGPS NMOsneuromuscular organoid

   Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026

Farnesylation amino acid targeted editing →

1. NPM1 knockdown increases genomic instability in human cells.

   Cellsunder Progerin expressiondepletion

   Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells · bioRxiv · 1 Oct 2026 · Preprint

2. NPM1 knockdown decreases H3K9me2 in human cells.

   Cellsat relocated LADsdepletion

   Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells · bioRxiv · 1 Oct 2026 · Preprint

NPM1 knockdown →

1. D-allose inhibits cGAS–STING signalling in human cells.

   Cellsnucleus pulposus cell

   D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway · Experimental & molecular medicine · 1 Oct 2026

2. D-allose activates mitophagy in human cells.

   Cellsnucleus pulposus cell

   D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway · Experimental & molecular medicine · 1 Oct 2026

D-allose →

1. Fenofibrate improves cognitive function in humans.

   Human trialin chronic traumatic brain injuryn = 40

   Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate · Science translational medicine · 30 Sep 2026

2. Fenofibrate decreases NfL in humans.

   Human trialin chronic traumatic brain injuryplasman = 40

   Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate · Science translational medicine · 30 Sep 2026

Fenofibrate →

1. Mtdna depletion decreases phosphorylated tau in human cells.

   Cellschronic mtDNA depletion (rho0)SH-SY5Y

   Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels · Journal of Alzheimer's disease : JAD · 29 Sep 2026

2. Mtdna depletion increases MAPT in human cells.

   Cellschronic mtDNA depletion (rho0)SH-SY5Y

   Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels · Journal of Alzheimer's disease : JAD · 29 Sep 2026

Mtdna depletion →

1. Rapamycin inhibits cellular senescence in human cells.

   Cellsepithelial cell

   Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint

2. Rapamycin decreases SFN in human cells.

   CellsA549

   Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint

Rapamycin →

1. Adherence to danish dietary guidelines are associated with DunedinPACE in humans (3.1% lower pace of aging).

   Humanscross-sectional individual analysesper 1 unit increase in index score

   Dietary benefits on epigenetic aging may largely reflect familial factors · GeroScience · 26 Sep 2026

2. Adherence to danish dietary guidelines are associated with PCGrimAge in humans (0.55-0.67 years lower PCGrimAge).

   Humanscross-sectional individual analysesper 1 unit increase in index score

   Dietary benefits on epigenetic aging may largely reflect familial factors · GeroScience · 26 Sep 2026

Adherence to danish dietary guidelines →

1. DNMT3A mutation decreases H3K27me3 in human cells.

   Cellsmacrophage

   DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration · bioRxiv · 25 Sep 2026 · Preprint

2. DNMT3A mutation decreases DNA methylation in human cells.

   Cellsmacrophage

   DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration · bioRxiv · 25 Sep 2026 · Preprint

DNMT3A mutation →

1. SIRT1 overexpression activates NRF2–KEAP1 antioxidant response in human cells.

   Cellsosteogenic inductionpcDNA3.1-Sirt1 transfectionaortic valve interstitial cell

   Activating Sirt1 reduces aortic valve calcification in mice and human cells · International journal of molecular medicine · 25 Sep 2026

2. SIRT1 overexpression inhibits ferroptosis in human cells.

   Cellsosteogenic inductionpcDNA3.1-Sirt1 transfectionaortic valve interstitial cell

   Activating Sirt1 reduces aortic valve calcification in mice and human cells · International journal of molecular medicine · 25 Sep 2026

SIRT1 overexpression →

1. Kl-evs improve osteogenic differentiation in human cells.

   “In particular, KL-EVs rescued the age-related differentiation bias of adult BMSCs by robustly prompting their osteogenic differentiation capacity.”

   CellsKlotho-enriched UC-EVsbone marrow mesenchymal stem cell

   Characterization of Umbilical Cord Mesenchymal Stromal Cells Overexpressing Klotho and In Vitro Anti-Aging Efficacy of Their Derived Extracellular Vesicles · International journal of molecular sciences · 19 Sep 2026

2. Kl-evs decrease cellular senescence in human cells.

   “More importantly, KL-EVs profoundly rescued multifaceted senescent phenotypes in both adult bone marrow mesenchymal stem cells (BMSCs) and human renal tubular epithelial cells (HK-2) in vitro.”

   CellsKlotho-enriched UC-EVsHK-2

   Characterization of Umbilical Cord Mesenchymal Stromal Cells Overexpressing Klotho and In Vitro Anti-Aging Efficacy of Their Derived Extracellular Vesicles · International journal of molecular sciences · 19 Sep 2026

Kl-evs →

1. Childhood food deprivation raises the risk of multimorbidity in humans (HR 1.43, 95% CI: 1.25-1.63).

   “Further adjustment for lifestyle and health-related covariates yielded HRs of 1.17 (95% CI: 1.07-1.28) and 1.43 (95% CI: 1.25-1.63).”

   Humansextreme deprivation, fully adjusted model2011-2020n = 4,546

   Early-life nutritional deprivation and multimorbidity in middle- aged and older adults: a longitudinal exploratory mediation analysis of biological aging · Frontiers in nutrition · 10 Sep 2026

2. Childhood food deprivation raises the risk of multimorbidity in humans (HR 1.17, 95% CI: 1.07-1.28).

   “Further adjustment for lifestyle and health-related covariates yielded HRs of 1.17 (95% CI: 1.07-1.28) and 1.43 (95% CI: 1.25-1.63).”

   Humansmoderate deprivation, fully adjusted model2011-2020n = 4,546

   Early-life nutritional deprivation and multimorbidity in middle- aged and older adults: a longitudinal exploratory mediation analysis of biological aging · Frontiers in nutrition · 10 Sep 2026

Childhood food deprivation →

1. Lifestyle modification program decreases HbA1c in humans (-0.4%).

   “waist circumference (-6.3 cm), and HbA1c (-0.4%; all p”

   Human trialprediabetes6 monthsn = 181

   Lifestyle modification reduces phenotypic age in adults with prediabetes · Frontiers in aging · 10 Sep 2026

2. Lifestyle modification program decreases PhenoAge in humans (-4.9 vs. +1.3 years).

   “participants in the lifestyle modification program (LMP) showed a significant reduction in PhenoAge (-4.9 vs. +1.3 years; between-group p”

   Human trialprediabetes6 monthsn = 181

   Lifestyle modification reduces phenotypic age in adults with prediabetes · Frontiers in aging · 10 Sep 2026

Lifestyle modification program →

1. MIR-193B-3P inhibits AP2M1 in human cells.

   Cellsmyoblast

   Extracellular vesicle microRNA promotes muscle regeneration by suppressing AP2M1 · Molecular therapy. Nucleic acids · 3 Sep 2026

2. MIR-193B-3P improves myogenic differentiation in human cells.

   Cellsin vitro myogenic differentiationmyoblast

   Extracellular vesicle microRNA promotes muscle regeneration by suppressing AP2M1 · Molecular therapy. Nucleic acids · 3 Sep 2026

MIR-193B-3P →

1. Nampt knockdown decreases NAD+ in human cells.

   CellssiRNAnucleus pulposus cell

   Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells · Frontiers in bioscience (Landmark edition) · 1 Sep 2026

2. Nampt knockdown decreases lactate in human cells.

   CellssiRNAnucleus pulposus cell

   Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells · Frontiers in bioscience (Landmark edition) · 1 Sep 2026

Nampt knockdown →

1. Lactate induces cellular senescence in human cells.

   Cellsnucleus pulposus cell

   Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells · Frontiers in bioscience (Landmark edition) · 1 Sep 2026

2. Lactate activates p38 MAPK signalling in human cells.

   Cellsnucleus pulposus cell

   Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells · Frontiers in bioscience (Landmark edition) · 1 Sep 2026

Lactate →

1. Tert overexpression decreases pigmentation in human cells.

   “Melanocyte differentiation and pigmentation programs were generally reduced, particularly in clonal cultures.”

   Cellsparticularly in clonal cultureslentiviral vectormelanocyte

   Lentiviral hTERT Overexpression Extends the Lifespan of Primary Human Epidermal Melanocytes and Reshapes Transcriptional Programs · Biomolecules · 27 Aug 2026

2. Tert overexpression extends lifespan in human cells (>10 passages).

   “hTERT overexpression extended melanocyte culture lifespan by more than 10 passages.”

   Cellslentiviral vectormelanocyte

   Lentiviral hTERT Overexpression Extends the Lifespan of Primary Human Epidermal Melanocytes and Reshapes Transcriptional Programs · Biomolecules · 27 Aug 2026

Tert overexpression →

1. INTERLEUKIN-1 beta increases CDK6 in human cells.

   “In IL-1β-treated C28/I2 cells, WEE1 mRNA decreased whereas CDK6 mRNA increased; representative immunoblots showed concordant qualitative trends.”

   CellsC28/I2

   Senescence-Associated Checkpoint Gene Dysregulation in Established Osteoarthritis: Integrated Transcriptomic Analysis and In Vitro Evaluation of CDK6 and WEE1 · Biomedicines · 26 Aug 2026

2. INTERLEUKIN-1 beta decreases WEE1 in human cells.

   “In IL-1β-treated C28/I2 cells, WEE1 mRNA decreased whereas CDK6 mRNA increased; representative immunoblots showed concordant qualitative trends.”

   CellsC28/I2

   Senescence-Associated Checkpoint Gene Dysregulation in Established Osteoarthritis: Integrated Transcriptomic Analysis and In Vitro Evaluation of CDK6 and WEE1 · Biomedicines · 26 Aug 2026

INTERLEUKIN-1 beta →

1. Yoga lifestyle programme has no effect on blood pressure in humans.

   Human trialdiastolic BP in type 2 diabetes mellitus15 daysn = 74

   Impact of a Short-term Yoga Lifestyle Programme on Circulating Serum Klotho Levels in Patients with Type 2 Diabetes: An Exploratory Study · Indian journal of endocrinology and metabolism · 1 Jul 2026

2. Yoga lifestyle programme increases KL in humans (+14.65%).

   Human trialin type 2 diabetes mellitusasanas, pranayama, meditation, kriyas, a satvik diet, and spiritual sessionsserum15 daysn = 74

   Impact of a Short-term Yoga Lifestyle Programme on Circulating Serum Klotho Levels in Patients with Type 2 Diabetes: An Exploratory Study · Indian journal of endocrinology and metabolism · 1 Jul 2026

Yoga lifestyle programme →

1. Mitotempo improves efferocytosis in human cells.

   Cellsunder FIN-56 treatmentTHP-1-derived macrophages

   Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice · International immunopharmacology · 2 Oct 2026

Mitotempo →

1. FERROSTATIN-1 improves efferocytosis in human cells.

   Cellsunder FIN-56 treatmentTHP-1-derived macrophages

   Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice · International immunopharmacology · 2 Oct 2026

FERROSTATIN-1 →

1. FIN-56 impairs efferocytosis in human cells.

   CellsTHP-1-derived macrophages5 μM48 h

   Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice · International immunopharmacology · 2 Oct 2026

FIN-56 →

1. SPHINGOSINE-1-PHOSPHATE increases stem cell pool in human cells.

   Cellsin aged culturesexogenousprimary muscle cells

   Aged human muscle secretes an enzyme that impairs stem cell maintenance · bioRxiv · 2 Oct 2026 · Preprint

SPHINGOSINE-1-PHOSPHATE →

1. Recombinant acid sphingomyelinase decreases PAX7+ MuSCs in human cells.

   Cellsin young culturesrecombinantprimary muscle cells

   Aged human muscle secretes an enzyme that impairs stem cell maintenance · bioRxiv · 2 Oct 2026 · Preprint

Recombinant acid sphingomyelinase →

1. Simulated microgravity increases transcriptomic age in human cells.

   “accompanied by higher transcriptomic-age estimates in neural and cardiac models”

   Cellsin rotating-wall vesselsrotating-wall vesselscardiac organoids24 hours

   Simulated microgravity increases transcriptomic age in human organoids · bioRxiv · 1 Oct 2026 · Preprint

Simulated microgravity →

1. Lmna mutation increases transcriptional ageing programs in human cells.

   Cellsfollowing Progerin expressionProgerin expression

   Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells · bioRxiv · 1 Oct 2026 · Preprint

Lmna mutation →

1. Iron is associated with GoldBA in humans (β = 0.35 for >18 mg/day).

   Humanssupplement>18 mg/dayn = 13,284

   Dietary iron links to slower biological aging while high supplement doses accelerate it · Asia Pacific journal of clinical nutrition · 1 Oct 2026

Iron →

1. Dietary iron is associated with GoldBA in humans (β = -0.09 per 2-fold increase).

   Humansn = 13,284

   Dietary iron links to slower biological aging while high supplement doses accelerate it · Asia Pacific journal of clinical nutrition · 1 Oct 2026

Dietary iron →

1. Aicar increases BMAL1 in human cells.

   CellsU2OS

   AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1 · bioRxiv · 30 Sep 2026 · Preprint

Aicar →

1. Epstein-barr virus infection is associated with chronic inflammation in humans.

   Review

   Lifelong Epstein-Barr virus persistence as a stress test of ageing immune surveillance: from infectious mononucleosis to chronic active EBV disease and virus-associated malignancy · Ageing research reviews · 30 Sep 2026

Epstein-barr virus infection →

1. ERO1A knockdown decreases cellular senescence in human cells.

   CellsTGF-β-induceddermal fibroblast

   Parthenolide reduces senescence and skin fibrosis in scleroderma models · Aging cell · 30 Sep 2026

ERO1A knockdown →

1. Parthenolide decreases cellular senescence in human cells.

   CellsTGF-β-induceddermal fibroblast

   Parthenolide reduces senescence and skin fibrosis in scleroderma models · Aging cell · 30 Sep 2026

Parthenolide →

1. Tocilizumab decreases valvular interstitial cell in human cells.

   Cellsaccelerated calcification from ASXL1-mutant macrophage media

   ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification · medRxiv · 29 Sep 2026 · Preprint

Tocilizumab →

1. Anakinra decreases valvular interstitial cell in human cells.

   Cellsaccelerated calcification from ASXL1-mutant macrophage media

   ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification · medRxiv · 29 Sep 2026 · Preprint

Anakinra →

1. FNDC5 decreases cellular senescence in human cells.

   Cellsdoxorubicin treatmentrecombinant irisincardiomyocyte

   Exercise protects mouse hearts from chemotherapy toxicity by suppressing cellular senescence · Research Square · 29 Sep 2026 · Preprint

FNDC5 →

1. Childhood and adolescence smoking raises the risk of dementia in humans (HR 1.187, 95% CI 1.106-1.275).

   Humans13.67 yearsn = 285,009

   Accelerated biological aging in the association between early-life tobacco smoke exposure and dementia risk: An exploratory mediation analysis · Journal of Alzheimer's disease : JAD · 29 Sep 2026

Childhood and adolescence smoking →

1. Prenatal tobacco smoke exposure raises the risk of dementia in humans (HR 1.094, 95% CI 1.025-1.168).

   Humans13.67 yearsn = 285,009

   Accelerated biological aging in the association between early-life tobacco smoke exposure and dementia risk: An exploratory mediation analysis · Journal of Alzheimer's disease : JAD · 29 Sep 2026

Prenatal tobacco smoke exposure →

1. Aerobic exercise increases microRNA-29 in humans.

   Human trial3-month

   Exercise-induced extracellular vesicles enhance aged cartilage health via microRNA-29 · Nature aging · 29 Sep 2026

Aerobic exercise →

1. Sunscreen decreases chronic inflammation in human cells.

   Cellsfollowing ultraviolet B exposuretopical sunscreenskin

   Long-term human skin platform models chronic inflammation and senolytic treatments · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 29 Sep 2026

Sunscreen →

1. Tofacitinib decreases chronic inflammation in human cells.

   Cellssustained IL-17/IL-22 stimulationskin3 weeks

   Long-term human skin platform models chronic inflammation and senolytic treatments · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 29 Sep 2026

Tofacitinib →

1. LOX-1 antibody decreases IL-6 in humans.

   Reviewin GOLDILOX-TIMI 69 trial

   An Update of Oxidative Stress in Atherosclerosis with Emphasis on the LOX-1-NLRP3 Inflammasome Axis · Current atherosclerosis reports · 29 Sep 2026

LOX-1 antibody →

1. Stress is associated with epigenetic clock in humans.

   Reviewin second- and third-generation clocks

   A Conceptual Framework for Understanding the Effects of Stress on Epigenetic Aging · Annual review of psychology · 29 Sep 2026

Stress →

1. MIR-6126 decreases PRNP in human cells.

   Cells

   Extracellular vesicles carrying two microRNAs reduce vascular aging markers in progeria cells · Pharmacological research · 29 Sep 2026

MIR-6126 →

1. MIR-4651 inhibits SRSF1 in human cells.

   Cells

   Extracellular vesicles carrying two microRNAs reduce vascular aging markers in progeria cells · Pharmacological research · 29 Sep 2026

MIR-4651 →

1. Melatonin-preconditioned mesenchymal stromal cell-derived small extracellular vesicles decrease H2AX in human cells.

   Cellsin HGPS fibroblastsfibroblast

   Extracellular vesicles carrying two microRNAs reduce vascular aging markers in progeria cells · Pharmacological research · 29 Sep 2026

Melatonin-preconditioned mesenchymal stromal cell-derived small extracellular vesicles →

1. Blood flow restricted resistance exercise increases macrophage in humans.

   Human trialskeletal muscle

   Resistance exercise shifts muscle progenitor cells to support growth in older adults · bioRxiv · 28 Sep 2026 · Preprint

Blood flow restricted resistance exercise →

1. Perfluorohexanesulfonic acid is associated with skin and blood clock in humans (β= -0.02 years, 95% CI= -0.04, -0.00).

   Humansleukocyten = 403

   Plasma per- and polyfluoroalkyl substance (PFAS) concentrations in mid-childhood and associations with DNA methylation and epigenetic aging through early adolescence · Environmental research · 28 Sep 2026

Perfluorohexanesulfonic acid →

1. Perfluorooctane sulfonate is associated with skin and blood clock in humans (β= -0.02 years, 95% CI= -0.04, -0.00).

   Humansleukocyten = 403

   Plasma per- and polyfluoroalkyl substance (PFAS) concentrations in mid-childhood and associations with DNA methylation and epigenetic aging through early adolescence · Environmental research · 28 Sep 2026

Perfluorooctane sulfonate →

1. GSK2656157 decreases cellular senescence in human cells.

   Cellsin ALI-cultured HBECs from severe asthmatic donorshuman bronchial epithelial cell

   Loss of PP4 drives airway senescence through endoplasmic reticulum stress · Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 27 Sep 2026

GSK2656157 →

1. Lysine is associated with epithelial barrier in human cells.

   Cellsin young and senescent digestive cells interacting with gut microbes and phages under infectious inflammation

   The Eukaryotic Host-Microbe-Phage-Nutrition Interplay Determines the Bacterial Effectors of Supplemental Lysine's Health Benefits: An Experimental Cellular Senescence Model of Digestive Conditions in Older Adults · Mechanisms of ageing and development · 26 Sep 2026

Lysine →

1. RNA polymerase ii inhibition improves growth in human cells.

   CellsHP1-deficient cells

   Innate immune stress activation drives pathology caused by heterochromatin loss · bioRxiv · 26 Sep 2026 · Preprint

RNA polymerase ii inhibition →

1. Multimodal exercise is associated with SASP Score in humans.

   “In an independent cohort, multimodal exercise significantly changed the SASP Score trajectory over 18 months.”

   Human trialin an independent randomized clinical trial cohortblood18 months

   A deep learning score for cellular senescence predicts human mortality and disease risk · Aging cell · 26 Sep 2026

Multimodal exercise →

1. HCAR1 knockdown induces cellular senescence in human cells.

   Cellsin early-passage cells

   Lactate receptor activation reduces cellular senescence and protects vascular health in mice · bioRxiv · 25 Sep 2026 · Preprint

HCAR1 knockdown →

1. SEPHIN1 decreases oxidative stress and ROS signalling in human cells.

   Cellsin PFFs-stimulated cells

   Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026

SEPHIN1 →

1. N-methyl-n-nitrosourea induces apoptosis in human cells.

   Cellsmesenchymal stem cell

   Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026

N-methyl-n-nitrosourea →

1. Neisseria flavescens are associated with biological age in humans.

   Humans

   Oral bacterium Neisseria flavescens promotes healthspan in worms and rejuvenates aged mice · Nature aging · 24 Sep 2026

Neisseria flavescens →

1. SCAF1 overexpression induces cellular senescence in human cells.

   CellsIMR-90

   Peroxisomal stress drives cellular senescence by relocating SCAF1 to mitochondria · bioRxiv : the preprint server for biology · 23 Sep 2026 · Preprint

SCAF1 overexpression →

1. SCAF1 knockdown increases oxidative phosphorylation in human cells.

   Cells

   Peroxisomal stress drives cellular senescence by relocating SCAF1 to mitochondria · bioRxiv : the preprint server for biology · 23 Sep 2026 · Preprint

SCAF1 knockdown →

1. Kl overexpression improves osteogenic differentiation in human cells.

   “Our data demonstrated that genetic modification endowed UC-MSCs with prominent osteogenic differentiation potency and angiogenesis efficacy.”

   Cellsumbilical cord mesenchymal stem cell

   Characterization of Umbilical Cord Mesenchymal Stromal Cells Overexpressing Klotho and In Vitro Anti-Aging Efficacy of Their Derived Extracellular Vesicles · International journal of molecular sciences · 19 Sep 2026

Kl overexpression →

1. Printed porous titanium is associated with subsidence in humans (5.5% of levels versus 24.4%).

   “printed porous titanium was associated with subsidence in 5.5% of levels versus 24.4% for solid titanium.”

   Reviewin a retrospective cohort of 163 lumbar interbody fusion levels versus 24.4% for solid titaniumporousbonen = 163

   3D-Printed and Biofabricated Scaffolds for Osteoporotic Bone Defect Repair: Mechanical Adaptation, Redox Control, Senescence Modulation and Osteoimmunomodulation · Bioengineering (Basel, Switzerland) · 19 Sep 2026

Printed porous titanium →

1. Lysophosphatidylethanolamine 18:1 decreases cellular senescence in human cells.

   “Moreover, exogenous LPE 18:1 attenuated selected markers of T-cell senescence in vitro.”

   Cellsin vitro18:1T cell

   Plasma metabolic shifts link to T-cell senescence and mortality in older COVID-19 patients · Biomedicines · 19 Sep 2026

Lysophosphatidylethanolamine 18:1 →

1. SB-431542 inhibits activin a in human cells.

   “and these effects were attenuated by SB431542, a small-molecule inhibitor of ALK4/5/7 signalling.”

   Cellsattenuating Activin A suppression of myogenic regulators in primary human MuSCssatellite cell

   Activin A from inflammatory macrophages impairs stem cell regulation in aging human muscle · International journal of molecular sciences · 17 Sep 2026

SB-431542 →

1. Activin a decreases myogenic regulators in human cells.

   “In primary human MuSCs, Activin A induced Activin-responsive genes and suppressed myogenic regulators”

   Cellsin primary human MuSCssatellite cell

   Activin A from inflammatory macrophages impairs stem cell regulation in aging human muscle · International journal of molecular sciences · 17 Sep 2026

Activin a →

1. Telomir-zn decreases reactive oxygen species in human cells.

   “Complementary studies in human ARPE-19 RPE cells showed attenuation of iron/copper-induced ROS and calcium dysregulation”

   Cellsunder iron/copper inductionretinal pigment epithelium

   Targeted metal modulation preserves retinal structure and vision in zebrafish · International journal of molecular sciences · 16 Sep 2026

Telomir-zn →

1. Vitamin d lowers the risk of type 1 diabetes in humans.

   Reviewduring childhood

   Vitamin D signaling in thymic development and longevity · Frontiers in nutrition · 15 Sep 2026

Vitamin d →

1. Lactobacillus acidophilus has no effect on collagen in human cells.

   “whereas LA-G80 showed no notable effects.”

   Cellsunder UVB exposureLA-G80Hs68

   Bifidobacterium animalis subsp. lactis BL-G101 Protects Against UVB-Induced Photoaging in HS68 Dermal Fibroblasts · Nutrients · 15 Sep 2026

Lactobacillus acidophilus →

1. Antioxidants improve muscle strength in humans (7/8 studies).

   “Comparative clinical benefits were reported primarily for strength or power (7/8 studies), with less support for physical performance (2/6 studies assessing this domain) or body composition-related muscle quantity (2/8 studies).”

   Reviewin older adults with aging-related muscle decline or sarcopeniaskeletal muscle

   Antioxidant Interventions on Muscle Function and Mass in Aging-Related Muscle Decline: A Systematic Review of Preclinical and Clinical Evidence · Antioxidants (Basel, Switzerland) · 15 Sep 2026

Antioxidants →

1. Fisetin decreases chronic inflammation in humans.

   “While some studies reported favorable changes in metabolic or inflammatory outcomes, others found no clear or significant clinical benefit.”

   Reviewin some human clinical trials

   Clinical Translation of Fisetin for Age-Related Diseases: Current Evidence and Future Opportunities · Nutrients · 14 Sep 2026

Fisetin →

1. Buddleja globosa decreases senescence-associated beta-galactosidase in human cells.

   “BgAE reduced H 2 O 2 -induced β-galactosidase positivity at 1 and 50 μg/mL and modulated TNFA , p16, p21, and NF-κB responses”

   Cellsin H2O2-treated THP-1-derived macrophagesaqueous extractTHP-1-derived macrophage1 and 50 μg/mL48 h

   Aqueous Extract of Buddleja globosa Modulates Oxidative Stress-Induced Senescence-Associated Responses in THP-1-Derived Macrophages · Pharmaceuticals (Basel, Switzerland) · 12 Sep 2026

Buddleja globosa →

1. Hydrogen peroxide induces cellular senescence in human cells.

   “H 2 O 2 increased senescence-associated β-galactosidase positivity, TNFA expression, p16 and p21 abundance, and NF-κB phosphorylation.”

   Cells50 μM for 1 hTHP-1-derived macrophage50 μM1 h

   Aqueous Extract of Buddleja globosa Modulates Oxidative Stress-Induced Senescence-Associated Responses in THP-1-Derived Macrophages · Pharmaceuticals (Basel, Switzerland) · 12 Sep 2026

Hydrogen peroxide →

1. Gulf war oil fire pollutants are associated with telomere attrition in humans.

   “The patient's Gulf War exposure to oil fire pollutants (benzene, toluene, PAHs, lead, cadmium, and particulate matter) likely contributed to telomere shortening and TSD-related multisystem disease.”

   Humansin a Gulf War veteranbenzene, toluene, PAHs, lead, cadmium, and particulate mattermalesn = 1

   A Military Veteran with Pulmonary Fibrosis, Hepatic Cirrhosis, Bone Marrow Dysfunction and Shortened Telomeres Found to Have GAVE, a Potential Unsuspected Consequence of Telomere Spectrum Disorder · Journal of clinical medicine · 11 Sep 2026

Gulf war oil fire pollutants →

1. Omega-3 fatty acids have no effect on cardiovascular disease in humans.

   “The VITAL and STRENGTH trials failed to demonstrate significant cardiovascular benefit with omega-3 supplementation”

   Reviewin the VITAL and STRENGTH trials

   Oxidative Stress in Vascular Aging: Therapeutic Potential of the Antioxidant Paradox. A State-of-the-Art Review · Antioxidants (Basel, Switzerland) · 10 Sep 2026

Omega-3 fatty acids →

1. Nicotinamide mononucleotide increases NAD+ in humans.

   “Short-term IV NAD + or NMN administration has been associated with transient increases in circulating NAD + levels”

   Reviewshort-term IV administrationintravenous

   Narrative review of intravenous NAD⁺ and NAD⁺ precursors in wellness and translational medicine · Frontiers in aging · 10 Sep 2026

Nicotinamide mononucleotide →

1. NAD+ increases NAD+ in humans.

   “Short-term IV NAD + or NMN administration has been associated with transient increases in circulating NAD + levels”

   Reviewshort-term IV administrationintravenous

   Narrative review of intravenous NAD⁺ and NAD⁺ precursors in wellness and translational medicine · Frontiers in aging · 10 Sep 2026

NAD+ →

1. Vitis vinifera is associated with cognitive function in humans.

   “report varied effects on improvements in clinical and experimental biomarkers indicative of cardiometabolic disease risk and healthy aging, such as serum lipids, blood pressure, insulin resistance, oxidative stress, gut dysbiosis, and cognitive function.”

   Review

   Effects of Grape and Grape-Derived Bioactives on Inflammation and Immune-Driven Mechanisms Within the Context of Cardiometabolic Health and Aging: A Review · Nutrients · 9 Sep 2026

Vitis vinifera →

1. L1HS overexpression induces type I interferon signalling in human cells.

   Cellstransient overexpressionIMR-90

   Acute LINE-1 transcription remodels the molecular landscape of human fibroblasts · bioRxiv : the preprint server for biology · 8 Sep 2026 · Preprint

L1HS overexpression →

1. Doxorubicin induces cellular senescence in human cells.

   “Here we show that doxorubicin-induced senescence disrupts mitochondrial function in primary human astrocytes and compromises their capacity to sustain neuronal bioenergetics.”

   Cellsastrocyte

   Senescent human astrocytes impair neuronal mitochondrial function through released factors · Antioxidants (Basel, Switzerland) · 6 Sep 2026

Doxorubicin →

1. Uqh 1,4-bis-hemi-glutarate decreases MMP1 in human cells.

   Cellsesterified derivativedermal fibroblast100 μM48 h

   Enhanced Extracellular Matrix Synthesis-Related Responses Induced by Ubiquinol-10 Derivatives in Human Dermal Fibroblasts · BioFactors (Oxford, England) · 1 Sep 2026

Uqh 1,4-bis-hemi-glutarate →

1. Nampt overexpression increases cellular senescence in human cells.

   Cellsplasmidnucleus pulposus cell

   Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells · Frontiers in bioscience (Landmark edition) · 1 Sep 2026

Nampt overexpression →

1. Lithium is associated with telomere length in humans.

   “Clinical findings further suggest that chronic lithium treatment may be associated with preserved telomere length and attenuated biological brain aging in BD.”

   Reviewin BDchronic

   Lithium as a Potential Senostatic Agent in Central Nervous System Aging and Bipolar Disorder · Pharmaceuticals (Basel, Switzerland) · 31 Aug 2026

Lithium →

1. Antioxidant-rich dietary patterns are associated with DNA methylation clock in humans.

   “The available evidence does not support a uniform epigenetic anti-aging effect. Instead, methylation-age responses were clock-specific, exposure-dependent and often most apparent in metabolically or biologically responsive subgroups.”

   Reviewin human intervention studies

   Natural-Product-Derived Antioxidants and DNA Methylation-Based Epigenetic Aging: A Systematic Review of Human Intervention Studies · Antioxidants (Basel, Switzerland) · 28 Aug 2026

Antioxidant-rich dietary patterns →

1. FUNDC1 knockdown increases mitochondrial dysfunction in human cells.

   “FUNDC1 knockdown aggravated photoaging-associated phenotypes, mitochondrial dysfunction, and altered autophagy/mitophagy-related activity”

   Cellsunder UVA exposurehuman dermal fibroblast

   FUNDC1 protects skin against UVA damage through mitophagy and P53 stability · Antioxidants (Basel, Switzerland) · 25 Aug 2026

FUNDC1 knockdown →

1. Heavy metals induce dysbiosis in humans.

   “Environmental toxicants capable of these direct and indirect effects have included heavy metals, pesticides, herbicides, polychlorinated biphenyl (PCB) congeners, and endocrine-disrupting chemicals.”

   Reviewgut

   The Oxidative Stress and Inflammatory Metabolic Pathways of Some Environmental Toxicants Inflicting Human Disorders · Toxics · 22 Aug 2026

Heavy metals →