DNA methylation
Pathway29 papers1 finding
- Human trial1
- Humans12
- Animals4
- Model organisms3
- Cells2
- In silico1
Associations
1Histone modification and chromatin remodelling
upin Mammalia1
1 study
Histone modification and chromatin remodelling
upin Mammalia1
DNA methylation is associated with histone modification and chromatin remodelling in Mammalia.
Reviewat PRC2-bound low-methylated regions in somatic mitotic tissuessomatic mitotic tissues
Mammalian cellular identity erodes with age through predictable chromatin drift · Nature · 30 Sep 2026
Latest
33Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
Multi-omics analysis reveals molecular networks driving muscle decline in aging vervet monkeys
Researchers identified coordinated changes in DNA methylation, miRNAs, and gene expression distinguishing older female monkeys with slower gait from middle-aged counterparts.
TET enzyme deficiency drives the selection of specific aneuploid cells in mice
Loss of DNA methylation regulators accelerates clonal expansion by enriching rare pre-existing chromosomal gains such as chromosome 17 trisomy.
Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
Blood cell composition explains substantial variation in DNA methylation age
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
Epigenetic puberty index tracks biological aging and adult health risks
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.
Blood methylation framework maps dependencies between aging hallmarks and organ aging
A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand participants.