NAD+ & sirtuinsCells30 Sep 2026

Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells

Frontiers in Bioscience

The paper

Zhang W, Mo L, Guo H et al.

Frontiers in Bioscience · 1 Sep 2026

doi.org/10.31083/fbl51724 PubMed

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Animals29 Sep

Macrophage CD38 drives age-related placental senescence by depleting NAD+

Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.

Nature Communications · Hua L et al.

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Activating Sirt1 reduces aortic valve calcification in mice and human cells

The sirtuin protects valves by activating the Nrf2 pathway, preserving mitochondrial function, and preventing iron-driven ferroptosis.

International Journal of Molecular Medicine · Yan F et al.

CellsPreprint1 Oct

AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1

Experiments in human cells and computational modeling show that fasting sensor AMPK requires NAD+ and PGC-1-alpha to modulate cellular circadian rhythms.

bioRxiv · Vandenberghe A et al.

Animals26 Sep

Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice

The herbal extract activates AMPK-SIRT1 signaling, enhancing antioxidant defenses and modulating apoptosis to alleviate tissue aging across both model organisms.

Biogerontology · Pu Y et al.

Protein kinase C θ deletion ameliorates bleomycin-induced pulmonary fibrosis via the improvement of SIRT1/AMPK signaling on autophagy and senescence

AnimalsIranian Journal of Basic Medical Sciences

26 Sep

Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells

The paper

More on NAD+ & sirtuins

Macrophage CD38 drives age-related placental senescence by depleting NAD+

Activating Sirt1 reduces aortic valve calcification in mice and human cells

AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1

Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice

Protein kinase C θ deletion ameliorates bleomycin-induced pulmonary fibrosis via the improvement of SIRT1/AMPK signaling on autophagy and senescence