SIRT1 overexpression
Intervention1 paper2 findings
- Animals1
Outcomes
2NRF2–KEAP1 antioxidant response
upin human cells1
1 study
NRF2–KEAP1 antioxidant response
upin human cells1
SIRT1 overexpression activates NRF2–KEAP1 antioxidant response in human cells.
Cellsosteogenic inductionpcDNA3.1-Sirt1 transfectionaortic valve interstitial cell
Activating Sirt1 reduces aortic valve calcification in mice and human cells · International journal of molecular medicine · 25 Sep 2026
Ferroptosis
downin human cells1
1 study
Ferroptosis
downin human cells1
SIRT1 overexpression inhibits ferroptosis in human cells.
Cellsosteogenic inductionpcDNA3.1-Sirt1 transfectionaortic valve interstitial cell
Activating Sirt1 reduces aortic valve calcification in mice and human cells · International journal of molecular medicine · 25 Sep 2026
Latest
1Activating Sirt1 reduces aortic valve calcification in mice and human cells
The sirtuin protects valves by activating the Nrf2 pathway, preserving mitochondrial function, and preventing iron-driven ferroptosis.