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Human trial·Peer-reviewed
The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.
Nature metabolism · 1 Oct · Koning M, Kovynev A, Fondevila MF et al.
Humans·Preprint
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
medRxiv · 1 Oct · Simpson DJ, Crofts SJ, Mavrommatis C et al.
Animals·Preprint
Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.
bioRxiv · 30 Sept · Shabanian K, Shabanian T, Da Dalt L et al.
Animals·Peer-reviewed
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Chinese journal of natural medicines · 1 Oct · Wang Y, Yin G, Niu M et al.
Animals·Peer-reviewed
Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.
Biochimica et biophysica acta. General subjects · 30 Sept · Xu J, Yang J, Sun W et al.
