BAG3 knockout
Intervention1 paper3 findings
- Cells1
Outcomes
3Amyloid-beta
downin human cells1
1 study
Amyloid-beta
downin human cells1
BAG3 knockout impairs amyloid-beta in human cells.
Cellscocultured with APP/PSEN1 mutant neuronsCRISPR/Cas9 editingastrocyte
Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease · Proceedings of the National Academy of Sciences of the United States of America · 28 Sep 2026
Ubiquitin–proteasome system
downin human cells1
1 study
Ubiquitin–proteasome system
downin human cells1
BAG3 knockout decreases ubiquitin–proteasome system in human cells.
Cellsin BAG3-deficient astrocytesCRISPR/Cas9 editingastrocyte
Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease · Proceedings of the National Academy of Sciences of the United States of America · 28 Sep 2026
Autophagy
downin human cells1
1 study
Autophagy
downin human cells1
BAG3 knockout decreases autophagy in human cells.
Cellsin BAG3-deficient astrocytesCRISPR/Cas9 editingastrocyte
Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease · Proceedings of the National Academy of Sciences of the United States of America · 28 Sep 2026
Latest
1Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease
Loss of the chaperone mediator in human astrocytes disrupts autophagy, proteasomes, and retromer traffic while impairing amyloid-beta proteostasis in neuron cocultures.