Altered intercellular communication
Hallmark of aging61 papers3 findings
- Human trial2
- Humans6
- Animals21
- Model organisms1
- Cells5
- In silico1
Upstream
1Hbegf
mediatesin rat cells1
1 study
Hbegf
mediatesin rat cells1
Hbegf mediates altered intercellular communication in rat cells.
CellsLSEC-hepatocyte interaction
Activating soluble guanylate cyclase restores amyloid-beta and LDL clearance in aged rats · The Journal of biological chemistry · 26 Sep 2026
Associations
2Exercise
mixedin humans1
1 study
Exercise
mixedin humans1
Exercise is associated with altered intercellular communication in humans.
Review
Muscle-brain crosstalk in sarcopenia and cognitive impairment: endocrine signaling, metabolic regulation, and exercise modulation · Frontiers in endocrinology · 16 Sep 2026
DNA damage response
upin mice1
1 study
DNA damage response
upin mice1
DNA damage response is associated with altered intercellular communication in mice.
Animalsbrain
Brain cells organize into distinct DNA repair niches during mouse aging · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint
Latest
61Aged human muscle secretes an enzyme that impairs stem cell maintenance
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
Neuropeptide signaling drives lipid breakdown during dietary restriction in roundworms
A relay involving sensory neurons, interneurons, and gut receptors coordinates fat mobilization when food intake drops.
Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
Altered cell communication impairs muscle recovery in older women after disuse
Single-nucleus sequencing reveals disrupted signaling between satellite cells and fibro-adipogenic progenitors during muscle regrowth in older females.
Deleting beta-catenin in mouse disc cells lowers inflammation and immune cell recruitment
Simulating age-related declines in disc Wnt signaling blunted chemotactic gene expression and cut injury-induced myeloid infiltration roughly in half.
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
Cathelicidin peptide aids fracture healing in young mice but impairs it in aged mice
Depleting Camp accelerated bone callus formation in aged mice while delaying repair in young mice through P2X7 receptor and NLRP3 signaling.
Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia
Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.