SEC filing ·
BioAge Labs files an 8-K with the SEC The filing reports other events.
Industry, trials and policy
News
What companies, regulators and the press said about aging biology this week, in our own words, with the source a tap away.
Yesterday
Regulatory
FDA will highlight aging and longevity medicine in regulatory science agenda
FDA Chief Scientist Steven Kozlowski announced that early fiscal year 2027 updates to the FARS will address longevity medicine and aging.
Research
Faster epigenetic aging links to subsequent cognitive and memory decline
Epigenetic clock measures track with future memory loss, though the biological reasons why these machine-learning-derived DNA methylation patterns predict decline remain unexplained.
Conference
Hong Kong summit honors ten longevity innovations across six nations
The awards recognized ten organizations working across AI, mobility, diagnostics, mitochondria, and regenerative medicine, including a cerebrospinal-fluid assay.
Funding
Tokyo startup Time Traveler advances in 101 million dollar XPRIZE Healthspan
Time Traveler was selected as a Milestone 2 Awardee in the 101 million dollar XPRIZE Healthspan competition for its plant-based longevity approach.
Regulatory2 sources
FDA officials outline approval pathways for longevity therapies at ARDD
Agency leadership described regulatory approaches for treatments targeting aging at ARDD 2026, marking longevity as an agency priority.
Research
David Sinclair's team finds small molecules that restore cells to youthful states
Researchers report identifying chemical compounds that rejuvenate cells, raising possibilities for an oral medication designed to broadly counter biological aging.
Other
Early stem cell therapies work via paracrine signaling rather than engraftment
First-generation cell therapies deliver benefits by transiently signaling native tissues to suppress inflammation rather than by surviving and directly engrafting into injured sites.
Research
Gut microbial polyamines influence cellular function and lifespan in flies
Research in flies shows that polyamines produced by gut microbes affect host longevity, linking microbiome metabolite production to aging.
Conference
Arvinas will report Phase 1 Parkinson's biomarker data
The company scheduled Phase 1 clinical trial biomarker presentations in Seoul for ARV-102, an investigational PROTAC degrader targeting LRRK2.
Company
Amprion and Prema Cognition partner to advance early neurodegenerative disease screening
The companies will link Prema’s fifteen-minute digital memory exam with Amprion’s seed-amplification technology to guide patients from initial screening through biomarker confirmation.
Conference
MitoRx Therapeutics presents preclinical data on lead molecule MTRX31
In diet-induced obese mice, the company reports that small molecule MTRX31 restored hepatic mitochondrial density per tissue area in an Oxford University study.
Trials2 sources
Monte Rosa shares positive Phase 1 trial data for MRT-8102
The four-week trial of 108 obese individuals at high cardiovascular risk showed sustained NEK7 degradation to counter heart inflammation, the company reports.
Research
Physical functional decline manifests years ahead of clinical cardiovascular disease
A JAMA Cardiology study reports that human physical capacity deteriorates many years before apparent cardiovascular events develop.
Thursday 1 October
Other
Healthspan metrics may fail to reflect progress in rejuvenation biotechnology
Because aging stems from multiple distinct causes, treating an individual cause may advance rejuvenation without producing measurable gains in overall healthspan.
Research
A top scientific journal highlights discoveries in menopause and chronic pain
The special issue reviews recent findings in women's health while underscoring unresolved research questions surrounding pain and menopause.
Trials2 sources
Trevogrumab prevents muscle loss during semaglutide treatment in Phase 2 trial
In an MRI substudy of the COURAGE trial, trevogrumab reduced semaglutide-associated muscle loss by 70 percent during weight reduction.
Research
Adherence to the MIND diet delays brain shrinkage in adults
Following the MIND diet correlated with reduced loss of grey matter, an effect comparable to delaying brain aging by roughly 2.5 years.
Research
Artery imaging uncovers hidden plaques in young, healthy adults
In a study of 16,000 healthy participants, arterial plaques appeared in roughly one in 13 adults under 30 years old.
Research
Pericytes carrying APOE2 better preserve the aging blood-brain barrier
Investigating how APOE variants lower dementia risk reveals that pericytes with the APOE2 allele strengthen vascular barrier integrity against age-related leakage.
Company
Longevica Therapeutics establishes advisory board to guide clinical transition
Following screening of 1,033 small molecules in mammals, the company formed a scientific advisory board and named Dr. Prasun Mishra as chief executive.
Research
Experimental interventions reverse vascular damage driven by the APOE4 gene
Researchers mitigated vascular and protein clearance defects caused by APOE4 in experimental models, revealing prospective therapeutic targets for neurodegenerative disorders.
Research
Blood protein alterations during menopause reveal mechanisms of cognitive risk
Tracking shifts in circulating proteins may explain menopause-related cognitive symptoms and suggest approaches to prevent dementia later in life.
Wednesday 30 September
Company
NeuroAge Therapeutics and academic partners launch six-month aging clock trial
The Younger competition will evaluate several biological aging clocks alongside partners including TruDiagnostic, Vero Bioscience, and Harvard researchers.
Research
Geomagnetic field shielding alters mitochondrial function and lifespan in flies
Shielding flies from natural geomagnetic fields altered mitochondrial function and longevity, demonstrating that low field strength influences cellular biochemistry.
Funding
Immortal Dragons invests in patient-matched cell startup Renewal Bio
The $40 million longevity fund backed the Israeli regenerative medicine company to support its Stembroid platform for producing patient-matched cells through natural developmental programs.
Research
Creatine supports muscle gains in middle-aged adults without workouts
A 12-week study showed creatine increased muscle mass and strength in middle-aged adults without exercise, with further improvements when paired with training.
Research
Structural studies reveal how abnormal tau propagates like prions in neurodegeneration
Research published in Nature indicates that fibrillized tau prompts normal tau to misfold, operating like self-propagating prions across neurodegenerative diseases.
Research
Speech clock tool predicts accelerated aging through vocal pitch and emotion
Researchers developed an artificial intelligence tool that assesses biological aging based on the pitch and emotional traits of human speech.
Tuesday 29 September
Research
Preprint finds transplanted hearts shift toward the recipient's epigenetic age
Donor heart tissue mirrors the molecular age and potential function of recipients, findings that could help inform organ rejuvenation strategies and donor availability.
Research
Large brain imaging study links specific psychiatric and cognitive disorders to accelerated aging
An MRI analysis showed that Alzheimer's disease and mild cognitive impairment exhibited the most pronounced accelerated brain aging, while ADHD and autism displayed no notable changes.
Monday 28 September
Research
Researchers design deep learning biomarker to assess overall SASP burden
The SASP Score uses deep learning to measure circulating senescence-associated secretory phenotype factors in blood, offering a tool to track systemic senescent cell burden.
Research
Urolithin A enhances cardiac performance in animal and engineered tissue models
In animal models and engineered human heart tissue, the gut metabolite improved cardiac function by up to 80% while decreasing fibrosis and pathological enlargement.
Research
Peripheral lymph node activation of immune cells drives Alzheimer's pathology in mice
Inhibiting damaging immune cells before they migrate from peripheral lymph nodes into the nervous system reduced neurodegeneration and protected cognitive function in mice.