NAD+ & sirtuinsReviewPreprint3 Oct 2026

Pulsed Reductive Impulses via Donor Addition or Acceptor Subtraction: A Novel Paradigm for Anti-Cancer and Anti-Aging Metabolic Therapy

Preprints.org

The paper

Freschi M

Preprints.org · 2 Oct 2026 · Preprint, not yet peer-reviewed

doi.org/10.20944/preprints202604.0237.v4 Europe PMC

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Pulsed Reductive Impulses via Donor Addition or Acceptor Subtraction: A Novel Paradigm for Anti-Cancer and Anti-Aging Metabolic Therapy

The paper

More on NAD+ & sirtuins

Macrophage CD38 drives age-related placental senescence by depleting NAD+

Activating Sirt1 reduces aortic valve calcification in mice and human cells

AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1

Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice

Protein kinase C θ deletion ameliorates bleomycin-induced pulmonary fibrosis via the improvement of SIRT1/AMPK signaling on autophagy and senescence