Fisetin
InterventionSenolytics1 paper2 findingsPubChem 5281614ChEBI 42567MeSH C017875
- Animals1
Outcomes
2Pathogenic capacity of CD4+ T cells
downin mice1
1 study
Pathogenic capacity of CD4+ T cells
downin mice1
Fisetin decreases pathogenic capacity of CD4+ T cells in mice.
AnimalsCD4-positive alpha-beta T cell
Senescent CD4 T cells drive age-associated autoimmunity in mice and humans · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint
Chronic inflammation
downin humans1
1 study
Chronic inflammation
downin humans1
Fisetin decreases chronic inflammation in humans.
“While some studies reported favorable changes in metabolic or inflammatory outcomes, others found no clear or significant clinical benefit.”
Reviewin some human clinical trials
Clinical Translation of Fisetin for Age-Related Diseases: Current Evidence and Future Opportunities · Nutrients · 14 Sep 2026
Latest
2Senescent CD4 T cells drive age-associated autoimmunity in mice and humans
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.