Brain aging

Centenarians and oldest olds in Liguria - COOL: A multidisciplinary cohort study to investigate the genetic determinants of cognitive well-being in Genoa, Italy. Rationale, study protocol and baseline cohort profile

Experimental gerontology · 1 Oct · Di Maria E, Gualco C, Muscolino E et al.

Muscle-brain crosstalk in sarcopenia and cognitive impairment: endocrine signaling, metabolic regulation, and exercise modulation

Frontiers in endocrinology · 16 Sept · Tian H, Huang L, Liu H et al.

Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease

The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.

bioRxiv · 1 Oct · Alsolami S, Wang M, Sarraf Sabedot T et al.

Differential effects of amyloid-β and tau on UCH gene expression in Drosophila models of Alzheimer's disease

Gene · 1 Oct · Arayesh MJ, Ataellahi F, Masoudi R

Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice

The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.

Glia · 1 Dec · Cimpean A, Mizerakova J, Martinez-Varea N et al.

Speech clocks reflect dementia phenotypes and biological aging markers

A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.

Science advances · 30 Sept · Hernandez H, Pedraza LK, Santamaria-Garcia H et al.

The microbiota-proteostasis axis: implications in neurodegenerative diseases

Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct · Czyż DM, Brown BM

Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease

Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct · Morley JF

Cellular and systemic modifiers of alpha-synuclein proteostasis

Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct · Couzijn S, Ainslie AP, Herron-Bedoya A et al.

From aggregate structure to disease trajectory: the role of the proteostasis network

Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct · Tittelmeier J, Nussbaum-Krammer C

Sleep and circadian regulation of DNA repair and retrotransposons in neuronal genome stability and neurodegenerative disease mechanisms

Frontiers in neuroscience · 15 Sept · Rajhans A, Kye E, Balu V et al.

A Neutrophil Membrane-Encapsulated Pd/hCeO<sub>2</sub> Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 30 Sept · Huang L, Cheng J, Xu H et al.

Differential proteostasis imbalance and the molecular basis of distinct synucleinopathies and tauopathies

Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct · Redeker V, Melki R