Chronic inflammation

1. CHK2 inhibition decreases chronic inflammation in mice.

   Animalstransient CHK2 inhibitiongranulosa celltransientfemales

   Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice · bioRxiv · 1 Oct 2026 · Preprint

CHK2 inhibition →

1. 4-methylumbelliferone decreases chronic inflammation in mice.

   Animalsbrain

   Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice · Glia · 1 Oct 2026

4-methylumbelliferone →

1. Gastrodia elata polysaccharides decrease chronic inflammation in mice.

   Animals

   Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice · Food science & nutrition · 30 Sep 2026

Gastrodia elata polysaccharides →

1. Neutrophil membrane-encapsulated pd/hceo2 nanoparticles decrease chronic inflammation in mice.

   Animalsin aged PND modelneutrophil membrane-encapsulatedbrain

   Biomimetic nanozymes reduce neuroinflammation and cognitive decline in aged mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 30 Sep 2026

Neutrophil membrane-encapsulated pd/hceo2 nanoparticles →

1. Sunscreen decreases chronic inflammation in human cells.

   Cellsfollowing ultraviolet B exposuretopical sunscreenskin

   Long-term human skin platform models chronic inflammation and senolytic treatments · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 29 Sep 2026

Sunscreen →

1. Tofacitinib decreases chronic inflammation in human cells.

   Cellssustained IL-17/IL-22 stimulationskin3 weeks

   Long-term human skin platform models chronic inflammation and senolytic treatments · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 29 Sep 2026

Tofacitinib →

1. Ghrelin decreases chronic inflammation in mice.

   “Ghrelin treatment improved cognitive function, attenuated microglial senescence, and suppressed inflammation”

   Animals

   Ghrelin alleviates aging-related cognitive impairment by restoring microglial autophagy · Aging cell · 29 Sep 2026

Ghrelin →

1. Car-t cell therapy decreases chronic inflammation in mice.

   Animalstargeting of aged inflammatory bone marrow myeloid progenitorsintravenous CAR T cellsbrain

   CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice · bioRxiv · 28 Sep 2026 · Preprint

Car-t cell therapy →

1. Crebanine decreases chronic inflammation in rats.

   Animalssevoflurane exposurehippocampusmales

   Crebanine protects aged rats from anesthesia-induced cognitive deficits by restoring mitophagy · Research Square · 28 Sep 2026 · Preprint

Crebanine →

1. PLXDC2 knockdown decreases chronic inflammation in mice.

   “and its silencing attenuates neuroinflammation and oxidative stress.”

   AnimalssiRNA

   Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

PLXDC2 knockdown →

1. Chronic inflammation increases sarcopenia in humans.

   Review

   The Interplay of Metabolic Dysfunction, Neuroinflammation, and Mitochondrial Dysfunction in Balance Impairment: Insights from Type 2 Diabetes Mellitus and Alzheimer's Disease · Molecular neurobiology · 25 Sep 2026

Sarcopenia →

1. Chronic inflammation impairs physical function in humans.

   Review

   The Interplay of Metabolic Dysfunction, Neuroinflammation, and Mitochondrial Dysfunction in Balance Impairment: Insights from Type 2 Diabetes Mellitus and Alzheimer's Disease · Molecular neurobiology · 25 Sep 2026

1. Mitochondrial dysfunction induces chronic inflammation.

   Review

   Mitochondria and associated complexes as therapeutic targets in aging: From biomacromolecular structure-function insights to clinical translation · Mitochondrion · 1 Oct 2026

2. Mitochondrial dysfunction increases chronic inflammation in humans.

   Review

   Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder · Nature reviews. Nephrology · 24 Sep 2026

Mitochondrial dysfunction →

1. Chek2 increases chronic inflammation in mice.

   Animalsgranulosa cellfemales

   Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice · bioRxiv · 1 Oct 2026 · Preprint

Chek2 →

1. Neutrophil increases chronic inflammation in mouse cells.

   Cellsexposure to conditioned media from aged neutrophils or IL-6-stimulated neutrophil-like cellsvascular smooth muscle and hepatocyte-derived cells

   Aging remodels mouse neutrophils across organs to drive inflammatory and senescence responses · Aging cell · 30 Sep 2026

1. Upper gastrointestinal cancer increases chronic inflammation in humans.

   Humans

   Investigating immunological, transcriptomic and metabolomic signatures and their association with pneumonia after upper gastrointestinal cancer surgery · Research Square · 29 Sep 2026 · Preprint

Upper gastrointestinal cancer →

1. Epigenetic alterations increase chronic inflammation in humans.

   Reviewin chronic environmental exposuresbrain

   Neuroepigenetics of the Environmental Exposome: Molecular and Clinical Implications in Neurodegeneration · The neurologist · 28 Sep 2026

Epigenetic alterations →

1. cGAS–STING signalling activates chronic inflammation.

   Reviewduring brain agingbrain

   [Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging] · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 1 Jul 2026

cGAS–STING signalling →

1. Chronic inflammation is associated with mitophagy in human cells.

   Cellsin high proinflammatory response THP-1 cybridsTHP-1

   Increased mtDNA Polymorphism Level and Defective Mitophagy are Associated With Proinflammatory Activation in THP-1-Based Cybrids · Frontiers in bioscience (Elite edition) · 1 Sep 2026

2. Mitophagy is associated with chronic inflammation in humans.

   “Mitochondrial dysfunction and impaired mitophagy remain fundamental, yet incompletely understood, mechanisms driving pancreatic β-cell failure, chronic inflammation, insulin resistance and diabetic complications.”

   Reviewimpaired mitophagy

   Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective · Biomedicines · 24 Aug 2026

Mitophagy →

1. Ferroptosis is associated with chronic inflammation in humans.

   Review

   Ferroptosis-Driven Inflammaging in Age-Associated Degenerative Disorders: Molecular Mechanisms and Therapeutic Potential of Natural Products · Ageing research reviews · 1 Oct 2026

Ferroptosis →

1. Chronic inflammation is associated with non-communicable disease in humans.

   Review

   Chronic Inflammation as an Underlying Pathogenetic Mechanism of Chronic Non-Communicable Diseases: Molecular, Cellular, and Therapeutic Dimensions · Preprints.org · 30 Sep 2026 · Preprint

Non-communicable disease →

1. Epstein-barr virus infection is associated with chronic inflammation in humans.

   Review

   Lifelong Epstein-Barr virus persistence as a stress test of ageing immune surveillance: from infectious mononucleosis to chronic active EBV disease and virus-associated malignancy · Ageing research reviews · 30 Sep 2026

Epstein-barr virus infection →

1. Clonal hematopoiesis of indeterminate potential is associated with chronic inflammation in humans.

   Review

   Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment · Nature immunology · 30 Sep 2026

Clonal hematopoiesis of indeterminate potential →

1. Spaceflight is associated with chronic inflammation in silico.

   In silicoage-conserved signaturekidney55–58 daysfemales

   Spaceflight Is Associated with an Age-Conserved Kidney Transcriptomic Signature Linked to Inflammation, Tubular Channelopathy, and Senescence · Preprints.org · 29 Sep 2026 · Preprint

Spaceflight →

1. Chronic inflammation is associated with pneumonia in humans.

   Humanspre-operative baseline in UGI surgical patientsn = 13

   Investigating immunological, transcriptomic and metabolomic signatures and their association with pneumonia after upper gastrointestinal cancer surgery · Research Square · 29 Sep 2026 · Preprint

Pneumonia →

1. Cellular senescence is associated with chronic inflammation in humans.

   “while senescent mesenchymal cells may amplify inflammation via SASP.”

   Reviewin oral lichen planus (OLP)oral mucosa

   T-cell senescence and immunosenescence in chronic oral mucosal inflammatory diseases: mechanisms and therapeutic implications · Journal of oral microbiology · 27 Sep 2026

Cellular senescence →

1. Chronic inflammation is associated with female infertility in humans.

   “Progressive extracellular matrix remodeling, stromal fibrosis, chronic inflammation, and heightened tissue stiffness seem to affect follicular homeostasis, granulosa-oocyte communication, and ovarian function.”

   Reviewovaryfemales

   The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility · Current issues in molecular biology · 8 Sep 2026

Female infertility →

1. Chronic inflammation is associated with mitochondrial dysfunction in human cells.

   Cellsin high proinflammatory response THP-1 cybridsTHP-1

   Increased mtDNA Polymorphism Level and Defective Mitophagy are Associated With Proinflammatory Activation in THP-1-Based Cybrids · Frontiers in bioscience (Elite edition) · 1 Sep 2026

Mitochondrial dysfunction →