SEPHIN1
Intervention1 paper4 findingsPubChem 9561611ChEBI 233229
- Cells1
Outcomes
4Parkinson's disease
downin mice1
1 study
Parkinson's disease
downin mice1
SEPHIN1 decreases Parkinson's disease in mice.
Animalsin A53T mice
Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026
Mitophagy
upin mice1
1 study
Mitophagy
upin mice1
SEPHIN1 activates mitophagy in mice.
Animalsin A53T mice
Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026
Motor dysfunction
downin mice1
1 study
Motor dysfunction
downin mice1
SEPHIN1 decreases motor dysfunction in mice.
Animalsin A53T mice
Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026
Oxidative stress and ROS signalling
downin human cells1
1 study
Oxidative stress and ROS signalling
downin human cells1
SEPHIN1 decreases oxidative stress and ROS signalling in human cells.
Cellsin PFFs-stimulated cells
Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026
Latest
1Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models
The compound directly binds Prohibitin-2 to activate PINK1-PRKN-dependent clearance of damaged mitochondria, easing motor deficits in transgenic mice.