Stem cell exhaustion
Hallmark of aging48 papers6 findings
Human cohorts link stem cell exhaustion to bone marrow, whilst human skeletal muscle cells associate it with SMPD1. Knocking out LIN28B induces exhaustion in cultured mouse haematopoietic cells, and tissue-specific associations occur in killifish and Botryllus schlosseri.
- Human trial1
- Humans4
- Animals10
- Model organisms3
- Cells10
Interventions
1LIN28B knockout
upin mouse cells1
1 study
LIN28B knockout
upin mouse cells1
LIN28B knockout induces stem cell exhaustion in mouse cells.
Cellsfollowing ex vivo expansion cultureshematopoietic stem cell
Fetal gene Lin28b improves ex vivo expansion of aged mouse blood stem cells · Blood · 1 Oct 2026
Associations
4Bone marrow
downin humans2
2 studies
Bone marrow
downin humans2
Stem cell exhaustion is associated with bone marrow in humans (r = -0.241).
Humansin individuals with higher age-adjusted stem-cell-maintenance mICblood
Blood methylation framework maps dependencies between aging hallmarks and organ aging · Qeios · 30 Sep 2026 · Preprint
Stem cell exhaustion is associated with bone marrow in humans (r = -0.241).
Humansamong people with higher age-adjusted stem-cell-maintenance mICblood
Blood methylation framework links aging hallmarks to organ patterns across humans · Preprints.org · 28 Sep 2026 · Preprint
SMPD1
upin human cells1
1 study
SMPD1
upin human cells1
SMPD1 is associated with stem cell exhaustion in human cells.
Cellsskeletal muscle
Aged human muscle secretes an enzyme that impairs stem cell maintenance · bioRxiv · 2 Oct 2026 · Preprint
Optic nerve
downin killifish1
1 study
Optic nerve
downin killifish1
Optic nerve is associated with stem cell exhaustion in killifish.
Animalsduring agingoptic nerve
Interferon-responsive oligodendrocytes emerge during white matter aging in killifish · bioRxiv · 25 Sep 2026 · Preprint
Brain
downin B. schlosseri1
1 study
Brain
downin B. schlosseri1
Stem cell exhaustion is associated with brain in B. schlosseri.
Model organismsacross cyclic renewalbrain
Neural stem cell exhaustion disrupts central nervous system renewal in aging colonial chordates · bioRxiv : the preprint server for biology · 13 Sep 2026 · Preprint
Latest
48Aged human muscle secretes an enzyme that impairs stem cell maintenance
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
Melissic acid reduces senescence in human stem cells via cAMP signaling
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Altered cell communication impairs muscle recovery in older women after disuse
Single-nucleus sequencing reveals disrupted signaling between satellite cells and fibro-adipogenic progenitors during muscle regrowth in older females.
Aging impairs blastema formation and tissue regeneration in Cladonema jellyfish
Older jellyfish medusae exhibit cell loss, heightened DNA damage, and defective wound closure that limit complex tentacle regrowth.
Cathelicidin peptide aids fracture healing in young mice but impairs it in aged mice
Depleting Camp accelerated bone callus formation in aged mice while delaying repair in young mice through P2X7 receptor and NLRP3 signaling.
Blood methylation framework maps dependencies between aging hallmarks and organ aging
A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand participants.
FOXO3 overexpression delays primordial follicle activation in chickens
Overexpressing the transcription factor kept avian follicles dormant and suppressed PI3K and AKT signaling during early ovarian development.