Cellular senescence

DNA methylation proxies of senescence markers track human disease and mortality

The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.

medRxiv · 1 Oct · Simpson DJ, Crofts SJ, Mavrommatis C et al.

Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.

Nature metabolism · 1 Oct · Koning M, Kovynev A, Fondevila MF et al.

Future directions of osteoanabolic therapies in osteoporosis: Integrating current anabolic agents and emerging senescence-targeted strategies

Best practice & research. Clinical rheumatology · 1 Oct · Brooks HW, Cusick NC, Wu S et al.

Crosstalk between exosomes and cellular senescence: A core vicious loop promoting α-synuclein pathology in Parkinson's disease

Neural regeneration research · 30 Sept · Mao W, Song W, Zhang Y et al.

Enhanced Extracellular Matrix Synthesis-Related Responses Induced by Ubiquinol-10 Derivatives in Human Dermal Fibroblasts

BioFactors (Oxford, England) · 1 Sept · Goto S, Harada M, Setoguchi S et al.

Senescence-associated prostate cancer cells promote fibroblast reprogramming and extracellular matrix remodeling

Neoplasia (New York, N.Y.) · 1 Oct · Lin C, Guo Q, Lai S

Early features of cellular ageing impair differentiation capacity in human lymph node fibroblasts prior to rheumatoid arthritis onset

RMD open · 1 Oct · Jiménez-Martínez M, De Jong TA, Houtman M et al.

Telomere Length Profile and Associated Clinical Factors among Tuberculosis Patients in Indonesia

International journal of mycobacteriology · 1 Jul · Fachrucha F, Andarini S, Burhan E et al.

Ormeloxifene, a non-steroidal selective estrogen receptor modulator induces senescence in breast cancer cells

Molecular biology reports · 1 Oct · Singh S, Srivastava S, Siddiqui S et al.

Artificial intelligence and in silico discovery of senolytic and senescence-associated food peptides

Food chemistry · 25 Sept · Lee CC, Suttikhana I, Ashaolu TJ

Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice

Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.

bioRxiv · 30 Sept · Shabanian K, Shabanian T, Da Dalt L et al.

Wound Healing, Senescence, and Senotherapeutics

Advances in wound care · 30 Sept · Pitcher LE, Zhu J, Schmidt EL et al.

Protective Effects of Nongxiang-Type <i>Tieguanyin</i> on the Liver of D-Galactose-Induced Aging C57BL/6 Mice via the NF-κB Signaling Pathway

Food science & nutrition · 29 Sept · Chen W, Li M, Ye L et al.

Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis

Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.

Biochimica et biophysica acta. General subjects · 30 Sept · Xu J, Yang J, Sun W et al.

The Spatiotemporal Coupling Imbalance of Senescent Grey Hair: Remodelling of the HFSC-MeSC-Niche Network and a New Paradigm of Stem Cell Senescence

Experimental dermatology · 1 Oct · Xu H, Song X

<i>Cornus officinalis</i> Fruit in the Modulation of Aging-Related Cellular Pathways: a short review

Journal of pharmacopuncture · 1 Sept · Choi YH

Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models

Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.

Chinese journal of natural medicines · 1 Oct · Wang Y, Yin G, Niu M et al.

IL-17A Induces Chondrocyte Senescence via the STAT3-OPA1-mtROS Axis in Temporomandibular Joint Osteoarthritis

Oral diseases · 30 Sept · Zhu M, Zhang C, Zhang Y et al.

Topological Quantum Biomaterials Enable Pyroptosis-Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 30 Sept · Chen Z, Mei K, Yang Y et al.