Farnesylation amino acid targeted editing
Intervention1 paper3 findings
- Cells1
Outcomes
3Progeria
downin human cells1
1 study
Progeria
downin human cells1
Farnesylation amino acid targeted editing protects against progeria in human cells.
CellsmRNA conjugated with lipid nanoparticlesneuromuscular organoid
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026
DNA repair
upin human cells1
1 study
DNA repair
upin human cells1
Farnesylation amino acid targeted editing activates DNA repair in human cells.
CellsHGPS NMOsneuromuscular organoid
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026
TP53BP1
upin human cells1
1 study
TP53BP1
upin human cells1
Farnesylation amino acid targeted editing improves TP53BP1 in human cells.
CellsHGPS NMOsneuromuscular organoid
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids · Nature communications · 31 Aug 2026
Latest
1Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.