Inflammaging

Somatic blood mutations associate with accelerated frailty and functional decline in humans

In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.

medRxiv · 1 Oct · Zhao K, Quin C, Pershad Y et al.

Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice

A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.

bioRxiv · 1 Oct · Yang L, Sun Z, Luo X et al.

Ferroptosis-Driven Inflammaging in Age-Associated Degenerative Disorders: Molecular Mechanisms and Therapeutic Potential of Natural Products

Ageing research reviews · 1 Oct · Mandlik DS, Mandlik SK

Chronic Inflammation as an Underlying Pathogenetic Mechanism of Chronic Non-Communicable Diseases: Molecular, Cellular, and Therapeutic Dimensions

Preprints.org · 30 Sept · Ivchuk V

β-Catenin-Deficient Intervertebral Disc Cells Reduce Chemotactic Transcription and Myeloid Cell Recruitment to Injured Discs of Mice

Aging cell · 1 Oct · Kroon TM, Munitz J, Ranzenigo A et al.

A 12-month structured exercise reduces epicardial adipose volume in a frequency-dependent manner and lowers serum M-CSF in community-dwelling older adults: a randomized controlled trial

Frontiers in public health · 16 Sept · Xue X, Chen S, Cheng Y et al.

Lifelong Epstein-Barr virus persistence as a stress test of ageing immune surveillance: from infectious mononucleosis to chronic active EBV disease and virus-associated malignancy

Ageing research reviews · 30 Sept · Cao Y, Liang Y, Zhao C et al.

Gut microbes from hearing loss patients trigger inner ear damage in young mice

Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.

Research Square · 30 Sept · Liu Y, Chen B, Zhang W et al.

Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia

Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.

bioRxiv · 30 Sept · Tan X, Simon M, Rosebrock D et al.

ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification

Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.

medRxiv · 29 Sept · Small A, Xue L, Ito S et al.

Hybrid-Fused Extracellular Vesicles from M2 Macrophages and Keratinocytes Attenuate Ultraviolet B-Induced Skin Photoaging via the Interleukin-4 Receptor Alpha/Janus Kinase/Signal Transducer and Activator of Transcription 3-Mediated Pathway

ACS applied materials & interfaces · 1 Oct · Hao Y, Shen Y, Chen X et al.

Age-Dependent Effects of Macrophage Derived Cathelicidin Antimicrobial Peptide on Bone Fracture Repair

bioRxiv · 30 Sept · Nguyen T, Alman B, Yahara Y et al.

Cranial bone marrow-derived monocytes promote neuroinflammation in chronic traumatic brain injury

Science translational medicine · 30 Sept · Lu Z, Wang C, Gong P et al.

CCL2 and CXCL2 are markers of delirium vulnerability in community dwelling older people

Age and ageing · 1 Sept · Moorey H, Botfield HF, Krogseth M et al.