Epoxomicin
Intervention1 paper3 findingsPubChem 11226684ChEBI 42265
- Cells1
Outcomes
3Phosphatidylserine
upin human cells1
1 study
Phosphatidylserine
upin human cells1
Epoxomicin increases phosphatidylserine in human cells.
“Physiological restoration of proteasome-inhibited RBCs caused accelerated ATP depletion, massive protein aggregation, reduced deformability, hemolysis, and phosphatidylserine exposure”
Cellsduring physiological restorationerythrocyte
Proteasome activity maintains red blood cell integrity during storage and restoration · Antioxidants (Basel, Switzerland) · 9 Sep 2026
Loss of proteostasis
upin human cells1
1 study
Loss of proteostasis
upin human cells1
Epoxomicin increases loss of proteostasis in human cells.
“Physiological restoration of proteasome-inhibited RBCs caused accelerated ATP depletion, massive protein aggregation, reduced deformability, hemolysis, and phosphatidylserine exposure”
Cellsduring physiological restorationerythrocyte
Proteasome activity maintains red blood cell integrity during storage and restoration · Antioxidants (Basel, Switzerland) · 9 Sep 2026
ATP
downin human cells1
1 study
ATP
downin human cells1
Epoxomicin decreases ATP in human cells.
“Proteasome inhibition during storage depleted ATP and altered RBC morphology without immediate oxidative damage.”
Cellsduring storageerythrocyte
Proteasome activity maintains red blood cell integrity during storage and restoration · Antioxidants (Basel, Switzerland) · 9 Sep 2026
Latest
1Proteasome activity maintains red blood cell integrity during storage and restoration
Inhibiting the proteasome accelerates ATP depletion, protein aggregation, and clearance markers in stored and aged red blood cells.