Mitophagy

1. D-allose activates mitophagy in human cells.

   Cellsnucleus pulposus cell

   D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway · Experimental & molecular medicine · 1 Oct 2026

D-allose →

1. Icariin activates mitophagy in mice.

   Animals

   Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice · Chinese journal of natural medicines · 1 Oct 2026

Icariin →

1. Natural products induce mitophagy.

   ReviewPINK1/Parkin- or BNIP3-mediatedkidney

   The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms · Mini reviews in medicinal chemistry · 30 Sep 2026

Natural products →

1. Unsaturated fatty acids activate mitophagy in worms.

   Model organisms

   Lipid metabolism regulators and snoRNPs control mitochondrial surveillance and mitophagy · GeroScience · 26 Sep 2026

Unsaturated fatty acids →

1. SEPHIN1 activates mitophagy in mice.

   Animalsin A53T mice

   Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models · Biochemical pharmacology · 25 Sep 2026

SEPHIN1 →

1. Src inhibitor induces mitophagy in mouse cells.

   Cellsmicroglia

   Blocking Src kinase reduces neuroinflammation by activating microglial mitophagy in mice · Biochemical pharmacology · 25 Sep 2026

Src inhibitor →

1. Aerobic exercise activates mitophagy.

   Review

   Autophagy in sarcopenic obesity: muscle-adipose crosstalk, metabolic regulation, and exercise-based interventions · Metabolism: clinical and experimental · 24 Sep 2026

Aerobic exercise →

1. Mitoq activates mitophagy in mice.

   Animals5XFAD mice with established Alzheimer's disease pathology

   Mitochondrial antioxidant MitoQ reduces Alzheimer's pathology in symptomatic mice · Aging and disease · 22 Sep 2026

Mitoq →

1. Nobiletin activates mitophagy.

   “The focus is placed on its antioxidant, anti-inflammatory, neuroprotective, cardioprotective, and metabolic regulatory effects, as well as its capacity to enhance mitophagy”

   Review

   Nobiletin as a Geroprotective Flavonoid: Mechanisms of Action, Therapeutic Potential, and Challenges of Bioavailability · Antioxidants (Basel, Switzerland) · 7 Sep 2026

Nobiletin →

1. Tardbp G376D mutation impairs mitophagy in human cells.

   “We show that TDP-43 G376D impairs mitophagic flux, as evidenced by reduced delivery of damaged mitochondria to lysosomes.”

   Cellsdermal fibroblast

   Mitochondrial Quality Control Impairment Is a Hallmark of TDP-43G376D ALS Patient-Derived Fibroblasts · Antioxidants (Basel, Switzerland) · 22 Aug 2026

Tardbp G376D mutation →

1. SMPD1 impairs mitophagy in human cells.

   Cellsin PD models

   Disrupted sphingolipid metabolism drives lysosomal and mitochondrial failure in Parkinson's disease · bioRxiv · 28 Sep 2026 · Preprint

SMPD1 →

1. CCN1 inhibits mitophagy in human cells.

   Cellsdecompensated hypoxic conditionsdermal fibroblast

   CCN1 upregulation in diabetic wounds suppresses PINK1/Parkin-mediated mitophagy in dermal fibroblasts by regulating HIF-1α protein stability under decompensated hypoxic conditions · Cellular signalling · 27 Sep 2026

CCN1 →

1. Chronic inflammation is associated with mitophagy in human cells.

   Cellsin high proinflammatory response THP-1 cybridsTHP-1

   Increased mtDNA Polymorphism Level and Defective Mitophagy are Associated With Proinflammatory Activation in THP-1-Based Cybrids · Frontiers in bioscience (Elite edition) · 1 Sep 2026

2. Mitophagy is associated with chronic inflammation in humans.

   “Mitochondrial dysfunction and impaired mitophagy remain fundamental, yet incompletely understood, mechanisms driving pancreatic β-cell failure, chronic inflammation, insulin resistance and diabetic complications.”

   Reviewimpaired mitophagy

   Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective · Biomedicines · 24 Aug 2026

Chronic inflammation →