Alzheimer's disease
Disease32 papers3 findingsMeSH D000544
In silico analysis associates Alzheimer's disease with the ubiquitin–proteasome system in vulnerable brain regions, while a worm study shows apigenin confers protection. Reviews link mosaic loss of the Y chromosome to increased disease risk in men.
- Humans3
- Animals7
- Model organisms3
- Cells2
- In silico1
Interventions
1Apigenin
downin worms1
1 study
Apigenin
downin worms1
Apigenin protects against Alzheimer's disease in worms.
Model organismsexpressing amyloid-beta or tau
Apigenin Improves Healthspan and Protects Against Alzheimer's Disease-Associated Proteotoxicity in C. elegans · bioRxiv · 29 Sep 2026 · Preprint
Associations
2Mosaic loss of the Y chromosome
upin humans1
1 study
Mosaic loss of the Y chromosome
upin humans1
Mosaic loss of the Y chromosome raises the risk of Alzheimer's disease in humans.
Reviewmales
Mosaic Loss of the Y Chromosome: Mechanisms and Diseases · Protein & cell · 1 Oct 2026
Ubiquitin–proteasome system
downin silico1
1 study
Ubiquitin–proteasome system
downin silico1
Alzheimer's disease is associated with ubiquitin–proteasome system in silico.
In silicoin vulnerable brain regionsbrain
A multi-region transcriptomic framework reveals global and region-specific ubiquitin-proteasome system biomarkers in Alzheimer's disease · Functional & integrative genomics · 29 Sep 2026
Latest
39Pan-AMPK activator MK-8722 improves spatial memory in Alzheimer's model mice
Systemic treatment activated liver AMPK, restored plasma metabolites, and enhanced dendritic spine maturation without altering hippocampal long-term potentiation.
Compartment-resolved brain aging reveals distinct vascular and neurodegenerative pathways
Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.