GLP-1 drugsCells
Semaglutide Attenuates Inflammatory Macrophage Polarization and Promotes Changes Associated with Mitochondrial Biogenesis Through cAMP-Dependent Signaling
Abstract · CC BY
Background/Objectives : Chronic metabolic inflammation is associated with pro-inflammatory macrophage activation and mitochondrial dysfunction.
- Exendin
- Semaglutide
- SQ22536
- Chronic inflammation
- Mitochondrial dysfunction
- GLP-1 and incretin signalling
- Mitochondrial biogenesis (PGC-1α)
- Sirtuin signalling
- CD163
- CD80
- CD86
- GLP1R
The paper
Semaglutide Attenuates Inflammatory Macrophage Polarization and Promotes Changes Associated with Mitochondrial Biogenesis Through cAMP-Dependent Signaling
Pavshintsev VV, Erbaeva AZ, Vatlin AA et al.
Biomedicines · 3 Sep 2026