Aqueous Extract of Buddleja globosa Modulates Oxidative Stress-Induced Senescence-Associated Responses in THP-1-Derived Macrophages
Abstract · CC BY
Background/Objectives : Cellular senescence and oxidative stress contribute to macrophage dysfunction and chronic inflammation during aging. Buddleja globosa (matico) is traditionally consumed as an infusion and has reported antioxidant and anti-inflammatory properties. This study evaluated whether an aqueous extract of B.
- Buddleja globosa
- Hydrogen peroxide
- Cellular senescence
- Chronic inflammation
- NF-κB signalling
- Oxidative stress and ROS signalling
- p16INK4a–RB pathway
- p53–p21 pathway
- CDKN1A
- CDKN2A
- TNF
- Senescence-associated beta-galactosidase
The paper
Aqueous Extract of Buddleja globosa Modulates Oxidative Stress-Induced Senescence-Associated Responses in THP-1-Derived Macrophages
Bravo-Sagua R, Gallardo J, Bergez D et al.
Pharmaceuticals · 12 Sep 2026