Partial reprogramming

Enhanced liver regeneration via targeted mRNA delivery for partial in vivo reprogramming

Cell reports. Medicine · 1 Oct · Jo BK, Song YS, Song W et al.

Pharmacological control of inflammation via innate immune memory manipulation

Current opinion in pharmacology · 15 Sept · Sharma C, Sharma S, Gupta S

Beyond survival: psychoneuroimmunology-driven cancer psychological rehabilitation-a paradigm shift from symptom management to biobehavioral remodeling

Frontiers in oncology · 16 Sept · Liu J, Shen Y, Liao J et al.

Mechanisms of resistance to PARP inhibitors in advanced epithelial ovarian cancer: biological determinants and therapeutic implications

Frontiers in oncology · 16 Sept · Incognito D, Ciappina G, Ettore G et al.

Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer

Molecular cancer · 17 Sept · Liu BX, Zhou L, Lai S et al.

Unravelling therapeutic resistance: role of cancer stem cell and microRNA in metastatic prostate cancer

Frontiers in molecular biosciences · 15 Sept · Moondra H, Choudhary GR, Ahirwar DK et al.

The BCG Vaccine: Pharmacological Biotechnology and Expanding Immunological Horizons

Frontiers in bioscience (Elite edition) · 1 Sept · Liu Y, Pepper M, Khatchadourian C et al.

STC2 promotes cisplatin resistance through metabolic reprogramming and lactylation-mediated epigenetic regulation in cervical cancer

Acta biochimica et biophysica Sinica · 29 Sept · Jin S, Gao D, Xiahou Y et al.

Epigenetic progression of pancreatic cancer to aggressive subtypes involves alternate routes of lineage reprogramming in subtype-intermediate progenitor cells

bioRxiv · 29 Sept · Hawthorne KA, Eng JR, Tsuda M et al.

Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives

Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions.

Journal of cellular and molecular medicine · 1 Oct · Jin C, Du D, Yu X et al.

A metabolic-epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition

Nature cardiovascular research · 28 Sept · Fan Y, Nuttall DJ, Zhao Y et al.

Epigenetic reprogramming in cadmium-associated liver injury: Evidence, mechanistic insights, and therapeutic perspectives

Environmental toxicology and pharmacology · 26 Sept · Zhang X, Liu N, Zhou J

Harnessing Medicinal Plants Through Advanced Drug Delivery: A New Era in Type 2 Diabetes Management

Type 2 diabetes mellitus (T2DM) remains a global health crisis, with nearly 589 million adults currently affected and projections pointing toward 853 million by 2050.

Pharmaceutics · 1 Sept · Dadhich A, Sharma V, Sharma S et al.

Developmental and Molecular Insights into AgNO₃-Induced Partial Masculinization and Stamen Abortion in <i>Siraitia grosvenorii</i> C. Jeffrey ex A.M. Lu and Zhi Y. Zhang

This study focuses on Siraitia grosvenorii , an economically important crop endemic to Guangxi Province, China, with significant value in both the pharmaceutical and food industries.

Plants (Basel, Switzerland) · 11 Sept · Wang Y, Pei Y, Ning K et al.

Environmental Exposures and Epigenetic Remodeling in Supraventricular Tachycardias: What Atrial Fibrillation Can and Cannot Tell Us

Supraventricular tachycardias (SVTs), including atrial fibrillation (AF), atrioventricular nodal re-entrant tachycardia (AVNRT), atrioventricular re-entrant tachycardia (AVRT), and focal atrial tachycardias, can possibly arise from the interaction of genetic predisposition and environmental exposures.

Life (Basel, Switzerland) · 9 Sept · Konstantinidis I, Tsokkou S, Keramas A et al.

CRISPR Technologies in Type 2 Diabetes: From Mechanistic Insights to Therapeutic Discovery

Type 2 diabetes (T2D) is a complex metabolic disorder driven by the interplay of genetic susceptibility, β -cell dysfunction, and insulin resistance.

International journal of molecular sciences · 19 Sept · Fan S, Liang R, Fei T

Targeted Intracellular Metal Modulation Attenuates Oxidative Stress and Preserves Retinal Integrity and Function in a Zebrafish Model of Mitochondrial Dysfunction and Age-Related Retinal Degeneration

Retinal degeneration is associated with mitochondrial dysfunction, oxidative stress, and disruption of metal homeostasis within the retinal pigment epithelium (RPE).

International journal of molecular sciences · 16 Sept · Angel I, Periyasamy K, Gladnikoff M et al.

HMGB1 Post-Translational Modifications in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma: Current Evidence, Emerging Mechanistic Concepts, and Unresolved Questions

Nasopharyngeal carcinoma (NPC) is a geographically distinct malignancy closely associated with Epstein-Barr virus (EBV) infection and characterized by extensive epigenetic reprogramming within a highly immunosuppressive tumor microenvironment (TME).

International journal of molecular sciences · 15 Sept · Lau CY, Khan KS, Kwong DL et al.

Molecular Signaling Pathways, Regulatory and Coactivator Networks, and Emerging Mechanisms in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer-related mortality worldwide. Despite advances in diagnosis and therapy, the prognosis for advanced HCC remains poor due to late-stage diagnosis, high recurrence rates, therapeutic resistance, and pronounced molecular heterogeneity.

Biomedicines · 11 Sept · Srivastava RK, Singh P, Lonard DM

Aging Biology of Bone-to-Tendon Healing and the Epigenetic Clock: A Biological-Age Readout of Rotator Cuff Healing Capacity

The "unexplained failure" of rotator cuff repair is multifactorial, but its structural endpoint is anatomically consistent, i.e., the failure of the tendon-to-bone interface (enthesis) to heal.

Biomedicines · 2 Sept · Yoon JP, Park SJ, Kim DH et al.

Bridging BET bromodomain and immune checkpoint inhibitors through generative bioorganic frameworks for next-generation cancer immunotherapy

Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that couple chromatin acetylation to oncogenic and immune-regulatory gene transcription, making them attractive targets for combination with immune checkpoint inhibitors (ICIs) in precision oncology.

RSC medicinal chemistry · 24 Sept · Diab MK, Yassen ASA, Fahmy SA et al.

Epigenetic mechanisms in traumatic brain injury: a focus on astrocytes and therapeutic implications

Traumatic brain injury (TBI) triggers complex molecular and cellular responses that persist well beyond the initial injury. Neuroinflammation is a prominent feature of the post-injury response and a significant contributor to progressive neuronal dysfunction and increased risk of chronic neurodegeneration.

Journal of neuroinflammation · 22 Jul · Li L, Bonfoey AM, Sun B et al.

Inhibition of Histone Methyltransferase G9a Hampers Early Embryonic Development through Disruption of Epigenetic Reprogramming and Transcriptomic Homeostasis

Research Square · 25 Sept · Song R, Pan X, Cheng Y et al.

Integrated cellular and molecular mechanisms of neuropsychiatric dysfunction in polycystic ovary syndrome

Journal of psychiatric research · 19 Sept · Shirasath KR, Awathale SN, Goyal SN

Potential Determinants of Progression from Cough-Variant Asthma to Classic Asthma in Children: Evidence, Mechanisms, and Clinical Research Gaps

Journal of asthma and allergy · 19 Sept · Zheng K, Ma R, Zhang Y

ISP 3 Platform powered by Geneformer: Framework for Cross-Species, Sequential, and Multi-Gene In Silico Perturbation Screens with Application to iPS Cell State Transitions

bioRxiv · 24 Sept · Sanaki Y, Shigenobu S, Niwa R

Genome-wide DNA methylation analysis of the liver in adult guinea pigs born preterm and term highlights the importance Cry1 and circadian rhythm in males

Research Square · 24 Sept · Clapham J, Dyson R, Barnes H et al.

Abasic site repair in APE1-deficient mouse embryonic stem cells: a matter for the MRN complex and ATM signaling

The dual role of base excision repair (BER) in resolving DNA base lesions and enabling active DNA demethylation positions BER proteins as central regulators of both genetic and epigenetic integrity.

Nucleic acids research · 1 Sept · Hrovat AM, Noreen F, Schwarz SD et al.

Maternal TRIM28 safeguards bovine embryonic genome activation by regulating SAM-dependent methylation via lipid metabolism

Human reproduction (Oxford, England) · 23 Sept · Zhan C, Guo J, Zhong C et al.

Aging as Loss of Biological Self-Correction: A Geroscience Framework for Longevity, Inflammaging, and Restored Resilience

Longevity science has shifted from the pursuit of lifespan extension toward preservation of healthspan, resilience, and functional independence. The hallmarks of aging provide a powerful descriptive structure, but they do not by themselves specify how diverse molecular defects translate into loss of adaptive function.

Geriatrics (Basel, Switzerland) · 16 Sept · Bar-Or D, Williams J, Paredes D

DNMT1-Mediated Epigenetic Reprogramming Drives KMT2A Amplifications and Rearrangements

bioRxiv · 22 Sept · Lineberger MA, Gray ZH, Ferman BI et al.

TEgment dissects transposable element reactivation upon CDK9 inhibition in acute myeloid leukemia

bioRxiv · 22 Sept · Prokopov D, Moussa A, Tunbak H et al.

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

bioRxiv · 23 Sept · Zhang S, Fu Z, Zhou Y et al.

Stepwise direct reprogramming of adult human dermal fibroblasts into tendon-like cells via transcription factor optimization and 3D culture

Research Square · 23 Sept · Konishi K, Kishida T, Iguchi M et al.

BORIS in Hormone-Driven Cancers: Epigenetic Reprogramming, Transcriptional Plasticity, and Therapeutic Implications

Preprints.org · 23 Sept · Saleem S, Gaughan L, Robson CN

Expression GWAS and Differential Methylome Profiling Reveal Upstream Regulators of Drought Memory Genes in Arabidopsis thaliana

Plant, cell & environment · 22 Sept · Marik D, Kumar R, Sadhukhan A

Persistent Epigenetic Reprogramming Is Associated With Contrasting Drought-Response Strategies in Citrus Scion-Rootstock Systems

Recurrent drought limits the productivity of perennial crops such as citrus, whose tolerance to water deficit largely depends on scion-rootstock interactions.

Physiologia plantarum · 1 Sept · da Silva MAA, Menezes FDS, Sammarco I et al.

Selective MicroRNA Dysregulation in IPF-Derived Mesenchymal Stromal Cells Suggests Restricted Regulatory Remodeling

The schematic workflow illustrates next-generation sequencing of lung-derived mesenchymal stromal cells (MSCs) from IPF patients and controls. Rather than broad epigenetic reprogramming, IPF-MSCs exhibit a remarkably restricted down-regulation of only three critical microRNAs: hsa-miR-373-3p, hsa-miR-486-5p, and hsa-miR-449a.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1 Sept · Di Vincenzo M, Mei F, Cavina P et al.

The telomere-to-telomere gap-free reference genome and DNA methylome unveil epigenetic regulation of proanthocyanidin biosynthesis during apricot fruit development

Apricot (Prunus armeniaca L.) is an economically significant fruit crop worldwide with remarkable germplasm diversity, and its fruit quality is primarily determined by key metabolites (e.g., sugars, organic acids, and flavonoids).

The Plant journal : for cell and molecular biology · 1 Sept · Qiang X, Zhang T, Wang M et al.

Genetic dissection of one-carbon metabolism: Roles in pluripotency and embryonic development

Developmental biology · 21 Sept · Lomelí H

Generation of an induced pluripotent stem cell line, JHUi010-A, from an arrhythmogenic cardiomyopathy patient harboring pathogenic DSG2 variant c.2358delA

Stem cell research · 17 Sept · Chua CJ, DiSilvestre D, Blazeski A et al.

Autophagy inhibition sensitizes radiotherapy responses in high-grade mutant IDH1 glioma

Nature communications · 18 Sept · Núñez FJ, Banerjee K, Mujeeb AA et al.

Dormancy and reactivation of disseminated tumor cells: From molecular mechanisms to therapeutic implications

Gene · 18 Sept · Li J, Zhu J, Yang M et al.

Histone modifications and chromatin landscapes in microglial function: Developmental imprinting and disease-associated reprogramming

Ageing research reviews · 18 Sept · Li X, Guo RL, Teng ZQ et al.

Placental dysfunction drives fetal growth restriction: mechanisms and translational perspectives

Fetal growth restriction (FGR) is a major obstetric complication characterized by the inability of the fetus to reach its genetic growth potential, most commonly due to placental insufficiency. It contributes substantially to perinatal morbidity, stillbirth, and long-term cardiometabolic disease.

Frontiers in molecular biosciences · 3 Sept · He L, Hong D, Chen H et al.

Molecular reprogramming in cutaneous melanoma: the central role of G9a and EZH2 methyltransferase inhibitors in tumor plasticity, immune evasion, and therapeutic resistance

Cutaneous melanoma remains a leading cause of skin cancer-related mortality despite significant therapeutic advances, with treatment resistance and immune evasion representing major clinical challenges.

Frontiers in pharmacology · 3 Sept · Nisimoto MYSM, de Oliveira DA, Bottura HR et al.

Mechanistic Pathways of Wound Healing: From Hemostasis to Scar-Free Regeneration

Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.

Cell biochemistry and function · 1 Sept · Mercy DJ, Girigoswami K, Girigoswami A

HBV induces immunosuppressive macrophages via metabolic and epigenetic reprogramming to facilitate the establishment of chronic persistent infection

Gut · 16 Sept · Wang Z, Liu N, Li Y et al.

DNA replication is dispensable for developmental progression, but required for heterochromatin organization at mouse zygotic genome activation

bioRxiv · 16 Sept · Arroyo-Jimenez A, Gallego A, Barral A et al.

Maternal high-fat diet and risk of cardiovascular disease in offspring: a review of mechanisms, controversies, and interventions

A high-fat diet (HFD) is a well-established risk factor for coronary artery disease (CAD). Accumulating evidence indicates that maternal nutritional status before and during pregnancy critically influences long-term cardiovascular outcomes in offspring.

Experimental biology and medicine (Maywood, N.J.) · 1 Sept · Meng H, Ruan J, Wang Q et al.