Mitochondria

Mitochondria and associated complexes as therapeutic targets in aging: From biomacromolecular structure-function insights to clinical translation

Mitochondrion · 1 Oct · Zhang X, Tao T, Liu W et al.

Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice

TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.

Aging cell · 1 Oct · Chen G, Shangguan Z, Gong J et al.

USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms

A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.

Cell reports · 30 Sept · Gordillo-García S, Fernandez-Abascal J, Hernando-Rodríguez B et al.

Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss

Molecular neurobiology · 30 Sept · Zhang S, Zhang Q, Sun N et al.

Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies

Frontiers in molecular neuroscience · 15 Sept · Otoda T, Nakajima H, Takayama T

Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice

Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.

Cell reports · 30 Sept · Matsumoto S, Seo H, Taketomi Y et al.

Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies

Ageing research reviews · 30 Sept · Bhattacharya K, Chanu NR, Khanal P et al.

D-allose reprogrammes the mitophagy-mtDNA-cGAS-STING-ADM2 axis to restore nucleus pulposus cell homeostasis in intervertebral disc degeneration

Experimental & molecular medicine · 1 Oct · Zhao Z, Li J, Lei L et al.

Icariin enhances PINK1-associated mitophagy to attenuate NLRP3/GSDMD-related microglial pyroptosis and cognitive impairment in Alzheimer's disease

Chinese journal of natural medicines · 1 Oct · Fan L, Jiang H, Yi M et al.

Regulation of cellular proteostasis via mitochondrial protein import

Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct · Nguyen NGT, Li J

The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms

Mini reviews in medicinal chemistry · 30 Sept · Wu Y, Gao J, Lin J et al.