mTOR & rapamycin

A Distinct Host-Microbiome Signature Underlies the Accelerated Malignant Potential of Colorectal Laterally Spreading Tumors

Gastro hep advances · 21 Aug · Lutsiv T, Thompson HJ, Fiehn O et al.

Chronic Inflammation as an Underlying Pathogenetic Mechanism of Chronic Non-Communicable Diseases: Molecular, Cellular, and Therapeutic Dimensions

Preprints.org · 30 Sept · Ivchuk V

Intermittent and periodic fasting: molecular mechanisms, health benefits and research challenges

Frontiers in nutrition · 15 Sept · Liu Y, Guo H

Inhalable mucus-penetrating and senescence-targeted nanoliposomes reverse senescence to overcome chemoresistance for enhanced lung cancer therapy

Biomaterials · 23 Sept · Man Y, Liu Y, Liu Y et al.

Green Extraction of Flavonoids from Cedrus deodara Pollen with Deep Eutectic Solvents and Their Potential Anti-Senescence Properties

Research Square · 29 Sept · li w, wu G, chen m et al.

Dietary CoQ10 Ameliorates Age-Related Megakaryocyte Dysfunction via COPS3-Mediated Activation of Autophagy

Age-related megakaryocyte (MK) dysfunction disrupts platelet production and may increase thrombotic risk, but whether coenzyme Q10 (CoQ10) restores MK homeostasis through autophagy remains unclear. Male C57BL/6J mice aged 1, 9, 15, 19, 21, or 23 months received CoQ10 for 12 weeks.

Aging cell · 1 Oct · Xu Y, Mao YH, Song F et al.

<i>Caenorhabditis</i> Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in <i>C. elegans</i>

The mechanistic target of rapamycin (mTOR), a protein kinase and master cell regulator, is one of the most validated longevity drug targets: mTOR inhibition by compounds like rapamycin has been shown to significantly extend lifespan in numerous model organisms.

microPublication biology · 14 Sept · Johnson E, Sedore CA, Coleman-Hulbert AL et al.

Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP

Fitoterapia · 28 Sept · Alanazi SM, Al-Kuraishy HM, Abdelaziz AM et al.

Nucleosome-scale p53–hormone receptor grammar distributed by Alu elements

bioRxiv · 28 Sept · Fu X, Cai Q, Satya P et al.

The p53–p21–Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLD

bioRxiv · 28 Sept · Torres G, Salladay-Perez IA, Deng CY et al.

RAPA triggers SFN-MDM2/p53 to alleviate pulmonary fibrosis via inhibiting AECII senescence

Research Square · 28 Sept · Liu M, Du B, Xu Z et al.

Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling

Journal of animal science · 26 Sept · Guo M, Gao Y, Zhang J et al.

Persistent Zn²⁺ Influx-Mediated Deacetylation of ANXA2 Regulates the "Zn²⁺-Autophagic Flux" and Alleviates Intervertebral Disc Degeneration

Intervertebral disc degeneration (IVDD) is an age-related disease accompanied by disrupted mitochondrial homeostasis and defective autophagy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sept · Jin Y, Chen Y, Xie Y et al.

Developing Metal-Polyphenol Network-Based Single-Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Sarcopenia has emerged as a major health challenge in the aging population. Whey protein (WP)-rich in branched-chain amino acids-is an important nutritional supplement for mitigating sarcopenia. However, the rapid digestion of WP limits its therapeutic efficacy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sept · Zhang Y, Zhang Y, Ai Y et al.

T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Renal fibrosis is a final common pathway in chronic kidney disease (CKD), yet available therapies rarely reverse established scarring. T lymphocytes are now recognized as dynamic regulators of this process rather than simple inflammatory bystanders.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sept · Li Q, Guan J, Song Y et al.

<i>Crataegus</i> Species as a Source of Geroprotective Phytochemicals: Biological Activities, Molecular Mechanisms and Therapeutic Perspectives

Population aging has intensified the search for natural compounds capable of promoting healthy aging and preventing age-related diseases. Among medicinal plants, species of the genus Crataegus (hawthorn) have attracted increasing attention because of their rich phytochemical composition and broad spectrum of biological activities.

Life (Basel, Switzerland) · 4 Sept · Kydyrbayeva A, Shalakhmetova T, Smalinskiene A et al.

The Preservation of Functional Reserve: A Control Systems Framework for Human Aging

The dominant clinical manifestation of aging is not mortality but the progressive depletion of functional reserve-the surplus physiological capacity separating independent function from disability. Existing geroscience frameworks describe molecular aging in detail yet give the point-of-care clinician little basis for prioritizing targets.

Life (Basel, Switzerland) · 31 Aug · O'Leary RT

<i>Withania somnifera</i> (Ashwagandha) Improves Fitness in Aged <i>Drosophila</i> by Reducing AKT Phosphorylation

With increasing global life expectancy, there is a growing need for strategies to mitigate age-related declines in fitness and health. Withania somnifera (WS), commonly known as ashwagandha, has been traditionally recognized by ayurvedic medicine for its benefits in promoting healthy aging.

International journal of molecular sciences · 18 Sept · Law AD, Brandes M, Bollen M et al.

Targeting Cancer Hallmarks with <i>Cirsium japonicum</i>: Molecular Mechanisms and Therapeutic Potential

Cirsium japonicum is a medicinal plant traditionally used in East Asian medicine and contains multiple bioactive constituents with potential anticancer properties. This review critically evaluates the anticancer effects of C. japonicum and its associated constituents within the Hallmarks of Cancer framework.

International journal of molecular sciences · 8 Sept · Kim KH, Yeo TK, Park SJ et al.

MORG1 Haploinsufficiency Is Associated with Stage- and Sex-Dependent Renoprotection and Signalling Alterations in Diabetic Kidney Disease

Type 2 diabetes mellitus (T2DM) is a major age-associated metabolic disease, and aging substantially contributes to the increasing burden and progression of chronic complications, including diabetic kidney disease (DKD).

International journal of molecular sciences · 8 Sept · Ihle JT, Duong L, Ziller N et al.

Rapamycin across biology and medicine: From molecular mechanisms to clinical and translational frontiers

Biochimica et biophysica acta. General subjects · 24 Sept · Nolasco LNRA, Dos Santos EVW, Trabach RSDR et al.

Autophagy in sarcopenic obesity: muscle-adipose crosstalk, metabolic regulation, and exercise-based interventions

Metabolism: clinical and experimental · 24 Sept · Jiang T, Wang X, Yao X et al.

Plasma as Proxy for Tissue Metabolism When Extending Lifespan in Mice

Despite most often used in research and medicine, it is unclear how well blood metabolite levels can reflect metabolic changes in tissues.

Metabolites · 25 Aug · Greenfield S, Brown CT, Fiehn O

Sirtuin signaling as therapeutic targets of immunosenescence

Expert opinion on therapeutic targets · 25 Sept · Calabrò A, Accardi G, Aiello A et al.

Immunity-metabolism-senescence axis in liver fibrosis: mechanistic insights, therapeutic targets, and translational opportunities

Clinical science (London, England : 1979) · 1 Oct · Cao Y, Chen Y, Tam KHP

Therapeutic Targeting of Inflammaging and Emerging Strategies for Managing Age-Related Multimorbidity: A Narrative Review

Clinical interventions in aging · 19 Sept · Ayoub NR

Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila

Nature · 23 Sept · Wang J, Cai Z, Gu J et al.

Mechanistic evidence on biological pathways affected by valproic acid: A systematic review

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 23 Sept · Drehmer I, Dos Santos AB, Carneiro RI et al.

Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice

Aging is a major risk factor for atherosclerosis and is accompanied by profound changes in the immune system, including effector T cell expansion, senescent cell accumulation, and increased pro-inflammatory signaling.

Aging cell · 1 Oct · de Mol J, de Korte DH, Depuydt MAC et al.

Immunosenescence in uveitis: From mechanistic insights to therapeutic implications

Ageing research reviews · 22 Sept · Wu Y, Zou Y, Yang M et al.

Tissue-specific aging clocks map structured aging-modulatory drug-score patterns across 49 human tissue and cell-line categories

Biogerontology · 22 Sept · Zhang D

Revisiting the Radiomimetic Effects of Caffeine on DNA: A Riddle in Need of Further Resolution

Preprints.org · 21 Sept · Alao J

mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes

Aging · 19 Sept · Bobok N

Evaluation the role of quinoa seeds in attenuation the brain cellular senescence and aging induced by D-galactose and γ-radiation in rats: insights into autophagy, telomerase activity, amyloid-β and tau proteins

Inflammopharmacology · 19 Sept · Mohamed MA, Elbakry MMM, Elbakary NM et al.

Somatic Mosaicism of the Brain: The Functional Implications of Post-Zygotic Mutations to Neural Circuits

The European journal of neuroscience · 1 Sept · Al-Hakeem MA, Almajidi YQ, Alshkarchy SS et al.

Selenium Deficiency is a Significant Risk Factor for Sarcopenia: Evidence and Selenoprotein-Mediated Mechanisms

Biological trace element research · 18 Sept · Ni Q, Wang H, Zhang J et al.

Anticipatory metabolic regulation drives the distinct and improved metabolic state of caloric restriction compared to Fasting-Refeeding cycles

Cell reports · 17 Sept · Velingkaar N, Astafev AA, Prabahar A et al.

Sex-dimorphic immune trajectories across the canine lifespan and early-life signatures of geroprotective interventions

bioRxiv · 15 Sept · Lai M, Xu F, Xu Y et al.

The Coupled Physico-Biochemical Mechanisms of Skin Aging: From Dermal Fluid Dynamics and Mechanotransduction to Nutrient-Sensing Dysfunction

Traditional theories of early skin aging have established a robust foundation by elucidating the accumulation of molecular damage, such as inflammation, oxidative stress, epigenetic drift, and telomere shortening, and related extracellular matrix (ECM) changes.

Cureus · 16 Aug · Zhang Z, Liao Y

Activation of aryl hydrocarbon receptor by cigarette smoke induces oxidative stress, autophagy impairment and cellular senescence

Cellular senescence is a core pathogenic mechanism of chronic obstructive pulmonary disease (COPD), and cigarette smoke (CS) acts as its primary risk factor. However, the molecular cascade linking CS exposure to pulmonary cellular senescence remains poorly defined.

Tobacco induced diseases · 9 Sept · Shi BY, Hu XD, Liu YC et al.

Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis

GeroScience · 16 Sept · Hasan M, Durandeau S, Thompson IR et al.

Multidimensional Regulatory Network of Cellular Senescence: From Mechanisms to Theranostics

ACS biomaterials science & engineering · 15 Sept · Lv Z, Liu Y, Liu Y et al.

Targeting MET and mTOR Synergistically Overcomes Adaptive Resistance in Glioblastoma

Glioblastoma (GBM) is the most aggressive primary brain tumor with limited therapeutic options and extremely poor prognosis. Aberrant activation of the receptor tyrosine kinase MET drives tumor progression, therapeutic resistance, and reduced survival, particularly in the mesenchymal GBM subtype.

International journal of molecular sciences · 30 Aug · Li Y, Khan H, Demirsoy S et al.

Geroprotective Effects of Drugs Modulating Metabolic Pathways: Perspectives of Pharmacology in Anti-Aging Therapy

Aging is the strongest risk factor for chronic diseases such as cardiovascular diseases, cancer, diabetes, and neurodegenerative disorders. Advances in geroscience indicate that pharmacological modulation of conserved molecular pathways may extend healthspan and delay multimorbidity.

International journal of molecular sciences · 22 Aug · Grycan M, Zyśk R, Grycan G et al.

Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK

Signal transduction and targeted therapy · 15 Sept · Yang Y, Chen H, Xiang S et al.

SFL-3D-cultured adipose mesenchymal cell-derived extracellular vesicles promote diabetic wound healing by alleviating microvascular endothelial senescence <i>via</i> PI3K/AKT/mTOR/4EBP1-mediated cap-dependent translation

Diabetic foot ulcers (DFUs) are severe complications of diabetes, and treatment options for DFUs are limited. Current research on impaired angiogenesis in DFUs predominantly relies on generic endothelial cells, which inadequately reflect the pathophysiological microenvironment of the diabetic microvasculature.

Burns & trauma · 22 Jun · Wang Y, Hu Z, Shi A et al.

Silibinin Ameliorated Lipid Accumulation Through Insulin/IGF-1 signaling Pathway in HGI C. elegans

The Journal of nutritional biochemistry · 12 Sept · Shao L, Zhang X, Xin J et al.

Resveratrol engages SIRT1/AMPK networks to restore BDNF signaling, autophagy, and mitochondrial function in age-related cognitive decline: A geroscience perspective

Progress in neuro-psychopharmacology & biological psychiatry · 12 Sept · Al-Dhahi AS, Al-Kuraishy HM, Fawzy MN et al.

AMPK activation by Aldometanib from Bigujing improves metabolic and cognitive dysfunction in aging mice

Metabolic brain disease · 12 Sept · Wang X, Zhang S, Wang Q et al.

Multi-omics approaches in idiopathic pulmonary fibrosis: from molecular mechanisms to therapeutic targets and precision medicine

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options and marked molecular heterogeneity. Despite available antifibrotic therapies, disease progression remains poorly predictable, highlighting the need for improved mechanistic understanding and therapeutic targeting.

Frontiers in pharmacology · 28 Aug · Hu W, Wang X