Hyperglycemia

1. Hyperglycemia induces cellular senescence in humans.

   “A hyperglycaemic microenvironment could damage the proximal tubular epithelial cells via mechanisms such as dedifferentiation, metabolic reprogramming, cell death and senescence”

   Reviewproximal tubular epithelial cell

   Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression-a narrative review · Frontiers in cell and developmental biology · 10 Sep 2026

Cellular senescence →

1. Hyperglycemia induces mitochondrial dysfunction in humans.

   “Chronic hyperglycaemia activates multiple pathogenic pathways, including the polyol, hexosamine, protein kinase C (PKC), and advanced glycation end-product pathways, resulting in excessive reactive oxygen species generation, mitochondrial dysfunction, inflammation”

   Reviewchronicproximal tubular epithelial cell

   Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression-a narrative review · Frontiers in cell and developmental biology · 10 Sep 2026

Mitochondrial dysfunction →

1. Hyperglycemia raises the risk of diabetic kidney disease in humans.

   “A hyperglycaemic microenvironment is a critical contributor of proximal tubular epithelial cell injury to disease initiation and progression.”

   Review

   Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression-a narrative review · Frontiers in cell and developmental biology · 10 Sep 2026

Diabetic kidney disease →