ReviewPeer-reviewed

Lifelong Epstein-Barr virus persistence as a stress test of ageing immune surveillance: from infectious mononucleosis to chronic active EBV disease and virus-associated malignancy

Ageing research reviews · 30 Sept · Cao Y, Liang Y, Zhao C et al.

The paper

Cao Y, Liang Y, Zhao C et al.

Ageing research reviews

doi.org/10.1016/j.arr.2026.103387

Our read

Relevance: Core geroscience
Newsworthiness: Routine
Evidence: Review
Status: Peer-reviewed
Topic: Inflammaging

HumansPreprint

Somatic blood mutations associate with accelerated frailty and functional decline in humans

In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.

medRxiv · 1 Oct · Zhao K, Quin C, Pershad Y et al.

Inflammaging

HumansPreprint

Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia

Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.

bioRxiv · 30 Sept · Tan X, Simon M, Rosebrock D et al.

Inflammaging

HumansPreprint

ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification

Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.

medRxiv · 29 Sept · Small A, Xue L, Ito S et al.

Inflammaging

AnimalsPreprint

Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice

A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.

bioRxiv · 1 Oct · Yang L, Sun Z, Luo X et al.

Inflammaging

AnimalsPreprint

Elevated TNFα induces hyperreactive platelets by reprogramming hematopoietic stem cells in mice

The inflammatory cytokine acts directly on stem cells rather than mature megakaryocytes, driving myeloid biasing and thromboinflammation through a persistent transcriptional program.

bioRxiv · 29 Sept · Siner JI, Brakhane M, Platten K et al.

Inflammaging