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Cranial bone marrow-derived monocytes promote neuroinflammation in chronic traumatic brain injury

Science translational medicine · 30 Sept · Lu Z, Wang C, Gong P et al.

Organ age acceleration and mortality risk reflect distinct biological processes

Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.

Research Square · 30 Sept · Na R, Shi C, Ruan X et al.

Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.

Nature metabolism · 1 Oct · Koning M, Kovynev A, Fondevila MF et al.

Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways

Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.

bioRxiv · 30 Sept · Grafton F, Rohani N, Lim WF et al.

Somatic blood mutations associate with accelerated frailty and functional decline in humans

In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.

medRxiv · 1 Oct · Zhao K, Quin C, Pershad Y et al.

Engineered cardiac transcription factor restores vision and reduces frailty in aging mice

A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.

bioRxiv · 30 Sept · Lu YRR, Shen H, Kajderowicz K et al.

Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease

The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.

bioRxiv · 1 Oct · Alsolami S, Wang M, Sarraf Sabedot T et al.

DNA methylation proxies of senescence markers track human disease and mortality

The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.

medRxiv · 1 Oct · Simpson DJ, Crofts SJ, Mavrommatis C et al.

Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids

Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.

Nature communications · 31 Aug · Kim DW, Kwon EJ, Jeon BJ et al.

Blood cell composition explains substantial variation in DNA methylation age

Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.

Genome medicine · 2 Oct · Jonkman TH, Richmond A, BIOS Consortium et al.

Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment

Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.

Nature immunology · 30 Sept · Aguilar-Navarro AG, Edun G, Gower M et al.

Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice

TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.

Aging cell · 1 Oct · Chen G, Shangguan Z, Gong J et al.

Declining ribosome function drives reproductive aging in fruit fly and mouse oocytes

A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.

bioRxiv · 30 Sept · Judson KL, Danielson KJ, Tang S et al.

Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia

Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.

bioRxiv · 30 Sept · Tan X, Simon M, Rosebrock D et al.

ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification

Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.

medRxiv · 29 Sept · Small A, Xue L, Ito S et al.

Speech clocks reflect dementia phenotypes and biological aging markers

A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.

Science advances · 30 Sept · Hernandez H, Pedraza LK, Santamaria-Garcia H et al.

Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice

A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.

bioRxiv · 1 Oct · Yang L, Sun Z, Luo X et al.

Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice

Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.

bioRxiv · 30 Sept · Shabanian K, Shabanian T, Da Dalt L et al.

D-allose reprogrammes the mitophagy-mtDNA-cGAS-STING-ADM2 axis to restore nucleus pulposus cell homeostasis in intervertebral disc degeneration

Experimental & molecular medicine · 1 Oct · Zhao Z, Li J, Lei L et al.

Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells

In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.

bioRxiv · 1 Oct · Mungo C, Bersaglieri C, Paganini D et al.