Tocilizumab
Intervention1 paper1 finding
- Humans1
Outcomes
1Valvular interstitial cell
downin human cells1
1 study
Valvular interstitial cell
downin human cells1
Tocilizumab decreases valvular interstitial cell in human cells.
Cellsaccelerated calcification from ASXL1-mutant macrophage media
ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification · medRxiv · 29 Sep 2026 · Preprint
Latest
1ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.