Conventional exercise improved physical function by 1.04 points versus usual care; virtual reality–enhanced exercise showed no clear advantage over usual care.Conventional exercise improved physical function by 1.04 points versus usual care; virtual reality–enhanced exercise showed no clear advantage over usual care.
Experiments in aged mice found better health span and fewer deaths from sepsis and inflammation after researchers raised taurine levels.Experiments in aged mice found better health span and fewer deaths from sepsis and inflammation after researchers raised taurine levels. Raising taurine also reduced deaths from sepsis, a life-threatening response to infection…
An observational study of human hippocampi collected after death found age-related gene activity patterns that differed by cell type, location and sex.An observational study of human hippocampi collected after death found age-related gene activity patterns that differed by cell type, location and sex.
Mice dependent on dietary vitamin B3 to make an energy-regulating molecule developed frailty, cataracts and shortened lifespan when researchers removed the vitamin.Mice dependent on dietary vitamin B3 to make an energy-regulating molecule developed frailty, cataracts and shortened lifespan when researchers removed the vitamin.
Experiments in worms found that reducing insulin-like signaling during development could improve reproduction and survival, but lifespan and fitness benefits depended on…Experiments in worms found that reducing insulin-like signaling during development could improve reproduction and survival, but lifespan and fitness benefits depended on temperature.
Applying mechanical force along the shinbone extended lifespan by 9.4%, or 79.5 days, in mice aged 20–24 months.Applying mechanical force along the shinbone extended lifespan by 9.4%, or 79.5 days, in mice aged 20–24 months. Experiments in mice tested whether bone’s ability to sense physical force affected whole-body aging.
In a randomized crossover trial involving young and older men, serum collected after fermented whey increased cell diameter compared with serum collected after…In a randomized crossover trial involving young and older men, serum collected after fermented whey increased cell diameter compared with serum collected after conventional whey.
Mortality risk-ranking scores were 0.747 for clinical walking speed versus 0.744 and 0.745 for two measures of everyday step rate.Mortality risk-ranking scores were 0.747 for clinical walking speed versus 0.744 and 0.745 for two measures of everyday step rate. The observational Whitehall II cohort study included 4,067 UK participants with an average age of…
The combined genetic analysis identified 14 DNA regions, including two not detected in analyses of any individual trait.The combined genetic analysis identified 14 DNA regions, including two not detected in analyses of any individual trait. A computational analysis used summary results from human genetic studies to examine six measures related to…
Becoming active was linked to a lower transition rate from independence to disability in complex daily tasks than staying inactive (relative rate 0.58).Becoming active was linked to a lower transition rate from independence to disability in complex daily tasks than staying inactive (relative rate 0.58).
In experiments with 12 mice per group, deleting the gene in bone-building cells reduced bone loss after 12 weeks of chemically induced aging.In experiments with 12 mice per group, deleting the gene in bone-building cells reduced bone loss after 12 weeks of chemically induced aging.
Compared with untreated worms, LSD extended the time until only 25% remained alive by up to 17.6%. In laboratory experiments, researchers exposed Caenorhabditis elegans…Compared with untreated worms, LSD extended the time until only 25% remained alive by up to 17.6%. In laboratory experiments, researchers exposed Caenorhabditis elegans worms to low concentrations of lysergic acid diethylamide…
In 276 neurotypical adults tested about five years apart, a nonrhythmic brain signal tracked slowing on an attention task but not changes in response control.In 276 neurotypical adults tested about five years apart, a nonrhythmic brain signal tracked slowing on an attention task but not changes in response control.
Experiments confirmed 53.8% of testable gene interactions predicted in human skin cells, a higher share than other methods or random predictions.Experiments confirmed 53.8% of testable gene interactions predicted in human skin cells, a higher share than other methods or random predictions.
Blocking CCL3, a signal that attracts immune cells, from day four after injury reduced their accumulation and accelerated wound closure in aged mice.Blocking CCL3, a signal that attracts immune cells, from day four after injury reduced their accumulation and accelerated wound closure in aged mice.
In a 16-week randomized trial of 53 adults, an inflammation marker fell after fasting began but did not change during eight weeks of diet alone.In a 16-week randomized trial of 53 adults, an inflammation marker fell after fasting began but did not change during eight weeks of diet alone.
Modeled spinal cord area peaked around the mid-30s in a cross-sectional study of 24,251 healthy or cognitively normal people aged 0–100.Modeled spinal cord area peaked around the mid-30s in a cross-sectional study of 24,251 healthy or cognitively normal people aged 0–100. They measured the size and shape of the spinal cord in the neck and built reference charts…
Experiments in worms found that boosting production of a cold-induced molecule in muscle promoted longevity and reduced protein clumping at normal or elevated…Experiments in worms found that boosting production of a cold-induced molecule in muscle promoted longevity and reduced protein clumping at normal or elevated temperatures.
At three months, participants assigned to the program improved by 1.3 more chair stands in 30 seconds than those in the control group.At three months, participants assigned to the program improved by 1.3 more chair stands in 30 seconds than those in the control group. A cluster-randomized trial in France analyzed 376 community-dwelling adults aged 60 or older.
Women had approximately four more years of estimated life than comparable men after at least a year with HIV suppressed to very low levels.Women had approximately four more years of estimated life than comparable men after at least a year with HIV suppressed to very low levels.
A randomized trial of 249 adults aged 65 or older found no differences between standard exercise and a 12-week program adding timing and coordination exercises.A randomized trial of 249 adults aged 65 or older found no differences between standard exercise and a 12-week program adding timing and coordination exercises. Their average age was 77.4 years.
Who was studied249 community-dwelling older adults with walking problems, 36 weeks
What changedWalking skills did not differ between older adults receiving added timing and coordination training and those receiving standard exercise alone
Over five years, exercise-based cardiac rehabilitation was linked to a lower rate of new dementia diagnoses than no documented cardiac rehabilitation (hazard ratio 0.70).Over five years, exercise-based cardiac rehabilitation was linked to a lower rate of new dementia diagnoses than no documented cardiac rehabilitation (hazard ratio 0.70).
The structures grew through more than 20 transfers to fresh cultures while preserving their mix of cell types and DNA integrity.The structures grew through more than 20 transfers to fresh cultures while preserving their mix of cell types and DNA integrity. In experiments with periosteal organoids—three-dimensional, lab-grown structures that model the…
Experiments in isolated hearts from 21-month-old male mice found better recovery without the protein after flow through the heart stopped and restarted.Experiments in isolated hearts from 21-month-old male mice found better recovery without the protein after flow through the heart stopped and restarted.
Each extra microgram of smoke particles per cubic meter was linked to a mortality hazard ratio—a measure of relative risk—of 1.032.Each extra microgram of smoke particles per cubic meter was linked to a mortality hazard ratio—a measure of relative risk—of 1.032. Researchers linked annual air pollution estimates to 77,470,752 US Medicare beneficiaries during…
Trained on 93 multi-tissue datasets, the computational model made smaller age-prediction errors than comparison models, including in tests on eight datasets excluded from…Trained on 93 multi-tissue datasets, the computational model made smaller age-prediction errors than comparison models, including in tests on eight datasets excluded from training.
Female flies producing human amyloid protein had a median lifespan of 47.5 days with increased Wwox gene activity, versus 29 days in controls.Female flies producing human amyloid protein had a median lifespan of 47.5 days with increased Wwox gene activity, versus 29 days in controls.
Frailty before surgery was linked to 2.35 times the adjusted odds of complications within 30 days, compared with no frailty.Frailty before surgery was linked to 2.35 times the adjusted odds of complications within 30 days, compared with no frailty. A prospective observational study followed 1,472 adults undergoing planned or emergency surgery under…
An eight-week randomized trial in 196 adults with prediabetes and short sleep found no significant added glucose or weight-loss benefit over lifestyle support alone.An eight-week randomized trial in 196 adults with prediabetes and short sleep found no significant added glucose or weight-loss benefit over lifestyle support alone. They delivered both programs individually by video call.
Experiments in diabetic mice linked the peptide’s kidney benefits to the breakdown of stored fat and reduced signs of cells entering a nondividing state.Experiments in diabetic mice linked the peptide’s kidney benefits to the breakdown of stored fat and reduced signs of cells entering a nondividing state.
In experiments with human blood-forming cells, an additional mutation reduced the defects caused by one inherited variant.In experiments with human blood-forming cells, an additional mutation reduced the defects caused by one inherited variant. The variants had been identified in two children with congenital neutropenia, a condition involving low…
A reanalysis of a randomized trial included 796 people with kidney disease and type 2 diabetes, including 307 with apparent treatment-resistant high blood pressure.A reanalysis of a randomized trial included 796 people with kidney disease and type 2 diabetes, including 307 with apparent treatment-resistant high blood pressure.
Compared with stable low burden, disability odds were 1.75 times as high with persistently high burden and 1.88 times as high with rapidly rising burden.Compared with stable low burden, disability odds were 1.75 times as high with persistently high burden and 1.88 times as high with rapidly rising burden.
A signal released by these nerves acted on immune cells to limit inflammation after kidney blood flow was interrupted and restored in mouse experiments.A signal released by these nerves acted on immune cells to limit inflammation after kidney blood flow was interrupted and restored in mouse experiments.
For one model group, the average score for distinguishing dependency outcomes fell from 0.795 in the original models to 0.592 for 12-month predictions.For one model group, the average score for distinguishing dependency outcomes fell from 0.795 in the original models to 0.592 for 12-month predictions.
In mouse experiments, pre-existing immunity to the vaccine’s protein scaffold enhanced responses to the attached bacterial antigens rather than weakening them.In mouse experiments, pre-existing immunity to the vaccine’s protein scaffold enhanced responses to the attached bacterial antigens rather than weakening them.
