In people with structural epilepsy, DNA-based age acceleration was greater in brain than blood, with median values of 7.3 versus 1.4 years.In people with structural epilepsy, DNA-based age acceleration was greater in brain than blood, with median values of 7.3 versus 1.4 years.
Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks. Male C57BL/6J mice purchased at eight weeks old were randomly assigned to groups of six in an animal experiment.
A 26-week randomized trial in adults with obesity but without type 2 diabetes found favorable changes in cholesterol-carrying particles with the three-drug combination.A 26-week randomized trial in adults with obesity but without type 2 diabetes found favorable changes in cholesterol-carrying particles with the three-drug combination.
In lab experiments, reducing alpha-synuclein, a protein, made layers of human brain blood-vessel cells leakier; suppressing an enzyme returned leakage to normal.In lab experiments, reducing alpha-synuclein, a protein, made layers of human brain blood-vessel cells leakier; suppressing an enzyme returned leakage to normal.
Experiments in young and aged mice identified a liver protein whose restoration reduced fat buildup but did not consistently reverse inflammation-related gene activity.Experiments in young and aged mice identified a liver protein whose restoration reduced fat buildup but did not consistently reverse inflammation-related gene activity.
Estimated kidney filtration rose 2.0 mL/min/1.73 m² with dapagliflozin versus 0.3 with placebo from two weeks to 12 months after treatment began.Estimated kidney filtration rose 2.0 mL/min/1.73 m² with dapagliflozin versus 0.3 with placebo from two weeks to 12 months after treatment began.
Among 176,468 men followed for a median 15.25 years, Y chromosome loss in blood cells was linked to abdominal aneurysms that caused symptoms.Among 176,468 men followed for a median 15.25 years, Y chromosome loss in blood cells was linked to abdominal aneurysms that caused symptoms.
Who was studied176,468 men free of AAA at baseline, median 15.25 years
What changedIncident symptomatic abdominal aortic aneurysm risk was higher with each standard deviation increase in chromosome Y loss (adjusted HR 1.01-1.09)
The catchThe cohort was predominantly of European ancestry
Lifestyle coaches preferred forecast-informed plans in 71.4% of paired reviews over plans based on wearable history alone.Lifestyle coaches preferred forecast-informed plans in 71.4% of paired reviews over plans based on wearable history alone. Participants in three cohorts—WEAR-ME (2,780), All of Us (22,748) and a longitudinal Fitbit cohort…
Who was studied49 participants across behavioral personas, against Generic Coaching
What changedCertified lifestyle coaches preferred counterfactual-grounded plans for overall quality in 71.4% of evaluations against 28.6% for Generic Coaching
The catchCoaching plans were evaluated offline without following users to measure real-world habit adherence
Across three hospital cohorts, models using repeated heart recordings outperformed a single-recording model for 11 of 13 outcomes.Across three hospital cohorts, models using repeated heart recordings outperformed a single-recording model for 11 of 13 outcomes. Hospital records from 189,539 patients at Beth Israel Deaconess Medical Center supported an…
In experiments involving 24 weeks of cigarette smoke exposure, mice lacking the protein had faster lung-function decline and more inflammation than their normal…In experiments involving 24 weeks of cigarette smoke exposure, mice lacking the protein had faster lung-function decline and more inflammation than their normal littermates.
Estimated shares linked to five risks were 52.3% for cardiovascular versus 16.3% for cancer deaths in women, and 44.4% versus 29.3% in men.Estimated shares linked to five risks were 52.3% for cardiovascular versus 16.3% for cancer deaths in women, and 44.4% versus 29.3% in men.
At age 45, the highest total exposure category was linked to estimated life expectancy gains of 0.64 years in the UK cohort and 1.35 in the US.At age 45, the highest total exposure category was linked to estimated life expectancy gains of 0.64 years in the UK cohort and 1.35 in the US.
Users had a lower relative rate of death than matched non-users, with a hazard ratio of 0.261 in an observational cohort of 288,260 adults.Users had a lower relative rate of death than matched non-users, with a hazard ratio of 0.261 in an observational cohort of 288,260 adults.
Experiments in male mice aged 18–24 months linked a protein from skin fat to immune cell buildup and delayed entry into the hair-growth phase.Experiments in male mice aged 18–24 months linked a protein from skin fat to immune cell buildup and delayed entry into the hair-growth phase.
Among patients with obesity and heart failure with preserved ejection fraction, exercise pressure fell 9.8 millimeters of mercury with semaglutide versus a 0.9 rise with…Among patients with obesity and heart failure with preserved ejection fraction, exercise pressure fell 9.8 millimeters of mercury with semaglutide versus a 0.9 rise with placebo.
Across 12 cohorts, type 2 diabetes was linked to a brain age gap 1.73 years higher than in people without diabetes.Across 12 cohorts, type 2 diabetes was linked to a brain age gap 1.73 years higher than in people without diabetes. The 47,994 participants from five countries contributed brain scans to a meta-analysis of 12 observational…
Cell experiments identified a pathway that activates a protein controlling lysosomes, the cell’s recycling compartments, during senescence, a state in which cells stop…Cell experiments identified a pathway that activates a protein controlling lysosomes, the cell’s recycling compartments, during senescence, a state in which cells stop dividing.
Protein-shortening mutations accounted for 34.2% of samples with the altered gene in solid cancers, versus 24.4% in blood cancers.Protein-shortening mutations accounted for 34.2% of samples with the altered gene in solid cancers, versus 24.4% in blood cancers. Human cancer datasets covering 10,639 solid tumor samples and 10,042 blood cancer samples formed…
At 68 weeks, pain scores fell 3.96 points with 9-milligram retatrutide versus 2.12 with placebo on a scale from 0 to 10.At 68 weeks, pain scores fell 3.96 points with 9-milligram retatrutide versus 2.12 with placebo on a scale from 0 to 10. Adults without diabetes who had painful knee osteoarthritis and a body mass index—a weight-to-height…
More types of recorded events were linked to stress-related disorders, with a hazard ratio of 1.62, and to anxiety, depression, other illnesses and frailty.More types of recorded events were linked to stress-related disorders, with a hazard ratio of 1.62, and to anxiety, depression, other illnesses and frailty.
Mouse experiments tracked tiny packages released by skeletal muscle after four weeks of exercise and tested their role in limiting heart damage.Mouse experiments tracked tiny packages released by skeletal muscle after four weeks of exercise and tested their role in limiting heart damage.
Of 575 blood chemicals measured in early adulthood, 11 were linked to thinking skills 23 years later, and five also to brain volume.Of 575 blood chemicals measured in early adulthood, 11 were linked to thinking skills 23 years later, and five also to brain volume. Black and White women and men in the observational CARDIA cohort had blood measurements at an…
Higher levels were linked to a lower risk of muscle loss and weakness over four years, with a hazard ratio of 0.64 per standard-deviation increase.Higher levels were linked to a lower risk of muscle loss and weakness over four years, with a hazard ratio of 0.64 per standard-deviation increase.
Loss of kidney filtering units under metabolic and cardiovascular stress led to wasting independent of calorie intake, with muscle loss and frailty-like features.Loss of kidney filtering units under metabolic and cardiovascular stress led to wasting independent of calorie intake, with muscle loss and frailty-like features.
The combined program reduced the upper blood pressure reading by 10.1 millimeters of mercury more than standard care over 18 months.The combined program reduced the upper blood pressure reading by 10.1 millimeters of mercury more than standard care over 18 months. The 1,706 adults with uncontrolled high blood pressure in Colombia and Jamaica averaged 61.4…
Average absolute age-estimation error was 7.74 years with federated training versus 8.04 years with pooled training in external testing.Average absolute age-estimation error was 7.74 years with federated training versus 8.04 years with pooled training in external testing. An independent cohort of 1,202,162 electrocardiograms—recordings of the heart’s electrical…
Compared with stable sleep duration, an increase of at least 30% was linked to a higher premature-death rate, expressed as a hazard ratio of 1.78.Compared with stable sleep duration, an increase of at least 30% was linked to a higher premature-death rate, expressed as a hazard ratio of 1.78.
Updated criteria linked sarcopenia and possible sarcopenia to higher mortality in older dialysis patients, with adjusted hazard ratios of 2.29 and 1.97, respectively.Updated criteria linked sarcopenia and possible sarcopenia to higher mortality in older dialysis patients, with adjusted hazard ratios of 2.29 and 1.97, respectively.
The model’s score for distinguishing disease from no disease was 0.80, versus 0.75 for prediction using clinical information and standard heart-tracing findings.The model’s score for distinguishing disease from no disease was 0.80, versus 0.75 for prediction using clinical information and standard heart-tracing findings.
In experiments with 22-month-old mice, a drug reduced kidney scarring and restored activity of genes involved in using fat for energy.In experiments with 22-month-old mice, a drug reduced kidney scarring and restored activity of genes involved in using fat for energy. Kidneys from 22-month-old mice were studied in experiments testing MSDC-0160, a drug that…
