An observational study of 46 healthy adults aged 20–77 linked older age to less restricted water movement and larger microscopic structural scales.An observational study of 46 healthy adults aged 20–77 linked older age to less restricted water movement and larger microscopic structural scales.
Experiments comparing male mice with and without a regulatory protein found altered fat composition and reduced senescence, a state in which cells stop dividing.Experiments comparing male mice with and without a regulatory protein found altered fat composition and reduced senescence, a state in which cells stop dividing.
Aging increased the involvement of gene-regulating proteins at more than 100,000 DNA sites in mouse hearts; endurance exercise opposed most increases.Aging increased the involvement of gene-regulating proteins at more than 100,000 DNA sites in mouse hearts; endurance exercise opposed most increases.
Experiments in fission yeast showed that the protein stabilizes machinery that joins mitochondria, the cells’ energy-producing structures, together.Experiments in fission yeast showed that the protein stabilizes machinery that joins mitochondria, the cells’ energy-producing structures, together.
An aging-pace measure showed an estimated rise of 0.13 on the study’s statistical scale from prepandemic levels across children, adolescents and adults.An aging-pace measure showed an estimated rise of 0.13 on the study’s statistical scale from prepandemic levels across children, adolescents and adults.
A measure combining breathlessness severity and duration was 2,647.9 millimeter-hours with acetazolamide versus 2,988.7 with dapagliflozin over 72 hours; lower scores…A measure combining breathlessness severity and duration was 2,647.9 millimeter-hours with acetazolamide versus 2,988.7 with dapagliflozin over 72 hours; lower scores meant more relief.
A cross-sectional study of 1,068 adults in Lithuania linked lower whole-blood levels of the molecule to heart and blood vessel disease and high blood pressure.A cross-sectional study of 1,068 adults in Lithuania linked lower whole-blood levels of the molecule to heart and blood vessel disease and high blood pressure.
Experiments in naturally aged mice found benefits from immune-cell particles, with aerobic exercise further improving selected tissue-rebuilding and movement measures.Experiments in naturally aged mice found benefits from immune-cell particles, with aerobic exercise further improving selected tissue-rebuilding and movement measures.
An experiment in young and aged mice found both higher and lower activity in gene programs in heart immune cells 24 hours after an inflammatory challenge.An experiment in young and aged mice found both higher and lower activity in gene programs in heart immune cells 24 hours after an inflammatory challenge.
An experiment involving 44 tree shrews found that liver and spleen gene activity followed human aging patterns more closely than mouse patterns.An experiment involving 44 tree shrews found that liver and spleen gene activity followed human aging patterns more closely than mouse patterns.
Infection susceptibility approximately doubled with each doubling of age in experiments involving a genetically mixed fruit fly population and 22 fly lines.Infection susceptibility approximately doubled with each doubling of age in experiments involving a genetically mixed fruit fly population and 22 fly lines.
In worm experiments, increasing a nerve-signaling molecule reduced excessive branching in aging sensory neurons without extending lifespan.In worm experiments, increasing a nerve-signaling molecule reduced excessive branching in aging sensory neurons without extending lifespan.
Restoring the protein’s activity restored nuclear structure and the ability to divide in cells from aged non-human primates and animals modeling a premature-aging…Restoring the protein’s activity restored nuclear structure and the ability to divide in cells from aged non-human primates and animals modeling a premature-aging disorder.
An observational analysis linked imipramine prescriptions to lower mortality over 10 years in Alzheimer’s patients compared with other antidepressants or none.An observational analysis linked imipramine prescriptions to lower mortality over 10 years in Alzheimer’s patients compared with other antidepressants or none.
Experiments in aged mouse neurons linked oxidative stress to looser mitochondrial DNA packaging, fewer RNA copies from that DNA and impaired energy production.Experiments in aged mouse neurons linked oxidative stress to looser mitochondrial DNA packaging, fewer RNA copies from that DNA and impaired energy production.
In an animal experiment, adding Synage to a brain region increased testosterone, sperm counts and forward sperm movement in 12-month-old mice.In an animal experiment, adding Synage to a brain region increased testosterone, sperm counts and forward sperm movement in 12-month-old mice.
Mapping 11 brain regions across five time points revealed changes to Tau’s molecular tags that might impair its breakdown in the hippocampus.Mapping 11 brain regions across five time points revealed changes to Tau’s molecular tags that might impair its breakdown in the hippocampus.
Functional worsening at discharge occurred in 29.7% of older patients after the program began, compared with 49.7% before it.Functional worsening at discharge occurred in 29.7% of older patients after the program began, compared with 49.7% before it. Six hundred patients aged 65 or older who left an Italian internal medicine ward alive were studied in a…
Unfavorable social conditions were linked to a 21% higher relative risk of a first bone or joint disease than favorable conditions.Unfavorable social conditions were linked to a 21% higher relative risk of a first bone or joint disease than favorable conditions. The 283,146 UK Biobank participants in this prospective observational study averaged 54.9 years…
At 104 weeks, a long-term blood sugar measure fell 0.7–1.0 percentage points more with semaglutide than placebo across kidney-disease groups.At 104 weeks, a long-term blood sugar measure fell 0.7–1.0 percentage points more with semaglutide than placebo across kidney-disease groups.
A global model estimated that replacing regular salt with potassium-enriched salt could avert a net 2.96 million deaths annually from cardiovascular and chronic kidney…A global model estimated that replacing regular salt with potassium-enriched salt could avert a net 2.96 million deaths annually from cardiovascular and chronic kidney disease.
Experiments in three fruit fly species challenged the idea that jumping DNA concentrated on the Y chromosome helps explain males’ shorter lives.Experiments in three fruit fly species challenged the idea that jumping DNA concentrated on the Y chromosome helps explain males’ shorter lives. Fruit flies from three species—Drosophila melanogaster, D. simulans and D.
Laboratory tests found that these cells were less able to multiply and send immune signals, and had a limited response to a type of immunotherapy.Laboratory tests found that these cells were less able to multiply and send immune signals, and had a limited response to a type of immunotherapy.
An observational study tracked 2,681 adults aged 46–65 at the start over 17 years, finding varied patterns of stability, decline and partial recovery.An observational study tracked 2,681 adults aged 46–65 at the start over 17 years, finding varied patterns of stability, decline and partial recovery.
Benchmarking studies focused on human tissues found that reference data, testing standards and experimental design shaped how well technologies detected mutations.Benchmarking studies focused on human tissues found that reference data, testing standards and experimental design shaped how well technologies detected mutations.
Experiments in mice aged 1–25 months linked excessive signaling by norepinephrine, a nerve messenger, to age-related deterioration of nerves and muscles.Experiments in mice aged 1–25 months linked excessive signaling by norepinephrine, a nerve messenger, to age-related deterioration of nerves and muscles.
Among 63 women who completed a six-week trial, the supplement was associated with a 5.89-point higher overall cognitive score than placebo.Among 63 women who completed a six-week trial, the supplement was associated with a 5.89-point higher overall cognitive score than placebo.
Five-year rates of major heart and blood vessel events were 6.1% after surgery versus 8.1% after starting medication in adults with obesity and type 2 diabetes.Five-year rates of major heart and blood vessel events were 6.1% after surgery versus 8.1% after starting medication in adults with obesity and type 2 diabetes.
In an experiment involving 48 rats, a drug-loaded gel improved tissue organization and tendon-to-bone strength after shoulder tendon repair in aged animals compared with…In an experiment involving 48 rats, a drug-loaded gel improved tissue organization and tendon-to-bone strength after shoulder tendon repair in aged animals compared with gel alone.
Longitudinal data from 15,733 older adults linked a new measure of later-life insecurity to differences in frailty between people and changes within individuals.Longitudinal data from 15,733 older adults linked a new measure of later-life insecurity to differences in frailty between people and changes within individuals.
In a six-month trial of 356 perimenopausal women, starting vaginal and gut microbial communities were linked to differences in hormone therapy responses.In a six-month trial of 356 perimenopausal women, starting vaginal and gut microbial communities were linked to differences in hormone therapy responses.
Who was studied327 perimenopausal women, 6 months, against women with P. copri-dominated microbiomes
What changedAfter hormone therapy, 4-week symptom remission was higher with P. vulgatus-dominated microbiomes: 38.7% versus 23.5% with P. copri-dominated microbiomes
The catchSymptom improvements could reflect temporal trends, placebo effects, or regression to the mean
Older trauma patients in the highest third of a weight-adjusted waist measure had a higher relative death rate than the lowest third (hazard ratio 1.72).Older trauma patients in the highest third of a weight-adjusted waist measure had a higher relative death rate than the lowest third (hazard ratio 1.72).
In mouse experiments, blocking an immune signal counteracted the harmful heart effects of losing KDM6A in blood-forming cells.In mouse experiments, blocking an immune signal counteracted the harmful heart effects of losing KDM6A in blood-forming cells. The loss increased recruitment of myeloid cells, a group of immune cells, to the injured heart.
Among women 40 and older, a male partner five years older was linked to 0.78 times the adjusted odds of a live birth.Among women 40 and older, a male partner five years older was linked to 0.78 times the adjusted odds of a live birth. Couples undergoing 22,013 first egg retrieval cycles at a specialist fertility center were included in a…
Median worst-group gaps in distinguishing outcomes were 0.028 by age, versus 0.004 by sex and 0.016 by race.Median worst-group gaps in distinguishing outcomes were 0.028 by age, versus 0.004 by sex and 0.016 by race. Researchers computationally tested four artificial intelligence models using 5.4 million electrocardiograms—recordings of…
The enzyme was identified in people who responded poorly to the diabetes drug; the authors proposed an enzyme-based approach to restoring its effectiveness.The enzyme was identified in people who responded poorly to the diabetes drug; the authors proposed an enzyme-based approach to restoring its effectiveness.
Perceived stress fell 18.7% 12 weeks after the tailored program, with greater reductions than in assessment-only and education groups.Perceived stress fell 18.7% 12 weeks after the tailored program, with greater reductions than in assessment-only and education groups. In a randomized trial, 426 adults aged 18–86 were assigned to a tailored stress program…
