In 44,526 UK Biobank participants, 10-year disease incidence differed up to 20-fold between people of the same age with different scores.In 44,526 UK Biobank participants, 10-year disease incidence differed up to 20-fold between people of the same age with different scores. Blood protein measurements from 44,526 UK Biobank participants formed the basis of an…
In male mice about 25 months old, two days of ibuprofen after disuse improved muscle function without increasing muscle mass.In male mice about 25 months old, two days of ibuprofen after disuse improved muscle function without increasing muscle mass. Male C57BL/6 mice about 4 or 25 months old underwent an experiment involving 14 days with their…
Major cardiovascular events had a hazard ratio of 0.92 versus placebo, with 1 meaning no difference; heart attacks were less frequent.Major cardiovascular events had a hazard ratio of 0.92 versus placebo, with 1 meaning no difference; heart attacks were less frequent. Among 25,871 US men aged 50 or older and women aged 55 or older, VITAL tested omega-3…
Gene activity differed between female and male turtles for 2,347 genes, or 13.4% of those analyzed. In 93 wild adult painted turtles (Chrysemys picta) spanning the entire…Gene activity differed between female and male turtles for 2,347 genes, or 13.4% of those analyzed. In 93 wild adult painted turtles (Chrysemys picta) spanning the entire lifespan, researchers studied how blood gene activity…
Two yeast lifespan measures shared regulators 1.7-fold more often than expected, but the direction of their effects agreed only 50% of the time.Two yeast lifespan measures shared regulators 1.7-fold more often than expected, but the direction of their effects agreed only 50% of the time.
Who was studiedYeast, nematodes, fruit flies, mice, and human cells
What changedHuman-cell effects matched lifespan effects for 82% of cleanup/protein-upkeep genes, against 51–54% of cell-division-arrest and inflammatory-secretion genes
The catchHuman cells were assessed for senescence, while whole organisms were assessed for lifespan
An analysis of 8.93 million adults aged 40 or older in six cohorts found that most prescription medications were linked to higher mortality.An analysis of 8.93 million adults aged 40 or older in six cohorts found that most prescription medications were linked to higher mortality.
Brain scans from 295 older adults linked age most strongly to smaller bundle size in the non-dominant groups of crossing nerve fibers.Brain scans from 295 older adults linked age most strongly to smaller bundle size in the non-dominant groups of crossing nerve fibers. Participants in the longitudinal observational Vanderbilt Memory and Aging Project were…
Mean weight fell 20.7% with 1.7 mg of each drug and 21.0% with 1.0 mg each, versus 2.0% with placebo over 68 weeks.Mean weight fell 20.7% with 1.7 mg of each drug and 21.0% with 1.0 mg each, versus 2.0% with placebo over 68 weeks. Adults without diabetes who had obesity, or overweight with at least one related complication, took part in a…
Greater accumulated frailty was linked to higher odds of developing depression across four cohorts, with odds ratios ranging from 3.46 to 6.09.Greater accumulated frailty was linked to higher odds of developing depression across four cohorts, with odds ratios ranging from 3.46 to 6.09.
A cross-sectional study of adults aged 18–75 with comparable body mass indexes linked older age to stronger senescence-related gene activity in fat inside the abdomen.A cross-sectional study of adults aged 18–75 with comparable body mass indexes linked older age to stronger senescence-related gene activity in fat inside the abdomen.
A cohort study followed 852 older siblings and 2,282 offspring and partners for up to 22 years, linking four blood proteins to longer survival.A cohort study followed 852 older siblings and 2,282 offspring and partners for up to 22 years, linking four blood proteins to longer survival. Researchers measured 326 proteins in blood plasma, the liquid part of blood.
Experiments in aged mice and isolated mouse aortas found that tiny particles released by Lactobacillus plantarum improved blood vessel relaxation and reduced oxidative…Experiments in aged mice and isolated mouse aortas found that tiny particles released by Lactobacillus plantarum improved blood vessel relaxation and reduced oxidative stress.
Low versus preserved kidney function on a second test was linked to higher death risk, with hazard ratios of 1.44 and 1.62.Low versus preserved kidney function on a second test was linked to higher death risk, with hazard ratios of 1.44 and 1.62. The 9,316 adults aged 65 or older in this two-cohort study had preserved kidney function estimated from…
Animal experiments found that aging and chronic ultraviolet B exposure changed the skin environment in ways that favored tumor growth.Animal experiments found that aging and chronic ultraviolet B exposure changed the skin environment in ways that favored tumor growth. Their skin showed increased inflammation and structural changes that led to an environment that…
Patients whose estimated age exceeded their actual age by more than five years had higher 30-day death odds than other patients (odds ratio 1.69).Patients whose estimated age exceeded their actual age by more than five years had higher 30-day death odds than other patients (odds ratio 1.69).
Genetic experiments in male and female mice aged 12–15 months also found less apathy-like behavior, assessed through activities such as nesting and burrowing.Genetic experiments in male and female mice aged 12–15 months also found less apathy-like behavior, assessed through activities such as nesting and burrowing.
At six months, symptom scores were an adjusted 6.4 points lower with hormone therapy than integrative care; at 24 months, the comparison found no clear difference.At six months, symptom scores were an adjusted 6.4 points lower with hormone therapy than integrative care; at 24 months, the comparison found no clear difference.
Across 28 diseases, median scores for distinguishing future cases from others were 0.95 versus 0.92 for a model keeping common genetic effects constant with age.Across 28 diseases, median scores for distinguishing future cases from others were 0.95 versus 0.92 for a model keeping common genetic effects constant with age.
An observational study of 28 donors linked one to three live births, compared with none, to ovarian patterns broadly opposing age-associated changes.An observational study of 28 donors linked one to three live births, compared with none, to ovarian patterns broadly opposing age-associated changes.
Laboratory experiments found that worms fed the protein through bacteria lived longer and stayed healthy longer without reduced fertility.Laboratory experiments found that worms fed the protein through bacteria lived longer and stayed healthy longer without reduced fertility. HSP90 is a protein that helps other proteins keep their shape.
Low versus normal vitamin D was linked to a 76% higher relative risk of developing frailty in China and 27% in England.Low versus normal vitamin D was linked to a 76% higher relative risk of developing frailty in China and 27% in England. Adults aged 65 or older in China and 50 or older in England and the United States made up three prospective…
Mouse embryonic stem cells reprogrammed with either of two gene-control proteins developed similar cancer-like marking patterns, despite activating different sets of…Mouse embryonic stem cells reprogrammed with either of two gene-control proteins developed similar cancer-like marking patterns, despite activating different sets of genes.
The natural experiment included 54,201 UK Biobank participants, with stronger associations among those exposed to rationing for longer during early life.The natural experiment included 54,201 UK Biobank participants, with stronger associations among those exposed to rationing for longer during early life.
Genetic experiments linked nerve-signaling molecules to a stress response and longer life in worms with restricted methionine, an amino acid used to build proteins.Genetic experiments linked nerve-signaling molecules to a stress response and longer life in worms with restricted methionine, an amino acid used to build proteins.
An imaging experiment in behaving mice found higher baseline brain-cell activity but weaker movement-driven responses in a brain region involved in memory.An imaging experiment in behaving mice found higher baseline brain-cell activity but weaker movement-driven responses in a brain region involved in memory.
Among older intensive care patients, 50.2% of kidney injury survivors recovered by discharge; frailty and other illnesses were linked to lower recovery.Among older intensive care patients, 50.2% of kidney injury survivors recovered by discharge; frailty and other illnesses were linked to lower recovery.
Tested across 20 independent fibroblast datasets, ECMExplainer used gene-activity comparisons to distinguish cell states and capture several processes related to aging.Tested across 20 independent fibroblast datasets, ECMExplainer used gene-activity comparisons to distinguish cell states and capture several processes related to aging.
Cold relative to local norms was linked to higher rates of multiple chronic conditions in 92.3% of city-and-year observations.Cold relative to local norms was linked to higher rates of multiple chronic conditions in 92.3% of city-and-year observations. Data from 23,725 adults aged 45 or older in 157 Chinese cities were linked to weather records in an…
In a two-year randomized controlled trial of 326 healthy older adults, daily walnuts had little effect on body composition compared with avoiding walnuts.In a two-year randomized controlled trial of 326 healthy older adults, daily walnuts had little effect on body composition compared with avoiding walnuts.
Among 55,263 UK Biobank participants, exposure before birth alone was linked to lower adult kidney disease risk than no rationing exposure, with a hazard ratio of 0.78.Among 55,263 UK Biobank participants, exposure before birth alone was linked to lower adult kidney disease risk than no rationing exposure, with a hazard ratio of 0.78.
Accepted, not yet published: cohort · 55,263 peopleKidney
Who was studied55,263 UK Biobank participants, against people without rationing exposure
What changedAdult kidney disease risk was lower with rationing exposure before birth alone versus no exposure (hazard ratio 0.78)
The catchOther changes around rationing’s end could account for lower kidney disease risk
