Adding scan-based age to clinical information raised a model’s prediction score for death from causes other than lung cancer from 0.69 to 0.73.Adding scan-based age to clinical information raised a model’s prediction score for death from causes other than lung cancer from 0.69 to 0.73. Researchers analysed 29,745 low-dose computed tomography scans.
An observational study of 182 people aged 90–100 and 306 adults aged 25–60 found weaker links between body-size measures and blood fats in the older group.An observational study of 182 people aged 90–100 and 306 adults aged 25–60 found weaker links between body-size measures and blood fats in the older group.
Animal experiments found that loss of an immune-signalling protein harmed early bone development but protected against age-related bone loss from middle age onward.Animal experiments found that loss of an immune-signalling protein harmed early bone development but protected against age-related bone loss from middle age onward.
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Get Plus for $49A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.
In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement. An experiment in 18-month-old mice tested TC-G 1005, a compound that activates TGR5, a…
An observational study of 100 people with colorectal cancer linked higher blood levels of an immune protein to more severe frailty.An observational study of 100 people with colorectal cancer linked higher blood levels of an immune protein to more severe frailty. They also analysed genetic data covering 264 cancer types.
Induced protein production reduced frailty progression by 44% in aged mice and was associated with a 14% extension of median lifespan.Induced protein production reduced frailty progression by 44% in aged mice and was associated with a 14% extension of median lifespan. In an experiment in aged mice, researchers induced production of SRSF1, a protein that helps…
Mitochondrial citrate metabolism drove inflammation through a pathway that acted independently of mitochondrial DNA-triggered immune signalling but cooperated with it to…Mitochondrial citrate metabolism drove inflammation through a pathway that acted independently of mitochondrial DNA-triggered immune signalling but cooperated with it to amplify inflammation.
Scans identified moderate or severe spinal fractures in 14.6% of 2,446 symptom-free UK Biobank participants aged 40–79, including people with normal bone density.Scans identified moderate or severe spinal fractures in 14.6% of 2,446 symptom-free UK Biobank participants aged 40–79, including people with normal bone density. The group included 1,151 men.
In a five-month intervention involving 42 people, sunscreen-treated arms showed smaller changes in DNA marks than the opposite arms under everyday conditions.In a five-month intervention involving 42 people, sunscreen-treated arms showed smaller changes in DNA marks than the opposite arms under everyday conditions.
An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the…An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the lab.
Long-read RNA sequencing detected switching in 19 genes in overloaded adult mouse muscle, compared with none in overloaded aged muscle.Long-read RNA sequencing detected switching in 19 genes in overloaded adult mouse muscle, compared with none in overloaded aged muscle. In an experiment in adult and aged mice, researchers mechanically overloaded skeletal muscle…
Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.
An observational study spanning 18,476 people in China linked an aging measure developed in a healthy group to chronic disease and death risk.An observational study spanning 18,476 people in China linked an aging measure developed in a healthy group to chronic disease and death risk.
An experiment in rats with puncture-induced disc degeneration tested iron-binding particles designed to target senescent cells, which have stopped dividing.An experiment in rats with puncture-induced disc degeneration tested iron-binding particles designed to target senescent cells, which have stopped dividing.
For each standard deviation increase—a measure of variation—in an inflammatory protein, the odds of muscle-related problems were 1.37–1.71-fold higher in older adults.For each standard deviation increase—a measure of variation—in an inflammatory protein, the odds of muscle-related problems were 1.37–1.71-fold higher in older adults.
Among 20,509 participants initially free of heart and metabolic disease, 783 developed multiple such conditions over a median 6.8 years.Among 20,509 participants initially free of heart and metabolic disease, 783 developed multiple such conditions over a median 6.8 years. The observational study pooled 20,509 participants initially free of cardiometabolic…
Research in models of aging, disuse and cancer-related wasting identified a fat-derived protein as a key mediator of protection from a metabolic supplement.Research in models of aging, disuse and cancer-related wasting identified a fat-derived protein as a key mediator of protection from a metabolic supplement.
The model improved prediction for 93 of 131 disease groups compared with a model based on existing disease burden.The model improved prediction for 93 of 131 disease groups compared with a model based on existing disease burden. In an observational study using Austrian inpatient records from 7.4 million patients, researchers analysed 13 years…
Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.
An evolutionary analysis of 2,171 human samples linked common mutations to expansion of normal cells, but found little advantage during progression to cancer.An evolutionary analysis of 2,171 human samples linked common mutations to expansion of normal cells, but found little advantage during progression to cancer.
An experiment in Alzheimer's disease mice found that the system also restored new neuron formation in a brain region involved in memory.An experiment in Alzheimer's disease mice found that the system also restored new neuron formation in a brain region involved in memory. In an animal experiment in mice with Alzheimer's disease, researchers tested a delivery…
Three of five tapping measures remained linked to motor reserve questionnaire scores after accounting for age in 100 healthy younger and older adults.Three of five tapping measures remained linked to motor reserve questionnaire scores after accounting for age in 100 healthy younger and older adults.
A blood-sugar measure fell 16 and 20 mmol/mol with 30 mg and 60 mg daily, versus 4 mmol/mol with placebo over 16 weeks.A blood-sugar measure fell 16 and 20 mmol/mol with 30 mg and 60 mg daily, versus 4 mmol/mol with placebo over 16 weeks. The randomised trial enrolled 155 Chinese adults aged 18–75 with type 2 diabetes.
Among 3,316 Chinese adults aged 60 or older, 1,947 (58.7%) developed frailty over seven years in an observational study.Among 3,316 Chinese adults aged 60 or older, 1,947 (58.7%) developed frailty over seven years in an observational study. Frailty is a reduced ability to cope with illness or other stresses.
Experiments in mice found that azilsartan reduced muscle fibre loss and declines in grip strength and exercise capacity when a hormone induced muscle wasting.Experiments in mice found that azilsartan reduced muscle fibre loss and declines in grip strength and exercise capacity when a hormone induced muscle wasting.
Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.
Having both conditions was linked to stroke odds 1.96 times as high in China and 2.38 times as high in England, compared with neither.Having both conditions was linked to stroke odds 1.96 times as high in China and 2.38 times as high in England, compared with neither. An observational study followed 10,153 middle-aged and older adults in China and 5,421 in…
The model categorised all high-risk cases as positive and pre-classified 40% of low-risk cases and 55% of negative cases as negative.The model categorised all high-risk cases as positive and pre-classified 40% of low-risk cases and 55% of negative cases as negative. Researchers analysed 461,576 eligible UK Biobank participants in a retrospective cohort study.
After six hours at 1.0 parts per million, mice had temporary breathing problems and lung tissue damage that remained seven days after exposure.After six hours at 1.0 parts per million, mice had temporary breathing problems and lung tissue damage that remained seven days after exposure.
Compared with matched adults without autism, social disadvantage was estimated to account for 39% of autistic adults’ higher mortality risk.Compared with matched adults without autism, social disadvantage was estimated to account for 39% of autistic adults’ higher mortality risk. Participants had a mean age of 51.6 years, and 66.4% were male.
Cell-transfer experiments in mice lacking lymphoid immune cells found that regulatory immune cells rescued regeneration inhibited by another immune-cell type.Cell-transfer experiments in mice lacking lymphoid immune cells found that regulatory immune cells rescued regeneration inhibited by another immune-cell type.
