An observational analysis of 197 older people with cardiovascular disease suggested that three small RNA molecules might serve as markers of frailty.An observational analysis of 197 older people with cardiovascular disease suggested that three small RNA molecules might serve as markers of frailty.
Experiments in genetically modified mice linked brain aging to greater activity of an inflammation-regulating pathway and reduced activity of another.Experiments in genetically modified mice linked brain aging to greater activity of an inflammation-regulating pathway and reduced activity of another.
Each blood cell carried about 300,000 acquired DNA-marking changes before birth, including more than 3,000 in large segments that remained stable for decades.Each blood cell carried about 300,000 acquired DNA-marking changes before birth, including more than 3,000 in large segments that remained stable for decades.
The main self-rated cognitive-function score changed at similar rates with buckwheat and placebo, with a difference of 0.03 during the 12-week trial.The main self-rated cognitive-function score changed at similar rates with buckwheat and placebo, with a difference of 0.03 during the 12-week trial.
Peak oxygen use increased by 2.80 milliliters per kilogram per minute more with soccer than with usual care over 14 weeks.Peak oxygen use increased by 2.80 milliliters per kilogram per minute more with soccer than with usual care over 14 weeks. Adults aged 40–70 with type 2 diabetes took part in a randomized trial involving 111 people.
An observational analysis of human lung and brain tissue mapped age-related differences in chemical marks on RNA and how RNA molecules were processed.An observational analysis of human lung and brain tissue mapped age-related differences in chemical marks on RNA and how RNA molecules were processed.
Early-adulthood activation of a stress-response protein reduced mortality risk by approximately 50% across all ages and improved nerve and muscle function in aged flies.Early-adulthood activation of a stress-response protein reduced mortality risk by approximately 50% across all ages and improved nerve and muscle function in aged flies.
In laboratory experiments, delivering several gene-regulating RNAs together enhanced activation and cell-killing responses in aged human T cells.In laboratory experiments, delivering several gene-regulating RNAs together enhanced activation and cell-killing responses in aged human T cells.
Without retraining, the model scored 0.913 for distinguishing Alzheimer’s from normal cognition and identified 95.2% of Alzheimer’s scans in the Chinese cohort.Without retraining, the model scored 0.913 for distinguishing Alzheimer’s from normal cognition and identified 95.2% of Alzheimer’s scans in the Chinese cohort. Participants averaged 66.1 years old, and 60.8% were women.
Over two years, 13.3% had persistently high, worsening frailty, while 50.5% had low, improving scores and 36.1% had moderate, stable frailty.Over two years, 13.3% had persistently high, worsening frailty, while 50.5% had low, improving scores and 36.1% had moderate, stable frailty.
An observational study initially identified 821 patients and linked resistant hypertension to stiffer arteries and blood-cell markers associated with senescence.An observational study initially identified 821 patients and linked resistant hypertension to stiffer arteries and blood-cell markers associated with senescence.
Experiments in aged mice found that clearing abnormal protein deposits around blood vessels with anselamimab restored liver regeneration after partial liver removal.Experiments in aged mice found that clearing abnormal protein deposits around blood vessels with anselamimab restored liver regeneration after partial liver removal. These deposits came from antibody fragments called light chains.
An observational analysis of 86 hippocampus samples spanning about 3–35 years linked older age to greater variation in chemical marks on DNA.An observational analysis of 86 hippocampus samples spanning about 3–35 years linked older age to greater variation in chemical marks on DNA. The researchers analyzed 86 samples: 56 female and 30 male.
A cross-sectional study of 1,068 adults in Lithuania linked lower whole-blood levels of the molecule to heart and blood vessel disease and high blood pressure.A cross-sectional study of 1,068 adults in Lithuania linked lower whole-blood levels of the molecule to heart and blood vessel disease and high blood pressure.
Fruit fly experiments identified signals that controlled the development of nutrient-absorbing gut cells; disrupting the circuit impaired renewal during aging and…Fruit fly experiments identified signals that controlled the development of nutrient-absorbing gut cells; disrupting the circuit impaired renewal during aging and shortened lifespan.
At 24 months, hypertension odds were lower with the six-month program than in the control group, with an odds ratio of 0.20.At 24 months, hypertension odds were lower with the six-month program than in the control group, with an odds ratio of 0.20. Community-dwelling adults with and without hypertension in 20 Chinese communities or villages took part…
Hospitalized adults with high frailty had 4.74 times the adjusted odds of dying in hospital compared with those with low frailty.Hospitalized adults with high frailty had 4.74 times the adjusted odds of dying in hospital compared with those with low frailty. Adults hospitalized with chronic lymphocytic leukemia, a blood cancer, were studied in an…
Patients in the lowest fifth for both sodium and chloride had 1.3- to 1.7-fold higher heart failure event and death rates than those with higher levels of both.Patients in the lowest fifth for both sodium and chloride had 1.3- to 1.7-fold higher heart failure event and death rates than those with higher levels of both.
Experiments comparing male mice with and without a regulatory protein found altered fat composition and reduced senescence, a state in which cells stop dividing.Experiments comparing male mice with and without a regulatory protein found altered fat composition and reduced senescence, a state in which cells stop dividing.
Among 6,351 adults aged 40 and older, the link between higher blood selenium and lower frailty leveled off above about 180–190 micrograms per liter.Among 6,351 adults aged 40 and older, the link between higher blood selenium and lower frailty leveled off above about 180–190 micrograms per liter.
In worm experiments, increasing a nerve-signaling molecule reduced excessive branching in aging sensory neurons without extending lifespan.In worm experiments, increasing a nerve-signaling molecule reduced excessive branching in aging sensory neurons without extending lifespan.
Life-years adjusted for health-related quality of life averaged 1.354 with planned care without dialysis versus 1.472 with dialysis preparation over 4.5 years’ average…Life-years adjusted for health-related quality of life averaged 1.354 with planned care without dialysis versus 1.472 with dialysis preparation over 4.5 years’ average follow-up.
Their joint link to mortality exceeded what adding their separate excess risks predicted, with an excess relative risk due to interaction of 0.570.Their joint link to mortality exceeded what adding their separate excess risks predicted, with an excess relative risk due to interaction of 0.570.
Muscle cells from six older adults with obesity showed no thinning after 24 hours of exposure to semaglutide or a gut hormone, compared with controls.Muscle cells from six older adults with obesity showed no thinning after 24 hours of exposure to semaglutide or a gut hormone, compared with controls.
Deaths unrelated to disease relapse reached 6.3% at one year, compared with historical rates of 25%, in 32 patients aged 60 or older.Deaths unrelated to disease relapse reached 6.3% at one year, compared with historical rates of 25%, in 32 patients aged 60 or older. Thirty-two patients aged 60 or older, with a median age of 69.3, underwent their first donor…
At age 52, cardiovascular event-free proportions were 0.98 in adults treated from childhood and 0.70 in affected parents without access to childhood statins.At age 52, cardiovascular event-free proportions were 0.98 in adults treated from childhood and 0.70 in affected parents without access to childhood statins.
Imaging in healthy adults linked older age to longer arteries, while bend spacing was consistent with predictions from a model of growth-driven buckling.Imaging in healthy adults linked older age to longer arteries, while bend spacing was consistent with predictions from a model of growth-driven buckling.
Six-minute walking distance was 64.20 meters greater with breathing-focused exercise than with no exercise, compared with 57.33 meters greater with standard exercise.Six-minute walking distance was 64.20 meters greater with breathing-focused exercise than with no exercise, compared with 57.33 meters greater with standard exercise.
Who was studied51 people with obesity, against controls receiving no exercise intervention
What changedSix-minute walking distance was 57.33 meters greater with standard exercise and 64.20 meters greater with breathing-focused exercise than controls
The catchExercise programs lasted only 10 weeks, leaving longer-term walking benefits unmeasured
Experiments in mice found that intermittent fasting expanded muscle stem cells and helped their descendants multiply and merge into muscle fibers.Experiments in mice found that intermittent fasting expanded muscle stem cells and helped their descendants multiply and merge into muscle fibers.
