In 14,462 independent recordings, predicted and actual ages had a correlation of 0.90, outperforming another model design and a model trained on a more uniform…In 14,462 independent recordings, predicted and actual ages had a correlation of 0.90, outperforming another model design and a model trained on a more uniform population.
In worm experiments, the ginseng-derived compound also preserved touch sensitivity and restored age-impaired function in nerve cells’ waste-processing compartments.In worm experiments, the ginseng-derived compound also preserved touch sensitivity and restored age-impaired function in nerve cells’ waste-processing compartments.
In mouse experiments, oral glyceryl tribenzoate improved the capacity of a memory-related brain region to change and protected learning.In mouse experiments, oral glyceryl tribenzoate improved the capacity of a memory-related brain region to change and protected learning. In experiments with 5xFAD mice, a model of Alzheimer’s disease, researchers gave glyceryl…
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Get Plus for $49An analysis of three published datasets, validated in 15 human skin samples, identified an aging-linked subgroup of cells that support small blood vessels.An analysis of three published datasets, validated in 15 human skin samples, identified an aging-linked subgroup of cells that support small blood vessels.
Over 12 weeks, cognitive test scores improved by an estimated 4.95 points more with Tai Chi than with health education.Over 12 weeks, cognitive test scores improved by an estimated 4.95 points more with Tai Chi than with health education. Forty postmenopausal women with mild cognitive impairment, meaning mild problems with memory or thinking, took…
Keeping immune cells in mouse tissues or increasing their numbers produced clusters across several organs without associated signs of disease.Keeping immune cells in mouse tissues or increasing their numbers produced clusters across several organs without associated signs of disease.
The disease-free share declined by nearly 1% annually, while most groups saw five-year death risks stall or rise after the mid-2000s.The disease-free share declined by nearly 1% annually, while most groups saw five-year death risks stall or rise after the mid-2000s. An observational study analysed 510,372 US adults aged 30 or older surveyed from 1997 to 2018…
The gap fell from 13.4 to 9.4 years in females and from 16.7 to 12.1 years in males, compared with Queensland’s general population.The gap fell from 13.4 to 9.4 years in females and from 16.7 to 12.1 years in males, compared with Queensland’s general population. A retrospective observational cohort study analysed linked hospital and death records for 255,448…
In simulations, prescreening could reduce bone-density scans by about 50% while retaining detection of 98–99% of osteoporosis cases.In simulations, prescreening could reduce bone-density scans by about 50% while retaining detection of 98–99% of osteoporosis cases. In a computational study, researchers developed an artificial intelligence model using paired…
At age 58, a blood fat marker threshold corresponded to 10.88% 10-year major cardiovascular event risk in men versus 4.34% in women after menopause.At age 58, a blood fat marker threshold corresponded to 10.88% 10-year major cardiovascular event risk in men versus 4.34% in women after menopause.
In a 12-week randomised trial of 38 postmenopausal women, exercise plus melatonin improved two blood-fat measures compared with exercise plus placebo.In a 12-week randomised trial of 38 postmenopausal women, exercise plus melatonin improved two blood-fat measures compared with exercise plus placebo. Both exercise groups trained three times a week.
In an animal experiment, targeted delivery of tiny packages from newborn mouse spinal cords improved movement and bladder control after spinal cord injury in adult mice.In an animal experiment, targeted delivery of tiny packages from newborn mouse spinal cords improved movement and bladder control after spinal cord injury in adult mice.
Blood flow in one brain region rose by 4.9 millilitres per 100 grams per minute more with spermidine than placebo over 12 months.Blood flow in one brain region rose by 4.9 millilitres per 100 grams per minute more with spermidine than placebo over 12 months. Researchers analysed brain scans from 75 adults aged 60–90 with self-reported cognitive decline in a…
Experiments in mice at 12 and 18 months found different behavioural and memory changes in males and females exposed to prenatal stress.Experiments in mice at 12 and 18 months found different behavioural and memory changes in males and females exposed to prenatal stress. In an experiment in C57BL/6J mice, researchers exposed pregnant mothers to unpredictable mild…
People with poor heart and metabolic health and pre-frailty or frailty had a heart failure hazard ratio of 2.76 versus healthy, non-frail participants.People with poor heart and metabolic health and pre-frailty or frailty had a heart failure hazard ratio of 2.76 versus healthy, non-frail participants.
An observational study of 453 older hospital patients linked obesity combined with low muscle mass and strength to poorer daily functioning at discharge.An observational study of 453 older hospital patients linked obesity combined with low muscle mass and strength to poorer daily functioning at discharge.
Experiments with lab-grown liver and muscle cells linked statin exposure to lower levels of insulin-like growth factor-1, a growth signal.Experiments with lab-grown liver and muscle cells linked statin exposure to lower levels of insulin-like growth factor-1, a growth signal. Lovastatin and atorvastatin induced senescence, a state in which cells stop dividing, in…
A 14-week randomised trial assigned 67 older women to pool exercise with added tasks, conventional pool exercise or no exercise.A 14-week randomised trial assigned 67 older women to pool exercise with added tasks, conventional pool exercise or no exercise. The exercise programmes scheduled two sessions a week for 14 weeks.
Lab experiments in bone marrow cells from patients with postmenopausal osteoporosis also found reduced senescence, a state in which cells stop dividing.Lab experiments in bone marrow cells from patients with postmenopausal osteoporosis also found reduced senescence, a state in which cells stop dividing. Osteoporosis weakens bones; this form occurs after menopause.
Stroke risk was 11.1% in people with an enlarged left atrium, the heart’s upper left chamber, versus 4.6% in those without enlargement.Stroke risk was 11.1% in people with an enlarged left atrium, the heart’s upper left chamber, versus 4.6% in those without enlargement. The observational study followed 10,024 participants from the Copenhagen General Population…
Mouse experiments found earlier loss of immune cells not yet activated by their targets in males, alongside faster lymph node shrinkage.Mouse experiments found earlier loss of immune cells not yet activated by their targets in males, alongside faster lymph node shrinkage. They shifted faster into virtual memory cells, which had memory-like features without…
Within 28 days, 14.8% of hip-fracture patients with nutritional risk died, compared with 5.2% of those with normal nutritional status.Within 28 days, 14.8% of hip-fracture patients with nutritional risk died, compared with 5.2% of those with normal nutritional status. Researchers examined 709 consecutive patients admitted with hip fracture in a retrospective…
In a prospective study of postmenopausal women, 12 weeks of vaginal estrogen shifted urinary bacterial communities towards those seen in women without tissue thinning or…In a prospective study of postmenopausal women, 12 weeks of vaginal estrogen shifted urinary bacterial communities towards those seen in women without tissue thinning or symptoms.
Participants with both conditions had a hazard ratio—a comparison of event rates over time—of 1.78 for cardiovascular events versus those with neither.Participants with both conditions had a hazard ratio—a comparison of event rates over time—of 1.78 for cardiovascular events versus those with neither.
Three weeks of protein injections reduced weight in male and female mice, with greater effects in older mice and those fed a high-fat diet.Three weeks of protein injections reduced weight in male and female mice, with greater effects in older mice and those fed a high-fat diet.
In an experiment on cultured muscle precursor cells, electrical metabolic monitoring tracked cellular senescence and predicted whether the cells could form muscle.In an experiment on cultured muscle precursor cells, electrical metabolic monitoring tracked cellular senescence and predicted whether the cells could form muscle.
Progression to diabetes was linked to 1.53 times the odds of later heart disease compared with consistently normal blood sugar, after accounting for other factors.Progression to diabetes was linked to 1.53 times the odds of later heart disease compared with consistently normal blood sugar, after accounting for other factors.
Mouse experiments traced the decline mainly to carbon dioxide exhalation; inhaling carbon dioxide in adulthood enabled retinal nerve fibres to regrow after injury.Mouse experiments traced the decline mainly to carbon dioxide exhalation; inhaling carbon dioxide in adulthood enabled retinal nerve fibres to regrow after injury.
Moderate-low and high index patterns were linked to 1.104-fold and 1.243-fold mortality risks, respectively; the abstract did not name the comparison group.Moderate-low and high index patterns were linked to 1.104-fold and 1.243-fold mortality risks, respectively; the abstract did not name the comparison group.
Participants with four or more long-term conditions had 4.64 times the adjusted odds of a large kidney estimate mismatch compared with those reporting none.Participants with four or more long-term conditions had 4.64 times the adjusted odds of a large kidney estimate mismatch compared with those reporting none.
Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere…Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere length.
Women’s relative hip fracture rate was 0.72 compared with women one standard deviation lower in neighbourhood walkability, an increment reflecting variation in scores.Women’s relative hip fracture rate was 0.72 compared with women one standard deviation lower in neighbourhood walkability, an increment reflecting variation in scores.
11 Oct