In 70,473 adults followed for up to 10 years, 210 wearable activity phenotypes were linked to 406 diseases, with step intensity and circadian rhythm…In 70,473 adults followed for up to 10 years, 210 wearable activity phenotypes were linked to 406 diseases, with step intensity and circadian rhythm showing prominent ties. In a cohort of 70,473 human participants followed for up to 10 years, researchers analyzed 11.8 million person-hours…
Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification…Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality. In mice, deficiency of the renal proximal tubule protein TMEM174 significantly shortened lifespan compared to wild-type…
Among non-smoking non-drinkers, adults with no schooling had a mortality rate ratio of 2.76 in men and 2.93 in women compared to higher education.Among non-smoking non-drinkers, adults with no schooling had a mortality rate ratio of 2.76 in men and 2.93 in women compared to higher education. In a prospective study of 500,810 adults aged 35 and older in Chennai, India, researchers evaluated how social inequality, smoking, and alcohol…
In a randomized trial, 12 weeks of the mind-body exercise lowered systolic blood pressure by 7.2 mmHg compared with habitual lifestyle.In a randomized trial, 12 weeks of the mind-body exercise lowered systolic blood pressure by 7.2 mmHg compared with habitual lifestyle. Forty-six sedentary postmenopausal women enrolled in a 12-week randomized controlled trial evaluating Baguazhang, a traditional Chinese mind-body…
An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues…An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues in a dose-dependent manner.
Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process. In human blood cells from donors ranging from neonatal to 101 years of age, researchers tracked cellular rejuvenation during direct lineage…
A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year…A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year follow-up. In 223,907 UK Biobank participants free of coronary artery disease at baseline, researchers tracked cardiovascular outcomes over…
In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune…In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron homeostasis. In aged mice, exposure to the fungus Kazachstania pintolopesii accelerates splenic senescence, according to a study…
Among older dialysis patients, living in highly disadvantaged neighborhoods was linked to adjusted hazard ratios of 1.09 for dementia and 1.25 for…Among older dialysis patients, living in highly disadvantaged neighborhoods was linked to adjusted hazard ratios of 1.09 for dementia and 1.25 for Alzheimer's disease. Older patients aged 55 and older who began dialysis between 2003 and 2021 were evaluated using United States Renal Data…
In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia…In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia (hazard ratio 1.30). In 2,606 Framingham Heart Study Offspring cohort participants (mean age 66 years), researchers examined how three DNA…
Trained on 1,088 participants, the machine learning framework predicted flortaucipir-PET with R² values of 0.34 to 0.71 and classified tau stages with…Trained on 1,088 participants, the machine learning framework predicted flortaucipir-PET with R² values of 0.34 to 0.71 and classified tau stages with 79% to 95% accuracy. In a study of 1,088 human participants spanning normal aging and Alzheimer’s disease and related disorders…
Across 468,266 adults followed for 13 years, genetics drove initial disease onset, whereas clinical and lifestyle factors dominated subsequent…Across 468,266 adults followed for 13 years, genetics drove initial disease onset, whereas clinical and lifestyle factors dominated subsequent polyvascular spread and mortality.
Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident…Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident Alzheimer’s disease risk. In human health records and cortical organoids, researchers evaluated aspirin as a repurposed candidate against…
Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic…Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic multimorbidity. Researchers analyzed 5,586 middle-aged and older participants from the China Health and Retirement Longitudinal Study who were…
In individuals with conventional zero scores, AI-detected calcium tracked a 7.7% 20-year coronary heart disease incidence compared with 3.8% in those…In individuals with conventional zero scores, AI-detected calcium tracked a 7.7% 20-year coronary heart disease incidence compared with 3.8% in those without. In a pooled analysis of 3,965 human participants from the Multi-Ethnic Study of Atherosclerosis and the Framingham Heart Study with…
Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their…Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their oxytocin signaling. In monogamous prairie voles, expressing dementia-linked tau P301L in the hypothalamus disrupts selective social bonds…
European Journal of Applied PhysiologyHuman trial·
An XGBoost model reached an AUC of 0.782 in an external cohort of 2,066 older adults to predict basic activities of daily living disability.An XGBoost model reached an AUC of 0.782 in an external cohort of 2,066 older adults to predict basic activities of daily living disability. In a study of older adults aged 65 and older, researchers developed and externally validated a machine learning model to predict disability risk.
In 39,468 women, each 0.1-unit rise in miscarriage propensity was associated with a hazard ratio of 1.38 for incident type 2 diabetes.In 39,468 women, each 0.1-unit rise in miscarriage propensity was associated with a hazard ratio of 1.38 for incident type 2 diabetes. In 42,313 gravid Sister Study participants, researchers evaluated whether a history-based measure of miscarriage propensity predicts subsequent gestational…
Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice. In experiments using cultured myoblasts, mice, and human tissues, researchers investigated how calcium overload hinders skeletal muscle regeneration.
Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers. Researchers retrospectively evaluated 260 adults aged 65 and older who received commercial CAR-T therapy for multiple myeloma or B-cell…
In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not…In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females. Researchers analyzed purified elastin networks from 17 human thoracic aortas from donors aged 26 to 92 years, including nine males…
The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway. In female mice experiencing reproductive aging, administration of the peptide elamipretide increased litter size and ameliorated age-related declines in oocyte…
In over 119,000 adults, 89.2% of COPD cases were underdiagnosed, which was associated with a 1.53 hazard ratio for mortality compared to having no…In over 119,000 adults, 89.2% of COPD cases were underdiagnosed, which was associated with a 1.53 hazard ratio for mortality compared to having no COPD. In a prospective study of 119,252 adults aged 35 to 70 across 25 countries, researchers assessed the burden and outcomes of chronic…
The Journal of Nutrition, Health & AgingHuman trial·
Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a…Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a colony to nearly a century.
In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical…In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical frailty, versus 0.224 toward further deterioration.
Compared with never-smokers, ever-smokers of waterpipe had about a 60% higher risk of cardiovascular death, with a hazard ratio of 1.57.Compared with never-smokers, ever-smokers of waterpipe had about a 60% higher risk of cardiovascular death, with a hazard ratio of 1.57. In a cohort of 35,646 Vietnamese adults aged 18 and older, ever-smoking waterpipe was associated with an increased risk of cardiovascular disease death.
Across 38 populations, total 2020–2025 excess deaths reached 0.92–2.49 million, offset by a 2024–2025 deficit of 0.39–1.08 million deaths.Across 38 populations, total 2020–2025 excess deaths reached 0.92–2.49 million, offset by a 2024–2025 deficit of 0.39–1.08 million deaths. In 38 human populations with reliable vital registration data, researchers evaluated excess mortality across 2020–2025 using granular age…
Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean…Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects. In a new mouse model of cesarean section scar defects, researchers investigated the mechanisms that disrupt uterine healing.
Pretrained on 10 million images, the model assessed 62 biomarkers across eight physiological systems, reaching a median Pearson's r of 0.172 across…Pretrained on 10 million images, the model assessed 62 biomarkers across eight physiological systems, reaching a median Pearson's r of 0.172 across four cohorts. In human datasets, researchers developed MedicalFaceFound, a facial foundation model trained on over 10 million images to…
Prior hospital-treated infection linked to lower general cognition (β = -0.11 SD), while each 1-SD higher cognitive score predicted a 36% lower risk…Prior hospital-treated infection linked to lower general cognition (β = -0.11 SD), while each 1-SD higher cognitive score predicted a 36% lower risk of future infection. In a study of 1,159 adults aged 65 and older from the English Longitudinal Study of Ageing, researchers investigated how…
Across six human cohorts and a 2.3-year follow-up, neural networks identified brain structural patterns tied to cardiometabolic and pulmonary…Across six human cohorts and a 2.3-year follow-up, neural networks identified brain structural patterns tied to cardiometabolic and pulmonary conditions. In human participants from six independent cohorts, researchers applied deep learning to T1-weighted MRI scans to isolate structural…
