In a cross-sectional study of 418 people aged 7–95, free-floating DNA levels increased across ages 7–80 but were lower at 81–95 than at 61–80.In a cross-sectional study of 418 people aged 7–95, free-floating DNA levels increased across ages 7–80 but were lower at 81–95 than at 61–80.
Experiments in aged mice found that clearing abnormal protein deposits around blood vessels with anselamimab restored liver regeneration after partial liver removal.Experiments in aged mice found that clearing abnormal protein deposits around blood vessels with anselamimab restored liver regeneration after partial liver removal. These deposits came from antibody fragments called light chains.
An observational analysis of human lung and brain tissue mapped age-related differences in chemical marks on RNA and how RNA molecules were processed.An observational analysis of human lung and brain tissue mapped age-related differences in chemical marks on RNA and how RNA molecules were processed.
In worm experiments, increasing a nerve-signaling molecule reduced excessive branching in aging sensory neurons without extending lifespan.In worm experiments, increasing a nerve-signaling molecule reduced excessive branching in aging sensory neurons without extending lifespan.
An experiment involving 44 tree shrews found that liver and spleen gene activity followed human aging patterns more closely than mouse patterns.An experiment involving 44 tree shrews found that liver and spleen gene activity followed human aging patterns more closely than mouse patterns.
Early-adulthood activation of a stress-response protein reduced mortality risk by approximately 50% across all ages and improved nerve and muscle function in aged flies.Early-adulthood activation of a stress-response protein reduced mortality risk by approximately 50% across all ages and improved nerve and muscle function in aged flies.
Experiments in aged mouse neurons linked oxidative stress to looser mitochondrial DNA packaging, fewer RNA copies from that DNA and impaired energy production.Experiments in aged mouse neurons linked oxidative stress to looser mitochondrial DNA packaging, fewer RNA copies from that DNA and impaired energy production.
An aging-pace measure showed an estimated rise of 0.13 on the study’s statistical scale from prepandemic levels across children, adolescents and adults.An aging-pace measure showed an estimated rise of 0.13 on the study’s statistical scale from prepandemic levels across children, adolescents and adults.
Experiments in naturally aged mice found benefits from immune-cell particles, with aerobic exercise further improving selected tissue-rebuilding and movement measures.Experiments in naturally aged mice found benefits from immune-cell particles, with aerobic exercise further improving selected tissue-rebuilding and movement measures.
A measure combining breathlessness severity and duration was 2,647.9 millimeter-hours with acetazolamide versus 2,988.7 with dapagliflozin over 72 hours; lower scores…A measure combining breathlessness severity and duration was 2,647.9 millimeter-hours with acetazolamide versus 2,988.7 with dapagliflozin over 72 hours; lower scores meant more relief.
In laboratory experiments, delivering several gene-regulating RNAs together enhanced activation and cell-killing responses in aged human T cells.In laboratory experiments, delivering several gene-regulating RNAs together enhanced activation and cell-killing responses in aged human T cells.
A cross-sectional study of 1,068 adults in Lithuania linked lower whole-blood levels of the molecule to heart and blood vessel disease and high blood pressure.A cross-sectional study of 1,068 adults in Lithuania linked lower whole-blood levels of the molecule to heart and blood vessel disease and high blood pressure.
Aging increased the involvement of gene-regulating proteins at more than 100,000 DNA sites in mouse hearts; endurance exercise opposed most increases.Aging increased the involvement of gene-regulating proteins at more than 100,000 DNA sites in mouse hearts; endurance exercise opposed most increases.
An observational study of 46 healthy adults aged 20–77 linked older age to less restricted water movement and larger microscopic structural scales.An observational study of 46 healthy adults aged 20–77 linked older age to less restricted water movement and larger microscopic structural scales.
Laboratory tests found that these cells were less able to multiply and send immune signals, and had a limited response to a type of immunotherapy.Laboratory tests found that these cells were less able to multiply and send immune signals, and had a limited response to a type of immunotherapy.
Mapping 11 brain regions across five time points revealed changes to Tau’s molecular tags that might impair its breakdown in the hippocampus.Mapping 11 brain regions across five time points revealed changes to Tau’s molecular tags that might impair its breakdown in the hippocampus.
Experiments in fission yeast showed that the protein stabilizes machinery that joins mitochondria, the cells’ energy-producing structures, together.Experiments in fission yeast showed that the protein stabilizes machinery that joins mitochondria, the cells’ energy-producing structures, together.
Experiments in three fruit fly species challenged the idea that jumping DNA concentrated on the Y chromosome helps explain males’ shorter lives.Experiments in three fruit fly species challenged the idea that jumping DNA concentrated on the Y chromosome helps explain males’ shorter lives. Fruit flies from three species—Drosophila melanogaster, D. simulans and D.
At 104 weeks, a long-term blood sugar measure fell 0.7–1.0 percentage points more with semaglutide than placebo across kidney-disease groups.At 104 weeks, a long-term blood sugar measure fell 0.7–1.0 percentage points more with semaglutide than placebo across kidney-disease groups.
Infection susceptibility approximately doubled with each doubling of age in experiments involving a genetically mixed fruit fly population and 22 fly lines.Infection susceptibility approximately doubled with each doubling of age in experiments involving a genetically mixed fruit fly population and 22 fly lines.
Unfavorable social conditions were linked to a 21% higher relative risk of a first bone or joint disease than favorable conditions.Unfavorable social conditions were linked to a 21% higher relative risk of a first bone or joint disease than favorable conditions. The 283,146 UK Biobank participants in this prospective observational study averaged 54.9 years…
A global model estimated that replacing regular salt with potassium-enriched salt could avert a net 2.96 million deaths annually from cardiovascular and chronic kidney…A global model estimated that replacing regular salt with potassium-enriched salt could avert a net 2.96 million deaths annually from cardiovascular and chronic kidney disease.
Restoring the protein’s activity restored nuclear structure and the ability to divide in cells from aged non-human primates and animals modeling a premature-aging…Restoring the protein’s activity restored nuclear structure and the ability to divide in cells from aged non-human primates and animals modeling a premature-aging disorder.
Functional worsening at discharge occurred in 29.7% of older patients after the program began, compared with 49.7% before it.Functional worsening at discharge occurred in 29.7% of older patients after the program began, compared with 49.7% before it. Six hundred patients aged 65 or older who left an Italian internal medicine ward alive were studied in a…
Fruit fly experiments identified signals that controlled the development of nutrient-absorbing gut cells; disrupting the circuit impaired renewal during aging and…Fruit fly experiments identified signals that controlled the development of nutrient-absorbing gut cells; disrupting the circuit impaired renewal during aging and shortened lifespan.
Experiments in mice found that intermittent fasting expanded muscle stem cells and helped their descendants multiply and merge into muscle fibers.Experiments in mice found that intermittent fasting expanded muscle stem cells and helped their descendants multiply and merge into muscle fibers.
Statin users had a relative risk of 0.80 compared with nonusers among older adults initially free of depression.Statin users had a relative risk of 0.80 compared with nonusers among older adults initially free of depression. Adults aged 70 or older, or 65 or older for US minorities, were followed for a median of 8.4 years in an…
Benchmarking studies focused on human tissues found that reference data, testing standards and experimental design shaped how well technologies detected mutations.Benchmarking studies focused on human tissues found that reference data, testing standards and experimental design shaped how well technologies detected mutations.
In an animal experiment, adding Synage to a brain region increased testosterone, sperm counts and forward sperm movement in 12-month-old mice.In an animal experiment, adding Synage to a brain region increased testosterone, sperm counts and forward sperm movement in 12-month-old mice.
An observational study tracked 2,681 adults aged 46–65 at the start over 17 years, finding varied patterns of stability, decline and partial recovery.An observational study tracked 2,681 adults aged 46–65 at the start over 17 years, finding varied patterns of stability, decline and partial recovery.
