An analysis of 108,062 cell nuclei from adult and aged mice found greater age-linked gene activity changes in the basal forebrain than the midbrain and brainstem.An analysis of 108,062 cell nuclei from adult and aged mice found greater age-linked gene activity changes in the basal forebrain than the midbrain and brainstem.
In 6-month-old genetically modified mice, deleting a bone-signaling gene prevented gains in bone density and spongy bone in males and reduced them in females.In 6-month-old genetically modified mice, deleting a bone-signaling gene prevented gains in bone density and spongy bone in males and reduced them in females.
In 81 healthy males aged 18–80, an observational study linked free testosterone to muscle gene activity, but not muscle mass or strength.In 81 healthy males aged 18–80, an observational study linked free testosterone to muscle gene activity, but not muscle mass or strength. Free testosterone—the portion not bound to proteins in blood—was strongly associated with…
Over one year, a heart rhythm disorder occurred in 1.63% of drug users and 2.62% of matched nonusers with obesity and chronic kidney disease.Over one year, a heart rhythm disorder occurred in 1.63% of drug users and 2.62% of matched nonusers with obesity and chronic kidney disease.
In two trials, genetically selected groups showed stronger stomach cancer protection than treating all infected participants, with hazard ratios of 0.44 and 0.20.In two trials, genetically selected groups showed stronger stomach cancer protection than treating all infected participants, with hazard ratios of 0.44 and 0.20.
Tai Chi reduced mobility-test time by 2.52 seconds more than health education plus home exercise at 12 weeks.Tai Chi reduced mobility-test time by 2.52 seconds more than health education plus home exercise at 12 weeks. A two-site randomized trial enrolled 96 adults aged 65–85 with sarcopenic knee osteoarthritis: knee joint disease…
Experiments in human cells found the protein was needed to reorganize DNA packaging as DNA damage pushed cells to stop dividing.Experiments in human cells found the protein was needed to reorganize DNA packaging as DNA damage pushed cells to stop dividing. They studied dividing cells and a model in which DNA damage triggered senescence, combining analyses…
People in the top 1% of genetic scores had 9-fold higher relative cardiovascular risk than those in the bottom 50%.People in the top 1% of genetic scores had 9-fold higher relative cardiovascular risk than those in the bottom 50%. An observational cohort study followed 266,917 UK Biobank adults aged 40–74 classified as having low…
An observational study followed 287 people with a sleep disorder for a median 4.2 years and linked dietary patterns to later brain disease.An observational study followed 287 people with a sleep disorder for a median 4.2 years and linked dietary patterns to later brain disease.
Participants in the highest versus lowest quarter of the blood index had a hazard ratio of 0.77 for vein clots, a relative measure of risk.Participants in the highest versus lowest quarter of the blood index had a hazard ratio of 0.77 for vein clots, a relative measure of risk.
For 107.6 million US adults with obesity, the simulation estimated 5.3 million preventable deaths over 10 years if treatment was forgone.For 107.6 million US adults with obesity, the simulation estimated 5.3 million preventable deaths over 10 years if treatment was forgone. A computational model simulated 107.6 million US adults with obesity, including people with…
In a laboratory experiment, 15-month-old female mice had higher blood flow in the brain’s outer layer than males, without a deficit in oxygen delivery through arteries.In a laboratory experiment, 15-month-old female mice had higher blood flow in the brain’s outer layer than males, without a deficit in oxygen delivery through arteries.
Mice lacking Matrin-3 in vessel-lining cells had a 1.41-fold increase in artery plaque area compared with mice without the deficiency.Mice lacking Matrin-3 in vessel-lining cells had a 1.41-fold increase in artery plaque area compared with mice without the deficiency. An animal experiment used mice lacking a receptor for cholesterol-carrying particles.
Adults meeting all three prediabetes criteria had an adjusted hazard ratio of 15.3 for diabetes compared with those with normal blood sugar.Adults meeting all three prediabetes criteria had an adjusted hazard ratio of 15.3 for diabetes compared with those with normal blood sugar. An observational cohort study followed 7,186 Korean adults aged 40–69 for up to 20 years.
Antibody responses persisted for 165 days after one dose, while immune cells from the spleen showed responses at 180 days.Antibody responses persisted for 165 days after one dose, while immune cells from the spleen showed responses at 180 days. In experiments in mice, researchers tested a vaccine delivery system designed to release its contents…
In an observational study of 1,297 people without dementia, combined brain and blood measures showed the strongest links to disease progression.In an observational study of 1,297 people without dementia, combined brain and blood measures showed the strongest links to disease progression.
In laboratory experiments, thicker fluid temporarily restored young-like monitoring behavior, particularly in a subgroup of aged human memory T cells.In laboratory experiments, thicker fluid temporarily restored young-like monitoring behavior, particularly in a subgroup of aged human memory T cells.
In animal experiments, loss of the protein worsened bone degeneration, while restoring it eased osteoporosis caused by removal of the ovaries.In animal experiments, loss of the protein worsened bone degeneration, while restoring it eased osteoporosis caused by removal of the ovaries.
Who was studiedFemale mice with ovariectomy-induced osteoporosis, 5 weeks
What changedBone volume fraction was approximately 2.0-fold higher after endothelial TRX2 restoration in ovariectomized mice than with a control vector
The catchBone preservation was assessed only 5 weeks after injection
In a before-and-after study, 37 older adults trained twice weekly for 12 weeks, with gains in physical performance and force from individual muscle fibers.In a before-and-after study, 37 older adults trained twice weekly for 12 weeks, with gains in physical performance and force from individual muscle fibers.
Agreement on heart-chamber enlargement reached 98.8–99.2% between untimed and heartbeat-timed scans, versus 98.6–98.9% between paired heartbeat-timed scans.Agreement on heart-chamber enlargement reached 98.8–99.2% between untimed and heartbeat-timed scans, versus 98.6–98.9% between paired heartbeat-timed scans.
Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1.Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1. In experiments in yeast cells, the metabolic byproduct S-adenosyl-L-homocysteine (SAH) extended chronological…
A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomized trial.A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomized trial. A randomized crossover trial tested dapagliflozin in 32 people with heart failure with preserved…
A cross-sectional study of 742 adults aged 70 or older linked activity-limiting pain to muscle gene activity patterns that differed between men and women.A cross-sectional study of 742 adults aged 70 or older linked activity-limiting pain to muscle gene activity patterns that differed between men and women. They analyzed gene activity in biopsies from a thigh muscle.
Models predicted a kidney-function transition after 1,727.43 days at nitrate exposure of 4.2 micrograms per cubic meter, versus 868.56 days at 7.0.Models predicted a kidney-function transition after 1,727.43 days at nitrate exposure of 4.2 micrograms per cubic meter, versus 868.56 days at 7.0.
Compared with women retaining their ovaries, the surgery group had no clear difference in blood pressure rises at 24 months (adjusted odds ratio 1.03).Compared with women retaining their ovaries, the surgery group had no clear difference in blood pressure rises at 24 months (adjusted odds ratio 1.03).
