An observational study spanning 18,476 people in China linked an aging measure developed in a healthy group to chronic disease and death risk.An observational study spanning 18,476 people in China linked an aging measure developed in a healthy group to chronic disease and death risk.
In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.
A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.
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Get Plus for $49Physical, psychological and cognitive disorders together were linked to 4.02 times the disability risk of having no disorders over two years.Physical, psychological and cognitive disorders together were linked to 4.02 times the disability risk of having no disorders over two years.
Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.
In a five-month intervention involving 42 people, sunscreen-treated arms showed smaller changes in DNA marks than the opposite arms under everyday conditions.In a five-month intervention involving 42 people, sunscreen-treated arms showed smaller changes in DNA marks than the opposite arms under everyday conditions.
The model categorised all high-risk cases as positive and pre-classified 40% of low-risk cases and 55% of negative cases as negative.The model categorised all high-risk cases as positive and pre-classified 40% of low-risk cases and 55% of negative cases as negative. Researchers analysed 461,576 eligible UK Biobank participants in a retrospective cohort study.
Compared with the reference group, relative rates of death were 1.19 for mild, 1.55 for moderate and 1.56 for moderately severe or worse hearing loss.Compared with the reference group, relative rates of death were 1.19 for mild, 1.55 for moderate and 1.56 for moderately severe or worse hearing loss.
Increasing the protein’s production in rat cells grown in the lab restored testosterone output and reversed signs of senescence, a state in which cells stop dividing.Increasing the protein’s production in rat cells grown in the lab restored testosterone output and reversed signs of senescence, a state in which cells stop dividing.
An experiment in Alzheimer's disease mice found that the system also restored new neuron formation in a brain region involved in memory.An experiment in Alzheimer's disease mice found that the system also restored new neuron formation in a brain region involved in memory. In an animal experiment in mice with Alzheimer's disease, researchers tested a delivery…
Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.
Among 3,316 Chinese adults aged 60 or older, 1,947 (58.7%) developed frailty over seven years in an observational study.Among 3,316 Chinese adults aged 60 or older, 1,947 (58.7%) developed frailty over seven years in an observational study. Frailty is a reduced ability to cope with illness or other stresses.
A longitudinal observational analysis of the Dallas Lifespan Brain Study found substantial differences in early and middle adulthood that diminished later in life.A longitudinal observational analysis of the Dallas Lifespan Brain Study found substantial differences in early and middle adulthood that diminished later in life.
Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial. In mouse experiments, researchers transplanted ovaries between younger and older animals…
In the Health and Retirement Study, scores for distinguishing future disability were 0.706 with grip strength versus 0.711 without it.In the Health and Retirement Study, scores for distinguishing future disability were 0.706 with grip strength versus 0.711 without it. Adults aged 65 or older with self-reported physician-diagnosed arthritis or rheumatism and…
Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice. In experiments in mice and heart muscle cells, researchers examined a protein involved in cell…
A 12-week randomised trial in 118 older care home residents with dementia found no significant cognitive improvement but linked acupuncture to better functional…A 12-week randomised trial in 118 older care home residents with dementia found no significant cognitive improvement but linked acupuncture to better functional independence.
Experiments in mice found that azilsartan reduced muscle fibre loss and declines in grip strength and exercise capacity when a hormone induced muscle wasting.Experiments in mice found that azilsartan reduced muscle fibre loss and declines in grip strength and exercise capacity when a hormone induced muscle wasting.
Compared with matched adults without autism, social disadvantage was estimated to account for 39% of autistic adults’ higher mortality risk.Compared with matched adults without autism, social disadvantage was estimated to account for 39% of autistic adults’ higher mortality risk. Participants had a mean age of 51.6 years, and 66.4% were male.
An observational study of 6,267 Chinese participants linked recorded health or safety reasons for unfinished tests to later disability and higher odds of death.An observational study of 6,267 Chinese participants linked recorded health or safety reasons for unfinished tests to later disability and higher odds of death.
An experiment in mouse neurons found shared early DNA changes in aging and brain-disease models, but differences in which organisational features remained.An experiment in mouse neurons found shared early DNA changes in aging and brain-disease models, but differences in which organisational features remained.
Rates rose from 39.4 to 150.54 per 100,000 person-years between ages 46 and 80 among 494,745 UK Biobank participants followed from 2010 to 2022.Rates rose from 39.4 to 150.54 per 100,000 person-years between ages 46 and 80 among 494,745 UK Biobank participants followed from 2010 to 2022.
An observational study of 174,718 UK adults over a median 14.6 years found weaker links between early-life risks and disease progression among those with healthier…An observational study of 174,718 UK adults over a median 14.6 years found weaker links between early-life risks and disease progression among those with healthier lifestyles.
Compared with the lowest risk category, the highest was associated with hazard ratios of 2.80, 1.84 and 1.71 for developing one, two and three conditions.Compared with the lowest risk category, the highest was associated with hazard ratios of 2.80, 1.84 and 1.71 for developing one, two and three conditions.
In animals with induced arthritis, blocking lactate transport reduced disease progression more effectively than blocking the body's own lactate production.In animals with induced arthritis, blocking lactate transport reduced disease progression more effectively than blocking the body's own lactate production.
Trained on over 4 million recordings from 202,000 users, the model achieved the best main scores across six prediction tasks.Trained on over 4 million recordings from 202,000 users, the model achieved the best main scores across six prediction tasks. In a modelling study, researchers used over 4 million wrist-worn pulse recordings from 202,000 users to…
In a six-week experiment, resistance training improved muscle strength, mass and physical performance in male mice with chronic liver disease.In a six-week experiment, resistance training improved muscle strength, mass and physical performance in male mice with chronic liver disease.
The lung cancer hazard ratio—a comparison of diagnosis rates over time—was 1.629 for participants with high versus normal strain across body systems.The lung cancer hazard ratio—a comparison of diagnosis rates over time—was 1.629 for participants with high versus normal strain across body systems.
In a 26-week pilot trial, 37% of participants dropped out, with no statistically significant difference between online and in-person exercise.In a 26-week pilot trial, 37% of participants dropped out, with no statistically significant difference between online and in-person exercise.
An experiment in rats with severe spinal disc degeneration found that a cell-carrying gel promoted new tissue formation and outperformed cells or a support scaffold…An experiment in rats with severe spinal disc degeneration found that a cell-carrying gel promoted new tissue formation and outperformed cells or a support scaffold alone.
Among 7,604 US adults aged 20 or older, each one-hour increase in night-to-night sleep-midpoint variability was associated with an all-cause mortality hazard ratio of…Among 7,604 US adults aged 20 or older, each one-hour increase in night-to-night sleep-midpoint variability was associated with an all-cause mortality hazard ratio of 1.22.
In an observational study of 1,861 adults, employment patterns from ages 18 to 50 were largely unrelated to DNA-based measures of accelerated aging.In an observational study of 1,861 adults, employment patterns from ages 18 to 50 were largely unrelated to DNA-based measures of accelerated aging.
Compared with no surgery, weight-loss surgery was associated with a lower obesity-related cancer rate, with an adjusted rate ratio of 0.81.Compared with no surgery, weight-loss surgery was associated with a lower obesity-related cancer rate, with an adjusted rate ratio of 0.81.
