Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial. In mouse experiments, researchers transplanted ovaries between younger and older animals…
The model categorised all high-risk cases as positive and pre-classified 40% of low-risk cases and 55% of negative cases as negative.The model categorised all high-risk cases as positive and pre-classified 40% of low-risk cases and 55% of negative cases as negative. Researchers analysed 461,576 eligible UK Biobank participants in a retrospective cohort study.
In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.
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Get Plus for $49In the Health and Retirement Study, scores for distinguishing future disability were 0.706 with grip strength versus 0.711 without it.In the Health and Retirement Study, scores for distinguishing future disability were 0.706 with grip strength versus 0.711 without it. Adults aged 65 or older with self-reported physician-diagnosed arthritis or rheumatism and…
Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice. In experiments in mice and heart muscle cells, researchers examined a protein involved in cell…
Compared with the reference group, relative rates of death were 1.19 for mild, 1.55 for moderate and 1.56 for moderately severe or worse hearing loss.Compared with the reference group, relative rates of death were 1.19 for mild, 1.55 for moderate and 1.56 for moderately severe or worse hearing loss.
An observational study of 6,267 Chinese participants linked recorded health or safety reasons for unfinished tests to later disability and higher odds of death.An observational study of 6,267 Chinese participants linked recorded health or safety reasons for unfinished tests to later disability and higher odds of death.
A 12-week randomised trial in 118 older care home residents with dementia found no significant cognitive improvement but linked acupuncture to better functional…A 12-week randomised trial in 118 older care home residents with dementia found no significant cognitive improvement but linked acupuncture to better functional independence.
Each decade of age was linked to 23% higher levels of a urine marker of how kidney tubes return filtered substances to the blood.Each decade of age was linked to 23% higher levels of a urine marker of how kidney tubes return filtered substances to the blood. In an observational study, researchers analysed 939 adults aged 37–55 and 1,014 adults aged 45–84…
An observational study of 174,718 UK adults over a median 14.6 years found weaker links between early-life risks and disease progression among those with healthier…An observational study of 174,718 UK adults over a median 14.6 years found weaker links between early-life risks and disease progression among those with healthier lifestyles.
Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.
Experiments compared mice aged 20 days, one year and two years, finding that effects on stress responses diminished in old age.Experiments compared mice aged 20 days, one year and two years, finding that effects on stress responses diminished in old age. Foxn1 produces a protein that regulates gene activity.
In injury experiments, intestinal cells temporarily had lower gene-based age estimates, with the timing differing between young and old mice.In injury experiments, intestinal cells temporarily had lower gene-based age estimates, with the timing differing between young and old mice.
An experiment in mouse neurons found shared early DNA changes in aging and brain-disease models, but differences in which organisational features remained.An experiment in mouse neurons found shared early DNA changes in aging and brain-disease models, but differences in which organisational features remained.
Each 1%-per-year drop in the volume of air forcibly exhaled in one second was linked to 1.47 times the odds of frailty at 10 years.Each 1%-per-year drop in the volume of air forcibly exhaled in one second was linked to 1.47 times the odds of frailty at 10 years. An observational cohort study followed 2,354 adults aged 45–80 with a cigarette smoking history…
A one-point higher social connection score was linked to a 0.04-point higher standardised capacity score, but not clearly slower decline.A one-point higher social connection score was linked to a 0.04-point higher standardised capacity score, but not clearly slower decline. Researchers conducted an observational cohort study of 39,021 adults aged 50 or older in the…
In killifish experiments, lifelong mating reduced inflammation in old females’ main liver cells, while models based on gene activity predicted “younger” ages for several…In killifish experiments, lifelong mating reduced inflammation in old females’ main liver cells, while models based on gene activity predicted “younger” ages for several liver cell types.
Pain was linked to higher frailty risk, with relative risks of 1.219 in China and 1.310 in England compared with no pain.Pain was linked to higher frailty risk, with relative risks of 1.219 in China and 1.310 in England compared with no pain. The prospective observational study followed 3,622 adults in China and 2,059 in England with metabolic…
In an observational study of 1,861 adults, employment patterns from ages 18 to 50 were largely unrelated to DNA-based measures of accelerated aging.In an observational study of 1,861 adults, employment patterns from ages 18 to 50 were largely unrelated to DNA-based measures of accelerated aging.
In animals with induced arthritis, blocking lactate transport reduced disease progression more effectively than blocking the body's own lactate production.In animals with induced arthritis, blocking lactate transport reduced disease progression more effectively than blocking the body's own lactate production.
Rates rose from 39.4 to 150.54 per 100,000 person-years between ages 46 and 80 among 494,745 UK Biobank participants followed from 2010 to 2022.Rates rose from 39.4 to 150.54 per 100,000 person-years between ages 46 and 80 among 494,745 UK Biobank participants followed from 2010 to 2022.
A Parkinson’s-linked change in the CHCHD2 protein worsened nerve-fibre damage and problems with thinking.A Parkinson’s-linked change in the CHCHD2 protein worsened nerve-fibre damage and problems with thinking. Researchers studied CHCHD2, a protein, and a mutated form linked to Parkinson’s disease, but the abstract did not identify…
Compared with the lowest risk category, the highest was associated with hazard ratios of 2.80, 1.84 and 1.71 for developing one, two and three conditions.Compared with the lowest risk category, the highest was associated with hazard ratios of 2.80, 1.84 and 1.71 for developing one, two and three conditions.
Trained on over 4 million recordings from 202,000 users, the model achieved the best main scores across six prediction tasks.Trained on over 4 million recordings from 202,000 users, the model achieved the best main scores across six prediction tasks. In a modelling study, researchers used over 4 million wrist-worn pulse recordings from 202,000 users to…
The profile was linked to higher mortality, with adjusted hazard ratios of 1.54 and 2.14 versus patients without it, depending on the muscle-estimation formula.The profile was linked to higher mortality, with adjusted hazard ratios of 1.54 and 2.14 versus patients without it, depending on the muscle-estimation formula.
Among 5,398 matched patients aged 90 or older, frailty was linked to higher one-year mortality than no frailty, with a hazard ratio of 1.66.Among 5,398 matched patients aged 90 or older, frailty was linked to higher one-year mortality than no frailty, with a hazard ratio of 1.66.
Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.
A 24-week trial sub-study followed 130 adults aged 60–79 at risk of dementia and found shifts towards a healthy reference microbial pattern within the intervention group.A 24-week trial sub-study followed 130 adults aged 60–79 at risk of dementia and found shifts towards a healthy reference microbial pattern within the intervention group.
In a 26-week pilot trial, 37% of participants dropped out, with no statistically significant difference between online and in-person exercise.In a 26-week pilot trial, 37% of participants dropped out, with no statistically significant difference between online and in-person exercise.
Among 7,604 US adults aged 20 or older, each one-hour increase in night-to-night sleep-midpoint variability was associated with an all-cause mortality hazard ratio of…Among 7,604 US adults aged 20 or older, each one-hour increase in night-to-night sleep-midpoint variability was associated with an all-cause mortality hazard ratio of 1.22.
