Longer telomeres were linked to lower odds of interstitial lung disease, with an odds ratio of 0.59 per standard-deviation increase in length.Longer telomeres were linked to lower odds of interstitial lung disease, with an odds ratio of 0.59 per standard-deviation increase in length.
Induced protein production reduced frailty progression by 44% in aged mice and was associated with a 14% extension of median lifespan.Induced protein production reduced frailty progression by 44% in aged mice and was associated with a 14% extension of median lifespan. In an experiment in aged mice, researchers induced production of SRSF1, a protein that helps…
Animal experiments found that loss of an immune-signalling protein harmed early bone development but protected against age-related bone loss from middle age onward.Animal experiments found that loss of an immune-signalling protein harmed early bone development but protected against age-related bone loss from middle age onward.
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Get Plus for $49An observational study of 100 people with colorectal cancer linked higher blood levels of an immune protein to more severe frailty.An observational study of 100 people with colorectal cancer linked higher blood levels of an immune protein to more severe frailty. They also analysed genetic data covering 264 cancer types.
A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.
In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement. An experiment in 18-month-old mice tested TC-G 1005, a compound that activates TGR5, a…
An observational study of 182 people aged 90–100 and 306 adults aged 25–60 found weaker links between body-size measures and blood fats in the older group.An observational study of 182 people aged 90–100 and 306 adults aged 25–60 found weaker links between body-size measures and blood fats in the older group.
An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the…An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the lab.
Scans identified moderate or severe spinal fractures in 14.6% of 2,446 symptom-free UK Biobank participants aged 40–79, including people with normal bone density.Scans identified moderate or severe spinal fractures in 14.6% of 2,446 symptom-free UK Biobank participants aged 40–79, including people with normal bone density. The group included 1,151 men.
In a five-month intervention involving 42 people, sunscreen-treated arms showed smaller changes in DNA marks than the opposite arms under everyday conditions.In a five-month intervention involving 42 people, sunscreen-treated arms showed smaller changes in DNA marks than the opposite arms under everyday conditions.
Experiments in mice producing a progeria-linked protein in heart muscle cells found that restoring an RNA-marking protein partly reduced abnormal heart changes.Experiments in mice producing a progeria-linked protein in heart muscle cells found that restoring an RNA-marking protein partly reduced abnormal heart changes.
Mitochondrial citrate metabolism drove inflammation through a pathway that acted independently of mitochondrial DNA-triggered immune signalling but cooperated with it to…Mitochondrial citrate metabolism drove inflammation through a pathway that acted independently of mitochondrial DNA-triggered immune signalling but cooperated with it to amplify inflammation.
Fifteen protein-based aging clocks were linked to death from any cause; 11 remained associated after lifestyle adjustment in 401 Finnish twins.Fifteen protein-based aging clocks were linked to death from any cause; 11 remained associated after lifestyle adjustment in 401 Finnish twins.
Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.
Adding scan-based age to clinical information raised a model’s prediction score for death from causes other than lung cancer from 0.69 to 0.73.Adding scan-based age to clinical information raised a model’s prediction score for death from causes other than lung cancer from 0.69 to 0.73. Researchers analysed 29,745 low-dose computed tomography scans.
Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signalling.Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signalling.
An observational study of healthy volunteers aged 9 months to 65 years found the most pronounced immune-cell shifts at ages 10–19, with different patterns by sex.An observational study of healthy volunteers aged 9 months to 65 years found the most pronounced immune-cell shifts at ages 10–19, with different patterns by sex. These immune cells help the body remember previous encounters.
An experiment in rats with puncture-induced disc degeneration tested iron-binding particles designed to target senescent cells, which have stopped dividing.An experiment in rats with puncture-induced disc degeneration tested iron-binding particles designed to target senescent cells, which have stopped dividing.
A commentary discussed evidence that an enzyme activated during dead-cell clearance helped tissue repair as artery plaques regressed in a mouse model.A commentary discussed evidence that an enzyme activated during dead-cell clearance helped tissue repair as artery plaques regressed in a mouse model. A commentary discussed this work, rather than reporting a new experiment.
Among 3,007 adults, artificial intelligence identified 91.0% of those with very low lower-spine bone density and correctly classified 82.7% of those without it.Among 3,007 adults, artificial intelligence identified 91.0% of those with very low lower-spine bone density and correctly classified 82.7% of those without it.
Research in models of aging, disuse and cancer-related wasting identified a fat-derived protein as a key mediator of protection from a metabolic supplement.Research in models of aging, disuse and cancer-related wasting identified a fat-derived protein as a key mediator of protection from a metabolic supplement.
Among adults with at least two recorded conditions, estimates were 92.3% using general practice records, 63.2% using hospital records and 100% using both.Among adults with at least two recorded conditions, estimates were 92.3% using general practice records, 63.2% using hospital records and 100% using both. The records covered 1987 to 2020.
An analysis of 69,871 melanoma cases and 1,616,233 comparison participants identified 156 independent genetic signals in 116 regions linked to risk.An analysis of 69,871 melanoma cases and 1,616,233 comparison participants identified 156 independent genetic signals in 116 regions linked to risk.
Long-read RNA sequencing detected switching in 19 genes in overloaded adult mouse muscle, compared with none in overloaded aged muscle.Long-read RNA sequencing detected switching in 19 genes in overloaded adult mouse muscle, compared with none in overloaded aged muscle. In an experiment in adult and aged mice, researchers mechanically overloaded skeletal muscle…
The model improved prediction for 93 of 131 disease groups compared with a model based on existing disease burden.The model improved prediction for 93 of 131 disease groups compared with a model based on existing disease burden. In an observational study using Austrian inpatient records from 7.4 million patients, researchers analysed 13 years…
Among 20,509 participants initially free of heart and metabolic disease, 783 developed multiple such conditions over a median 6.8 years.Among 20,509 participants initially free of heart and metabolic disease, 783 developed multiple such conditions over a median 6.8 years. The observational study pooled 20,509 participants initially free of cardiometabolic…
A blood-sugar measure fell 16 and 20 mmol/mol with 30 mg and 60 mg daily, versus 4 mmol/mol with placebo over 16 weeks.A blood-sugar measure fell 16 and 20 mmol/mol with 30 mg and 60 mg daily, versus 4 mmol/mol with placebo over 16 weeks. The randomised trial enrolled 155 Chinese adults aged 18–75 with type 2 diabetes.
In a retrospective study of 363 older patients with heart failure, 24.0% had muscle loss with swallowing difficulty, which was associated with poorer one-year outcomes.In a retrospective study of 363 older patients with heart failure, 24.0% had muscle loss with swallowing difficulty, which was associated with poorer one-year outcomes.
An experiment in Alzheimer's disease mice found that the system also restored new neuron formation in a brain region involved in memory.An experiment in Alzheimer's disease mice found that the system also restored new neuron formation in a brain region involved in memory. In an animal experiment in mice with Alzheimer's disease, researchers tested a delivery…
An evolutionary analysis of 2,171 human samples linked common mutations to expansion of normal cells, but found little advantage during progression to cancer.An evolutionary analysis of 2,171 human samples linked common mutations to expansion of normal cells, but found little advantage during progression to cancer.
Over five years, atrial fibrillation, an irregular heartbeat, affected 8.3% and stroke 7.3% of patients with all five risk factors; both rates were lowest with none.Over five years, atrial fibrillation, an irregular heartbeat, affected 8.3% and stroke 7.3% of patients with all five risk factors; both rates were lowest with none.
Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.
