In 502,355 UK Biobank participants, diagnoses tied to more functional disease units showed steeper rises in incidence with age (Spearman rho = 0.50).In 502,355 UK Biobank participants, diagnoses tied to more functional disease units showed steeper rises in incidence with age (Spearman rho = 0.50). In linked health records from 502,355 UK Biobank participants, researchers analyzed co-occurrence patterns across 232 diagnoses.
In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation…In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation reversed. In Klotho heterozygous knockout mice, reduced Klotho levels led to hyperkalemia and decreased urinary potassium excretion.
Overexpressing the receptor in adrenergic-like neurons prolonged lifespan, restored calcium signaling, and improved locomotor performance in aged…Overexpressing the receptor in adrenergic-like neurons prolonged lifespan, restored calcium signaling, and improved locomotor performance in aged fruit flies. In fruit flies (Drosophila), aging leads to neurodegeneration, diminished locomotion, and increased oxidative whole-brain…
GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19…GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19 survivors. In a study of COVID-19 survivors aged 50 years and older with type 2 diabetes, researchers compared the outcomes of initiating…
Mutant blood cells induced stromal senescence, while depleting senescent non-haematopoietic cells reduced clonal burden and delayed progression to…Mutant blood cells induced stromal senescence, while depleting senescent non-haematopoietic cells reduced clonal burden and delayed progression to myeloid neoplasia in mice. In mouse models and primary human samples, researchers investigated how mutant haematopoietic stem and progenitor…
Mid-adulthood functional hypothalamic amenorrhea was linked to a 62% higher cardiovascular disease risk and an HR of 1.91 for coronary heart disease…Mid-adulthood functional hypothalamic amenorrhea was linked to a 62% higher cardiovascular disease risk and an HR of 1.91 for coronary heart disease compared to regular cycles.
Simulations show DE-SWAN is sensitive to age distribution and window size, questioning reported peaks in aging rates across the life course.Simulations show DE-SWAN is sensitive to age distribution and window size, questioning reported peaks in aging rates across the life course. In a preprint using computational simulations, researchers evaluated DE-SWAN, a method used to study how large ensembles of omics biomarkers change…
People with intramuscular fat fractions above 10% showed significantly lower paraspinal muscle mass and strength than those with levels below 5%.People with intramuscular fat fractions above 10% showed significantly lower paraspinal muscle mass and strength than those with levels below 5%. In people with spinal sarcopenia, researchers found that the intramuscular fat fraction, rather than perimuscular fat fraction, was an…
In 70,473 adults followed for up to 10 years, 210 wearable activity phenotypes were linked to 406 diseases, with step intensity and circadian rhythm…In 70,473 adults followed for up to 10 years, 210 wearable activity phenotypes were linked to 406 diseases, with step intensity and circadian rhythm showing prominent ties. In a cohort of 70,473 human participants followed for up to 10 years, researchers analyzed 11.8 million person-hours…
Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without…Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without altering cumulative energy intake.
Using a microarray platform, researchers identified shared growth drivers in breast and lung cancer cells that required cellular alterations to…Using a microarray platform, researchers identified shared growth drivers in breast and lung cancer cells that required cellular alterations to promote proliferation. In cultured breast and lung cells and mouse xenografts, researchers used a microenvironment microarray platform to…
Initiating moderate-to-vigorous physical activity was associated with an all-cause mortality hazard ratio of 0.89 compared with remaining inactive…Initiating moderate-to-vigorous physical activity was associated with an all-cause mortality hazard ratio of 0.89 compared with remaining inactive over a median 7.9-year follow-up.
A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory…A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory diseases. In a prospective cohort of 181,955 UK Biobank participants, researchers examined how cardiovascular health and biological aging…
In a PolgA-mutant mouse model, gut microbiota reduced systemic mitochondrial function while driving energy-demanding immune remodeling and protein…In a PolgA-mutant mouse model, gut microbiota reduced systemic mitochondrial function while driving energy-demanding immune remodeling and protein synthesis through mTOR signaling.
Favourable cognitive frailty dynamics were linked to lower odds of next-wave diabetes compared with unfavourable dynamics (OR 0.66).Favourable cognitive frailty dynamics were linked to lower odds of next-wave diabetes compared with unfavourable dynamics (OR 0.66). In a multinational study of 23,458 adults aged 45 years and older without baseline diabetes from CHARLS, HRS, and ELSA, researchers tracked cognitive frailty…
In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect…In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect joints. In aged mice, low-intensity swimming exercise attenuated age-related osteoarthritis.
In 364 cardiac surgery patients, age (odds ratio 1.71 per decade) and a PITX2 variant (odds ratio 1.91) independently predicted postoperative atrial…In 364 cardiac surgery patients, age (odds ratio 1.71 per decade) and a PITX2 variant (odds ratio 1.91) independently predicted postoperative atrial fibrillation, while inflammatory markers did not.
Mean excursion amplitude was approximately 40 bpm at age 40 versus 32 bpm at 80; duration was approximately 90 versus 104 minutes, respectively.Mean excursion amplitude was approximately 40 bpm at age 40 versus 32 bpm at 80; duration was approximately 90 versus 104 minutes, respectively. In 750 participants in the Baltimore Longitudinal Study of Aging, older age was associated with a smaller heart rate range and changes in its…
In a preprint using iPSC-derived organoids, serial passaging re-established aging trajectories while disease-associated mutations drove additional…In a preprint using iPSC-derived organoids, serial passaging re-established aging trajectories while disease-associated mutations drove additional cell-intrinsic shifts in epigenetic age.
In an external validation cohort, predicted peak VO₂ correlated with observed values at r = 0.654, with a root mean square error of 4.73 mL/kg/min.In an external validation cohort, predicted peak VO₂ correlated with observed values at r = 0.654, with a root mean square error of 4.73 mL/kg/min. In a retrospective study of 3,577 clinical patients who underwent cardiopulmonary exercise testing, researchers evaluated how performance on…
Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung…Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung cancer patient-derived organoids.
In 33,258 newly diagnosed adults and 16,807 five-year survivors, non-cancer multimorbidity affected 60% to 86% at diagnosis and 70% to 90% in…In 33,258 newly diagnosed adults and 16,807 five-year survivors, non-cancer multimorbidity affected 60% to 86% at diagnosis and 70% to 90% in survivorship. In a retrospective cohort study of adults aged 18 and older diagnosed with or surviving five years after breast, prostate, colorectal…
Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification…Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality. In mice, deficiency of the renal proximal tubule protein TMEM174 significantly shortened lifespan compared to wild-type…
Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process. In human blood cells from donors ranging from neonatal to 101 years of age, researchers tracked cellular rejuvenation during direct lineage…
In mice exposed to ionizing radiation, deleting Brn2 altered DNA damage responses and triggered permanent hair depigmentation linked to melanocyte…In mice exposed to ionizing radiation, deleting Brn2 altered DNA damage responses and triggered permanent hair depigmentation linked to melanocyte stem cell depletion. In mice and human cell datasets, researchers investigated how the transcription factor BRN2 preserves adult melanocyte…
An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues…An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues in a dose-dependent manner.
In a preprint study of 39 older adults, previewing routes mitigated dual-task increases in stepping errors and cross-steps while promoting forward…In a preprint study of 39 older adults, previewing routes mitigated dual-task increases in stepping errors and cross-steps while promoting forward gaze transitions. In a preprint study, 39 community-dwelling older adults completed adaptive walking trials to test whether previewing a path…
In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune…In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron homeostasis. In aged mice, exposure to the fungus Kazachstania pintolopesii accelerates splenic senescence, according to a study…
In a cross-sectional study of 6,690 adults, healthy plant-rich eating patterns and specific foods like fruits and vegetables tracked with lower rates…In a cross-sectional study of 6,690 adults, healthy plant-rich eating patterns and specific foods like fruits and vegetables tracked with lower rates of hyposmia. In a cross-sectional study of 6,690 participants from the general population in South Tyrol, researchers examined how diet…
Among non-smoking non-drinkers, adults with no schooling had a mortality rate ratio of 2.76 in men and 2.93 in women compared to higher education.Among non-smoking non-drinkers, adults with no schooling had a mortality rate ratio of 2.76 in men and 2.93 in women compared to higher education. In a prospective study of 500,810 adults aged 35 and older in Chennai, India, researchers evaluated how social inequality, smoking, and alcohol…
