Later birth years were linked to higher capacity at entry than earlier birth years, with a model coefficient—a measure of association—of 0.797.Later birth years were linked to higher capacity at entry than earlier birth years, with a model coefficient—a measure of association—of 0.797.
Mouse experiments found earlier loss of immune cells not yet activated by their targets in males, alongside faster lymph node shrinkage.Mouse experiments found earlier loss of immune cells not yet activated by their targets in males, alongside faster lymph node shrinkage. They shifted faster into virtual memory cells, which had memory-like features without…
An observational analysis of 2,609 apparently healthy people linked the balance of two memory immune-cell groups to healthy and disease-associated aging patterns.An observational analysis of 2,609 apparently healthy people linked the balance of two memory immune-cell groups to healthy and disease-associated aging patterns.
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Get Plus for $49In simulations, prescreening could reduce bone-density scans by about 50% while retaining detection of 98–99% of osteoporosis cases.In simulations, prescreening could reduce bone-density scans by about 50% while retaining detection of 98–99% of osteoporosis cases. In a computational study, researchers developed an artificial intelligence model using paired…
Experiments that altered gene activity in human spinal disc cells found that restoring the protein also reduced senescence, a state in which cells stop dividing.Experiments that altered gene activity in human spinal disc cells found that restoring the protein also reduced senescence, a state in which cells stop dividing.
Over a median 5.1 years, bleeding-related lesions appeared in 33.7% of participants with severe enlargement versus 13.6% without severe enlargement.Over a median 5.1 years, bleeding-related lesions appeared in 33.7% of participants with severe enlargement versus 13.6% without severe enlargement.
Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.
Across 985,026 participants, disease-causing DNA expansions occurred in about 1 in 1,527, compared with earlier disease prevalence estimates of 1 in 3,000–8,000.Across 985,026 participants, disease-causing DNA expansions occurred in about 1 in 1,527, compared with earlier disease prevalence estimates of 1 in 3,000–8,000.
In a mouse model of lung cancer, restricting food before tumour induction preserved lean mass and prolonged survival where targeting individual candidate factors failed.In a mouse model of lung cancer, restricting food before tumour induction preserved lean mass and prolonged survival where targeting individual candidate factors failed.
In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.
Definite childhood loneliness was linked to faster frailty progression than no childhood loneliness, with an estimated difference of 0.289 in the statistical model.Definite childhood loneliness was linked to faster frailty progression than no childhood loneliness, with an estimated difference of 0.289 in the statistical model.
In 5,834 community-dwelling older Americans, intrinsic capacity scores showed progressive age-related decline and were lower in females than in males.In 5,834 community-dwelling older Americans, intrinsic capacity scores showed progressive age-related decline and were lower in females than in males.
Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere…Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere length.
The highest-scoring quarter had a hazard ratio of 0.70—a measure comparing death rates over time—versus the lowest-scoring quarter.The highest-scoring quarter had a hazard ratio of 0.70—a measure comparing death rates over time—versus the lowest-scoring quarter. Researchers analysed data from 105,812 adults in the Lifelines observational cohort study, with a…
In lab-grown human fibroblasts, tiny vesicles from senescent cells prompted dividing cells to halt division and activate a DNA damage response.In lab-grown human fibroblasts, tiny vesicles from senescent cells prompted dividing cells to halt division and activate a DNA damage response.
An observational study followed 5,474 Chinese participants from 2011 to 2020 and linked higher marker values to progression to clinical cardiovascular disease.An observational study followed 5,474 Chinese participants from 2011 to 2020 and linked higher marker values to progression to clinical cardiovascular disease.
Higher carbon dioxide concentrations and more frequent heatwaves were linked to diabetes, with odds ratios—comparisons of diabetes odds—of 1.14 and 1.48, respectively.Higher carbon dioxide concentrations and more frequent heatwaves were linked to diabetes, with odds ratios—comparisons of diabetes odds—of 1.14 and 1.48, respectively.
In mice with severe mitochondrial disease, a two-drug treatment extended median lifespan from 62 days to 158 days.In mice with severe mitochondrial disease, a two-drug treatment extended median lifespan from 62 days to 158 days. In an experiment in mice, researchers tested a two-drug regimen designed to mimic the effects of breathing…
An observational analysis of 247,863 adults aged 45–100 linked older age to stroke progression, with the strength of those links differing across countries.An observational analysis of 247,863 adults aged 45–100 linked older age to stroke progression, with the strength of those links differing across countries.
Compared with participants without low muscle mass, those with it had a hazard ratio of 2.02, indicating a higher rate of later self-reported cancer.Compared with participants without low muscle mass, those with it had a hazard ratio of 2.02, indicating a higher rate of later self-reported cancer.
When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.
In an experiment on cultured muscle precursor cells, electrical metabolic monitoring tracked cellular senescence and predicted whether the cells could form muscle.In an experiment on cultured muscle precursor cells, electrical metabolic monitoring tracked cellular senescence and predicted whether the cells could form muscle.
Data from 5,228 participants and 302 interviews across 13 countries identified seven core physical, mental, and social domains to track during menopause.Data from 5,228 participants and 302 interviews across 13 countries identified seven core physical, mental, and social domains to track during menopause.
In an observational study of over 100,000 older adults across five countries, upward educational mobility was linked to higher overall physical and mental capacity.In an observational study of over 100,000 older adults across five countries, upward educational mobility was linked to higher overall physical and mental capacity.
The adjusted hazard ratio, which compares death rates over time, was 1.10 for consistently high, rising social stress versus initially lower, rising stress.The adjusted hazard ratio, which compares death rates over time, was 1.10 for consistently high, rising social stress versus initially lower, rising stress.
The basic blood fat–glucose measure had a hazard ratio—a comparison of glaucoma rates—of 1.05 in a cohort of 396,213 UK participants.The basic blood fat–glucose measure had a hazard ratio—a comparison of glaucoma rates—of 1.05 in a cohort of 396,213 UK participants. Researchers followed 396,213 UK participants of European ancestry without glaucoma, a disease…
Transplanted human neurons survived for up to 5 months, with a proportion remaining up to 10 months, in mice lacking normal immune defences.Transplanted human neurons survived for up to 5 months, with a proportion remaining up to 10 months, in mice lacking normal immune defences.
Adults with both problems were linked to rapidly rising rather than persistently low depressive symptoms, with an odds ratio of 4.130.Adults with both problems were linked to rapidly rising rather than persistently low depressive symptoms, with an odds ratio of 4.130. Adults aged 45 and older from the China Health and Retirement Longitudinal Study were studied…
In over 109,000 Danish cancer survivors followed for a median 6.9 years, new illness rates exceeded those of cancer-free peers, with short education linked to further…In over 109,000 Danish cancer survivors followed for a median 6.9 years, new illness rates exceeded those of cancer-free peers, with short education linked to further increases.
The engineered particles cut friction over 90% compared with commercial hyaluronic acid and reversed chondrocyte senescence in lab models of osteoarthritis.The engineered particles cut friction over 90% compared with commercial hyaluronic acid and reversed chondrocyte senescence in lab models of osteoarthritis.
In a 35-year cohort of adults around age 61, each year of cumulative cannabis use was linked to higher odds of prolonged nighttime wakefulness.In a 35-year cohort of adults around age 61, each year of cumulative cannabis use was linked to higher odds of prolonged nighttime wakefulness.
A flush combining a metabolic inhibitor with a mitochondrial protectant reduced tissue injury and improved survival after warm storage in rat liver transplants.A flush combining a metabolic inhibitor with a mitochondrial protectant reduced tissue injury and improved survival after warm storage in rat liver transplants.
Adults with moderate and high increases in estimated arterial stiffness had odds ratios of 1.32 and 1.78 for tooth loss compared with a low-stable group.Adults with moderate and high increases in estimated arterial stiffness had odds ratios of 1.32 and 1.78 for tooth loss compared with a low-stable group.
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