One-year mortality was 18.7% in severely frail patients compared with 0.9% in fit individuals in an Israeli health maintenance organization.One-year mortality was 18.7% in severely frail patients compared with 0.9% in fit individuals in an Israeli health maintenance organization.
Mouse experiments found that raising the molecule caused cognitive decline, while drugs blocking certain enzymes counteracted the induced inflammation and cognitive…Mouse experiments found that raising the molecule caused cognitive decline, while drugs blocking certain enzymes counteracted the induced inflammation and cognitive changes.
The ratio comparing age’s associations with memory-first and strength-first transition rates was 1.110 per five years across four cohorts.The ratio comparing age’s associations with memory-first and strength-first transition rates was 1.110 per five years across four cohorts. An observational analysis included 46,356 adults aged 50–100 from four long-term cohorts.
Experiments across multiple aging mouse models found that a vaccine cleared targeted fat cells in senescence, a state in which cells stop dividing.Experiments across multiple aging mouse models found that a vaccine cleared targeted fat cells in senescence, a state in which cells stop dividing.
Experiments with human bone marrow cells found that support cells’ ability to protect blood-forming stem cells during regeneration-related stress was impaired with age.Experiments with human bone marrow cells found that support cells’ ability to protect blood-forming stem cells during regeneration-related stress was impaired with age.
A 12-week randomized trial in 72 older adults without cognitive impairment found memory-test improvement and less decline in a brain-scan measure.A 12-week randomized trial in 72 older adults without cognitive impairment found memory-test improvement and less decline in a brain-scan measure.
Across 210 placebo-controlled trials, the odds of serious disorders in one soft-tissue disease group were 3.88 times those with placebo.Across 210 placebo-controlled trials, the odds of serious disorders in one soft-tissue disease group were 3.88 times those with placebo. Researchers analyzed genetic data from over 900,000 FinnGen and UK Biobank participants to…
An analysis of 47,537 cells from young and old male mice linked aging to altered immune balance in tear-producing glands.An analysis of 47,537 cells from young and old male mice linked aging to altered immune balance in tear-producing glands. They analyzed gene activity in 47,537 individual cells to examine cell types, their states and possible…
Cognitive test scores improved by 2.3 points more with the six-month video-based exercise and nutrition program than with usual health promotion services.Cognitive test scores improved by 2.3 points more with the six-month video-based exercise and nutrition program than with usual health promotion services.
Experiments in adult flies traced how machinery associated with stem cells became active again with age, undermining mature gut cells’ specialized identity.Experiments in adult flies traced how machinery associated with stem cells became active again with age, undermining mature gut cells’ specialized identity.
Surgery intended to cure the cancer did not take place in 9.9% of the exercise group versus 7.9% with usual care.Surgery intended to cure the cancer did not take place in 9.9% of the exercise group versus 7.9% with usual care. The randomized trial analyzed 202 people with gastroesophageal adenocarcinoma, a type of stomach or esophageal…
An observational analysis linked statin use to slower annual declines in bone mineral density among postmenopausal women.An observational analysis linked statin use to slower annual declines in bone mineral density among postmenopausal women. In separate experimental work, the researchers reported that atorvastatin promoted bone formation…
An observational study followed 1,396 generally healthy adults aged 36–108 for an average of 5.0 years, separating cognitive performance from subsequent decline.An observational study followed 1,396 generally healthy adults aged 36–108 for an average of 5.0 years, separating cognitive performance from subsequent decline.
In 20-month-old mice, 12 weeks of supplementation restored blood vessel relaxation controlled by the vessel lining and reduced signs of inflammation.In 20-month-old mice, 12 weeks of supplementation restored blood vessel relaxation controlled by the vessel lining and reduced signs of inflammation.
Blood analyses in two aging cohorts of 22 and 33 people linked physical frailty to immune signals involved in cell movement and inflammation.Blood analyses in two aging cohorts of 22 and 33 people linked physical frailty to immune signals involved in cell movement and inflammation.
Relative telomere length in white blood cells remained unchanged: 1.000 at 9 months, 0.939 at 16 months and 1.120 at 24 months.Relative telomere length in white blood cells remained unchanged: 1.000 at 9 months, 0.939 at 16 months and 1.120 at 24 months. Researchers studied 51 Sprague-Dawley rats in a cross-sectional animal study, examining separate…
The model’s predictions differed from actual ages by 5.89 years on average, and by 5.41 years in an independent validation group.The model’s predictions differed from actual ages by 5.89 years on average, and by 5.41 years in an independent validation group. In participants from four study cohorts, researchers trained and evaluated a brain-age model using…
Among 2,006 older hospital patients, each one-point rise on a clinical frailty scale was associated with a 50% higher relative risk of death within six months.Among 2,006 older hospital patients, each one-point rise on a clinical frailty scale was associated with a 50% higher relative risk of death within six months.
Experiments in aged male mice found that ginsenoside Rg2 also improved muscle mass, strength and exercise endurance while reducing age-associated weight gain.Experiments in aged male mice found that ginsenoside Rg2 also improved muscle mass, strength and exercise endurance while reducing age-associated weight gain.
In a 40-week randomized trial of 40 older adults with insulin resistance, metformin preserved regional brain glucose uptake, volume and coordination between brain…In a 40-week randomized trial of 40 older adults with insulin resistance, metformin preserved regional brain glucose uptake, volume and coordination between brain regions.
Who was studied40 older adults with insulin resistance, 40 weeks, against placebo
What changedMetformin preserved regional brain volume and coordination between brain regions compared with placebo in older adults with insulin resistance
The catchThe brain-preservation finding comes from only 40 older adults
The model scored 0.764 in distinguishing who developed frailty in internal validation, versus 0.747 in a separate Korean cohort.The model scored 0.764 in distinguishing who developed frailty in internal validation, versus 0.747 in a separate Korean cohort. A retrospective observational study used data from 2,126 Chinese adults aged 45 or older who had…
Median lifespan ranged from 14 years in small dogs to less than 10 years in giant dogs from American Kennel Club-recognized breeds.Median lifespan ranged from 14 years in small dogs to less than 10 years in giant dogs from American Kennel Club-recognized breeds. Researchers analyzed 41,047 companion dogs in the Dog Aging Project, a prospective cohort study…
Among 70,982 adults followed for up to five years, researchers identified 65 lower-risk and 53 higher-risk associations compared with other diabetes drugs.Among 70,982 adults followed for up to five years, researchers identified 65 lower-risk and 53 higher-risk associations compared with other diabetes drugs.
At 10 weeks, adjusted physical performance scores averaged 9.62 in the program group versus 7.80 in the control group.At 10 weeks, adjusted physical performance scores averaged 9.62 in the program group versus 7.80 in the control group. In a non-randomized controlled evaluation, 184 community-dwelling adults aged 65 or older joined an exercise…
Experiments in aged animal hearts linked the benefit to suppression of a small RNA involved in excessive splitting of mitochondria, the cell’s energy-producing…Experiments in aged animal hearts linked the benefit to suppression of a small RNA involved in excessive splitting of mitochondria, the cell’s energy-producing structures.
Obesity with weak grip was linked to 3.14 times the odds of multiple heart and metabolic conditions compared with neither feature.Obesity with weak grip was linked to 3.14 times the odds of multiple heart and metabolic conditions compared with neither feature. The cross-sectional observational analysis included 46,563 Indian adults aged 50 or older from the…
Two-year survival was 78.9% in fit adults, 66.0% in those classified as prefrail and 51.7% in those classified as frail.Two-year survival was 78.9% in fit adults, 66.0% in those classified as prefrail and 51.7% in those classified as frail. The retrospective cohort study included 992 adults undergoing donor blood-forming stem cell transplants for…
An experiment in young and aged virgin mice isolated uterine effects from ovarian and embryonic factors and found reduced tissue growth in older animals.An experiment in young and aged virgin mice isolated uterine effects from ovarian and embryonic factors and found reduced tissue growth in older animals.
After 12 months, whole-brain lesion volume differed by minus 0.016 log-transformed cubic centimeters versus balance and tone exercises, with no clear group difference.After 12 months, whole-brain lesion volume differed by minus 0.016 log-transformed cubic centimeters versus balance and tone exercises, with no clear group difference.
Compared with no reported exposure, famine exposure was linked to 20%–29% higher odds of five chronic conditions and 10% higher odds of two others.Compared with no reported exposure, famine exposure was linked to 20%–29% higher odds of five chronic conditions and 10% higher odds of two others.
Experiments linked a chemical change in a cell-recycling protein to exercise-related improvements in insulin responses and liver fat metabolism.Experiments linked a chemical change in a cell-recycling protein to exercise-related improvements in insulin responses and liver fat metabolism.
