An observational analysis of adult cohorts linked thickness more strongly than surface area to changes in thinking abilities over time.An observational analysis of adult cohorts linked thickness more strongly than surface area to changes in thinking abilities over time. In adults spanning a wide age range, an observational study linked the thickness of the…
Lens thickening during drug-triggered focusing increased by 0.24 millimeters compared with before injection, and the increased anatomical response lasted up to 16 months.Lens thickening during drug-triggered focusing increased by 0.24 millimeters compared with before injection, and the increased anatomical response lasted up to 16 months.
In an injury experiment, 12-month-old mice lacking three related proteins had smaller regenerating muscle fibers after seven days than mice with the proteins.In an injury experiment, 12-month-old mice lacking three related proteins had smaller regenerating muscle fibers after seven days than mice with the proteins.
An 18-month randomized trial of 482 adults aged 60–82 found the largest gains with a combined exercise program that included mental tasks.An 18-month randomized trial of 482 adults aged 60–82 found the largest gains with a combined exercise program that included mental tasks. Researchers assigned participants to Nordic walking, or walking with poles; water aerobics…
Experiments in fruit flies identified pileup, a molecule involved in microbial defense, as a regulator of aging gut-cell removal.Experiments in fruit flies identified pileup, a molecule involved in microbial defense, as a regulator of aging gut-cell removal. In experiments in Drosophila fruit flies, researchers studied how the gut shed aging enterocytes…
In UK Biobank’s highest age-acceleration groups, hazard ratios—comparing progression rates—were 1.44 for PhenoAge versus 1.22 for another biological age measure.In UK Biobank’s highest age-acceleration groups, hazard ratios—comparing progression rates—were 1.44 for PhenoAge versus 1.22 for another biological age measure.
An observational study detected these clones in 8.5% of each analysis cohort and in 4.0% of adults aged 18–39.An observational study detected these clones in 8.5% of each analysis cohort and in 4.0% of adults aged 18–39. An observational study analyzed DNA sequencing and health records from 59,598 adults in Mount Sinai’s multi-ancestry…
Muscle protein production rose 216% from baseline with 20 grams of corn protein, versus 77% with a low-energy placebo without protein.Muscle protein production rose 216% from baseline with 20 grams of corn protein, versus 77% with a low-energy placebo without protein. A randomized, double-blind, placebo-controlled trial studied 48 healthy older adults whose…
The adjusted odds ratio was 0.99 for veterans with HIV versus those without; a value of one would mean no association.The adjusted odds ratio was 0.99 for veterans with HIV versus those without; a value of one would mean no association. Researchers assessed 1,524 older US veterans with HIV and 852 without HIV for clonal hematopoiesis of…
The weighted share with at least two chronic conditions was 36%, ranging from 6.6% in rural The Gambia to 62.0% in urban South Africa.The weighted share with at least two chronic conditions was 36%, ranging from 6.6% in rural The Gambia to 62.0% in urban South Africa. Researchers studied 5,296 adults aged 40 or older in The Gambia, South Africa, and Zimbabwe.
In 981 blood donors, all 80 references covering six cell types reversed an immune cell’s estimated age association compared with data carrying known cell labels.In 981 blood donors, all 80 references covering six cell types reversed an immune cell’s estimated age association compared with data carrying known cell labels.
Damaraland mole-rats developed no tumors over more than three years, while their immune response to cancer-causing chemicals differed from that of naked mole-rats.Damaraland mole-rats developed no tumors over more than three years, while their immune response to cancer-causing chemicals differed from that of naked mole-rats.
Over four to five years, disability risk ranged from 4.6% in the lowest frailty group to 19.8% in the highest in the US cohort.Over four to five years, disability risk ranged from 4.6% in the lowest frailty group to 19.8% in the highest in the US cohort. An observational analysis pooled four studies of 19,324 adults aged 50 or older who initially had no…
In an experiment in aged mice, re-expressing the protein increased the density of dendritic spines, small signal-receiving structures on neurons, and improved memory…In an experiment in aged mice, re-expressing the protein increased the density of dendritic spines, small signal-receiving structures on neurons, and improved memory performance.
In two cohorts of 937 and 470 heart valve replacement patients, faster biological aging was linked to higher mortality over two to three years.In two cohorts of 937 and 470 heart valve replacement patients, faster biological aging was linked to higher mortality over two to three years.
In a 12-week experiment in male mice, restricting daily eating times was linked to preserved lean mass and muscle insulin responsiveness in midlife.In a 12-week experiment in male mice, restricting daily eating times was linked to preserved lean mass and muscle insulin responsiveness in midlife.
A 12-week randomized trial in 25 people found that a personalized program increased muscles’ capacity to use oxygen. Nineteen exercised, while six received usual care.A 12-week randomized trial in 25 people found that a personalized program increased muscles’ capacity to use oxygen. Nineteen exercised, while six received usual care.
In aged mice with spinal cord injuries, boosting the protein increased the maturation of precursor cells into nerve-insulating cells inside tissue lesions.In aged mice with spinal cord injuries, boosting the protein increased the maturation of precursor cells into nerve-insulating cells inside tissue lesions.
Vaccination was associated with 43.1% lower overall mortality relative to no vaccination among 453,500 adults aged 60 and older.Vaccination was associated with 43.1% lower overall mortality relative to no vaccination among 453,500 adults aged 60 and older. Researchers in Guangzhou, China, studied 453,500 adults aged 60 and older in a retrospective…
Exposed mice developed dose-dependent movement and thinking problems, alongside signs of senescence, a state in which cells stop dividing, in brain immune cells.Exposed mice developed dose-dependent movement and thinking problems, alongside signs of senescence, a state in which cells stop dividing, in brain immune cells.
Each 0.10-point higher score was linked to greater 30-day death risk, with a relative-risk measure called a hazard ratio of 1.68.Each 0.10-point higher score was linked to greater 30-day death risk, with a relative-risk measure called a hazard ratio of 1.68. Researchers studied 199 hospitalized adults with confirmed carbapenem-resistant Acinetobacter…
Experiments in mice aged 4–6 and 18–24 months found that deleting one copy of a gene also increased intestinal leakage and inflammation.Experiments in mice aged 4–6 and 18–24 months found that deleting one copy of a gene also increased intestinal leakage and inflammation. In an animal experiment, mice aged 4–6 months and 18–24 months lacked one copy of Akap1 or…
Glycated hemoglobin, a long-term blood sugar measure, fell 1.98 to 2.16 percentage points with UBT251, versus 1.77 with semaglutide and 0.66 with placebo at 24 weeks.Glycated hemoglobin, a long-term blood sugar measure, fell 1.98 to 2.16 percentage points with UBT251, versus 1.77 with semaglutide and 0.66 with placebo at 24 weeks.
Among long-term care residents with atrial fibrillation, an irregular heartbeat, stopping versus continuing blood thinners had hazard ratios of 1.07 for stroke and 1.02…Among long-term care residents with atrial fibrillation, an irregular heartbeat, stopping versus continuing blood thinners had hazard ratios of 1.07 for stroke and 1.02 for bleeding.
Estimated aerobic capacity was 3.59 milliliters of oxygen per kilogram per minute higher with Zumba than usual habits at 12 weeks, accounting for starting values.Estimated aerobic capacity was 3.59 milliliters of oxygen per kilogram per minute higher with Zumba than usual habits at 12 weeks, accounting for starting values.
In an experiment in 18-month-old mice with a partial enzyme deficiency, disabling a second enzyme in blood-vessel lining cells improved abnormal artery responses.In an experiment in 18-month-old mice with a partial enzyme deficiency, disabling a second enzyme in blood-vessel lining cells improved abnormal artery responses.
An observational study of 6,775 participants linked more frequent activities with children within and outside their families to survival over 12 years.An observational study of 6,775 participants linked more frequent activities with children within and outside their families to survival over 12 years. Researchers assessed survival as of 2022.
Ten-year cancer incidence was 1.84% at normal weight, 2.24% with class I obesity and 2.62% with class II obesity.Ten-year cancer incidence was 1.84% at normal weight, 2.24% with class I obesity and 2.62% with class II obesity. An observational cohort study followed 6,313,338 Korean adults aged 20 to 39 without prior cancer who participated…
In UK Biobank data, predictions explained variation in heart measurements with a score of 0.310, versus 0.269 for the best electrical-recording-only model.In UK Biobank data, predictions explained variation in heart measurements with a score of 0.310, versus 0.269 for the best electrical-recording-only model.
Who was studiedHuman heart recordings and cardiac images
What changedHeart measurement predictions explained more variation with CardioNets, scoring 0.310 against 0.269 for the best electrical-recording-only model
The catchPrediction accuracy in prospective clinical care was not measured
In experiments with blood vessel muscle cells, the signal also promoted an inflammatory state and impaired mitochondria, the cells’ energy-producing structures.In experiments with blood vessel muscle cells, the signal also promoted an inflammatory state and impaired mitochondria, the cells’ energy-producing structures.
Higher fitness was linked to 0.26 meters per second lower artery-wall stiffness per minute on the study’s fitness measure, among 799 older adults.Higher fitness was linked to 0.26 meters per second lower artery-wall stiffness per minute on the study’s fitness measure, among 799 older adults.
Higher intake was associated with more new blood cancer diagnoses among 204,494 UK Biobank participants followed for a median 10.5 years.Higher intake was associated with more new blood cancer diagnoses among 204,494 UK Biobank participants followed for a median 10.5 years. An observational cohort study followed 204,494 UK Biobank participants without…
Who was studied204,494 UK Biobank participants without hospital-recorded myeloid neoplasms
What changedMyeloid blood cancer diagnosis rates were higher with higher ultra-processed food intake (hazard ratio 1.12 per standard-deviation increase)
The catchHospital inpatient records could miss myeloid cancers managed entirely in outpatient care
A mouse experiment linked sleep deprivation during pregnancy to altered fetal brain and liver gene activity and later metabolic and behavioral changes in offspring.A mouse experiment linked sleep deprivation during pregnancy to altered fetal brain and liver gene activity and later metabolic and behavioral changes in offspring.
Forearm fracture rates were 1.22 times as high in men and 1.24 times in women in the highest versus lowest thirds of fine-particle pollution.Forearm fracture rates were 1.22 times as high in men and 1.24 times in women in the highest versus lowest thirds of fine-particle pollution.
