A cohort study followed 852 older siblings and 2,282 offspring and partners for up to 22 years, linking four blood proteins to longer survival.A cohort study followed 852 older siblings and 2,282 offspring and partners for up to 22 years, linking four blood proteins to longer survival. Researchers measured 326 proteins in blood plasma, the liquid part of blood.
Nighttime scans of 31 young and 41 older adults linked reduced fluid flow to weaker waves of brain activity and blood-volume change.Nighttime scans of 31 young and 41 older adults linked reduced fluid flow to weaker waves of brain activity and blood-volume change. Adults aged 18–39 (31 people) and 60–84 (41 people) underwent nighttime brain scans and…
Genetic experiments linked nerve-signaling molecules to a stress response and longer life in worms with restricted methionine, an amino acid used to build proteins.Genetic experiments linked nerve-signaling molecules to a stress response and longer life in worms with restricted methionine, an amino acid used to build proteins.
Animal experiments found that aging and chronic ultraviolet B exposure changed the skin environment in ways that favored tumor growth.Animal experiments found that aging and chronic ultraviolet B exposure changed the skin environment in ways that favored tumor growth. Their skin showed increased inflammation and structural changes that led to an environment that…
The natural experiment included 54,201 UK Biobank participants, with stronger associations among those exposed to rationing for longer during early life.The natural experiment included 54,201 UK Biobank participants, with stronger associations among those exposed to rationing for longer during early life.
A four-week randomized, double-blind trial in 30 older adults with a history of falls found improvements in balance, hip strength and sensing ankle movement.A four-week randomized, double-blind trial in 30 older adults with a history of falls found improvements in balance, hip strength and sensing ankle movement.
Across 28 diseases, median scores for distinguishing future cases from others were 0.95 versus 0.92 for a model keeping common genetic effects constant with age.Across 28 diseases, median scores for distinguishing future cases from others were 0.95 versus 0.92 for a model keeping common genetic effects constant with age.
Laboratory experiments found that worms fed the protein through bacteria lived longer and stayed healthy longer without reduced fertility.Laboratory experiments found that worms fed the protein through bacteria lived longer and stayed healthy longer without reduced fertility. HSP90 is a protein that helps other proteins keep their shape.
Australians of European ancestry in the score’s top 10% had 10.04 times the odds of glaucoma compared with the remaining participants.Australians of European ancestry in the score’s top 10% had 10.04 times the odds of glaucoma compared with the remaining participants. More than 6 million people from multiple ancestry groups contributed genetic data to a genetic…
Experiments in aged mice and isolated mouse aortas found that tiny particles released by Lactobacillus plantarum improved blood vessel relaxation and reduced oxidative…Experiments in aged mice and isolated mouse aortas found that tiny particles released by Lactobacillus plantarum improved blood vessel relaxation and reduced oxidative stress.
Low versus normal vitamin D was linked to a 76% higher relative risk of developing frailty in China and 27% in England.Low versus normal vitamin D was linked to a 76% higher relative risk of developing frailty in China and 27% in England. Adults aged 65 or older in China and 50 or older in England and the United States made up three prospective…
Mouse embryonic stem cells reprogrammed with either of two gene-control proteins developed similar cancer-like marking patterns, despite activating different sets of…Mouse embryonic stem cells reprogrammed with either of two gene-control proteins developed similar cancer-like marking patterns, despite activating different sets of genes.
Older adults with hobbies had a 20–40% lower relative risk of moving from normal cognition to mild decline in three of four cohorts, compared with nonparticipants.Older adults with hobbies had a 20–40% lower relative risk of moving from normal cognition to mild decline in three of four cohorts, compared with nonparticipants.
Among 7,151 older adults, those impaired across all areas had 26.53 times the odds of disability in daily activities compared with the strongest group.Among 7,151 older adults, those impaired across all areas had 26.53 times the odds of disability in daily activities compared with the strongest group.
Mice given a heart-cell-targeted gene-silencing injection at 90 weeks had less inflammation and better heart relaxation when assessed at 110 weeks.Mice given a heart-cell-targeted gene-silencing injection at 90 weeks had less inflammation and better heart relaxation when assessed at 110 weeks.
A 25-protein signature predicted how serum from 88 healthy adults aged 22 to 92 affected the energy-making capacity of human skin cells.A 25-protein signature predicted how serum from 88 healthy adults aged 22 to 92 affected the energy-making capacity of human skin cells. Of these participants, 42% were female.
Experiments in living worms tracked six internal cell structures across adulthood and found that most age-related remodeling appeared suddenly rather than gradually.Experiments in living worms tracked six internal cell structures across adulthood and found that most age-related remodeling appeared suddenly rather than gradually.
Quercetin and dasatinib improved thinking and muscle function in genetically modified mice used to model amyotrophic lateral sclerosis, a disease affecting movement.Quercetin and dasatinib improved thinking and muscle function in genetically modified mice used to model amyotrophic lateral sclerosis, a disease affecting movement.
A doubling of exposure to the chemical 2-hydroxyfluorene was linked to a 0.491-year increase in a DNA-based measure of accelerated aging.A doubling of exposure to the chemical 2-hydroxyfluorene was linked to a 0.491-year increase in a DNA-based measure of accelerated aging. Among 666 older adults, an observational analysis examined 13 environmental chemical…
Dementia or mild cognitive impairment occurred at 3.69 versus 3.89 events per 100 person-years with intensive versus standard treatment over a median 3.8 years.Dementia or mild cognitive impairment occurred at 3.69 versus 3.89 events per 100 person-years with intensive versus standard treatment over a median 3.8 years.
Who was studied12,434 adults with type 2 diabetes, against standard blood pressure treatment
What changedDementia or mild cognitive impairment showed no clear difference with intensive versus standard blood pressure treatment (hazard ratio 0.96)
The catchMissed mild cognitive impairment at baseline could dilute the apparent treatment effect
Arm and leg muscle mass, divided by height squared, had severe-reduction thresholds below 6.4 kilograms per square meter for men and 5.0 for women.Arm and leg muscle mass, divided by height squared, had severe-reduction thresholds below 6.4 kilograms per square meter for men and 5.0 for women.
A meta-analysis found six newly identified DNA regions linked to recombination in women and a seventh linked to recombination in men.A meta-analysis found six newly identified DNA regions linked to recombination in women and a seventh linked to recombination in men. Human genetic data covering 112,144 maternal and 78,653 paternal meiosis events across four…
In experiments, aged mice had less of the protein and more injury than young mice after liver blood supply was interrupted and restored.In experiments, aged mice had less of the protein and more injury than young mice after liver blood supply was interrupted and restored. Their liver macrophages, a type of immune cell, contained less SIRT3, a protein that removes…
A commentary on macaque brain studies describes context-dependent molecular aging and links to Alzheimer’s disease.A commentary on macaque brain studies describes context-dependent molecular aging and links to Alzheimer’s disease. Macaque brains were the focus of a commentary on research mapping aging across cell types, brain regions and…
In a two-year randomized controlled trial of 326 healthy older adults, daily walnuts had little effect on body composition compared with avoiding walnuts.In a two-year randomized controlled trial of 326 healthy older adults, daily walnuts had little effect on body composition compared with avoiding walnuts.
Greater accumulated frailty was linked to higher odds of developing depression across four cohorts, with odds ratios ranging from 3.46 to 6.09.Greater accumulated frailty was linked to higher odds of developing depression across four cohorts, with odds ratios ranging from 3.46 to 6.09.
Experiments in mice lacking the enzyme throughout their bodies found age-related heart enlargement and weaker pumping, alongside overactive signals inside heart cells.Experiments in mice lacking the enzyme throughout their bodies found age-related heart enlargement and weaker pumping, alongside overactive signals inside heart cells.
Tested across 20 independent fibroblast datasets, ECMExplainer used gene-activity comparisons to distinguish cell states and capture several processes related to aging.Tested across 20 independent fibroblast datasets, ECMExplainer used gene-activity comparisons to distinguish cell states and capture several processes related to aging.
Accelerated biological aging was linked to 2.3-fold higher relative death risk in men and 1.8-fold higher risk in women, compared with slower biological aging.Accelerated biological aging was linked to 2.3-fold higher relative death risk in men and 1.8-fold higher risk in women, compared with slower biological aging.
In animal experiments, a gel carrying tiny sacs made from spirulina and immune cells accelerated healing in aged wounds.In animal experiments, a gel carrying tiny sacs made from spirulina and immune cells accelerated healing in aged wounds. Wounds in aging animals healed faster in experiments testing a heat-sensitive gel loaded with tiny…
Death rates were 5.68% in 2023 and 5.62% in 2024, versus 5.15% in 2018 and 5.22% in 2019, but age- and sex-adjusted trends mostly declined.Death rates were 5.68% in 2023 and 5.62% in 2024, versus 5.15% in 2018 and 5.22% in 2019, but age- and sex-adjusted trends mostly declined.
Experiments in young and aged mice lacking a protein-cutting enzyme found less organ aging despite persistent signs of immune aging.Experiments in young and aged mice lacking a protein-cutting enzyme found less organ aging despite persistent signs of immune aging. Mice without the enzyme still showed major features of immune aging, including impaired function…
The modeled death rate was about 0.16 per person-year with frailty alone versus 0.07 with neither frailty nor diabetes.The modeled death rate was about 0.16 per person-year with frailty alone versus 0.07 with neither frailty nor diabetes. Chinese adults aged 45 and older living in the community—16,658 people—were tracked across five survey waves…
A measure of chemical tagging on nuclear DNA fell from 29.87% in untreated cells to 26.84% after exposure to a saturated fatty acid.A measure of chemical tagging on nuclear DNA fell from 29.87% in untreated cells to 26.84% after exposure to a saturated fatty acid. Human adipose-derived mesenchymal stem cells, stem cells from healthy fat tissue, were exposed to…
In cell experiments, kidney-risk protein variants entered an internal membrane more readily than the comparison variant, while rapamycin reduced protein levels and cell…In cell experiments, kidney-risk protein variants entered an internal membrane more readily than the comparison variant, while rapamycin reduced protein levels and cell harm.
