A longitudinal study of 50 captive adults linked faster increases in DNA-based age to shorter lifespans.A longitudinal study of 50 captive adults linked faster increases in DNA-based age to shorter lifespans. Fifty captive adult zebra finches (Taeniopygia castanotis) were monitored until natural death in a longitudinal study of DNA…
The combined cardiovascular outcome occurred in 3.7% on survodutide versus 4.1% on placebo over a median 22.0 months.The combined cardiovascular outcome occurred in 3.7% on survodutide versus 4.1% on placebo over a median 22.0 months. Among 5,530 adults aged 18 or older with overweight or obesity and cardiovascular disease, chronic kidney…
Across three studies combining tasks and learning simulations, adults aged 70–80 accessed word meanings faster than those aged 18–25 when tasks matched accumulated…Across three studies combining tasks and learning simulations, adults aged 70–80 accessed word meanings faster than those aged 18–25 when tasks matched accumulated knowledge.
A 34-year observational study of 3,285 western harvester ant colonies found declining mortality and increasing reproduction as colonies aged.A 34-year observational study of 3,285 western harvester ant colonies found declining mortality and increasing reproduction as colonies aged.
An experiment with six female mice per group tested dasatinib and quercetin, which reduced immune-cell buildup in salivary glands.An experiment with six female mice per group tested dasatinib and quercetin, which reduced immune-cell buildup in salivary glands. Ten-week-old female non-obese diabetic mice, used to model primary Sjögren’s disease, were randomly…
Women with these disorders had higher odds of two or more chronic conditions 27 years later than women with normal pregnancy blood pressure (odds ratio 1.93).Women with these disorders had higher odds of two or more chronic conditions 27 years later than women with normal pregnancy blood pressure (odds ratio 1.93).
Who was studied2,954 women with a previous pregnancy, 27y
What changedWomen with pregnancy blood pressure disorders had higher odds of multiple illnesses than women with normal blood pressure (odds ratio 1.93)
The catchSelf-reported conditions could miss undiagnosed illnesses
A four-week randomized trial in 30 healthy men aged 60–75 found greater diaphragm thickening with resistance and breathing exercises than with usual lifestyles.A four-week randomized trial in 30 healthy men aged 60–75 found greater diaphragm thickening with resistance and breathing exercises than with usual lifestyles.
A 48-hour screen of 489 compounds identified lanatoside C as a candidate for preferentially killing human immune cells with reduced TET2 gene function.A 48-hour screen of 489 compounds identified lanatoside C as a candidate for preferentially killing human immune cells with reduced TET2 gene function.
Among 176,468 men followed for a median 15.25 years, Y chromosome loss in blood cells was linked to abdominal aneurysms that caused symptoms.Among 176,468 men followed for a median 15.25 years, Y chromosome loss in blood cells was linked to abdominal aneurysms that caused symptoms.
Who was studied176,468 men free of AAA at baseline, median 15.25 years
What changedIncident symptomatic abdominal aortic aneurysm risk was higher with each standard deviation increase in chromosome Y loss (adjusted HR 1.01-1.09)
The catchThe cohort was predominantly of European ancestry
Experiments in nutrient-deprived yeast identified how an enzyme labels the cell’s protein-making machinery for breakdown through a recycling process.Experiments in nutrient-deprived yeast identified how an enzyme labels the cell’s protein-making machinery for breakdown through a recycling process.
Higher versus lower frailty scores were linked to multiple heart, blood-vessel or metabolic diseases, with a hazard ratio—a relative rate measure—of 1.33.Higher versus lower frailty scores were linked to multiple heart, blood-vessel or metabolic diseases, with a hazard ratio—a relative rate measure—of 1.33.
In skeletal muscle, exercise and the drug rapamycin partly reversed age-related shifts in protein solubility, which were greater in females.In skeletal muscle, exercise and the drug rapamycin partly reversed age-related shifts in protein solubility, which were greater in females.
The combined rate of heart attack, stroke or death was 2.01 times as high among people who stopped treatment as among those who continued.The combined rate of heart attack, stroke or death was 2.01 times as high among people who stopped treatment as among those who continued. People with type 2 diabetes and no cardiovascular disease—80,302 people attending 301…
In an animal experiment, one week of oral pretreatment improved blood pressure control and survival during blood pressure reduction in old rats.In an animal experiment, one week of oral pretreatment improved blood pressure control and survival during blood pressure reduction in old rats.
Experiments in engineered worms found that nano-polystyrene and perfluorononanoic acid together, rather than either alone, accelerated protein clumping and paralysis.Experiments in engineered worms found that nano-polystyrene and perfluorononanoic acid together, rather than either alone, accelerated protein clumping and paralysis.
A 24-month observational study of 172 adults aged 70 and older linked two sensor-detected movement patterns to functional differences not captured by stopwatch scoring.A 24-month observational study of 172 adults aged 70 and older linked two sensor-detected movement patterns to functional differences not captured by stopwatch scoring.
Lean soft tissue fell 3.57 kg with resistance exercise versus 4.67 kg with usual activities over 40 weeks of tirzepatide treatment.Lean soft tissue fell 3.57 kg with resistance exercise versus 4.67 kg with usual activities over 40 weeks of tirzepatide treatment. The 120 adults aged 50–70 with overweight or obesity—60 men and 60 postmenopausal women—received…
In lab experiments, reducing alpha-synuclein, a protein, made layers of human brain blood-vessel cells leakier; suppressing an enzyme returned leakage to normal.In lab experiments, reducing alpha-synuclein, a protein, made layers of human brain blood-vessel cells leakier; suppressing an enzyme returned leakage to normal.
Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks. Male C57BL/6J mice purchased at eight weeks old were randomly assigned to groups of six in an animal experiment.
A simultaneous 10-percentage-point increase in both green-space and water coverage was associated with 0.968 years higher life expectancy in a county-level analysis.A simultaneous 10-percentage-point increase in both green-space and water coverage was associated with 0.968 years higher life expectancy in a county-level analysis.
Experiments in young and aged mice identified a liver protein whose restoration reduced fat buildup but did not consistently reverse inflammation-related gene activity.Experiments in young and aged mice identified a liver protein whose restoration reduced fat buildup but did not consistently reverse inflammation-related gene activity.
In people with structural epilepsy, DNA-based age acceleration was greater in brain than blood, with median values of 7.3 versus 1.4 years.In people with structural epilepsy, DNA-based age acceleration was greater in brain than blood, with median values of 7.3 versus 1.4 years.
Over 52 weeks, average hourly breathing disruptions fell by 17.8 with orforglipron versus 4.5 with placebo in one trial, and 17.3 versus 5.3 in the other.Over 52 weeks, average hourly breathing disruptions fell by 17.8 with orforglipron versus 4.5 with placebo in one trial, and 17.3 versus 5.3 in the other.
Compared with 2010, projected pollution-related deaths in 2050 fell by about 1.1 million under a sustainable pathway but rose by about 0.5 million under regional rivalry.Compared with 2010, projected pollution-related deaths in 2050 fell by about 1.1 million under a sustainable pathway but rose by about 0.5 million under regional rivalry.
Who was studiedGlobal populations under alternative socioeconomic pathways
What changedProjected pollution deaths fall by approximately 1.1 million under sustainability but rise by approximately 0.5 million under regional rivalry versus baseline
The catchOverlapping training and test locations and times make model accuracy look better than independent validation
Chinese participants aged 40 and up reporting fair or poor hearing had 1.42 times the odds of at least two chronic conditions versus those reporting better hearing.Chinese participants aged 40 and up reporting fair or poor hearing had 1.42 times the odds of at least two chronic conditions versus those reporting better hearing.
Scan guidance prompted statin recommendations for 18% of women versus 67% with a traditional risk score, without a statistically significant difference in major health…Scan guidance prompted statin recommendations for 18% of women versus 67% with a traditional risk score, without a statistically significant difference in major health outcomes.
Higher neighborhood vulnerability was linked to an extra 3.11 milliliters per year of decline in air forcefully exhaled in one second.Higher neighborhood vulnerability was linked to an extra 3.11 milliliters per year of decline in air forcefully exhaled in one second. The 2,362 current and former smokers in this prospective cohort study were aged 40 to 75 at…
Detection scores were 0.95 in internal testing and 0.94 in external testing, where higher scores mean better separation of people with and without disease.Detection scores were 0.95 in internal testing and 0.94 in external testing, where higher scores mean better separation of people with and without disease.
Light drinkers had higher relative death risk than occasional drinkers over a median 19.2 years, with an adjusted hazard ratio of 1.146.Light drinkers had higher relative death risk than occasional drinkers over a median 19.2 years, with an adjusted hazard ratio of 1.146. Korean adults—1,103,981 people in the primary analysis—were followed for a median 19.2 years…
Higher intensity during the day’s most active minute was linked to lower mortality after accounting for total activity, with a hazard ratio of 0.58.Higher intensity during the day’s most active minute was linked to lower mortality after accounting for total activity, with a hazard ratio of 0.58.
Meeting World Health Organization fine-particle guidelines could postpone 9.43 million deaths in one year, a modeled 22.97% reduction from the current mortality burden.Meeting World Health Organization fine-particle guidelines could postpone 9.43 million deaths in one year, a modeled 22.97% reduction from the current mortality burden.
