Over two years, average time free of major cardiovascular events or death was 2.0 weeks shorter after stopping statins than continuing them.Over two years, average time free of major cardiovascular events or death was 2.0 weeks shorter after stopping statins than continuing them.
Experiments implicated a gene-regulating protein in senescence, a state in which cells stop dividing, in human retinal cells grown in the lab.Experiments implicated a gene-regulating protein in senescence, a state in which cells stop dividing, in human retinal cells grown in the lab.
Updated criteria linked sarcopenia and possible sarcopenia to higher mortality in older dialysis patients, with adjusted hazard ratios of 2.29 and 1.97, respectively.Updated criteria linked sarcopenia and possible sarcopenia to higher mortality in older dialysis patients, with adjusted hazard ratios of 2.29 and 1.97, respectively.
Loss of kidney filtering units under metabolic and cardiovascular stress led to wasting independent of calorie intake, with muscle loss and frailty-like features.Loss of kidney filtering units under metabolic and cardiovascular stress led to wasting independent of calorie intake, with muscle loss and frailty-like features.
Who was studiedAnimals and older human CKD kidneys
What changedAnimals under metabolic and cardiovascular stress developed wasting, muscle loss, and frailty-like features after losing kidney filtering units
The catchAnimal group sizes are missing, limiting assessment of the wasting results
Greater symptom severity was linked to up to about two years of advanced age on one DNA-based measure among 21,999 US veterans.Greater symptom severity was linked to up to about two years of advanced age on one DNA-based measure among 21,999 US veterans. US military veterans—43,155 people, 92.96% male—were studied in an observational analysis of…
At 24 weeks, training improved verbal fluency by 1.2 letters and forward digit recall by 0.7 points compared with low-intensity exercise.At 24 weeks, training improved verbal fluency by 1.2 letters and forward digit recall by 0.7 points compared with low-intensity exercise. Physically independent adults aged 65 or older with probable mild cognitive impairment took…
Cell-released packages carrying genetic instructions and an antioxidant accelerated bone regeneration in experiments on aged rats with osteoporosis and skull defects.Cell-released packages carrying genetic instructions and an antioxidant accelerated bone regeneration in experiments on aged rats with osteoporosis and skull defects.
At assessments from ages 70 to 100, 22% to 44% said they did not feel healthy, without a clear trend over time.At assessments from ages 70 to 100, 22% to 44% said they did not feel healthy, without a clear trend over time. Community-dwelling Jerusalem adults born in 1920–1921 were assessed between ages 70 and 100 in a cross-sectional and…
An observational study of shark-bite wounds in Fraser’s dolphins traced the rebuilding of skin folds and associated blood vessels after full-thickness injuries.An observational study of shark-bite wounds in Fraser’s dolphins traced the rebuilding of skin folds and associated blood vessels after full-thickness injuries.
Over three years, cardiovascular events occurred in 8.5% of patients starting statin–ezetimibe therapy versus 7.9% starting a statin alone.Over three years, cardiovascular events occurred in 8.5% of patients starting statin–ezetimibe therapy versus 7.9% starting a statin alone.
Across five trials, perceived walking-distance scores rose 10.01 points with exercise versus 3.10 with control over six months.Across five trials, perceived walking-distance scores rose 10.01 points with exercise versus 3.10 with control over six months. Among 626 people with lower-extremity peripheral artery disease, which reduces blood flow to the legs…
More types of recorded events were linked to stress-related disorders, with a hazard ratio of 1.62, and to anxiety, depression, other illnesses and frailty.More types of recorded events were linked to stress-related disorders, with a hazard ratio of 1.62, and to anxiety, depression, other illnesses and frailty.
An observational analysis of two midlife cohorts linked a brain-imaging marker to accelerated biological aging over 7–15 years.An observational analysis of two midlife cohorts linked a brain-imaging marker to accelerated biological aging over 7–15 years. The marker was developed from magnetic resonance imaging scans collected at a single point in time.
A retrospective comparison of 269 people with one heart failure form, 275 with another and 186 controls found different protein-based aging patterns.A retrospective comparison of 269 people with one heart failure form, 275 with another and 186 controls found different protein-based aging patterns.
Muscle mass in the arms and legs rose 0.70 kg with high-intensity intervals versus 0.11 kg with moderate continuous exercise over 12 weeks.Muscle mass in the arms and legs rose 0.70 kg with high-intensity intervals versus 0.11 kg with moderate continuous exercise over 12 weeks.
A spatial mapping method measured five types of marks on DNA-packaging proteins alongside gene activity across the adult mouse lifespan.A spatial mapping method measured five types of marks on DNA-packaging proteins alongside gene activity across the adult mouse lifespan. Mouse brains were analyzed across the adult lifespan in a laboratory study using SPACE-Tag, a…
An observational analysis of 278,164 UK Biobank participants and analyses of human genetic data linked aging and osteoporosis-related traits in both directions.An observational analysis of 278,164 UK Biobank participants and analyses of human genetic data linked aging and osteoporosis-related traits in both directions.
Major cardiovascular events occurred in 10.9% of the intensive-treatment group versus 13.5% with standard treatment over a median 3.9 years.Major cardiovascular events occurred in 10.9% of the intensive-treatment group versus 13.5% with standard treatment over a median 3.9 years.
A controlled mouse experiment found smaller plaques than with unrestricted feeding or at baseline, without additional blood-fat lowering at the study’s end.A controlled mouse experiment found smaller plaques than with unrestricted feeding or at baseline, without additional blood-fat lowering at the study’s end.
Childhood adversity was associated with 30% higher relative risk of heart and blood vessel disease in 7,184 Chinese adults aged 45 and older.Childhood adversity was associated with 30% higher relative risk of heart and blood vessel disease in 7,184 Chinese adults aged 45 and older. Median follow-up lasted 84 months.
At 90 days, 14.7% of patients aged 80 and older met a disability-adjusted recovery measure, compared with 18.9% of younger patients.At 90 days, 14.7% of patients aged 80 and older met a disability-adjusted recovery measure, compared with 18.9% of younger patients. Among 377 people with strokes involving large areas of brain damage from blocked arteries, 75…
Exenatide altered 527 of 4,979 measured proteins compared with placebo among 3,973 trial participants with type 2 diabetes.Exenatide altered 527 of 4,979 measured proteins compared with placebo among 3,973 trial participants with type 2 diabetes. For 392 altered proteins, statistical analyses indicated that changes in weight or blood sugar helped…
Within 90 days, abnormal rhythms or specified related findings were detected in 0.74% of the AI-guided group versus 0.48% of controls.Within 90 days, abnormal rhythms or specified related findings were detected in 0.74% of the AI-guided group versus 0.48% of controls. Adults aged 40–85 without previous atrial fibrillation or atrial flutter, two abnormal heart…
In experiments, male mice aged 10–15 months learned and retained object locations, but reminders did not readily make those memories open to change.In experiments, male mice aged 10–15 months learned and retained object locations, but reminders did not readily make those memories open to change.
Over 60 months, 2,186 of 12,989 older adults developed care needs, with step length and walking speed linked to different severity levels.Over 60 months, 2,186 of 12,989 older adults developed care needs, with step length and walking speed linked to different severity levels. Participants averaged 74.8 years old, and 45.2% were men.
Pain scores fell 1.24 points more with 12 weeks of supervised exercise than with usual activity in a randomized trial of 48 people.Pain scores fell 1.24 points more with 12 weeks of supervised exercise than with usual activity in a randomized trial of 48 people. Twenty-four were assigned to each group, and 44 completed the study.
In 24 people with diabetic kidney disease, higher tissue-aging scores were linked to faster kidney-function loss, with an adjusted correlation of -0.61.In 24 people with diabetic kidney disease, higher tissue-aging scores were linked to faster kidney-function loss, with an adjusted correlation of -0.61.
Older mice given vanadyl sulfate in drinking water for 13 weeks had better hanging endurance and less fat accumulation than controls.Older mice given vanadyl sulfate in drinking water for 13 weeks had better hanging endurance and less fat accumulation than controls. Male mice given oral vanadyl sulfate, a mineral dietary supplement, lived longer in animal…
The model scored 0.86 for distinguishing scans labeled as showing prominent fat around the heart, on a statistical measure of how well it separated groups.The model scored 0.86 for distinguishing scans labeled as showing prominent fat around the heart, on a statistical measure of how well it separated groups.
People meeting scan-based osteoporosis thresholds had up to 2.86 times higher major fracture risk than those not meeting them.People meeting scan-based osteoporosis thresholds had up to 2.86 times higher major fracture risk than those not meeting them. Clinical computed tomography (CT) scans from 2,368 males and 2,050 females were analyzed in a…
Major cardiovascular events occurred in 6.0% with intensive therapy versus 6.7% with standard therapy over a median 4.0 years in patients with type 2 diabetes.Major cardiovascular events occurred in 6.0% with intensive therapy versus 6.7% with standard therapy over a median 4.0 years in patients with type 2 diabetes.
In transplant experiments, microbes from young donors partly reversed heart dysfunction in old mice aged 18–24 months.In transplant experiments, microbes from young donors partly reversed heart dysfunction in old mice aged 18–24 months. The researchers studied both mice with an intact Akap1 gene and mice missing one copy.
