Trained in a European cohort and tested in three others, the model estimated lifespan trajectories associated with observed mortality outcomes.Trained in a European cohort and tested in three others, the model estimated lifespan trajectories associated with observed mortality outcomes.
Who was studiedPeople across multiple geographic regions
What changedPersonalized lifespan trajectories modeled from retinal photographs were associated with observed mortality outcomes, including age of death
The catchHealth improvements and survival gains from using the model for screening were not measured
Laboratory experiments found that restoring one fatty acid caused senescent cells to die through an iron-dependent process called ferroptosis.Laboratory experiments found that restoring one fatty acid caused senescent cells to die through an iron-dependent process called ferroptosis.
Image-based age estimates differed from actual ages by a mean absolute error of 0.78 months in rats excluded from model training.Image-based age estimates differed from actual ages by a mean absolute error of 0.78 months in rats excluded from model training. In 32 male rats aged 9, 18, 21 and 25 months, researchers combined kidney imaging with measurements…
Worm experiments traced the lifespan benefit to vitamin B12-dependent enzymes and a process that removes mitochondria, the cell’s energy-producing structures.Worm experiments traced the lifespan benefit to vitamin B12-dependent enzymes and a process that removes mitochondria, the cell’s energy-producing structures.
Protein changes appeared by age 30 in immature human eggs, compared with age 35 or 40 in mature eggs. Mature eggs showed changes later, at 35 or 40.Protein changes appeared by age 30 in immature human eggs, compared with age 35 or 40 in mature eggs. Mature eggs showed changes later, at 35 or 40.
A 12-week randomized trial of 69 adults aged 60–85 found differences between groups in breathing-muscle strength and selected biological markers, but not lung function.A 12-week randomized trial of 69 adults aged 60–85 found differences between groups in breathing-muscle strength and selected biological markers, but not lung function.
In rodent pesticide studies, 27 of 154 substances were linked to survival increases of at least 10% at study termination.In rodent pesticide studies, 27 of 154 substances were linked to survival increases of at least 10% at study termination. Researchers analyzed long-term pesticide safety experiments in rodents, with at least 50 animals per dose…
Delirium was linked to higher relative rates of mild cognitive impairment and dementia, with adjusted hazard ratios of 3.67 and 5.39, respectively, versus no delirium.Delirium was linked to higher relative rates of mild cognitive impairment and dementia, with adjusted hazard ratios of 3.67 and 5.39, respectively, versus no delirium.
Smartphone assessments of 318 adults aged 70–90 across up to six annual rounds found limited links between loneliness and later cognitive change.Smartphone assessments of 318 adults aged 70–90 across up to six annual rounds found limited links between loneliness and later cognitive change.
The workflow increased protein coverage 3–6-fold and identified 3,992 groups of proteins from 20 microliters of mouse serum.The workflow increased protein coverage 3–6-fold and identified 3,992 groups of proteins from 20 microliters of mouse serum. In a cross-sectional analysis, researchers examined serum—the liquid left after blood clots—from 30 mice…
At the next assessment, estimated deterioration risk was 54.5% after recent recovery versus 34.9% with consistently favorable assessments in one of three cohorts.At the next assessment, estimated deterioration risk was 54.5% after recent recovery versus 34.9% with consistently favorable assessments in one of three cohorts.
Among prefrail adults over 65 with hypertension and chronic kidney disease, dapagliflozin users had lower frailty-progression odds than nonusers at one year (adjusted…Among prefrail adults over 65 with hypertension and chronic kidney disease, dapagliflozin users had lower frailty-progression odds than nonusers at one year (adjusted odds ratio 0.130).
DNA sequencing of 722 samples from 25 donors revealed tissue-specific patterns of chromosome changes, including widespread losses of sex chromosomes.DNA sequencing of 722 samples from 25 donors revealed tissue-specific patterns of chromosome changes, including widespread losses of sex chromosomes.
Preprint: cross-sectional study of 722 peopleMechanisms
In experiments, ziyu glycoside I reduced functional decline and organ abnormalities in naturally aging mice and mice with chemically induced aging.In experiments, ziyu glycoside I reduced functional decline and organ abnormalities in naturally aging mice and mice with chemically induced aging.
Cell experiments linked protected iron storage to senescence, a state in which cells stop dividing, and resistance to iron-dependent cell death.Cell experiments linked protected iron storage to senescence, a state in which cells stop dividing, and resistance to iron-dependent cell death.
Experiments in 3- and 21-month-old female mice found larger clumps of fluorescent material in brain immune cells and age-related changes in emitted light.Experiments in 3- and 21-month-old female mice found larger clumps of fluorescent material in brain immune cells and age-related changes in emitted light.
Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing…Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing structures.
A two-year observational study of 10,216 older adults in China linked full digital exclusion to new frailty, reporting a relative risk of 1.42.A two-year observational study of 10,216 older adults in China linked full digital exclusion to new frailty, reporting a relative risk of 1.42.
An observational study in patients with lymphoma linked expanding blood-cell clones to poorer immune recovery and treatment-related blood cancers after engineered…An observational study in patients with lymphoma linked expanding blood-cell clones to poorer immune recovery and treatment-related blood cancers after engineered immune-cell therapy.
The high-risk group included 20% of women and 9% of men in a Swedish survey that followed 6,328 people for 42 years.The high-risk group included 20% of women and 9% of men in a Swedish survey that followed 6,328 people for 42 years. An observational study followed 6,328 people in a population-representative Swedish survey over 42 years and…
Eggs from aged mice fertilized in the lab formed early embryos at rates comparable to young controls and developed without detectable impairment in young recipients.Eggs from aged mice fertilized in the lab formed early embryos at rates comparable to young controls and developed without detectable impairment in young recipients.
Experiments in four female fibroblast lines tracked molecular changes that resembled key features of aging in cells from the body.Experiments in four female fibroblast lines tracked molecular changes that resembled key features of aging in cells from the body. Researchers studied four female human fibroblast lines—connective tissue cells grown in the lab—in…
Lens stiffness measured 11.9 kilopascals at the higher dose, versus 17.9 in mice with diet-induced metabolic syndrome given no active compound.Lens stiffness measured 11.9 kilopascals at the higher dose, versus 17.9 in mice with diet-induced metabolic syndrome given no active compound.
Eleven-year survival was 21.0% with type 2 diabetes, cardiovascular disease and chronic kidney disease, versus 54.2% with type 2 diabetes alone.Eleven-year survival was 21.0% with type 2 diabetes, cardiovascular disease and chronic kidney disease, versus 54.2% with type 2 diabetes alone.
In older adults hospitalized for heart failure, rising markers were linked to 49.7 meters less improvement in six-minute walking distance over three months.In older adults hospitalized for heart failure, rising markers were linked to 49.7 meters less improvement in six-minute walking distance over three months.
An observational study followed 90,807 Japanese adults for 18.9 years on average, finding neither fat linked to higher mortality in this relatively low-intake population.An observational study followed 90,807 Japanese adults for 18.9 years on average, finding neither fat linked to higher mortality in this relatively low-intake population.
Each 29-minute increase in night-to-night sleep-duration variability was linked to higher cardiovascular risk, with a hazard ratio (a relative risk measure) of 1.24.Each 29-minute increase in night-to-night sleep-duration variability was linked to higher cardiovascular risk, with a hazard ratio (a relative risk measure) of 1.24.
In an animal experiment, a compound that activated a DNA repair protein eased aging-related features in mice with a premature-aging disorder.In an animal experiment, a compound that activated a DNA repair protein eased aging-related features in mice with a premature-aging disorder.
