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The Journal of Clinical Investigation

Dapagliflozin linked to lower frailty odds in kidney disease study

Among prefrail adults over 65 with hypertension and chronic kidney disease, dapagliflozin users had lower frailty-progression odds than nonusers at one year (adjusted…Among prefrail adults over 65 with hypertension and chronic kidney disease, dapagliflozin users had lower frailty-progression odds than nonusers at one year (adjusted odds ratio 0.130).

A kidney cross-section with damaged patches sits between upright groups of people beside dense dark blue-green muscle fibers and sparse gray fibers.
Cohort · 105 peopleKidney
Paper

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Journal of Advanced Research

Plant compound lessened age-related decline in mice

In experiments, ziyu glycoside I reduced functional decline and organ abnormalities in naturally aging mice and mice with chemically induced aging.In experiments, ziyu glycoside I reduced functional decline and organ abnormalities in naturally aging mice and mice with chemically induced aging.

Mouse studyInterventions
Paper
Aging Cell

Human cells in long-term culture mirror features of aging

Experiments in four female fibroblast lines tracked molecular changes that resembled key features of aging in cells from the body.Experiments in four female fibroblast lines tracked molecular changes that resembled key features of aging in cells from the body. Researchers studied four female human fibroblast lines—connective tissue cells grown in the lab—in…

Human cell studyInterventions
Paper

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Research Square

Recent health recovery linked to later decline in older adults

At the next assessment, estimated deterioration risk was 54.5% after recent recovery versus 34.9% with consistently favorable assessments in one of three cohorts.At the next assessment, estimated deterioration risk was 54.5% after recent recovery versus 34.9% with consistently favorable assessments in one of three cohorts.

Cross-national architecture of multidomain health states.
Preprint: cohort studyPopulations
Paper
Nature Communications

Compound extends lifespan in mice with premature aging

In an animal experiment, a compound that activated a DNA repair protein eased aging-related features in mice with a premature-aging disorder.In an animal experiment, a compound that activated a DNA repair protein eased aging-related features in mice with a premature-aging disorder.

Mouse studyInterventions
Paper
iScience

An enzyme inhibitor extended lifespan in aged mice

In an experiment in naturally aged C57BL/6 mice, long-term treatment also reduced frailty and improved physical and cognitive performance.In an experiment in naturally aged C57BL/6 mice, long-term treatment also reduced frailty and improved physical and cognitive performance. In an experiment in naturally aged C57BL/6 mice, researchers tested whether long-term…

Mouse studyInterventions
Paper
Chinese Sociological Review

China’s aging-in-place policy linked to better memory

An observational analysis of four survey waves from 2011–2018 linked the policy to better recall of information after a delay.An observational analysis of four survey waves from 2011–2018 linked the policy to better recall of information after a delay. Aging in place means remaining in one’s home and community while growing older.

People gather closely beneath whole leaves, while a smaller, scattered gray group stands beneath fragmented leaves.
Cohort studyIndustry & policy
Paper
BMC Public Health

Urine marker linked to muscle loss in middle-aged and older US adults

An observational analysis of US survey data from 2011–2018 found links to sarcopenia and sarcopenia with obesity, with stronger associations in older adults.An observational analysis of US survey data from 2011–2018 found links to sarcopenia and sarcopenia with obesity, with stronger associations in older adults.

Cross-sectional studyMuscle
Paper
NPJ Aging

Seasonal heart-rate swings were smaller in older adults

Seasonal swings in resting heart rate were about 29% smaller, and swings in heart rate variability about 48% smaller, in older than younger adults.Seasonal swings in resting heart rate were about 29% smaller, and swings in heart rate variability about 48% smaller, in older than younger adults. In an observational study of 16,415 U.S.

Cohort · 16,415 peoplePopulations
Paper
Aging Cell

Aging shifts the brain’s natural glow toward red in mice

Experiments in 3- and 21-month-old female mice found larger clumps of fluorescent material in brain immune cells and age-related changes in emitted light.Experiments in 3- and 21-month-old female mice found larger clumps of fluorescent material in brain immune cells and age-related changes in emitted light.

Mouse studyBiomarkers
Paper
bioRxiv

Tardigrade stress proteins shortened lifespan in worms

Experiments in genetically engineered worms found that each of four proteins impaired movement and reproduction and failed to improve resistance to most environmental…Experiments in genetically engineered worms found that each of four proteins impaired movement and reproduction and failed to improve resistance to most environmental stresses.

A dark blue-green worm has fewer eggs and sparse protein clumps, while a smaller gray worm has abundant eggs and dense protein clumps.
Preprint: worm studyInterventions
Paper
Explore

Yoga plus a supplement linked to fewer depression symptoms

Depression scores fell 45.1% with yoga plus astaxanthin, versus 28.5% with yoga and 10.9% with the supplement alone, in postmenopausal women.Depression scores fell 45.1% with yoga plus astaxanthin, versus 28.5% with yoga and 10.9% with the supplement alone, in postmenopausal women.

Randomized trial · 100 peopleDepressive symptoms
Paper

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Phytomedicine

Cepharanthine clears senescent cells in naturally aged mice

Experiments in naturally aged mice found that the compound also improved organ function and prolonged lifespan.Experiments in naturally aged mice found that the compound also improved organ function and prolonged lifespan. Researchers tested cepharanthine in zebrafish, Caenorhabditis elegans worms, naturally aged mice and mice modeling…

Mouse studyInterventions
Paper
Aging Cell

Rodent safety archives flag compounds linked to better survival

In rodent pesticide studies, 27 of 154 substances were linked to survival increases of at least 10% at study termination.In rodent pesticide studies, 27 of 154 substances were linked to survival increases of at least 10% at study termination. Researchers analyzed long-term pesticide safety experiments in rodents, with at least 50 animals per dose…

Experiments in rodentsInterventions
Paper
Research Square

Digital exclusion linked to frailty in older Chinese adults

A two-year observational study of 10,216 older adults in China linked full digital exclusion to new frailty, reporting a relative risk of 1.42.A two-year observational study of 10,216 older adults in China linked full digital exclusion to new frailty, reporting a relative risk of 1.42.

Flow of participants through the study, CHARLS 2018–2020. note.
Preprint: cohort · 7,296 peoplePopulations
Paper
Frontiers in Microbiology

Nicotinamide mononucleotide reduced lens stiffness in mice

Lens stiffness measured 11.9 kilopascals at the higher dose, versus 17.9 in mice with diet-induced metabolic syndrome given no active compound.Lens stiffness measured 11.9 kilopascals at the higher dose, versus 17.9 in mice with diet-induced metabolic syndrome given no active compound.

Mouse study · 94 miceNicotinamide mononucleotide
Paper
BMC Geriatrics

Tabletop and screen games linked to memory gains in older adults

In a randomized trial of 60 adults aged 60 or older, both game groups scored higher than controls after 15 sessions. Each group had 20 participants.In a randomized trial of 60 adults aged 60 or older, both game groups scored higher than controls after 15 sessions. Each group had 20 participants.

Randomized trial · 60 peopleInterventions
Paper
Cell Death Discovery

Loss of a regulatory protein worsened bone loss in mice

Experiments found that mice lacking SIRT5, a protein that modifies other proteins, had poorer bone formation and more severe bone loss than normal mice.Experiments found that mice lacking SIRT5, a protein that modifies other proteins, had poorer bone formation and more severe bone loss than normal mice.

Mouse studyBones and joints
Paper
Research Square

Artery disease and diabetic foot ulcers share gene-activity patterns

An analysis of human gene-activity datasets identified 72 genes shared by both conditions and associated with senescence, a state in which cells stop dividing.An analysis of human gene-activity datasets identified 72 genes shared by both conditions and associated with senescence, a state in which cells stop dividing.

Cellular senescence is a common pathological feature of diabetic foot and atherosclerosis.
Preprint: computational studyBiomarkers
Paper
Journal of Hazardous Materials

Chemical exposure induced an aging state in animal nerve cells

Deleting a gene reduced this response in animal experiments examining how an emerging environmental chemical affected nerve cells.Deleting a gene reduced this response in animal experiments examining how an emerging environmental chemical affected nerve cells. In animal experiments, the environmental chemical hexafluoropropylene oxide dimer acid induced…

Animal studyMechanisms
Paper
bioRxiv

A persistent virus benefited flies under temperature stress

Experiments in fruit flies found that persistent Nora virus infection extended lifespan and improved reproductive output and behavioral performance under ongoing…Experiments in fruit flies found that persistent Nora virus infection extended lifespan and improved reproductive output and behavioral performance under ongoing temperature stress.

Fruit flies face beneath heat waves; the dark blue-green fly has virus particles and many offspring, while the gray fly has fewer offspring.
Preprint: fly studyMechanisms
Paper
Open Research

Stomach inflammation linked to age-related eye disease

An observational study of 500,000 UK Biobank participants over 13 years linked stomach inflammation to a higher risk of developing age-related macular degeneration.An observational study of 500,000 UK Biobank participants over 13 years linked stomach inflammation to a higher risk of developing age-related macular degeneration.

Cohort · 496,361 peopleEye
Paper
Scientific Reports

Obesity profiles linked to muscle and spinal disc disease

Higher-risk subtypes had hazard ratios, a relative-risk measure, of 1.43 for sarcopenia (muscle wasting) and 1.31 for spinal disc disease versus non-obese participants.Higher-risk subtypes had hazard ratios, a relative-risk measure, of 1.43 for sarcopenia (muscle wasting) and 1.31 for spinal disc disease versus non-obese participants.

Cohort · 247,107 peopleBiomarkers
Paper
Nature Communications

Memory-linked brain cells reactivate less in aged mice

Experiments comparing young and aged mice found changes in the organization of memory-related brain activity and in gene responses during recall.Experiments comparing young and aged mice found changes in the organization of memory-related brain activity and in gene responses during recall.

Mouse studyMechanisms
Paper