In two human cohorts, a shift toward slower waves during rapid eye movement sleep was associated with Alzheimer’s-related proteins and poorer overnight memory…In two human cohorts, a shift toward slower waves during rapid eye movement sleep was associated with Alzheimer’s-related proteins and poorer overnight memory consolidation.
Deleting the RNA from cells lining mouse blood vessels also improved vessel widening and new blood vessel growth in a model of restricted blood flow.Deleting the RNA from cells lining mouse blood vessels also improved vessel widening and new blood vessel growth in a model of restricted blood flow.
Semaglutide users had higher odds of improved daily functioning than comparison patients at 24 months, with an odds ratio of 4.03.Semaglutide users had higher odds of improved daily functioning than comparison patients at 24 months, with an odds ratio of 4.03. An observational study compared patients aged 80 or older with heart failure, type 2 diabetes and…
Experiments in lab-grown cells tested a peptide that disrupted a protein interaction and reduced senescence, a state in which cells stop dividing.Experiments in lab-grown cells tested a peptide that disrupted a protein interaction and reduced senescence, a state in which cells stop dividing.
In a 12-week randomized trial, adding dairy protein to home exercise offered no overall advantage among 54 Japanese adults aged 65 or older.In a 12-week randomized trial, adding dairy protein to home exercise offered no overall advantage among 54 Japanese adults aged 65 or older.
After more than 200 generations, populations selected for long life showed a near doubling of lifespan compared with those selected for short life.After more than 200 generations, populations selected for long life showed a near doubling of lifespan compared with those selected for short life.
An observational cohort study of Chinese adults aged 50 and older identified four patterns, from high and stable to low and rapidly declining capacity.An observational cohort study of Chinese adults aged 50 and older identified four patterns, from high and stable to low and rapidly declining capacity.
Who was studied5,067 Chinese adults aged 50 years and older
What changedFour patterns emerged in physical and mental capacity: high-stable, high-slowly declining, moderate-rapidly declining, and low-rapidly declining
The catchCapacity scores relied on subjective reports, which are vulnerable to recall and interviewer biases
People with COVID-19 had blood gene-activity age estimates averaging 9.34 years above a healthy-aging reference after correction for each cohort’s baseline.People with COVID-19 had blood gene-activity age estimates averaging 9.34 years above a healthy-aging reference after correction for each cohort’s baseline.
In UK Biobank, a higher genetic score tracked higher death risk: the hazard ratio, a relative risk measure, was 1.05 per standard-deviation increase.In UK Biobank, a higher genetic score tracked higher death risk: the hazard ratio, a relative risk measure, was 1.05 per standard-deviation increase.
Women assigned aspirin had a small extra decline versus placebo, with an estimated effect of minus 0.006 on the capacity score; men showed no effect.Women assigned aspirin had a small extra decline versus placebo, with an estimated effect of minus 0.006 on the capacity score; men showed no effect.
A laboratory test designed to assess many samples identified proteins involved in selective cell cleanup as factors in lifespan resetting during reproductive-cell…A laboratory test designed to assess many samples identified proteins involved in selective cell cleanup as factors in lifespan resetting during reproductive-cell formation.
Experiments in fruit flies linked age-related changes in protein assemblies to reduced protein production and memory impairment.Experiments in fruit flies linked age-related changes in protein assemblies to reduced protein production and memory impairment. In experiments in Drosophila melanogaster fruit flies, researchers mapped structures of Orb2 amyloid…
Reversible cognitive frailty was linked to higher risk of multiple chronic diseases than robust status, with a hazard ratio (a relative risk measure) of 2.74.Reversible cognitive frailty was linked to higher risk of multiple chronic diseases than robust status, with a hazard ratio (a relative risk measure) of 2.74.
Experiments in female mice also reported reversed cognitive decline and longer lifespan after researchers restored a bacterium that declined with ovarian failure.Experiments in female mice also reported reversed cognitive decline and longer lifespan after researchers restored a bacterium that declined with ovarian failure.
Across bone sites, the estimated decrease from age 40 to 80 was a median 34.1% in women versus 12.8% in men.Across bone sites, the estimated decrease from age 40 to 80 was a median 34.1% in women versus 12.8% in men. In 78,620 patients aged 15–100 at nine Japanese academic hospitals, researchers examined age and sex patterns in bone…
Brain blood-flow responses during mental tasks rose from 18% to 21% with supplementation, versus a decline from 21% to 19% with placebo over 12 weeks.Brain blood-flow responses during mental tasks rose from 18% to 21% with supplementation, versus a decline from 21% to 19% with placebo over 12 weeks.
In mouse experiments, targeted drug delivery restored lung and liver function, reduced toxicity and made liver and lung cancers more responsive to immunotherapy.In mouse experiments, targeted drug delivery restored lung and liver function, reduced toxicity and made liver and lung cancers more responsive to immunotherapy.
An observational analysis of 2,401 adults aged 50 to 84 found little evidence that the links varied by race or ethnicity.An observational analysis of 2,401 adults aged 50 to 84 found little evidence that the links varied by race or ethnicity. An observational study examined 2,401 adults aged 50 to 84 from a nationally representative US survey.
Experiments in neurons made from healthy donors aged 11 to 91 found impaired removal of damaged mitochondria, the cells’ energy-producing structures.Experiments in neurons made from healthy donors aged 11 to 91 found impaired removal of damaged mitochondria, the cells’ energy-producing structures.
Two months of treatment also reduced markers of cell senescence, a state in which cells stop dividing, in aged male mice.Two months of treatment also reduced markers of cell senescence, a state in which cells stop dividing, in aged male mice. In an animal experiment, researchers compared young and aged mice of both sexes.
Over three months, decline scores for combined physical and mental abilities were 1.2 with integrated discharge services versus 3.1 with routine care.Over three months, decline scores for combined physical and mental abilities were 1.2 with integrated discharge services versus 3.1 with routine care.
An observational cohort compared 3,876 people exposed to two parasite-fighting drugs with 77,520 matched controls, finding links to lower mortality and fewer age-related…An observational cohort compared 3,876 people exposed to two parasite-fighting drugs with 77,520 matched controls, finding links to lower mortality and fewer age-related conditions.
Average weight fell 5.9%, 8.7% and 7.9% with daily doses of 6, 12 and 36 mg, respectively, versus 0.6% with placebo over 72 weeks.Average weight fell 5.9%, 8.7% and 7.9% with daily doses of 6, 12 and 36 mg, respectively, versus 0.6% with placebo over 72 weeks. The double-blind randomized trial enrolled 238 Japanese adults aged 18 or older with obesity and…
Experiments with mice lacking the protein showed that it was required to maintain chromosome connections until egg cells finished maturing.Experiments with mice lacking the protein showed that it was required to maintain chromosome connections until egg cells finished maturing.
An observational study of human bone samples linked tissue properties to local tissue age, while older tissue occupied more bone as donor age increased.An observational study of human bone samples linked tissue properties to local tissue age, while older tissue occupied more bone as donor age increased.
In two external populations, a personalized model reduced errors in estimating immune age by 32% and 42% compared with the best existing method.In two external populations, a personalized model reduced errors in estimating immune age by 32% and 42% compared with the best existing method.
Experiments in aged male mice found that the drug reduced inflammatory changes, likely through effects on both inflammatory and antioxidant pathways.Experiments in aged male mice found that the drug reduced inflammatory changes, likely through effects on both inflammatory and antioxidant pathways.
Within-group changes accounted for 98.8–99.5% of a 41-gene pattern’s adjusted age-related difference, versus 0.8–1.2% from changes in group proportions.Within-group changes accounted for 98.8–99.5% of a 41-gene pattern’s adjusted age-related difference, versus 0.8–1.2% from changes in group proportions.
What changedWithin-state gene changes accounted for 98.8-99.5% of the adjusted age-related difference; changes in cell-state proportions contributed little
The catchThe breakdown omits age-related gene changes outside the 41-gene program
A controlled experiment comparing older and younger mouse mothers found fat-related molecular patterns that persisted in descendants through the fourth generation.A controlled experiment comparing older and younger mouse mothers found fat-related molecular patterns that persisted in descendants through the fourth generation.
A 12-week randomized trial involving 59 older adults with speed deficits found no power or functional advantage from matching exercise loads to that deficit.A 12-week randomized trial involving 59 older adults with speed deficits found no power or functional advantage from matching exercise loads to that deficit.
Over 18 months, total coronary plaque volume fell 69.8 cubic millimeters with more intensive cholesterol-lowering therapy versus 39.0 cubic millimeters with intensive…Over 18 months, total coronary plaque volume fell 69.8 cubic millimeters with more intensive cholesterol-lowering therapy versus 39.0 cubic millimeters with intensive therapy.
Seventeen proteins were associated with mortality in a cohort of 1,025 older adults followed for an average of 8.05 years.Seventeen proteins were associated with mortality in a cohort of 1,025 older adults followed for an average of 8.05 years. In a prospective observational cohort study, researchers analyzed 4,265 proteins in plasma, the liquid part…
In experiments on immune cells from aged mice, spermidine, a molecule involved in cell metabolism, reduced oxygen use in one subgroup but not another.In experiments on immune cells from aged mice, spermidine, a molecule involved in cell metabolism, reduced oxygen use in one subgroup but not another.
Virus-based supplementation of a stem-cell regulator eased obesity, osteoporosis or both across three mouse models.Virus-based supplementation of a stem-cell regulator eased obesity, osteoporosis or both across three mouse models. In mouse experiments, researchers studied ITGBL1, a protein that helps regulate whether stem cells develop into…
Complete tooth loss was linked to higher odds of disability in basic daily activities than retaining teeth, with a pooled odds ratio of 1.30.Complete tooth loss was linked to higher odds of disability in basic daily activities than retaining teeth, with a pooled odds ratio of 1.30.
