In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher…In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death. Researchers analysed 9,105 blood samples collected at up to three time points from 4,100 people aged 25 to 88 in an…
Experiments found increased release of the hormone in aged mice with normal or reduced responses to insulin, which lowers blood sugar.Experiments found increased release of the hormone in aged mice with normal or reduced responses to insulin, which lowers blood sugar. They examined pancreatic alpha cells, which release glucagon, a hormone that raises blood sugar.
Across both cohorts, the odds ratio for frailty was 0.52 when comparing Spanish older adults in the highest versus lowest third of diet scores.Across both cohorts, the odds ratio for frailty was 0.52 when comparing Spanish older adults in the highest versus lowest third of diet scores. An observational study followed community-dwelling Spanish adults in two cohorts: 3,289 people aged 60 or older and 3,273 aged 65 or older.
Mean Fatigue Severity Scale scores were 0.43 points lower than placebo at day 60 and 0.58 points lower at day 90.Mean Fatigue Severity Scale scores were 0.43 points lower than placebo at day 60 and 0.58 points lower at day 90. In Brazil, 399 adults with fatigue 90 days to 24 months after confirmed COVID-19 infection participated in a randomised, placebo-controlled trial.
The maximum observed lifespan was approximately two years in a laboratory experiment comparing animals fed five times per week with those fed three…The maximum observed lifespan was approximately two years in a laboratory experiment comparing animals fed five times per week with those fed three times. In an experiment with Hydra oligactis, a freshwater animal, researchers tracked death rates and asexual reproduction across the…
Scores of four or more versus zero were linked to higher risks of depression and anxiety, with hazard ratios of 3.96 and 3.03, respectively.Scores of four or more versus zero were linked to higher risks of depression and anxiety, with hazard ratios of 3.96 and 3.03, respectively. This prospective observational cohort study included 212,033 UK Biobank participants recruited between 2006 and 2010.
In two observational cohorts, genetic scores were linked to faster progression to Alzheimer’s disease, with hazard ratios, a measure of risk over…In two observational cohorts, genetic scores were linked to faster progression to Alzheimer’s disease, with hazard ratios, a measure of risk over time, of 1.25 to 2.02. In participants from the Alzheimer’s Disease Neuroimaging Initiative and Framingham Heart Study, researchers evaluated…
In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased…In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival. They delivered the genes in a single dose of a virus and switched them on intermittently with doxycycline, an antibiotic, once a…
Across 60 healthy younger and older adults in the UK and Belgium, researchers found shared bacterial associations with cognitive performance despite…Across 60 healthy younger and older adults in the UK and Belgium, researchers found shared bacterial associations with cognitive performance despite geographic microbiome differences. Sixty healthy adults in the UK and Belgium took part, with 15 young and 15 older adults at each location.
Six-month sustained abstinence reached 8.8% with incentives plus free medication, versus 4.3% with usual care and 5.1% with usual care plus free…Six-month sustained abstinence reached 8.8% with incentives plus free medication, versus 4.3% with usual care and 5.1% with usual care plus free medication. Researchers randomized 3,259 participants at five centers across four US health systems; 3,220 entered the primary analysis.
Any bodily pain in later life was 30.6 percentage points more common in countries with the lowest human development scores than in those with the…Any bodily pain in later life was 30.6 percentage points more common in countries with the lowest human development scores than in those with the highest. In an observational study of 6,125,459 participants in 118 countries, researchers combined self-reported pain data from 902…
In experiments in mice, blocking a protein-recycling pathway in immune cells increased the build-up of senescent cells, which had stopped dividing.In experiments in mice, blocking a protein-recycling pathway in immune cells increased the build-up of senescent cells, which had stopped dividing. In experiments in mice and cells, researchers examined chaperone-mediated autophagy, a pathway that selectively breaks down proteins inside…
An analysis using inherited genetic differences prioritised 31 of 306 assessable comparisons between organ aging measures and age-related conditions…An analysis using inherited genetic differences prioritised 31 of 306 assessable comparisons between organ aging measures and age-related conditions in European-ancestry datasets.
Experiments in mouse models of aging found reduced tissue senescence, in which cells stop dividing, alongside improvements in measures linked to…Experiments in mouse models of aging found reduced tissue senescence, in which cells stop dividing, alongside improvements in measures linked to healthy lifespan. In mouse models of aging, researchers tested two experimental compounds derived from fisetin in animal experiments.
Classification accuracy remained high (AUC=0.91–0.95) up to a decade before death, with higher sensitivity and specificity than plasma p-tau217.Classification accuracy remained high (AUC=0.91–0.95) up to a decade before death, with higher sensitivity and specificity than plasma p-tau217. In people whose brains were examined at autopsy, blood eMTBR-tau was strongly associated with Alzheimer neuropathologic change.
Five-year cancer detection was higher with colonoscopy than with no early colonoscopy: the hazard ratio, comparing event rates over time, was 1.78…Five-year cancer detection was higher with colonoscopy than with no early colonoscopy: the hazard ratio, comparing event rates over time, was 1.78; overall mortality was unchanged.
Overexpressing the receptor in adrenergic-like neurons prolonged lifespan, restored calcium signaling, and improved locomotor performance in aged…Overexpressing the receptor in adrenergic-like neurons prolonged lifespan, restored calcium signaling, and improved locomotor performance in aged fruit flies. In fruit flies (Drosophila), aging leads to neurodegeneration, diminished locomotion, and increased oxidative whole-brain…
A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals.A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals. In experiments with human fibroblasts, cells that help form connective tissue, researchers screened drugs for effects on senescent cells.
In an experiment in mice with ovaries removed and fed a high-fat diet, the drug also reduced fat in bone marrow.In an experiment in mice with ovaries removed and fed a high-fat diet, the drug also reduced fat in bone marrow. In an experiment in mice, researchers modelled osteoporosis, a condition that weakens bones, alongside hyperlipidemia, high blood fat levels.
In Korean adults under 50, risk of early-onset colorectal adenocarcinoma was 93% higher in those with accelerated biological aging than in those…In Korean adults under 50, risk of early-onset colorectal adenocarcinoma was 93% higher in those with accelerated biological aging than in those without it. An observational study followed 198,491 Korean adults under 50 years of age for a median of 7.7 years.
In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised. In an animal experiment, aged male and female mice received pipecolic acid and succinate, two compounds derived from microbes, or a control in…
After accounting for age, the rate rose from 0.65 deaths per 100,000 in 1999 to 1.32 in 2020 in US mortality records.After accounting for age, the rate rose from 0.65 deaths per 100,000 in 1999 to 1.32 in 2020 in US mortality records. Researchers analysed mortality records for people in the US from 1999 to 2020 in a cross-sectional observational study.
An observational study followed 462 healthy adults for a year, finding stronger health links using individual sleep cut-offs than a fixed six-hour…An observational study followed 462 healthy adults for a year, finding stronger health links using individual sleep cut-offs than a fixed six-hour limit. Researchers compared nights with less than six hours of sleep against nights defined as short using each person’s recorded…
In an animal experiment, mice whose ovaries had been removed showed worse osteoporosis and anxiety- and depression-like behaviour after eight weeks of…In an animal experiment, mice whose ovaries had been removed showed worse osteoporosis and anxiety- and depression-like behaviour after eight weeks of chronic stress. Bone tissue contained more cathepsin K, a protein-cutting enzyme, alongside markers of inflammation and cell death.
PM2.5 showed the strongest association, with a hazard ratio of 1.22 per 5 µg/m³ higher exposure in 313,534 UK Biobank participants.PM2.5 showed the strongest association, with a hazard ratio of 1.22 per 5 µg/m³ higher exposure in 313,534 UK Biobank participants. In 313,534 UK Biobank participants, researchers examined associations between annual average air pollution exposure, genetic susceptibility and chronic…
Across 4,825 adults followed for 14.8 years on average, thyroid antibodies were linked to cardiovascular risk in participants under 40 but not in…Across 4,825 adults followed for 14.8 years on average, thyroid antibodies were linked to cardiovascular risk in participants under 40 but not in those aged 40 and older. In a prospective cohort study, researchers followed 4,825 adults aged 20 or older who had no cardiovascular disease at…
Among Norwegian participants who developed lung cancer, the median interval after starting smoking was 53.3 years, longer than the previously reported…Among Norwegian participants who developed lung cancer, the median interval after starting smoking was 53.3 years, longer than the previously reported lag of up to 40 years. In an observational study of 80,761 people in Norway who had ever smoked, 1,336 developed lung cancer.
Blood DNA fragments indicated packaging units spaced 145 base pairs apart at chromosome ends, compared with about 170 base pairs across the genome.Blood DNA fragments indicated packaging units spaced 145 base pairs apart at chromosome ends, compared with about 170 base pairs across the genome. In an observational study of human plasma, the liquid part of blood, researchers analysed cell-free DNA—DNA fragments circulating outside…
At least four weekly hours of moderate to vigorous activity was linked to an estimated 18 fewer liver cancers per 100,000 by age 67 than under four…At least four weekly hours of moderate to vigorous activity was linked to an estimated 18 fewer liver cancers per 100,000 by age 67 than under four hours. An observational analysis of 263,184 participants in the NIH-AARP Diet and Health Study evaluated physical activity and liver cancer…
In 765 Chinese workers, a cross-sectional study linked greater cumulative noise exposure to higher blood fat risk measures and shorter protective caps…In 765 Chinese workers, a cross-sectional study linked greater cumulative noise exposure to higher blood fat risk measures and shorter protective caps on chromosomes. For the Chinese workers, researchers combined job histories and workplace noise measurements to estimate cumulative…
The study covered the full adult age range in chimpanzees, bonobos, gorillas and orangutans, including individuals of advanced age.The study covered the full adult age range in chimpanzees, bonobos, gorillas and orangutans, including individuals of advanced age. In chimpanzees, bonobos, gorillas and orangutans, brain weight showed no significant change across adulthood and into advanced age.
In asymptomatic carotid stenosis, five-year rates of cognitive decline or dementia were 18.06% after carotid stenting versus 15.24% after carotid…In asymptomatic carotid stenosis, five-year rates of cognitive decline or dementia were 18.06% after carotid stenting versus 15.24% after carotid endarterectomy. Adults with symptom-free narrowing of the carotid arteries, which supply blood to the brain, and no existing cognitive…
A three-year observational study of 150 hospitalised adults found greater early frailty after severe lung injury than after pneumonia requiring only…A three-year observational study of 150 hospitalised adults found greater early frailty after severe lung injury than after pneumonia requiring only oxygen through nasal tubes.
Five or more years of childhood assistance was associated with 69 percent lower adult diabetes risk and 39 percent lower hypertension risk than no…Five or more years of childhood assistance was associated with 69 percent lower adult diabetes risk and 39 percent lower hypertension risk than no childhood assistance. Researchers studied children whose families received housing assistance and similar children whose families did not…
The low-risk living-environment group had a lower rate of new cases than the high-risk group, with a hazard ratio, comparing these rates, of 0.51.The low-risk living-environment group had a lower rate of new cases than the high-risk group, with a hazard ratio, comparing these rates, of 0.51. An observational cohort study followed 6,330 adults aged 45 or older in China who initially did not have cardiometabolic multimorbidity…
An observational study followed 337,334 UK Biobank participants for a median of approximately 13 years and linked groups based on routine health…An observational study followed 337,334 UK Biobank participants for a median of approximately 13 years and linked groups based on routine health measures to differing disease progression.
