Every aging paper worth knowing about, the day it appears.
Researchers derived biological age uncertainty across UK Biobank participants, finding that higher uncertainty reflects reduced physiological coherence and predicts worse health outcomes.
From: Uncertainty redefines biological age
medRxiv · 28 Sept · Li Y, Feng G, Yan S et al.
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.
Research Square · 30 Sept · Na R, Shi C, Ruan X et al.
The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.
Nature metabolism · 1 Oct · Koning M, Kovynev A, Fondevila MF et al.
Restoring cardiolipin synthesis in knockout mice reversed muscle atrophy and prevented premature death.
Nature aging · 29 Sept · Finger F, Frost M, Watanabe S et al.
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.
bioRxiv · 27 Sept · Shemtov SJ, Hwang E, Chung CS et al.
Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.
bioRxiv · 28 Sept · Harris AS, Rouse JA, Guo G et al.
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.
bioRxiv · 30 Sept · Grafton F, Rohani N, Lim WF et al.
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.
medRxiv · 1 Oct · Zhao K, Quin C, Pershad Y et al.
A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.
bioRxiv · 30 Sept · Lu YRR, Shen H, Kajderowicz K et al.
Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.
Nature communications · 27 Aug · Hua L, Yang X, Gao D et al.
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
bioRxiv · 28 Sept · Torres G, Salladay-Perez IA, Deng CY et al.
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
bioRxiv · 1 Oct · Alsolami S, Wang M, Sarraf Sabedot T et al.
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
medRxiv · 1 Oct · Simpson DJ, Crofts SJ, Mavrommatis C et al.
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Aging cell · 1 Oct · Pyrgioti M, Eguiagaray IM, Redmond P et al.
The Journal of pharmacy and pharmacology · 1 Oct · Li J, Cai M, Li H et al.
Mitochondrion · 1 Oct · Zhang X, Tao T, Liu W et al.
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
Genome medicine · 2 Oct · Jonkman TH, Richmond A, BIOS Consortium et al.
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
bioRxiv · 1 Oct · Yang L, Sun Z, Luo X et al.
bioRxiv · 1 Oct · Goryanin I, Goryanin I, Damms B
bioRxiv · 1 Oct · Patel MS, Frye B, Negrey JD et al.
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.
bioRxiv · 1 Oct · Mungo C, Bersaglieri C, Paganini D et al.
Aging cell · 1 Oct · Kanehisa R, Nakatani H, Takatori S et al.
Ageing research reviews · 1 Oct · Mandlik DS, Mandlik SK
Experimental gerontology · 1 Oct · Di Maria E, Gualco C, Muscolino E et al.
Best practice & research. Clinical rheumatology · 1 Oct · Brooks HW, Cusick NC, Wu S et al.
Protein & cell · 1 Oct · Zhang Q, Yu J, Zhai X et al.
Science (New York, N.Y.) · 1 Oct · Dubal DB, Ambrosio F, Stout MB et al.
The American naturalist · 5 May · Liguori A, Korm S, Profetto A et al.
JAR life · 23 Sept · Morishita S, Iida N, Sato T et al.
Preprints.org · 30 Sept · Ivchuk V
Frontiers in endocrinology · 16 Sept · Tian H, Huang L, Liu H et al.
Redox biology · 28 Sept · Zhang L, Schmidt F, Yasar F et al.
Neural regeneration research · 30 Sept · Mao W, Song W, Zhang Y et al.
American journal of physiology. Regulatory, integrative and comparative physiology · 1 Oct · Buckley DJ, Bogale K, Cuellar N et al.
PloS one · 1 Oct · Shah N
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · 1 Oct · Chen G, Shangguan Z, Gong J et al.
Molecular biology reports · 1 Oct · Vahidinia Z, Behdarvandy M, Azami Tameh A et al.
BioFactors (Oxford, England) · 1 Sept · Goto S, Harada M, Setoguchi S et al.
bioRxiv · 1 Oct · López-Moyado IF, Suzuki K, Hernández-Espinosa L et al.
Neoplasia (New York, N.Y.) · 1 Oct · Lin C, Guo Q, Lai S
Aging cell · 1 Oct · Kroon TM, Munitz J, Ranzenigo A et al.
microPublication biology · 15 Sept · Desnos CA, Tamez Gonzalez AA, Van Raamsdonk JM
RMD open · 1 Oct · Jiménez-Martínez M, De Jong TA, Houtman M et al.
Gene · 1 Oct · Arayesh MJ, Ataellahi F, Masoudi R
International journal of mycobacteriology · 1 Jul · Fachrucha F, Andarini S, Burhan E et al.
Frontiers in public health · 16 Sept · Xue X, Chen S, Cheng Y et al.
Molecular therapy. Nucleic acids · 3 Sept · Choi S, Sung MJ, An HJ et al.
Nutrition and cancer · 1 Oct · Ye Q, Jiang S, Chen J et al.
MedComm · 30 Sept · Wang W, Jiang X, Qiu R et al.
Stem cells international · 30 Sept · Iyer VC, Lerman LO, Eirin A
Molecular biology reports · 1 Oct · Singh S, Srivastava S, Siddiqui S et al.
A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.
Cell reports · 30 Sept · Gordillo-García S, Fernandez-Abascal J, Hernando-Rodríguez B et al.
Researchers built a predictive model in roundworms, validated ten life-extending compounds, and identified conserved aging modules linked to frailty in mice.
Science advances · 30 Sept · Huai W, Ng LF, Lee JH et al.