Across two large health record databases followed for up to a decade, severely low vitamin D was tied to higher mortality, with hazard ratios of 2.57 and 1.59.Across two large health record databases followed for up to a decade, severely low vitamin D was tied to higher mortality, with hazard ratios of 2.57 and 1.59.
In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.
In a 52-week randomised trial, disease rating scores rose by 2.45 points with the supplement compared with a 0.27-point fall with placebo.In a 52-week randomised trial, disease rating scores rose by 2.45 points with the supplement compared with a 0.27-point fall with placebo. In a randomised, double-blind, placebo-controlled trial across 11 centres in Norway…
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See PlusOverfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.
In adults with less childhood stimulation, 1 part per million higher second-trimester lead was linked to 0.34 standard deviations lower cognitive scores, but not with…In adults with less childhood stimulation, 1 part per million higher second-trimester lead was linked to 0.34 standard deviations lower cognitive scores, but not with high stimulation.
In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.
In an observational study of over 100,000 older adults across five countries, upward educational mobility was linked to higher overall physical and mental capacity.In an observational study of over 100,000 older adults across five countries, upward educational mobility was linked to higher overall physical and mental capacity.
An epigenetic clock built from 894 domestic dogs predicted mortality and linked faster biological aging to larger body size and male sex.An epigenetic clock built from 894 domestic dogs predicted mortality and linked faster biological aging to larger body size and male sex. In an observational molecular study, researchers analysed 1,640 DNA methylomes—chemical tags…
In a prospective study of 965 stroke-free patients with preserved-ejection heart failure followed for two years, dementia and its progression were linked to higher death…In a prospective study of 965 stroke-free patients with preserved-ejection heart failure followed for two years, dementia and its progression were linked to higher death rates.
Across two validation cohorts of over 22,000 patients, an AI score from overnight heart traces yielded hazard ratios of 2.03 and 2.72 for atrial fibrillation.Across two validation cohorts of over 22,000 patients, an AI score from overnight heart traces yielded hazard ratios of 2.03 and 2.72 for atrial fibrillation.
In a preprint, top-decile integrated genetic risk was linked to 23.9% more hospital days, and elevated diabetes risk corresponded to 1.50 lost healthy life-years.In a preprint, top-decile integrated genetic risk was linked to 23.9% more hospital days, and elevated diabetes risk corresponded to 1.50 lost healthy life-years.
In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated…In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated oxidative stress.
The mortality hazard ratio was 2.03 for participants with under 5 nanograms per millilitre of vitamin D compared with those with at least 20.The mortality hazard ratio was 2.03 for participants with under 5 nanograms per millilitre of vitamin D compared with those with at least 20.
A healthy lifestyle mediated 20.5% of socioeconomic inequity in all-cause mortality and 16.4% in unhealthy aging across a 20-year Chinese cohort.A healthy lifestyle mediated 20.5% of socioeconomic inequity in all-cause mortality and 16.4% in unhealthy aging across a 20-year Chinese cohort.
In six-month-old mice with accelerated aging, ER272 was linked to better cognition and preserved markers of new brain cells in males, but showed limited effects in…In six-month-old mice with accelerated aging, ER272 was linked to better cognition and preserved markers of new brain cells in males, but showed limited effects in females.
In 35,193 healthy adults followed for over a decade, each one-unit score rise was linked to a hazard ratio of 2.60 for disease progression.In 35,193 healthy adults followed for over a decade, each one-unit score rise was linked to a hazard ratio of 2.60 for disease progression.
Over 12 months, adults with mild cognitive impairment scored 1 point higher on the Montreal Cognitive Assessment than controls maintaining usual activity.Over 12 months, adults with mild cognitive impairment scored 1 point higher on the Montreal Cognitive Assessment than controls maintaining usual activity.
In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.
In an analysis of 889,215 people, clonal blood mutations were associated with serious bacterial infections, with a hazard ratio of 1.22.In an analysis of 889,215 people, clonal blood mutations were associated with serious bacterial infections, with a hazard ratio of 1.22. In an observational study of 590,537 people from three population cohorts, validated across…
A screen of 3,985 bacterial strains identified an iron-gathering molecule whose effects in worms depended on a stress response in cells’ energy-producing structures.A screen of 3,985 bacterial strains identified an iron-gathering molecule whose effects in worms depended on a stress response in cells’ energy-producing structures.
The engineered particles cut friction over 90% compared with commercial hyaluronic acid and reversed chondrocyte senescence in lab models of osteoarthritis.The engineered particles cut friction over 90% compared with commercial hyaluronic acid and reversed chondrocyte senescence in lab models of osteoarthritis.
Older adults starting lemborexant had a lower rate of hip fracture than those starting Z-drugs, with a hazard ratio of 0.31 over one year.Older adults starting lemborexant had a lower rate of hip fracture than those starting Z-drugs, with a hazard ratio of 0.31 over one year. In an observational cohort study, researchers analysed regional health databases in Japan…
When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.
Across 21,577 cancer survivors, higher baseline frailty was associated with an increased risk of 28 out of 39 chronic diseases.Across 21,577 cancer survivors, higher baseline frailty was associated with an increased risk of 28 out of 39 chronic diseases. In an observational cohort study, researchers analysed records from 21,577 cancer survivors aged 39 to…
In mice with bone loss or fractures, honokiol promoted bone formation predominantly linked to sirtuin 3, while broader effects appeared only partly dependent on the…In mice with bone loss or fractures, honokiol promoted bone formation predominantly linked to sirtuin 3, while broader effects appeared only partly dependent on the enzyme.
Carrying one faulty copy of the LTBP2 gene was linked to a fourfold higher risk of adult glaucoma and diagnosis eight years earlier.Carrying one faulty copy of the LTBP2 gene was linked to a fourfold higher risk of adult glaucoma and diagnosis eight years earlier. In an observational study of more than 450,000 participants in the UK Biobank, researchers…
In a study of UK adults, the highest fitness quartile had a 24% lower depression risk and 17% lower anxiety risk than the lowest quartile.In a study of UK adults, the highest fitness quartile had a 24% lower depression risk and 17% lower anxiety risk than the lowest quartile. In a prospective cohort study, researchers followed 46,062 UK Biobank participants who had…
A screen of 2,782 drugs approved by US regulators identified 31 that reproducibly increased heat-stress resistance in worms.A screen of 2,782 drugs approved by US regulators identified 31 that reproducibly increased heat-stress resistance in worms. In experiments in Caenorhabditis elegans worms, researchers screened 2,782 drugs approved by US…
Using lineage tracing across the lifespan of female mice, researchers mapped how secondary follicles regulate the survival of activated egg cells to support long-term…Using lineage tracing across the lifespan of female mice, researchers mapped how secondary follicles regulate the survival of activated egg cells to support long-term fertility.
In a study of 10,643 adults aged 50 and older, each adverse childhood experience was linked to a 3% to 12% higher risk across four frailty patterns.In a study of 10,643 adults aged 50 and older, each adverse childhood experience was linked to a 3% to 12% higher risk across four frailty patterns.
In mice lacking ovaries to mimic estrogen loss, deleting the Camkk1 gene from bone-degrading cells attenuated the loss of spongy bone.In mice lacking ovaries to mimic estrogen loss, deleting the Camkk1 gene from bone-degrading cells attenuated the loss of spongy bone. In an experiment using cultured cells and mice, researchers investigated how bone-resorbing…
In adults later diagnosed with cancer, estimated 15-year survival probabilities rose from 39.3% to 77.4% across the estimated cardiorespiratory fitness range.In adults later diagnosed with cancer, estimated 15-year survival probabilities rose from 39.3% to 77.4% across the estimated cardiorespiratory fitness range.
In 503 retired adults in China, each 0.1-micrometre rise in a marker of vessel lining damage was linked to 12% higher odds of asymptomatic heart dysfunction.In 503 retired adults in China, each 0.1-micrometre rise in a marker of vessel lining damage was linked to 12% higher odds of asymptomatic heart dysfunction.
In postmenopausal women with metabolic dysfunction-associated steatotic liver disease, an eight-week elastic band workout reduced a liver fat measure by 36.77 dB/m…In postmenopausal women with metabolic dysfunction-associated steatotic liver disease, an eight-week elastic band workout reduced a liver fat measure by 36.77 dB/m against controls.
In people with MASLD, drinking 1 to 2 cups of tea daily was linked to an all-cause mortality hazard ratio of 0.85 versus none.In people with MASLD, drinking 1 to 2 cups of tea daily was linked to an all-cause mortality hazard ratio of 0.85 versus none. In an observational prospective cohort study, researchers analysed 360,548 UK Biobank participants.
Only one pair shared the immune-blocking proteins while 35 pairs differed, with autoantibodies detected in 1.5% of the 3,270 older twins tested.Only one pair shared the immune-blocking proteins while 35 pairs differed, with autoantibodies detected in 1.5% of the 3,270 older twins tested.
Mexican adults with the highest levels of non-DHA omega-3 fats had a 20% lower hazard of death than those with the lowest.Mexican adults with the highest levels of non-DHA omega-3 fats had a 20% lower hazard of death than those with the lowest. In an observational cohort study, researchers analysed data from 144,900 Mexican adults aged 35 years and…
In a mouse model of lung cancer, restricting food before tumour induction preserved lean mass and prolonged survival where targeting individual candidate factors failed.In a mouse model of lung cancer, restricting food before tumour induction preserved lean mass and prolonged survival where targeting individual candidate factors failed.
9 Oct