An observational analysis combined data from more than 375,000 human blood vessel cells across 12 tissues to map gene activity throughout adulthood.An observational analysis combined data from more than 375,000 human blood vessel cells across 12 tissues to map gene activity throughout adulthood.
Experiments in worms found that reducing insulin-like signaling during development could improve reproduction and survival, but lifespan and fitness benefits depended on…Experiments in worms found that reducing insulin-like signaling during development could improve reproduction and survival, but lifespan and fitness benefits depended on temperature.
Age- and sex-adjusted wear scores were 2.13 at the lower end of US socioeconomic scores and 1.68 at the higher end.Age- and sex-adjusted wear scores were 2.13 at the lower end of US socioeconomic scores and 1.68 at the higher end. The observational study analyzed data from 24,187 US adults and 17,507 Chinese adults.
Mice dependent on dietary vitamin B3 to make an energy-regulating molecule developed frailty, cataracts and shortened lifespan when researchers removed the vitamin.Mice dependent on dietary vitamin B3 to make an energy-regulating molecule developed frailty, cataracts and shortened lifespan when researchers removed the vitamin.
Castration at 240 days increased median lifespan by 32.9%, compared with increases of 19.3% at 20 days and 25.8% at 60 days.Castration at 240 days increased median lifespan by 32.9%, compared with increases of 19.3% at 20 days and 25.8% at 60 days. In an animal experiment, researchers removed the testes of male UM-HET3 mice, a stock with varied genetic…
Conventional exercise improved physical function by 1.04 points versus usual care; virtual reality–enhanced exercise showed no clear advantage over usual care.Conventional exercise improved physical function by 1.04 points versus usual care; virtual reality–enhanced exercise showed no clear advantage over usual care.
Experiments in aged mice found better health span and fewer deaths from sepsis and inflammation after researchers raised taurine levels.Experiments in aged mice found better health span and fewer deaths from sepsis and inflammation after researchers raised taurine levels. Raising taurine also reduced deaths from sepsis, a life-threatening response to infection…
Applying mechanical force along the shinbone extended lifespan by 9.4%, or 79.5 days, in mice aged 20–24 months.Applying mechanical force along the shinbone extended lifespan by 9.4%, or 79.5 days, in mice aged 20–24 months. Experiments in mice tested whether bone’s ability to sense physical force affected whole-body aging.
Blocking CCL3, a signal that attracts immune cells, from day four after injury reduced their accumulation and accelerated wound closure in aged mice.Blocking CCL3, a signal that attracts immune cells, from day four after injury reduced their accumulation and accelerated wound closure in aged mice.
An observational study of 1,204 middle-aged adults found no link between parental dementia history and faster aging on DNA-based measures or brain scans.An observational study of 1,204 middle-aged adults found no link between parental dementia history and faster aging on DNA-based measures or brain scans.
An observational study of more than 200 adults found lower consistency at older ages and declines within individuals over a mean of four years.An observational study of more than 200 adults found lower consistency at older ages and declines within individuals over a mean of four years.
In a randomized crossover trial involving young and older men, serum collected after fermented whey increased cell diameter compared with serum collected after…In a randomized crossover trial involving young and older men, serum collected after fermented whey increased cell diameter compared with serum collected after conventional whey.
Levels of 50 muscle proteins and 17 ovarian proteins correlated with their levels in blood plasma in an observational study of adults aged 20–87.Levels of 50 muscle proteins and 17 ovarian proteins correlated with their levels in blood plasma in an observational study of adults aged 20–87.
In experiments with 12 mice per group, deleting the gene in bone-building cells reduced bone loss after 12 weeks of chemically induced aging.In experiments with 12 mice per group, deleting the gene in bone-building cells reduced bone loss after 12 weeks of chemically induced aging.
In 276 neurotypical adults tested about five years apart, a nonrhythmic brain signal tracked slowing on an attention task but not changes in response control.In 276 neurotypical adults tested about five years apart, a nonrhythmic brain signal tracked slowing on an attention task but not changes in response control.
Compared with untreated worms, LSD extended the time until only 25% remained alive by up to 17.6%. In laboratory experiments, researchers exposed Caenorhabditis elegans…Compared with untreated worms, LSD extended the time until only 25% remained alive by up to 17.6%. In laboratory experiments, researchers exposed Caenorhabditis elegans worms to low concentrations of lysergic acid diethylamide…
Disease-network density, a measure of connectedness, was 0.089 in young adults, 0.153 in middle-aged adults and 0.178 in older adults.Disease-network density, a measure of connectedness, was 0.089 in young adults, 0.153 in middle-aged adults and 0.178 in older adults. Researchers analyzed 73,023 electronic health records from adults at Xiangya Hospital in…
A randomized trial of 249 adults aged 65 or older found no differences between standard exercise and a 12-week program adding timing and coordination exercises.A randomized trial of 249 adults aged 65 or older found no differences between standard exercise and a 12-week program adding timing and coordination exercises. Their average age was 77.4 years.
Who was studied249 community-dwelling older adults with walking problems, 36 weeks
What changedWalking skills did not differ between older adults receiving added timing and coordination training and those receiving standard exercise alone
In a cohort of 615 older patients, all four tools predicted outcomes; a 32-item index took 18 minutes versus six for the quickest assessment.In a cohort of 615 older patients, all four tools predicted outcomes; a 32-item index took 18 minutes versus six for the quickest assessment.
The structures grew through more than 20 transfers to fresh cultures while preserving their mix of cell types and DNA integrity.The structures grew through more than 20 transfers to fresh cultures while preserving their mix of cell types and DNA integrity. In experiments with periosteal organoids—three-dimensional, lab-grown structures that model the…
A reanalysis of a randomized trial included 796 people with kidney disease and type 2 diabetes, including 307 with apparent treatment-resistant high blood pressure.A reanalysis of a randomized trial included 796 people with kidney disease and type 2 diabetes, including 307 with apparent treatment-resistant high blood pressure.
No measure consistently performed best in a cohort of 56,182 older adults with type 2 diabetes followed for a median 5.56 years.No measure consistently performed best in a cohort of 56,182 older adults with type 2 diabetes followed for a median 5.56 years. They compared five measures based on blood sugar and triglycerides, a type of blood fat, with or…
Over 52 weeks, diabetes developed in 6.4% taking obicetrapib versus 8.5% taking placebo, but the results did not rule out no difference.Over 52 weeks, diabetes developed in 6.4% taking obicetrapib versus 8.5% taking placebo, but the results did not rule out no difference. A pooled analysis of two randomized trials studied 1,700 people without diabetes: 899 with…
Researchers linked a 271-gene activity pattern to cognitive performance independently of age, including genes involved in building and moving tiny, hairlike cell…Researchers linked a 271-gene activity pattern to cognitive performance independently of age, including genes involved in building and moving tiny, hairlike cell projections.
Compared with two diabetes drug classes, tirzepatide had flare-up hazard ratios, measures of relative risk over time, of 0.73 and 0.72.Compared with two diabetes drug classes, tirzepatide had flare-up hazard ratios, measures of relative risk over time, of 0.73 and 0.72. In adults with chronic obstructive pulmonary disease (COPD) and type 2 diabetes, researchers…
An eight-week randomized trial in 196 adults with prediabetes and short sleep found no significant added glucose or weight-loss benefit over lifestyle support alone.An eight-week randomized trial in 196 adults with prediabetes and short sleep found no significant added glucose or weight-loss benefit over lifestyle support alone. They delivered both programs individually by video call.
Each extra microgram of smoke particles per cubic meter was linked to a mortality hazard ratio—a measure of relative risk—of 1.032.Each extra microgram of smoke particles per cubic meter was linked to a mortality hazard ratio—a measure of relative risk—of 1.032. Researchers linked annual air pollution estimates to 77,470,752 US Medicare beneficiaries during…
Experiments in isolated hearts from 21-month-old male mice found better recovery without the protein after flow through the heart stopped and restarted.Experiments in isolated hearts from 21-month-old male mice found better recovery without the protein after flow through the heart stopped and restarted.
In experiments with human blood-forming cells, an additional mutation reduced the defects caused by one inherited variant.In experiments with human blood-forming cells, an additional mutation reduced the defects caused by one inherited variant. The variants had been identified in two children with congenital neutropenia, a condition involving low…
A signal released by these nerves acted on immune cells to limit inflammation after kidney blood flow was interrupted and restored in mouse experiments.A signal released by these nerves acted on immune cells to limit inflammation after kidney blood flow was interrupted and restored in mouse experiments.
An observational analysis of 13,094 people aged 30–100 found no statistically significant associations after accounting for other factors.An observational analysis of 13,094 people aged 30–100 found no statistically significant associations after accounting for other factors. In an observational analysis, researchers examined 24,915 eyes from 13,094 people aged…
An exploratory analysis linked combined exercise to lower 24-hour average glucose than non-exercise days, with a model estimate of minus 0.513.An exploratory analysis linked combined exercise to lower 24-hour average glucose than non-exercise days, with a model estimate of minus 0.513.
Female flies producing human amyloid protein had a median lifespan of 47.5 days with increased Wwox gene activity, versus 29 days in controls.Female flies producing human amyloid protein had a median lifespan of 47.5 days with increased Wwox gene activity, versus 29 days in controls.
In mouse experiments, pre-existing immunity to the vaccine’s protein scaffold enhanced responses to the attached bacterial antigens rather than weakening them.In mouse experiments, pre-existing immunity to the vaccine’s protein scaffold enhanced responses to the attached bacterial antigens rather than weakening them.
Mortality risk-ranking scores were 0.747 for clinical walking speed versus 0.744 and 0.745 for two measures of everyday step rate.Mortality risk-ranking scores were 0.747 for clinical walking speed versus 0.744 and 0.745 for two measures of everyday step rate. The observational Whitehall II cohort study included 4,067 UK participants with an average age of…
