Each extra year of walking-based age above actual age was associated with a 7% higher relative risk of future cognitive impairment in initially cognitively normal adults.Each extra year of walking-based age above actual age was associated with a 7% higher relative risk of future cognitive impairment in initially cognitively normal adults.
Experiments in human natural killer cells linked age-related fat buildup to altered cell mechanics and weaker killing of target cells.Experiments in human natural killer cells linked age-related fat buildup to altered cell mechanics and weaker killing of target cells. Their membranes were more fluid, and the supporting layer beneath the membrane was less stiff.
A study comparing young and aged mice found weaker two- to six-hour cycles in movement and body temperature, alongside changes in the brain’s daily clock.A study comparing young and aged mice found weaker two- to six-hour cycles in movement and body temperature, alongside changes in the brain’s daily clock.
Chair-stand performance rose by 5.5 repetitions with high-intensity exercise, compared with 3.6 at moderate and 1.9 at low intensity over 24 weeks.Chair-stand performance rose by 5.5 repetitions with high-intensity exercise, compared with 3.6 at moderate and 1.9 at low intensity over 24 weeks.
Over 70 weeks of follow-up, aged obese mice given the combination had a 60% increase in lifespan compared with mice given control viral carriers.Over 70 weeks of follow-up, aged obese mice given the combination had a 60% increase in lifespan compared with mice given control viral carriers.
At day 90, a lung gas-transfer measure rose by a median 1.36 mL/min/mmHg with fisetin versus 0.13 with placebo.At day 90, a lung gas-transfer measure rose by a median 1.36 mL/min/mmHg with fisetin versus 0.13 with placebo. Ten adults with common variable immunodeficiency, an immune disorder, and granulomatous-lymphocytic interstitial lung…
Death risk was 2.60 times as high among smokers with physically demanding jobs as among nonsmokers with low physical work demands.Death risk was 2.60 times as high among smokers with physically demanding jobs as among nonsmokers with low physical work demands. Adults aged 36–62 from England, Finland, France and the US took part in a multicohort study…
Walking speed was 0.14 meters per second higher than with home exercise alone after 12 weeks in a randomized trial.Walking speed was 0.14 meters per second higher than with home exercise alone after 12 weeks in a randomized trial. In Guangzhou, China, 51 adults aged 60 or older living at home with at least one chronic disease completed a…
Experiments in zebrafish linked interferon-gamma signaling in immune cells to scar remodeling and heart muscle renewal after injury.Experiments in zebrafish linked interferon-gamma signaling in immune cells to scar remodeling and heart muscle renewal after injury. They cleared debris and remodeled collagen less effectively.
Removing precursor cells reduced valve thickening and scarring in mice given daily D-galactose injections to model aging for about two months.Removing precursor cells reduced valve thickening and scarring in mice given daily D-galactose injections to model aging for about two months.
Higher starting values were linked to greater frailty risk in two cohorts, with hazard ratios—measures of relative risk—of 1.32 and 1.56.Higher starting values were linked to greater frailty risk in two cohorts, with hazard ratios—measures of relative risk—of 1.32 and 1.56. Middle-aged and older adults—6,173 in one cohort and 2,736 in another—were included in a…
Animal experiments linked persistent lung scarring to poor clearance of dying cells, while activating a metabolic regulator promoted scarring resolution in aged mice.Animal experiments linked persistent lung scarring to poor clearance of dying cells, while activating a metabolic regulator promoted scarring resolution in aged mice. This cleanup process is called efferocytosis.
A longitudinal study of 50 captive adults linked faster increases in DNA-based age to shorter lifespans.A longitudinal study of 50 captive adults linked faster increases in DNA-based age to shorter lifespans. Fifty captive adult zebra finches (Taeniopygia castanotis) were monitored until natural death in a longitudinal study of DNA…
Participants with the condition had higher risk than those without it, with a hazard ratio of 1.153, a measure comparing risk over time.Participants with the condition had higher risk than those without it, with a hazard ratio of 1.153, a measure comparing risk over time. Among 258,566 UK Biobank participants in a prospective cohort study, 8,113 had clonal…
Mouse experiments found impaired shifts toward bile duct cells during chronic injury, but no substantial impairment of liver cell survival or basic metabolic function.Mouse experiments found impaired shifts toward bile duct cells during chronic injury, but no substantial impairment of liver cell survival or basic metabolic function.
Four or more physical and mental deficits were linked to higher diabetes risk than none over 13.63 years’ median follow-up (hazard ratio 2.37).Four or more physical and mental deficits were linked to higher diabetes risk than none over 13.63 years’ median follow-up (hazard ratio 2.37).
After catheter-based valve replacement, 12-month death or worsening heart failure rates were 15.2% with dapagliflozin versus 22.7% with standard care in patients with…After catheter-based valve replacement, 12-month death or worsening heart failure rates were 15.2% with dapagliflozin versus 22.7% with standard care in patients with diabetes and prior heart failure.
An eight-week experiment using 13 male human donors found better maze performance in mice given gut microbes from donors with higher processing-speed scores.An eight-week experiment using 13 male human donors found better maze performance in mice given gut microbes from donors with higher processing-speed scores.
Women with these disorders had higher odds of two or more chronic conditions 27 years later than women with normal pregnancy blood pressure (odds ratio 1.93).Women with these disorders had higher odds of two or more chronic conditions 27 years later than women with normal pregnancy blood pressure (odds ratio 1.93).
Who was studied2,954 women with a previous pregnancy, 27y
What changedWomen with pregnancy blood pressure disorders had higher odds of multiple illnesses than women with normal blood pressure (odds ratio 1.93)
The catchSelf-reported conditions could miss undiagnosed illnesses
Analyses of two randomized trials found broadly consistent reductions in the top blood pressure number among adults with obesity or overweight at 72 weeks.Analyses of two randomized trials found broadly consistent reductions in the top blood pressure number among adults with obesity or overweight at 72 weeks.
A 48-hour screen of 489 compounds identified lanatoside C as a candidate for preferentially killing human immune cells with reduced TET2 gene function.A 48-hour screen of 489 compounds identified lanatoside C as a candidate for preferentially killing human immune cells with reduced TET2 gene function.
An observational analysis of 52,667 UK Biobank participants found that three types of organ protein measures were related but not interchangeable.An observational analysis of 52,667 UK Biobank participants found that three types of organ protein measures were related but not interchangeable. One estimated how far an organ’s predicted age differed from chronological age.
In hemodialysis patients, low muscle power was linked to higher relative death risk than higher power over 24 months; the adjusted hazard ratio was 1.67.In hemodialysis patients, low muscle power was linked to higher relative death risk than higher power over 24 months; the adjusted hazard ratio was 1.67.
A 12-week randomized trial in 44 men aged 23–32 found the largest improvements in blood sugar measures with combined exercise and supplementation.A 12-week randomized trial in 44 men aged 23–32 found the largest improvements in blood sugar measures with combined exercise and supplementation.
A 34-year observational study of 3,285 western harvester ant colonies found declining mortality and increasing reproduction as colonies aged.A 34-year observational study of 3,285 western harvester ant colonies found declining mortality and increasing reproduction as colonies aged.
Compared with 2010, projected pollution-related deaths in 2050 fell by about 1.1 million under a sustainable pathway but rose by about 0.5 million under regional rivalry.Compared with 2010, projected pollution-related deaths in 2050 fell by about 1.1 million under a sustainable pathway but rose by about 0.5 million under regional rivalry.
Who was studiedGlobal populations under alternative socioeconomic pathways
What changedProjected pollution deaths fall by approximately 1.1 million under sustainability but rise by approximately 0.5 million under regional rivalry versus baseline
The catchOverlapping training and test locations and times make model accuracy look better than independent validation
Measured vision impairment affected 14.57% of adults with age-related macular degeneration alone, versus 7.09% with retinopathy alone.Measured vision impairment affected 14.57% of adults with age-related macular degeneration alone, versus 7.09% with retinopathy alone. Among 5,593 US adults aged 40 and older, a cross-sectional study compared two eye conditions…
In an animal experiment, one week of oral pretreatment improved blood pressure control and survival during blood pressure reduction in old rats.In an animal experiment, one week of oral pretreatment improved blood pressure control and survival during blood pressure reduction in old rats.
The median share of JAK2 gene copies carrying a mutation was 13.0% at diagnosis in monitored cases versus 41.3% in referral-diagnosed cases.The median share of JAK2 gene copies carrying a mutation was 13.0% at diagnosis in monitored cases versus 41.3% in referral-diagnosed cases.
In a four-month mouse experiment, adding epigallocatechin-3-gallate to urolithin A was associated with broader improvements in mitochondrial and neuronal measures.In a four-month mouse experiment, adding epigallocatechin-3-gallate to urolithin A was associated with broader improvements in mitochondrial and neuronal measures.
Across three observational cohorts totaling 2,784 people, links with lower protein levels appeared mainly among participants with memory and thinking problems.Across three observational cohorts totaling 2,784 people, links with lower protein levels appeared mainly among participants with memory and thinking problems. Average ages were 68.1, 73.7 and 65.7 years across the cohorts.
An experiment using four months of 30% calorie restriction found less gut immune activation in rhesus macaques after infection and antiviral drug therapy.An experiment using four months of 30% calorie restriction found less gut immune activation in rhesus macaques after infection and antiviral drug therapy.
After clinical screening, an imaging model reduced false alarms by 43.0% while retaining 97.3% of correctly flagged future diabetes cases.After clinical screening, an imaging model reduced false alarms by 43.0% while retaining 97.3% of correctly flagged future diabetes cases. Among 46,129 UK Biobank participants without diabetes at scanning, a retrospective cohort…
Experiments in engineered worms found that nano-polystyrene and perfluorononanoic acid together, rather than either alone, accelerated protein clumping and paralysis.Experiments in engineered worms found that nano-polystyrene and perfluorononanoic acid together, rather than either alone, accelerated protein clumping and paralysis.
