After 12 months, estimated heart age relative to actual age fell 0.73 years with semaglutide, versus no significant change after weight-loss surgery.After 12 months, estimated heart age relative to actual age fell 0.73 years with semaglutide, versus no significant change after weight-loss surgery.
Female mice with a muscle-specific gene deletion retained strength and had an 11% longer median lifespan than female controls.Female mice with a muscle-specific gene deletion retained strength and had an 11% longer median lifespan than female controls. Terf2 encodes TRF2, a protein that protects chromosome ends.
After six months of oral exposure in male mice, their first-generation offspring developed aging-like tissue changes and had shorter lifespans.After six months of oral exposure in male mice, their first-generation offspring developed aging-like tissue changes and had shorter lifespans.
An observational study of 208 Cuban adults aged 20–104 linked an immune cell marker to age, poorer physical function and cognitive decline.An observational study of 208 Cuban adults aged 20–104 linked an immune cell marker to age, poorer physical function and cognitive decline.
In a randomized trial, 600 hospitalized adults with swallowing difficulties received one of two care programs; most differences were no longer evident at six months.In a randomized trial, 600 hospitalized adults with swallowing difficulties received one of two care programs; most differences were no longer evident at six months.
Accepted, not yet published: randomized trial · 600 peopleInterventions
Who was studied600 hospitalized older adults with oropharyngeal dysphagia, six months
What changedQuality of life was better with enhanced swallowing care than with the minimal program at one month
The catchRecovery after hospitalization could explain improvements shared by both care programs
Experiments in human natural killer cells linked age-related fat buildup to altered cell mechanics and weaker killing of target cells.Experiments in human natural killer cells linked age-related fat buildup to altered cell mechanics and weaker killing of target cells. Their membranes were more fluid, and the supporting layer beneath the membrane was less stiff.
A cohort analysis of 1,895 people taking HIV-suppressing drugs linked viral reservoir measurements to biological aging scores and several diseases.A cohort analysis of 1,895 people taking HIV-suppressing drugs linked viral reservoir measurements to biological aging scores and several diseases.
Among adults with normal standard-range hearing, average very high-frequency thresholds ranged from −12.5 to 97.5 decibels of hearing level.Among adults with normal standard-range hearing, average very high-frequency thresholds ranged from −12.5 to 97.5 decibels of hearing level.
In the 12-week trial, estimated differences in score trends versus controls were 0.39 for thinking and minus 1.28 for loneliness, favoring walking.In the 12-week trial, estimated differences in score trends versus controls were 0.39 for thinking and minus 1.28 for loneliness, favoring walking.
Among 14,139 people, 44 blood proteins were linked to future stroke risk, with 26 associations replicated in two independent groups.Among 14,139 people, 44 blood proteins were linked to future stroke risk, with 26 associations replicated in two independent groups. Among 14,139 people without a previous stroke, researchers combined results from two cohort…
Over 36 months, 46.1% of older hospital patients in the lowest phase-angle group died, compared with 25.1% in the highest group.Over 36 months, 46.1% of older hospital patients in the lowest phase-angle group died, compared with 25.1% in the highest group. The 538 hospitalized older adults in this prospective multicenter study averaged 81.2 years of age…
A laboratory experiment used sperm collected from male fish at three ages to assess reproduction, finding no trade-off between early reproductive success and lifespan.A laboratory experiment used sperm collected from male fish at three ages to assess reproduction, finding no trade-off between early reproductive success and lifespan.
Later cancer-promoting mutations were linked to growth advantages up to 100-fold larger than those of early mutations in blood cell families.Later cancer-promoting mutations were linked to growth advantages up to 100-fold larger than those of early mutations in blood cell families.
At 26 weeks, lean mass fell 6.6% with semaglutide plus placebo; adding 200 mg trevogrumab reduced that decline by 3.1 percentage points.At 26 weeks, lean mass fell 6.6% with semaglutide plus placebo; adding 200 mg trevogrumab reduced that decline by 3.1 percentage points. Adults aged 18–80 with obesity joined a two-part, phase 2, double-blind, placebo-controlled…
Some immune cells in the small intestine showed metabolic changes with aging, while those in the colon were relatively resistant to fat buildup.Some immune cells in the small intestine showed metabolic changes with aging, while those in the colon were relatively resistant to fat buildup. These cells help regulate the gut’s nerve and muscle function.
Higher versus lower brain scan scores were linked to lower mortality in 34,268 UK Biobank participants (hazard ratio 0.85, a relative measure of risk).Higher versus lower brain scan scores were linked to lower mortality in 34,268 UK Biobank participants (hazard ratio 0.85, a relative measure of risk). The sample included 18,213 women and 16,055 men.
Relative risks with sustained increases versus persistently lower activity were 0.776 in the US, 0.764 in Europe and 0.725 in South Korea; below 1 means lower risk.Relative risks with sustained increases versus persistently lower activity were 0.776 in the US, 0.764 in Europe and 0.725 in South Korea; below 1 means lower risk.
For weight-lowering interventions, median lifespan gains over controls rose from 6.2% in the lightest quarter of males to 20.2% in the heaviest.For weight-lowering interventions, median lifespan gains over controls rose from 6.2% in the lightest quarter of males to 20.2% in the heaviest.
Who was studied33,780 mice allowed to eat freely, against male mice in lightest weight quartile
What changedWith weight-lowering interventions, male mice's median lifespan gains over controls rose from 6.2% in the lightest quarter to 20.2% in the heaviest
The catchPoor control health could inflate apparent lifespan benefits in heavier mice
At day 90, a lung gas-transfer measure rose by a median 1.36 mL/min/mmHg with fisetin versus 0.13 with placebo.At day 90, a lung gas-transfer measure rose by a median 1.36 mL/min/mmHg with fisetin versus 0.13 with placebo. Ten adults with common variable immunodeficiency, an immune disorder, and granulomatous-lymphocytic interstitial lung…
Five weeks after receiving T cells from young or old donors, older mice had stiffer arteries regardless of the cells’ age.Five weeks after receiving T cells from young or old donors, older mice had stiffer arteries regardless of the cells’ age. Young and old mice genetically lacking T and B cells, two types of immune cell, received T cells from young…
Age estimates differed from actual ages by an average of 3.76 years in internal testing and 4.82–5.15 years in external testing.Age estimates differed from actual ages by an average of 3.76 years in internal testing and 4.82–5.15 years in external testing. Brain MRI scans from 4,346 adults with normal thinking and memory were used to develop an…
In cell-culture experiments, SenLect labeled senescent cells and enriched them by selectively eliminating neighboring cells that were still dividing.In cell-culture experiments, SenLect labeled senescent cells and enriched them by selectively eliminating neighboring cells that were still dividing. Senescence is a state in which cells stop dividing.
Nonfatal heart attacks and strokes plus cardiovascular deaths totaled 683 with oral semaglutide versus 791 with placebo over a median 49.5 months.Nonfatal heart attacks and strokes plus cardiovascular deaths totaled 683 with oral semaglutide versus 791 with placebo over a median 49.5 months.
The adjusted odds ratio for major amputation with versus without blood-flow procedures was 0.30 with low frailty and 1.05 with high frailty.The adjusted odds ratio for major amputation with versus without blood-flow procedures was 0.30 with low frailty and 1.05 with high frailty.
Who was studied2,588,159 weighted admissions for diabetic foot ulcers, during hospitalization
What changedAmputation odds with versus without revascularization were lower at low frailty (OR 0.30), but not clearly different at highest frailty (1.05)
The catchIschemic severity and procedural suitability affect treatment selection but were inadequately captured
Walking speed was 0.14 meters per second higher than with home exercise alone after 12 weeks in a randomized trial.Walking speed was 0.14 meters per second higher than with home exercise alone after 12 weeks in a randomized trial. In Guangzhou, China, 51 adults aged 60 or older living at home with at least one chronic disease completed a…
A three-stage comparison found molecular signs of altered fat handling, while a five-week feeding experiment supported the hypothesis that dietary spermidine may counter…A three-stage comparison found molecular signs of altered fat handling, while a five-week feeding experiment supported the hypothesis that dietary spermidine may counter these aging-related changes.
Australians of European ancestry in the score’s top 10% had 10.04 times the odds of glaucoma compared with the remaining participants.Australians of European ancestry in the score’s top 10% had 10.04 times the odds of glaucoma compared with the remaining participants. More than 6 million people from multiple ancestry groups contributed genetic data to a genetic…
Experiments in a rat model supported the bone-regenerating potential of a scaffold that generates electrical stimulation when activated by ultrasound.Experiments in a rat model supported the bone-regenerating potential of a scaffold that generates electrical stimulation when activated by ultrasound.
Sodium-glucose cotransporter 2 inhibitors were linked to lower relative death rates versus nonuse, with hazard ratios of 0.56 at one year and 0.62 at five years.Sodium-glucose cotransporter 2 inhibitors were linked to lower relative death rates versus nonuse, with hazard ratios of 0.56 at one year and 0.62 at five years.
Short-term injections were associated with sustained hearing preservation in C57BL/6J mice, most clearly at mid-to-high sound frequencies.Short-term injections were associated with sustained hearing preservation in C57BL/6J mice, most clearly at mid-to-high sound frequencies. C57BL/6J mice given platelet factor 4, a protein derived from blood platelets, had delayed…
