Aged mice given an inhibitor of immune signaling starting four weeks before nerve injury showed better nerve fiber regrowth and rebuilding of insulation.Aged mice given an inhibitor of immune signaling starting four weeks before nerve injury showed better nerve fiber regrowth and rebuilding of insulation.
An observational study of 21 non-diseased human valves from people aged 6–63 mapped age-related differences among cells that help maintain valve tissue.An observational study of 21 non-diseased human valves from people aged 6–63 mapped age-related differences among cells that help maintain valve tissue.
The genetic analysis used bone-density data from 426,824 people and estimated an association size of 0.067 between higher DNA-based aging and higher estimated heel bone…The genetic analysis used bone-density data from 426,824 people and estimated an association size of 0.067 between higher DNA-based aging and higher estimated heel bone density.
Among 108 people with HIV-associated fat buildup in a randomized trial, semaglutide recipients retained weight and waist reductions at week 56 after stopping at week 32.Among 108 people with HIV-associated fat buildup in a randomized trial, semaglutide recipients retained weight and waist reductions at week 56 after stopping at week 32.
Mouse experiments found the fragment in heart muscle cells’ DNA-containing centers, near genes involved in heart structure and stress responses.Mouse experiments found the fragment in heart muscle cells’ DNA-containing centers, near genes involved in heart structure and stress responses.
After 12 months of training, 46% of participants met the study’s threshold for a high response in two to five physical outcomes.After 12 months of training, 46% of participants met the study’s threshold for a high response in two to five physical outcomes. Community-dwelling older adults (314 people, average age 74.5) were randomized to physical training…
In a randomized trial of 60 adults aged 60–75, 12 weeks of supervised resistance training improved breathing muscle strength and blood markers of inflammation.In a randomized trial of 60 adults aged 60–75, 12 weeks of supervised resistance training improved breathing muscle strength and blood markers of inflammation.
An experiment in aged mice found smaller damaged brain areas and better movement-related test results 48 hours after stroke.An experiment in aged mice found smaller damaged brain areas and better movement-related test results 48 hours after stroke. In an animal experiment in aged mice, researchers tested partial cell reprogramming, which activates…
Compared with people without diabetes, death hazard ratios were 2.00 for artery disease diagnosed at ages 35–50 and 1.30 after 50.Compared with people without diabetes, death hazard ratios were 2.00 for artery disease diagnosed at ages 35–50 and 1.30 after 50. In a retrospective cohort study, researchers examined 4,538 adults diagnosed with peripheral artery…
Relative risks of later disability were 1.68 with one vulnerability and 2.19 with both, compared with neither.Relative risks of later disability were 1.68 with one vulnerability and 2.19 with both, compared with neither. In an observational analysis of six prospective cohorts, researchers studied 257,922 adults aged 45 or older.
Castration at 240 days increased median lifespan by 32.9%, compared with increases of 19.3% at 20 days and 25.8% at 60 days.Castration at 240 days increased median lifespan by 32.9%, compared with increases of 19.3% at 20 days and 25.8% at 60 days. In an animal experiment, researchers removed the testes of male UM-HET3 mice, a stock with varied genetic…
Relative grip strength lower by one standard deviation, a statistical measure of variation, was linked to 68% higher odds of multiple heart and metabolic conditions.Relative grip strength lower by one standard deviation, a statistical measure of variation, was linked to 68% higher odds of multiple heart and metabolic conditions.
Moderate or severe frailty rose from 22.8% in 2005 to 42.1% in 2019 among adults hospitalized with heart attacks in England and Wales.Moderate or severe frailty rose from 22.8% in 2005 to 42.1% in 2019 among adults hospitalized with heart attacks in England and Wales. Researchers assessed frailty, reduced resilience to illness and other stresses, at admission…
A randomized crossover trial analyzed 48 people with stable coronary artery disease and blood cell groups sharing genetic changes; colchicine altered inflammatory protein…A randomized crossover trial analyzed 48 people with stable coronary artery disease and blood cell groups sharing genetic changes; colchicine altered inflammatory protein networks.
Higher counts of past infection diagnoses were linked to larger estimated age gaps in 12 of 18 organs among 42,395 UK Biobank participants.Higher counts of past infection diagnoses were linked to larger estimated age gaps in 12 of 18 organs among 42,395 UK Biobank participants.
Animal experiments found that raising levels of the protein MAPK15 worsened heart muscle cell senescence and promoted atrial fibrillation, an irregular heartbeat.Animal experiments found that raising levels of the protein MAPK15 worsened heart muscle cell senescence and promoted atrial fibrillation, an irregular heartbeat.
In both groups, 96% tolerated the full dose; height-adjusted kidney volume grew 10.5% a year with empagliflozin versus 5.1% with placebo.In both groups, 96% tolerated the full dose; height-adjusted kidney volume grew 10.5% a year with empagliflozin versus 5.1% with placebo. The pilot randomized trial studied 50 adults aged 18–55 with autosomal dominant polycystic…
High activity was linked to lower pneumonia and COVID-19 mortality than inactivity, with relative-hazard measures of 0.554 and 0.520, respectively, accounting for other…High activity was linked to lower pneumonia and COVID-19 mortality than inactivity, with relative-hazard measures of 0.554 and 0.520, respectively, accounting for other causes of death.
Experiments in five cell models tested leptin blockade, which reduced inflammatory responses in blood-vessel cells and some immune cells.Experiments in five cell models tested leptin blockade, which reduced inflammatory responses in blood-vessel cells and some immune cells. Researchers used five models of age-related inflammation.
Mice engineered to lack a protein developed abnormal kidney-filter deposits, but the loss did not severely impair kidney function.Mice engineered to lack a protein developed abnormal kidney-filter deposits, but the loss did not severely impair kidney function. In experiments in mice, researchers deleted the gene for R3HDML, a protein made and released by…
An observational study of 612 healthy Korean adults aged 20 to their 80s provided age- and sex-specific reference values from an electronic walkway.An observational study of 612 healthy Korean adults aged 20 to their 80s provided age- and sex-specific reference values from an electronic walkway. Researchers recruited participants across 18 age- and sex-defined groups.
Over 12 weeks, new or worsening health problems occurred in 50.8% of women taking elinzanetant and 43.2% taking placebo.Over 12 weeks, new or worsening health problems occurred in 50.8% of women taking elinzanetant and 43.2% taking placebo. An exploratory pooled analysis of four randomized, placebo-controlled trials included 1,519 postmenopausal…
Levels of 50 muscle proteins and 17 ovarian proteins correlated with their levels in blood plasma in an observational study of adults aged 20–87.Levels of 50 muscle proteins and 17 ovarian proteins correlated with their levels in blood plasma in an observational study of adults aged 20–87.
Mouse experiments found that suppressing senescence in tissue surrounding developing teeth delayed eruption, supporting its role in normal development.Mouse experiments found that suppressing senescence in tissue surrounding developing teeth delayed eruption, supporting its role in normal development.
In a six-month randomized study, 100 people with chronic heart failure received hospital-started, supervised home exercise or standard care.In a six-month randomized study, 100 people with chronic heart failure received hospital-started, supervised home exercise or standard care. Training began during hospitalization and continued at home under supervision.
Lean status was linked to higher mortality in the first decade (hazard ratio, a relative risk measure, 1.68), but not clearly afterward.Lean status was linked to higher mortality in the first decade (hazard ratio, a relative risk measure, 1.68), but not clearly afterward. Researchers conducted an observational study of 3,568 participants with metabolic…
Estimated incidence rose from 556.87 per 100,000 in 1990 to 1,088.96 in 2023 among adults aged 60 and older.Estimated incidence rose from 556.87 per 100,000 in 1990 to 1,088.96 in 2023 among adults aged 60 and older. The estimated incidence rate rose by 58.46% after adjusting for differences in age distribution.
Complications occurred in 47.5% of the preparation group versus 45.0% receiving standard care in a randomized trial of adults undergoing colon and rectal cancer surgery.Complications occurred in 47.5% of the preparation group versus 45.0% receiving standard care in a randomized trial of adults undergoing colon and rectal cancer surgery.
Compared with no cleanings, the adjusted relative death rate at a given time was 0.32 with one yearly cleaning and 0.11 with at least two.Compared with no cleanings, the adjusted relative death rate at a given time was 0.32 with one yearly cleaning and 0.11 with at least two. The retrospective cohort study tracked 117,968 adults in Taiwan aged 18–70 who were newly…
Experiments in mouse melanoma models found that dietary restriction suppressed tumor growth through effects that depended on the immune system.Experiments in mouse melanoma models found that dietary restriction suppressed tumor growth through effects that depended on the immune system.
In normal-weight adults with type 2 diabetes, abdominal obesity was linked to higher combined death and cardiovascular risk, with a relative-risk measure of 1.13 versus…In normal-weight adults with type 2 diabetes, abdominal obesity was linked to higher combined death and cardiovascular risk, with a relative-risk measure of 1.13 versus no abdominal obesity.
Who was studied323,029 normal-weight adults with newly diagnosed type 2 diabetes, median 6.0 years
What changedCombined risk of death, heart attack, stroke, or heart failure hospitalization was higher with abdominal obesity than without (adjusted hazard ratio 1.13)
The catchPhysical activity was self-reported and could be misclassified
The age-adjusted death rate rose 2.28% annually in 2016–2024, after remaining stable through 2016, according to a national observational analysis.The age-adjusted death rate rose 2.28% annually in 2016–2024, after remaining stable through 2016, according to a national observational analysis.
In an experiment with at least 10 mice per group, ABT-263 also depleted connective-tissue and immune cells linked to scarring.In an experiment with at least 10 mice per group, ABT-263 also depleted connective-tissue and immune cells linked to scarring. C3H/HeN mice received radiation to one hind leg in an animal experiment on skin fibrosis, a buildup of…
High versus low illness burden was linked to 42% higher relative death risk in non-frail heart failure patients, versus 13% in frail patients.High versus low illness burden was linked to 42% higher relative death risk in non-frail heart failure patients, versus 13% in frail patients.
Compared with adults with more than 27 teeth, those with fewer teeth had relative risk measures ranging from 1.15 to 1.84.Compared with adults with more than 27 teeth, those with fewer teeth had relative risk measures ranging from 1.15 to 1.84. Researchers conducted a retrospective observational study of 5,893,325 adults registered in the Swedish…
An observational study of 1,204 middle-aged adults found no link between parental dementia history and faster aging on DNA-based measures or brain scans.An observational study of 1,204 middle-aged adults found no link between parental dementia history and faster aging on DNA-based measures or brain scans.
A ranked comparison of death, heart failure hospitalizations and quality of life favored liraglutide over standard care, with a win ratio of 1.36 over 30 months.A ranked comparison of death, heart failure hospitalizations and quality of life favored liraglutide over standard care, with a win ratio of 1.36 over 30 months.
By December 2021, 72% of adults with cardiovascular disease before cancer diagnosis had died, compared with 38% without it.By December 2021, 72% of adults with cardiovascular disease before cancer diagnosis had died, compared with 38% without it. Researchers conducted an observational cohort study of 344,336 adults aged 18 or older with primary…
Disease-network density, a measure of connectedness, was 0.089 in young adults, 0.153 in middle-aged adults and 0.178 in older adults.Disease-network density, a measure of connectedness, was 0.089 in young adults, 0.153 in middle-aged adults and 0.178 in older adults. Researchers analyzed 73,023 electronic health records from adults at Xiangya Hospital in…
Patients with restricted social activity had a higher relative rate of death over four years than those without restrictions, with a hazard ratio of 1.752.Patients with restricted social activity had a higher relative rate of death over four years than those without restrictions, with a hazard ratio of 1.752.
In an animal experiment, deleting an RNA-processing gene in egg cells caused complete female infertility and progressive depletion of the structures that house developing…In an animal experiment, deleting an RNA-processing gene in egg cells caused complete female infertility and progressive depletion of the structures that house developing eggs.
A four-week low-oxygen experiment in rats found changes in lung-lining cells and identified interventions that eased disease progression.A four-week low-oxygen experiment in rats found changes in lung-lining cells and identified interventions that eased disease progression. Cells lining the lungs’ air sacs developed more pronounced signs associated with senescence…
