In the follow-up analysis, each extra nighttime heatwave day was linked to 0.0147 years of greater biological age acceleration under one heatwave definition.In the follow-up analysis, each extra nighttime heatwave day was linked to 0.0147 years of greater biological age acceleration under one heatwave definition.
In laboratory experiments, reducing the protein weakened two drugs’ cell-killing effects without changing the usual signs of senescence, a state in which cells stop…In laboratory experiments, reducing the protein weakened two drugs’ cell-killing effects without changing the usual signs of senescence, a state in which cells stop dividing.
Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1.Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1. In experiments in yeast cells, the metabolic byproduct S-adenosyl-L-homocysteine (SAH) extended chronological…
Rates of patients with recorded falls were 19.3 versus 21.2 per 100 patient-years in intervention and control practices, respectively, over 12–23 months.Rates of patients with recorded falls were 19.3 versus 21.2 per 100 patient-years in intervention and control practices, respectively, over 12–23 months.
The observational cohort study assessed life expectancy at age 15 and found differing pandemic-era death patterns linked to HIV, diabetes and high blood pressure.The observational cohort study assessed life expectancy at age 15 and found differing pandemic-era death patterns linked to HIV, diabetes and high blood pressure.
A 10-year cohort study of 13,357 adults aged 50 and older in China also linked estimated cognitive reserve to slower cognitive decline.A 10-year cohort study of 13,357 adults aged 50 and older in China also linked estimated cognitive reserve to slower cognitive decline. They assessed childhood socioeconomic status through parents’ education and job complexity.
Experiments in aged animals and animals with reduced weight-bearing found that a membrane targeting inflammation and responses to mechanical forces increased outer bone…Experiments in aged animals and animals with reduced weight-bearing found that a membrane targeting inflammation and responses to mechanical forces increased outer bone thickness.
In laboratory experiments, thicker fluid temporarily restored young-like monitoring behaviour, particularly in a subgroup of aged human memory T cells.In laboratory experiments, thicker fluid temporarily restored young-like monitoring behaviour, particularly in a subgroup of aged human memory T cells.
In patients under 55, higher levels of a gene-regulating RNA were associated with death, with a reported odds ratio of 6.00.In patients under 55, higher levels of a gene-regulating RNA were associated with death, with a reported odds ratio of 6.00. In COVID-19 patients under 55, an observational analysis linked higher levels of miR-21-5p, a small RNA…
In a before-and-after study, 37 older adults trained twice weekly for 12 weeks, with gains in physical performance and force from individual muscle fibres.In a before-and-after study, 37 older adults trained twice weekly for 12 weeks, with gains in physical performance and force from individual muscle fibres.
A computational analysis of 57 placental mammal species found that an apparent link between predicted protein stability and lifespan disappeared when researchers changed…A computational analysis of 57 placental mammal species found that an apparent link between predicted protein stability and lifespan disappeared when researchers changed the structural template.
Frailty was linked to higher risk of 458 of 536 chronic diseases in participants followed for a median of 13.8 years.Frailty was linked to higher risk of 458 of 536 chronic diseases in participants followed for a median of 13.8 years. Researchers followed 466,864 UK Biobank participants in a prospective observational cohort study.
The statistical estimate of the difference in decline in planning and task-management skills was minus 0.07 for variant carriers versus noncarriers.The statistical estimate of the difference in decline in planning and task-management skills was minus 0.07 for variant carriers versus noncarriers.
In laboratory experiments, depleting the protein triggered premature senescence, a state in which cells stop dividing, in human umbilical vein cells.In laboratory experiments, depleting the protein triggered premature senescence, a state in which cells stop dividing, in human umbilical vein cells. MTR4, a protein that unwinds RNA, declined in senescent cells.
A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomised trial.A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomised trial. A randomised crossover trial tested dapagliflozin in 32 people with heart failure with preserved…
Adults with persistently low airflow and low, declining grip strength had 3.49 times the odds of death compared with those with very high readings.Adults with persistently low airflow and low, declining grip strength had 3.49 times the odds of death compared with those with very high readings.
Staining brain samples from mole rats of different ages revealed pigment accumulation beginning after two years of age.Staining brain samples from mole rats of different ages revealed pigment accumulation beginning after two years of age. This animal study asked whether long-lived rodents accumulate the pigment, which remains undetectable in mouse…
Among participants aged 45 or older in China, the highest frailty-score quarter had 17.0 times the odds of pain at multiple sites versus the lowest quarter.Among participants aged 45 or older in China, the highest frailty-score quarter had 17.0 times the odds of pain at multiple sites versus the lowest quarter.
Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.
In a 28-day randomised trial of 61 older men, extra protein or leucine added no measurable benefit overall during alternate-day fasting.In a 28-day randomised trial of 61 older men, extra protein or leucine added no measurable benefit overall during alternate-day fasting. Their body mass index, a measure of weight relative to height, was at least 23.
A standard-deviation score increase was linked to coronary disease hazard ratios (relative event rates) of 0.74 in mutation carriers versus 0.68 in noncarriers.A standard-deviation score increase was linked to coronary disease hazard ratios (relative event rates) of 0.74 in mutation carriers versus 0.68 in noncarriers.
Experiments in mice suggested that an enzyme released by nerve cells helps compensate for age-related brain changes and preserve memory.Experiments in mice suggested that an enzyme released by nerve cells helps compensate for age-related brain changes and preserve memory. The gene for this enzyme became more active during aging in dentate granule cells, a type of…
Cell experiments implicated tiny particles released by these platelets and an RNA molecule they carried in this premature non-dividing state.Cell experiments implicated tiny particles released by these platelets and an RNA molecule they carried in this premature non-dividing state.
The paper describes a research network’s map of mutations acquired during life, providing a reference for testing their roles in aging and disease.The paper describes a research network’s map of mutations acquired during life, providing a reference for testing their roles in aging and disease. Human cells each carry a genome shaped by mutations acquired over a lifetime.
An experiment comparing mice modelling the nerve disease with mice across the lifespan mapped shared and distinct patterns of gene activity in muscle.An experiment comparing mice modelling the nerve disease with mice across the lifespan mapped shared and distinct patterns of gene activity in muscle.
For timed eating, the 12-week liver fat change was 0.4 percentage points lower than with usual care; the range of likely values included no difference.For timed eating, the 12-week liver fat change was 0.4 percentage points lower than with usual care; the range of likely values included no difference.
Laboratory tests and experiments in living organisms used an enzyme-activated probe to image senescent cells and eliminate senescent tumour cells with light-generated…Laboratory tests and experiments in living organisms used an enzyme-activated probe to image senescent cells and eliminate senescent tumour cells with light-generated heat.
In frail patients, dapagliflozin was linked to lower relative risk of death or worsening heart failure versus controls at one year (hazard ratio 0.53).In frail patients, dapagliflozin was linked to lower relative risk of death or worsening heart failure versus controls at one year (hazard ratio 0.53).
In tests using four retinal image datasets, the model achieved 94.7% accuracy and outperformed models built for individual tasks.In tests using four retinal image datasets, the model achieved 94.7% accuracy and outperformed models built for individual tasks. Researchers tested a computer model on retinal fundus images, photographs of the back of the eye…
Across Philadelphia census tracts, median changes from 2017–2019 to 2020–2022 were declines of 2.10 years for men and 1.37 years for women.Across Philadelphia census tracts, median changes from 2017–2019 to 2020–2022 were declines of 2.10 years for men and 1.37 years for women.
Among veterans with sleep apnoea, non-Hispanic Asian veterans had 0.30 times the odds of death of non-Hispanic White veterans, after adjustments.Among veterans with sleep apnoea, non-Hispanic Asian veterans had 0.30 times the odds of death of non-Hispanic White veterans, after adjustments.
