In an observational study of 468,801 adults, reversing physical frailty was linked to lower cardiovascular risk, partly mediated by a signature of 309 blood proteins.In an observational study of 468,801 adults, reversing physical frailty was linked to lower cardiovascular risk, partly mediated by a signature of 309 blood proteins.
Experiments in worms found that boosting production of a cold-induced molecule in muscle promoted longevity and reduced protein clumping at normal or elevated…Experiments in worms found that boosting production of a cold-induced molecule in muscle promoted longevity and reduced protein clumping at normal or elevated temperatures.
At three months, participants assigned to the program improved by 1.3 more chair stands in 30 seconds than those in the control group.At three months, participants assigned to the program improved by 1.3 more chair stands in 30 seconds than those in the control group. A cluster-randomized trial in France analyzed 376 community-dwelling adults aged 60 or older.
Trained on 93 multi-tissue datasets, the computational model made smaller age-prediction errors than comparison models, including in tests on eight datasets excluded from…Trained on 93 multi-tissue datasets, the computational model made smaller age-prediction errors than comparison models, including in tests on eight datasets excluded from training.
In a 16-week randomized trial of 53 adults, an inflammation marker fell after fasting began but did not change during eight weeks of diet alone.In a 16-week randomized trial of 53 adults, an inflammation marker fell after fasting began but did not change during eight weeks of diet alone.
Experiments in hypothalamic neurons found that reducing a key metabolic molecule shortened hair-like cell projections and reduced activity in cellular recycling…Experiments in hypothalamic neurons found that reducing a key metabolic molecule shortened hair-like cell projections and reduced activity in cellular recycling compartments.
Higher overall plant-based diet scores, compared with lower scores, were linked to lower frailty odds, with odds ratios of 0.71 to 0.80.Higher overall plant-based diet scores, compared with lower scores, were linked to lower frailty odds, with odds ratios of 0.71 to 0.80. An observational study examined diet and frailty over time in 8,628 older adults from three…
At 80 weeks, breathing disruptions fell 34.3 per hour with 9 mg retatrutide versus 9.9 with placebo in adults without type 2 diabetes.At 80 weeks, breathing disruptions fell 34.3 per hour with 9 mg retatrutide versus 9.9 with placebo in adults without type 2 diabetes. All had moderate-to-severe obstructive sleep apnea, which involves repeated pauses or…
Links at five previously identified DNA sites were confirmed in two additional Korean groups of 389 and 417 adults.Links at five previously identified DNA sites were confirmed in two additional Korean groups of 389 and 417 adults. In an observational study of 1,527 Korean adults, researchers examined links between blood fats and DNA…
Patients scored 1.17 higher than controls on a blood DNA measure of accelerated aging in an adjusted analysis of two observational cohorts.Patients scored 1.17 higher than controls on a blood DNA measure of accelerated aging in an adjusted analysis of two observational cohorts.
In an experiment with mesenchymal stem cells, an RNA-based method restored several cell functions without conversion into a more versatile stem cell type.In an experiment with mesenchymal stem cells, an RNA-based method restored several cell functions without conversion into a more versatile stem cell type.
In 208 older adults, frailty was linked to muscle and bone loss in females, while males showed lower leg strength and altered muscle protein breakdown.In 208 older adults, frailty was linked to muscle and bone loss in females, while males showed lower leg strength and altered muscle protein breakdown.
At 12 months, grip strength rose 1.45 kg with denosumab versus 0.66 kg with zoledronic acid in postmenopausal women with osteoporosis.At 12 months, grip strength rose 1.45 kg with denosumab versus 0.66 kg with zoledronic acid in postmenopausal women with osteoporosis. Researchers followed 186 postmenopausal women with osteoporosis and prescreened risk of…
Experiments in cultured cells show that cell enlargement reorganizes DNA and alters RNA splicing, while restoring a single protein variant resumes cell division.Experiments in cultured cells show that cell enlargement reorganizes DNA and alters RNA splicing, while restoring a single protein variant resumes cell division.
Experiments in human nerve-cell models found that apelin-13 restored a cellular recycling process disrupted by D-galactose, a sugar used to induce aging-like changes.Experiments in human nerve-cell models found that apelin-13 restored a cellular recycling process disrupted by D-galactose, a sugar used to induce aging-like changes.
Candidates whose frailty score improved by at least 0.4 had about 50% lower mortality than those who did not reach that improvement.Candidates whose frailty score improved by at least 0.4 had about 50% lower mortality than those who did not reach that improvement. An observational cohort study included 1,275 liver transplant candidates, whose average age was…
Analyzing 10,757 control mice across 18 years revealed unexpected year-to-year variation, altering the statistical significance of two rapamycin regimens when an outlier…Analyzing 10,757 control mice across 18 years revealed unexpected year-to-year variation, altering the statistical significance of two rapamycin regimens when an outlier cohort was excluded.
Experiments in human valve cells found that Gas6, a protein, helped release tiny packages that promoted calcium deposits in other valve cells.Experiments in human valve cells found that Gas6, a protein, helped release tiny packages that promoted calcium deposits in other valve cells.
Helper T cell responses persisted for 24 months after vaccination, with comparable responses in younger and older adults.Helper T cell responses persisted for 24 months after vaccination, with comparable responses in younger and older adults. Researchers analyzed immune responses to mRNA-1345, a vaccine against respiratory syncytial virus (RSV), in…
Estimated years lived with disability rose from 2,367.81 to 2,941.68 per 100,000 people aged 60 or older between 2000 and 2023.Estimated years lived with disability rose from 2,367.81 to 2,941.68 per 100,000 people aged 60 or older between 2000 and 2023. Researchers used observational modeling in an economic evaluation of multiple coexisting health…
An observational analysis of 71,488 European-ancestry UK Biobank participants identified 60 regions linked to liver fat, including 31 not previously reported.An observational analysis of 71,488 European-ancestry UK Biobank participants identified 60 regions linked to liver fat, including 31 not previously reported.
Genetic analyses suggested blood pressure potentially accounted for 42.9–66.7% of the association between higher protein levels and cardiovascular disease risk.Genetic analyses suggested blood pressure potentially accounted for 42.9–66.7% of the association between higher protein levels and cardiovascular disease risk.
Experiments in aged mice found that long-term reductions in brain blood flow altered the mix and gene activity of T cells, a type of immune cell.Experiments in aged mice found that long-term reductions in brain blood flow altered the mix and gene activity of T cells, a type of immune cell.
The combined genetic analysis identified 14 DNA regions, including two not detected in analyses of any individual trait.The combined genetic analysis identified 14 DNA regions, including two not detected in analyses of any individual trait. A computational analysis used summary results from human genetic studies to examine six measures related to…
In a preprint trial, delirium occurred in 21.2% of older patients given the sedative versus 45.7% given placebo within seven days of hip fracture surgery.In a preprint trial, delirium occurred in 21.2% of older patients given the sedative versus 45.7% given placebo within seven days of hip fracture surgery.
Across all six species, researchers identified four female-biased and 18 male-biased aging markers, plus three markers shared by both sexes.Across all six species, researchers identified four female-biased and 18 male-biased aging markers, plus three markers shared by both sexes.
An observational study linked 12 blood proteins to prostate cancer diagnosed more than 15 years after blood collection.An observational study linked 12 blood proteins to prostate cancer diagnosed more than 15 years after blood collection. Researchers analyzed blood samples from 982 people who later developed prostate cancer and a study subgroup of…
A randomized trial in 24 men with metabolic syndrome linked twice-weekly high-intensity functional exercise for 12 weeks to lower levels of two metabolic stress proteins.A randomized trial in 24 men with metabolic syndrome linked twice-weekly high-intensity functional exercise for 12 weeks to lower levels of two metabolic stress proteins.
For sulfate particles, the hazard ratio—a relative risk measure—was 1.056 per exposure increase spanning the middle half of levels, compared with lower exposure.For sulfate particles, the hazard ratio—a relative risk measure—was 1.056 per exposure increase spanning the middle half of levels, compared with lower exposure.
Experiments across species and tissues identified a chemical signature that could predict chronological age but was largely hidden when researchers analyzed whole…Experiments across species and tissues identified a chemical signature that could predict chronological age but was largely hidden when researchers analyzed whole tissues.
An analysis of 1 million human neutrophils, a type of white blood cell, mapped distinct groups and differences linked to health and disease.An analysis of 1 million human neutrophils, a type of white blood cell, mapped distinct groups and differences linked to health and disease.
Experiments with influenza A found higher virus levels in senescent lung cells, with a distinct antiviral response in cells from people with idiopathic pulmonary…Experiments with influenza A found higher virus levels in senescent lung cells, with a distinct antiviral response in cells from people with idiopathic pulmonary fibrosis.
In a nationwide Danish twin study, additive genetic effects accounted for 0.49 of the variance in liability to tears, while unique environmental effects accounted for…In a nationwide Danish twin study, additive genetic effects accounted for 0.49 of the variance in liability to tears, while unique environmental effects accounted for 0.51.
