The odds of persistently low successful aging were 1.97 times as high with widespread childhood adversity as with low adversity.The odds of persistently low successful aging were 1.97 times as high with widespread childhood adversity as with low adversity. A prospective cohort study used 2011–2018 data from 3,092 community-dwelling adults aged 60 or older…
In experiments in aged mice, blocking a receptor for a protein that supports nerve cells impaired cognitive improvements after young donor bone marrow transplants.In experiments in aged mice, blocking a receptor for a protein that supports nerve cells impaired cognitive improvements after young donor bone marrow transplants.
Experiments across species and tissues identified a chemical signature that could predict chronological age but was largely hidden when researchers analyzed whole…Experiments across species and tissues identified a chemical signature that could predict chronological age but was largely hidden when researchers analyzed whole tissues.
In laboratory experiments, inhibiting a protein involved in moving lactate out of cells improved the quality of aged egg cells.In laboratory experiments, inhibiting a protein involved in moving lactate out of cells improved the quality of aged egg cells. In a laboratory study of mouse and human oocytes, or egg cells, researchers measured proteins and RNA…
Among 13,331 US adults, each additional year of hearing age gap was associated with higher mortality, with an adjusted hazard ratio of 1.024.Among 13,331 US adults, each additional year of hearing age gap was associated with higher mortality, with an adjusted hazard ratio of 1.024.
Researchers tested a patch designed to release muscle-targeted packages from human umbilical cord stem cells in mice with age-related muscle loss.Researchers tested a patch designed to release muscle-targeted packages from human umbilical cord stem cells in mice with age-related muscle loss.
Adults reporting both problems had a higher rate of combined physical and psychological conditions than those reporting neither, with a hazard ratio of 2.18.Adults reporting both problems had a higher rate of combined physical and psychological conditions than those reporting neither, with a hazard ratio of 2.18.
Who was studied15,022 adults aged 45 and older, against people with neither sensory impairment
What changedCombined physical and psychological conditions developed at a higher rate with both sight and hearing impairments than neither (hazard ratio 2.18)
The catchVision and hearing impairments relied on self-reports
In the lowest kidney-function subgroup, serious medical events were reported in 56.4% receiving semaglutide versus 60.4% receiving placebo.In the lowest kidney-function subgroup, serious medical events were reported in 56.4% receiving semaglutide versus 60.4% receiving placebo.
A 10-year observational analysis of 2,397 older adults found no clear memory-decline link at high healthcare access among those with uncorrected hearing loss.A 10-year observational analysis of 2,397 older adults found no clear memory-decline link at high healthcare access among those with uncorrected hearing loss.
Genetic experiments also identified a role for the segment in heat resistance associated with the removal of worms’ reproductive cells. In C.Genetic experiments also identified a role for the segment in heat resistance associated with the removal of worms’ reproductive cells. In C.
In the meta-analysis, each 0.1-unit higher waist-to-height ratio was linked to a relative risk of 1.32 for tears in the main artery’s inner wall.In the meta-analysis, each 0.1-unit higher waist-to-height ratio was linked to a relative risk of 1.32 for tears in the main artery’s inner wall.
Chronic kidney disease was linked to thinning across 87.7% of the left kidney’s inner region and 72.8% of the right.Chronic kidney disease was linked to thinning across 87.7% of the left kidney’s inner region and 72.8% of the right. In an observational study of 70,270 UK Biobank participants, researchers used magnetic resonance imaging to map…
An animal study of the mouse hippocampus found cell-specific changes in DNA marks while the basic patterns of gene regulation remained intact.An animal study of the mouse hippocampus found cell-specific changes in DNA marks while the basic patterns of gene regulation remained intact.
Links at five previously identified DNA sites were confirmed in two additional Korean groups of 389 and 417 adults.Links at five previously identified DNA sites were confirmed in two additional Korean groups of 389 and 417 adults. In an observational study of 1,527 Korean adults, researchers examined links between blood fats and DNA…
A randomized trial of 44 adults aged 60–69 compared eight weeks of exercise and found greater gains in balance and walking speed with aerobic training.A randomized trial of 44 adults aged 60–69 compared eight weeks of exercise and found greater gains in balance and walking speed with aerobic training. Aerobic training involved three 30-minute sessions weekly.
Patients reached the healthy comparison group’s median level on a blood-based measure of thymus output about six years earlier.Patients reached the healthy comparison group’s median level on a blood-based measure of thymus output about six years earlier. An observational study in China compared 562 people with familial hypercholesterolemia, an inherited…
An experiment found greater exclusion of cells that can develop into nerve-insulating cells from areas where scar-forming cells accumulated in older mice.An experiment found greater exclusion of cells that can develop into nerve-insulating cells from areas where scar-forming cells accumulated in older mice.
Each standard-deviation increase in the index was linked to a transition-rate ratio of 1.215 for developing a first condition—diabetes, heart disease or stroke.Each standard-deviation increase in the index was linked to a transition-rate ratio of 1.215 for developing a first condition—diabetes, heart disease or stroke.
Comparing extreme heat with less-hot days, the first-week relative risk of death was 1.119 below 65 and 1.329 at 85 or older.Comparing extreme heat with less-hot days, the first-week relative risk of death was 1.119 below 65 and 1.329 at 85 or older. In an observational study, researchers analyzed daily records of 11,038,656 deaths from natural causes…
A material injected into the scrotum stuck to tissue around the testes, sustaining local hydrogen delivery and promoting sperm production in aged mice.A material injected into the scrotum stuck to tissue around the testes, sustaining local hydrogen delivery and promoting sperm production in aged mice. The formulation combined tiny silicon sheets with an adhesive polymer.
Over 13 years, 54.4% of participants without teeth or dentures died, compared with 24.3% of those who retained teeth.Over 13 years, 54.4% of participants without teeth or dentures died, compared with 24.3% of those who retained teeth. The observational cohort study followed 752 adults with intellectual disabilities aged 40 or older in the…
Pretrained on 74,425 brain MRI scans, Brain2Vec predicted brain age more accurately and learned faster than a model starting from random settings.Pretrained on 74,425 brain MRI scans, Brain2Vec predicted brain age more accurately and learned faster than a model starting from random settings.
High alcohol intake was linked to higher death rates than never or occasional drinking (hazard ratio 1.24, comparing death rates over time).High alcohol intake was linked to higher death rates than never or occasional drinking (hazard ratio 1.24, comparing death rates over time).
A randomized trial sub-study in 15 older adults with macular degeneration found no significant differences in individual genes, but tentative inflammation-related…A randomized trial sub-study in 15 older adults with macular degeneration found no significant differences in individual genes, but tentative inflammation-related signals.
The observational dataset includes more than 6,000 scans from 1,645 adults aged 42–97, spanning healthy aging to Alzheimer disease with symptoms.The observational dataset includes more than 6,000 scans from 1,645 adults aged 42–97, spanning healthy aging to Alzheimer disease with symptoms.
In human skin cell experiments, melatonin reduced the share of cells testing positive for a senescence marker by 38.5%–41.6%.In human skin cell experiments, melatonin reduced the share of cells testing positive for a senescence marker by 38.5%–41.6%. They studied senescence caused by repeated cell division, irradiation or exposure to the drug…
One genetic analysis linked a one-standard-deviation increase in eosinophils, a white blood cell type, to 1.07 times the odds of macular degeneration.One genetic analysis linked a one-standard-deviation increase in eosinophils, a white blood cell type, to 1.07 times the odds of macular degeneration.
