In the follow-up analysis, each extra nighttime heatwave day was linked to 0.0147 years of greater biological age acceleration under one heatwave definition.In the follow-up analysis, each extra nighttime heatwave day was linked to 0.0147 years of greater biological age acceleration under one heatwave definition.
Rates of patients with recorded falls were 19.3 versus 21.2 per 100 patient-years in intervention and control practices, respectively, over 12–23 months.Rates of patients with recorded falls were 19.3 versus 21.2 per 100 patient-years in intervention and control practices, respectively, over 12–23 months.
Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1.Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1. In experiments in yeast cells, the metabolic byproduct S-adenosyl-L-homocysteine (SAH) extended chronological…
In laboratory experiments, reducing the protein weakened two drugs’ cell-killing effects without changing the usual signs of senescence, a state in which cells stop…In laboratory experiments, reducing the protein weakened two drugs’ cell-killing effects without changing the usual signs of senescence, a state in which cells stop dividing.
The statistical estimate of the difference in decline in planning and task-management skills was minus 0.07 for variant carriers versus noncarriers.The statistical estimate of the difference in decline in planning and task-management skills was minus 0.07 for variant carriers versus noncarriers.
Experiments in aged animals and animals with reduced weight-bearing found that a membrane targeting inflammation and responses to mechanical forces increased outer bone…Experiments in aged animals and animals with reduced weight-bearing found that a membrane targeting inflammation and responses to mechanical forces increased outer bone thickness.
In a before-and-after study, 37 older adults trained twice weekly for 12 weeks, with gains in physical performance and force from individual muscle fibres.In a before-and-after study, 37 older adults trained twice weekly for 12 weeks, with gains in physical performance and force from individual muscle fibres.
In laboratory experiments, thicker fluid temporarily restored young-like monitoring behaviour, particularly in a subgroup of aged human memory T cells.In laboratory experiments, thicker fluid temporarily restored young-like monitoring behaviour, particularly in a subgroup of aged human memory T cells.
In patients under 55, higher levels of a gene-regulating RNA were associated with death, with a reported odds ratio of 6.00.In patients under 55, higher levels of a gene-regulating RNA were associated with death, with a reported odds ratio of 6.00. In COVID-19 patients under 55, an observational analysis linked higher levels of miR-21-5p, a small RNA…
A computational analysis of 57 placental mammal species found that an apparent link between predicted protein stability and lifespan disappeared when researchers changed…A computational analysis of 57 placental mammal species found that an apparent link between predicted protein stability and lifespan disappeared when researchers changed the structural template.
The observational cohort study assessed life expectancy at age 15 and found differing pandemic-era death patterns linked to HIV, diabetes and high blood pressure.The observational cohort study assessed life expectancy at age 15 and found differing pandemic-era death patterns linked to HIV, diabetes and high blood pressure.
A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomised trial.A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomised trial. A randomised crossover trial tested dapagliflozin in 32 people with heart failure with preserved…
A 10-year cohort study of 13,357 adults aged 50 and older in China also linked estimated cognitive reserve to slower cognitive decline.A 10-year cohort study of 13,357 adults aged 50 and older in China also linked estimated cognitive reserve to slower cognitive decline. They assessed childhood socioeconomic status through parents’ education and job complexity.
Frailty was linked to higher risk of 458 of 536 chronic diseases in participants followed for a median of 13.8 years.Frailty was linked to higher risk of 458 of 536 chronic diseases in participants followed for a median of 13.8 years. Researchers followed 466,864 UK Biobank participants in a prospective observational cohort study.
Laboratory tests and experiments in living organisms used an enzyme-activated probe to image senescent cells and eliminate senescent tumour cells with light-generated…Laboratory tests and experiments in living organisms used an enzyme-activated probe to image senescent cells and eliminate senescent tumour cells with light-generated heat.
Among participants aged 45 or older in China, the highest frailty-score quarter had 17.0 times the odds of pain at multiple sites versus the lowest quarter.Among participants aged 45 or older in China, the highest frailty-score quarter had 17.0 times the odds of pain at multiple sites versus the lowest quarter.
In frail patients, dapagliflozin was linked to lower relative risk of death or worsening heart failure versus controls at one year (hazard ratio 0.53).In frail patients, dapagliflozin was linked to lower relative risk of death or worsening heart failure versus controls at one year (hazard ratio 0.53).
Staining brain samples from mole rats of different ages revealed pigment accumulation beginning after two years of age.Staining brain samples from mole rats of different ages revealed pigment accumulation beginning after two years of age. This animal study asked whether long-lived rodents accumulate the pigment, which remains undetectable in mouse…
Cell experiments implicated tiny particles released by these platelets and an RNA molecule they carried in this premature non-dividing state.Cell experiments implicated tiny particles released by these platelets and an RNA molecule they carried in this premature non-dividing state.
A standard-deviation score increase was linked to coronary disease hazard ratios (relative event rates) of 0.74 in mutation carriers versus 0.68 in noncarriers.A standard-deviation score increase was linked to coronary disease hazard ratios (relative event rates) of 0.74 in mutation carriers versus 0.68 in noncarriers.
In a 28-day randomised trial of 61 older men, extra protein or leucine added no measurable benefit overall during alternate-day fasting.In a 28-day randomised trial of 61 older men, extra protein or leucine added no measurable benefit overall during alternate-day fasting. Their body mass index, a measure of weight relative to height, was at least 23.
Moderate and severe frailty were linked to 66% and 141% higher odds of developing hearing loss, respectively, compared with the study’s reference group.Moderate and severe frailty were linked to 66% and 141% higher odds of developing hearing loss, respectively, compared with the study’s reference group.
The paper describes a research network’s map of mutations acquired during life, providing a reference for testing their roles in aging and disease.The paper describes a research network’s map of mutations acquired during life, providing a reference for testing their roles in aging and disease. Human cells each carry a genome shaped by mutations acquired over a lifetime.
In laboratory experiments, depleting the protein triggered premature senescence, a state in which cells stop dividing, in human umbilical vein cells.In laboratory experiments, depleting the protein triggered premature senescence, a state in which cells stop dividing, in human umbilical vein cells. MTR4, a protein that unwinds RNA, declined in senescent cells.
Among veterans with sleep apnoea, non-Hispanic Asian veterans had 0.30 times the odds of death of non-Hispanic White veterans, after adjustments.Among veterans with sleep apnoea, non-Hispanic Asian veterans had 0.30 times the odds of death of non-Hispanic White veterans, after adjustments.
In tests using four retinal image datasets, the model achieved 94.7% accuracy and outperformed models built for individual tasks.In tests using four retinal image datasets, the model achieved 94.7% accuracy and outperformed models built for individual tasks. Researchers tested a computer model on retinal fundus images, photographs of the back of the eye…
Experiments in mice suggested that an enzyme released by nerve cells helps compensate for age-related brain changes and preserve memory.Experiments in mice suggested that an enzyme released by nerve cells helps compensate for age-related brain changes and preserve memory. The gene for this enzyme became more active during aging in dentate granule cells, a type of…
Testosterone’s estimated effect on exercise capacity was minus 0.05 versus placebo, with the range of likely values including no difference.Testosterone’s estimated effect on exercise capacity was minus 0.05 versus placebo, with the range of likely values including no difference.
An observational study compared 15 measures in 4,258,033 Chinese adults, finding better prediction of cardiovascular and diabetes outcomes with combined measures.An observational study compared 15 measures in 4,258,033 Chinese adults, finding better prediction of cardiovascular and diabetes outcomes with combined measures.
Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.
An analysis of immune receptor data across cohorts found shared patterns that supported a healthy reference for comparisons between people.An analysis of immune receptor data across cohorts found shared patterns that supported a healthy reference for comparisons between people.
Who was studiedPeople contributing T cell receptor data
What changedTCRmeta enabled immune receptor comparisons across people that resisted technical variation while remaining sensitive to biological differences
The catchThe abstract omitted cohort sizes and participants’ ages
An observational analysis of 67,374 adults aged 50 or older across five cohorts linked developing or recovering from pain to later osteoarthritis risk.An observational analysis of 67,374 adults aged 50 or older across five cohorts linked developing or recovering from pain to later osteoarthritis risk. These patterns held across pain severity levels.
