Every aging paper worth knowing about, the day it appears.
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.
From: Age Acceleration and Mortality Risk Constitute Distinct Dimensions of Organ Aging
Research Square · 30 Sept · Na R, Shi C, Ruan X et al.
The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.
Nature metabolism · 1 Oct · Koning M, Kovynev A, Fondevila MF et al.
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.
bioRxiv · 30 Sept · Grafton F, Rohani N, Lim WF et al.
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.
medRxiv · 1 Oct · Zhao K, Quin C, Pershad Y et al.
A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.
bioRxiv · 30 Sept · Lu YRR, Shen H, Kajderowicz K et al.
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
bioRxiv · 1 Oct · Alsolami S, Wang M, Sarraf Sabedot T et al.
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
medRxiv · 1 Oct · Simpson DJ, Crofts SJ, Mavrommatis C et al.
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.
Nature communications · 31 Aug · Kim DW, Kwon EJ, Jeon BJ et al.
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
Genome medicine · 2 Oct · Jonkman TH, Richmond A, BIOS Consortium et al.
Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.
Nature immunology · 30 Sept · Aguilar-Navarro AG, Edun G, Gower M et al.
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · 1 Oct · Chen G, Shangguan Z, Gong J et al.
A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.
bioRxiv · 30 Sept · Judson KL, Danielson KJ, Tang S et al.
Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.
bioRxiv · 30 Sept · Tan X, Simon M, Rosebrock D et al.
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Aging cell · 1 Oct · Pyrgioti M, Eguiagaray IM, Redmond P et al.
The Journal of pharmacy and pharmacology · 1 Oct · Li J, Cai M, Li H et al.
Mitochondrion · 1 Oct · Zhang X, Tao T, Liu W et al.
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
bioRxiv · 1 Oct · Yang L, Sun Z, Luo X et al.
bioRxiv · 1 Oct · Goryanin I, Goryanin I, Damms B
bioRxiv · 1 Oct · Patel MS, Frye B, Negrey JD et al.
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.
bioRxiv · 1 Oct · Mungo C, Bersaglieri C, Paganini D et al.
Aging cell · 1 Oct · Kanehisa R, Nakatani H, Takatori S et al.
Ageing research reviews · 1 Oct · Mandlik DS, Mandlik SK
Experimental gerontology · 1 Oct · Di Maria E, Gualco C, Muscolino E et al.
Best practice & research. Clinical rheumatology · 1 Oct · Brooks HW, Cusick NC, Wu S et al.
Protein & cell · 1 Oct · Zhang Q, Yu J, Zhai X et al.
Science (New York, N.Y.) · 1 Oct · Dubal DB, Ambrosio F, Stout MB et al.
The American naturalist · 5 May · Liguori A, Korm S, Profetto A et al.
JAR life · 23 Sept · Morishita S, Iida N, Sato T et al.
Preprints.org · 30 Sept · Ivchuk V
Frontiers in endocrinology · 16 Sept · Tian H, Huang L, Liu H et al.
Redox biology · 28 Sept · Zhang L, Schmidt F, Yasar F et al.
Neural regeneration research · 30 Sept · Mao W, Song W, Zhang Y et al.
American journal of physiology. Regulatory, integrative and comparative physiology · 1 Oct · Buckley DJ, Bogale K, Cuellar N et al.
PloS one · 1 Oct · Shah N
Molecular biology reports · 1 Oct · Vahidinia Z, Behdarvandy M, Azami Tameh A et al.
BioFactors (Oxford, England) · 1 Sept · Goto S, Harada M, Setoguchi S et al.
bioRxiv · 1 Oct · López-Moyado IF, Suzuki K, Hernández-Espinosa L et al.
Neoplasia (New York, N.Y.) · 1 Oct · Lin C, Guo Q, Lai S
Aging cell · 1 Oct · Kroon TM, Munitz J, Ranzenigo A et al.
microPublication biology · 15 Sept · Desnos CA, Tamez Gonzalez AA, Van Raamsdonk JM
RMD open · 1 Oct · Jiménez-Martínez M, De Jong TA, Houtman M et al.
Gene · 1 Oct · Arayesh MJ, Ataellahi F, Masoudi R
MedComm · 30 Sept · Wang W, Jiang X, Qiu R et al.
Frontiers in public health · 16 Sept · Xue X, Chen S, Cheng Y et al.
International journal of mycobacteriology · 1 Jul · Fachrucha F, Andarini S, Burhan E et al.
Nutrition and cancer · 1 Oct · Ye Q, Jiang S, Chen J et al.
Molecular therapy. Nucleic acids · 3 Sept · Choi S, Sung MJ, An HJ et al.
Stem cells international · 30 Sept · Iyer VC, Lerman LO, Eirin A
Molecular biology reports · 1 Oct · Singh S, Srivastava S, Siddiqui S et al.
Researchers built a predictive model in roundworms, validated ten life-extending compounds, and identified conserved aging modules linked to frailty in mice.
Science advances · 30 Sept · Huai W, Ng LF, Lee JH et al.
A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.
Cell reports · 30 Sept · Gordillo-García S, Fernandez-Abascal J, Hernando-Rodríguez B et al.
Qeios · 30 Sept · Xiong J
The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.
bioRxiv · 30 Sept · Goryanin I, Damms B, Goryanin I