Brain agingReview28 Sep 2026

Traditional Chinese medicine for Alzheimer's disease: pathological mechanisms and multi-target interventions

3 Biotech

The paper

Zhang Y, Song R, Wang J et al.

3 Biotech · 27 Sep 2026

doi.org/10.1007/s13205-026-05078-2 PubMed

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Human neurons accumulate far more mutations over lifespan than shorter-lived mammals

Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.

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CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice

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Auditory nerve myelin degeneration defines a subtype of age-related hearing loss

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medRxiv · Harris KC et al.

Traditional Chinese medicine for Alzheimer's disease: pathological mechanisms and multi-target interventions

The paper

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Human neurons accumulate far more mutations over lifespan than shorter-lived mammals

CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice

Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice

Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease

Auditory nerve myelin degeneration defines a subtype of age-related hearing loss