Baicalein

1. Baicalein decreases dysbiosis in rats.

   “baicalein ameliorated the unloading-induced gut microbiota disorder through the diminished abundance of Proteobacteria and elevated abundance of Actinobacteria and Firmicutes”

   Animalsunloading-induced30 mg·kg -1 ·day -14 weeks

   Baicalein reduces disuse-driven skeletal senescence and alters gut microbes in rats · Molecules (Basel, Switzerland) · 20 Sep 2026

Dysbiosis →

1. Baicalein decreases chronic inflammation in rats.

   “baicalein suppressed the inflammatory response caused by mechanical unloading”

   Animalsmechanical unloading30 mg·kg -1 ·day -14 weeks

   Baicalein reduces disuse-driven skeletal senescence and alters gut microbes in rats · Molecules (Basel, Switzerland) · 20 Sep 2026

Chronic inflammation →

1. Baicalein decreases cellular senescence in rats.

   “downregulating senescence-associated markers p16, p21, p53 in tibial tissue.”

   Animalshind limb unloadingtibia30 mg·kg -1 ·day -14 weeks

   Baicalein reduces disuse-driven skeletal senescence and alters gut microbes in rats · Molecules (Basel, Switzerland) · 20 Sep 2026

Cellular senescence →

1. Baicalein improves biomechanical strength in rats (+31.64%).

   “improving biomechanical strength (ultimate load +31.64%)”

   Animalshind limb unloading30 mg·kg -1 ·day -14 weeks

   Baicalein reduces disuse-driven skeletal senescence and alters gut microbes in rats · Molecules (Basel, Switzerland) · 20 Sep 2026

1. Baicalein increases bone mineral density in rats (1.20-fold vs. model group).

   “increasing bone mineral density (1.20-fold vs. model group)”

   Animalshind limb unloading30 mg·kg -1 ·day -14 weeks

   Baicalein reduces disuse-driven skeletal senescence and alters gut microbes in rats · Molecules (Basel, Switzerland) · 20 Sep 2026

Bone mineral density →