Clonal hematopoiesis of indeterminate potential
Disease1 paper4 findings
- Humans1
Effects
3TGF-β signalling
upin human cells1
1 study
TGF-β signalling
upin human cells1
Clonal hematopoiesis of indeterminate potential activates TGF-β signalling in human cells.
Cellsbone marrow
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment · Nature immunology · 30 Sep 2026
Collagen
upin human cells1
1 study
Collagen
upin human cells1
Clonal hematopoiesis of indeterminate potential induces collagen in human cells.
Cellsbone marrow
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment · Nature immunology · 30 Sep 2026
Fibroblast
upin human cells1
1 study
Fibroblast
upin human cells1
Clonal hematopoiesis of indeterminate potential induces fibroblast in human cells.
Cellsbone marrow
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment · Nature immunology · 30 Sep 2026
Associations
1Chronic inflammation
upin humans1
1 study
Chronic inflammation
upin humans1
Clonal hematopoiesis of indeterminate potential is associated with chronic inflammation in humans.
Review
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment · Nature immunology · 30 Sep 2026
Latest
4Somatic blood mutations associate with accelerated frailty and functional decline in humans
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.
ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment
Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.
Clonal blood mutations in ASXL1 associate with higher lung cancer risk
Researchers analyzing two large human cohorts found that ASXL1-mutant clonal hematopoiesis linked to more than triple the risk of lung cancer in smokers.