Review
The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility
Abstract · CC BY
Endocrine disorders and inherent flaws in oocyte quality are traditional causes of female infertility. Increasing research indicates that structural and biomechanical alterations in the ovarian microenvironment may significantly contribute to reproductive decline.
- Altered intercellular communication
- Chronic inflammation
- Hippo–YAP signalling
- Oxidative stress and ROS signalling
- TGF-β signalling
- Female infertility
- Polycystic ovary syndrome
- Reduced ovarian reserve
- Homo sapiens
The paper
The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility
Voros C, Chatzinikolaou F, Papadimas G et al.
Current Issues in Molecular Biology · 8 Sep 2026