Female infertility
Disease1 paper2 findings
Associations
2TGF-β signalling
upin humans1
1 study
TGF-β signalling
upin humans1
TGF-β signalling is associated with female infertility in humans.
“Fibro-inflammatory pathways, including transforming growth factor-β (TGF-β), Hippo/YAP-TAZ signaling, oxidative stress, macrophage activation, and mechanotransduction, are increasingly associated with ovarian ageing, polycystic ovary syndrome, reduced ovarian reserve”
Reviewovaryfemales
The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility · Current issues in molecular biology · 8 Sep 2026
Chronic inflammation
upin humans1
1 study
Chronic inflammation
upin humans1
Chronic inflammation is associated with female infertility in humans.
“Progressive extracellular matrix remodeling, stromal fibrosis, chronic inflammation, and heightened tissue stiffness seem to affect follicular homeostasis, granulosa-oocyte communication, and ovarian function.”
Reviewovaryfemales
The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility · Current issues in molecular biology · 8 Sep 2026