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Humans·Preprint
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.
medRxiv · 1 Oct · Zhao K, Quin C, Pershad Y et al.
Humans·Preprint
Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.
bioRxiv · 30 Sept · Tan X, Simon M, Rosebrock D et al.
Humans·Preprint
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
medRxiv · 29 Sept · Small A, Xue L, Ito S et al.
Animals·Preprint
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
bioRxiv · 1 Oct · Yang L, Sun Z, Luo X et al.
Animals·Preprint
Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.
Research Square · 30 Sept · Liu Y, Chen B, Zhang W et al.
