ReviewPeer-reviewed

Ferroptosis-Driven Inflammaging in Age-Associated Degenerative Disorders: Molecular Mechanisms and Therapeutic Potential of Natural Products

Ageing research reviews · 1 Oct · Mandlik DS, Mandlik SK

The paper

Mandlik DS, Mandlik SK

Ageing research reviews

doi.org/10.1016/j.arr.2026.103384

Our read

Relevance: Core geroscience
Newsworthiness: Routine
Evidence: Review
Status: Peer-reviewed
Topic: Inflammaging

HumansPreprint

Somatic blood mutations associate with accelerated frailty and functional decline in humans

In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.

medRxiv · 1 Oct · Zhao K, Quin C, Pershad Y et al.

Inflammaging

HumansPreprint

Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia

Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.

bioRxiv · 30 Sept · Tan X, Simon M, Rosebrock D et al.

Inflammaging

HumansPreprint

ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification

Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.

medRxiv · 29 Sept · Small A, Xue L, Ito S et al.

Inflammaging

AnimalsPreprint

Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice

A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.

bioRxiv · 1 Oct · Yang L, Sun Z, Luo X et al.

Inflammaging

AnimalsPreprint

Gut microbes from hearing loss patients trigger inner ear damage in young mice

Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.

Research Square · 30 Sept · Liu Y, Chen B, Zhang W et al.

Inflammaging