ReviewPeer-reviewed

Mitochondria and associated complexes as therapeutic targets in aging: From biomacromolecular structure-function insights to clinical translation

Mitochondrion · 1 Oct · Zhang X, Tao T, Liu W et al.

The paper

Zhang X, Tao T, Liu W et al.

Mitochondrion

doi.org/10.1016/j.mito.2026.102221

Our read

Relevance: Core geroscience
Newsworthiness: Routine
Evidence: Review
Status: Peer-reviewed
Topic: Mitochondria

AnimalsPeer-reviewed

Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice

TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.

Aging cell · 1 Oct · Chen G, Shangguan Z, Gong J et al.

Mitochondria

AnimalsPeer-reviewed

Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice

Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.

Cell reports · 30 Sept · Matsumoto S, Seo H, Taketomi Y et al.

Mitochondria

Model organismsPeer-reviewed

USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms

A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.

Cell reports · 30 Sept · Gordillo-García S, Fernandez-Abascal J, Hernando-Rodríguez B et al.

Mitochondria

ReviewPeer-reviewed

Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss

Molecular neurobiology · 30 Sept · Zhang S, Zhang Q, Sun N et al.

Mitochondria

ReviewPeer-reviewed

Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies

Frontiers in molecular neuroscience · 15 Sept · Otoda T, Nakajima H, Takayama T

Mitochondria