Sarcopenia
Disease14 papers7 findingsMeSH D055948
In a human cohort, arterial stiffness increases sarcopenia risk, mediated partly by biological age. Reviews link sarcopenia to chronic inflammation and cognitive impairment, while separate in silico analyses associate the condition with Spi1 and AP2M1 expression in muscle.
- Humans2
- Animals5
- Cells1
- In silico1
Upstream
2Klemera-Doubal biological age
mediatesin humans1
1 study
Klemera-Doubal biological age
mediatesin humans1
Klemera-Doubal biological age mediates sarcopenia in humans (18.85%).
“KDM-BAacc significantly mediated 8.66 and 18.85% of the associations with probable sarcopenia and sarcopenia, respectively.”
Humansassociation between arterial stiffness and sarcopenian = 32,451
Arterial stiffness increases sarcopenia risk partly through accelerated biological aging · Frontiers in public health · 14 Sep 2026
Klemera-Doubal biological age mediates sarcopenia in humans (8.66%).
“KDM-BAacc significantly mediated 8.66 and 18.85% of the associations with probable sarcopenia and sarcopenia, respectively.”
Humansassociation between arterial stiffness and probable sarcopenian = 32,451
Arterial stiffness increases sarcopenia risk partly through accelerated biological aging · Frontiers in public health · 14 Sep 2026
Chronic inflammation
upin humans1
1 study
Chronic inflammation
upin humans1
Chronic inflammation increases sarcopenia in humans.
Review
The Interplay of Metabolic Dysfunction, Neuroinflammation, and Mitochondrial Dysfunction in Balance Impairment: Insights from Type 2 Diabetes Mellitus and Alzheimer's Disease · Molecular neurobiology · 25 Sep 2026
Associations
4Spi1
upin silico1
1 study
Spi1
upin silico1
Spi1 is associated with sarcopenia in silico.
In silicogastrocnemius muscle
Transcription factor activity divergence across muscle atrophy conditions: A comparative analysis of spaceflight, aging, and disuse using decoupleR · PloS one · 1 Oct 2026
Cognitive impairment
upin humans1
1 study
Cognitive impairment
upin humans1
Sarcopenia is associated with cognitive impairment in humans.
Review
Muscle-brain crosstalk in sarcopenia and cognitive impairment: endocrine signaling, metabolic regulation, and exercise modulation · Frontiers in endocrinology · 16 Sep 2026
Arterial stiffness index
upin humans1HR 1.56
1 study
Arterial stiffness index
upin humans1HR 1.56
Arterial stiffness index raises the risk of sarcopenia in humans (HR 1.56, 95% CI 1.11-2.18).
“and sarcopenia (HR 1.56, 95% CI 1.11-2.18).”
Humanshighest tertile vs lowest tertilen = 32,451
Arterial stiffness increases sarcopenia risk partly through accelerated biological aging · Frontiers in public health · 14 Sep 2026
AP2M1
upin silico1
1 study
AP2M1
upin silico1
AP2M1 is associated with sarcopenia in silico.
In silicodegenerative muscle statesskeletal muscle
Extracellular vesicle microRNA promotes muscle regeneration by suppressing AP2M1 · Molecular therapy. Nucleic acids · 3 Sep 2026
Latest
17Genetically predicted TNF-beta protects against sarcopenia traits in humans
A Mendelian randomization analysis of 91 circulating inflammatory markers identified tumor necrosis factor-beta as causally linked to better muscle mass, grip strength, and walking pace.
Multi-omics analysis reveals molecular networks driving muscle decline in aging vervet monkeys
Researchers identified coordinated changes in DNA methylation, miRNAs, and gene expression distinguishing older female monkeys with slower gait from middle-aged counterparts.
Extracellular vesicle microRNA promotes muscle regeneration by suppressing AP2M1
Delivering miR-193b-3p improved muscle repair in injured mice and targeted a protein elevated in sarcopenic human tissue.
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Arterial stiffness increases sarcopenia risk partly through accelerated biological aging
A large UK Biobank study finds vascular stiffness links to muscle loss, with accelerated biological age explaining part of the risk in non-frail adults.