Brain agingReview29 Sep 2026

Neuroepigenetics of the Environmental Exposome: Molecular and Clinical Implications in Neurodegeneration

The Neurologist

The paper

Avendaño-Arango E, Salom-Palacio I, Castillo-Támara EE et al.

The Neurologist · 28 Sep 2026

doi.org/10.1097/nrl.0000000000000694 PubMed

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Human neurons accumulate far more mutations over lifespan than shorter-lived mammals

Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.

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CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice

Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.

bioRxiv · Harris AS et al.

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Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.

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Auditory nerve myelin degeneration defines a subtype of age-related hearing loss

Researchers linked poor auditory nerve synchrony and myelin degradation to amplified communication difficulties in older humans, beyond standard hearing thresholds.

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Neuroepigenetics of the Environmental Exposome: Molecular and Clinical Implications in Neurodegeneration

The paper

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Human neurons accumulate far more mutations over lifespan than shorter-lived mammals

CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice

Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice

Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease

Auditory nerve myelin degeneration defines a subtype of age-related hearing loss