CCN1

1. CCN1 inhibits mitophagy in human cells.

   Cellsdecompensated hypoxic conditionsdermal fibroblast

   CCN1 upregulation in diabetic wounds suppresses PINK1/Parkin-mediated mitophagy in dermal fibroblasts by regulating HIF-1α protein stability under decompensated hypoxic conditions · Cellular signalling · 27 Sep 2026

Mitophagy →

1. CCN1 decreases HIF1A in human cells.

   Cellshuman dermal fibroblasts

   CCN1 upregulation in diabetic wounds suppresses PINK1/Parkin-mediated mitophagy in dermal fibroblasts by regulating HIF-1α protein stability under decompensated hypoxic conditions · Cellular signalling · 27 Sep 2026

HIF1A →

1. CCN1 increases EGLN1 in human cells.

   Cellshuman dermal fibroblasts

   CCN1 upregulation in diabetic wounds suppresses PINK1/Parkin-mediated mitophagy in dermal fibroblasts by regulating HIF-1α protein stability under decompensated hypoxic conditions · Cellular signalling · 27 Sep 2026

EGLN1 →