Mitochondrial biogenesis (PGC-1α)
Pathway29 papers3 findings
- Animals11
- Cells4
Interventions
3Natural products
upin reviews1
1 study
Natural products
upin reviews1
Natural products activate mitochondrial biogenesis (PGC-1α).
Reviewvia AMPK/SIRT1/PGC-1alpha pathwaykidney
The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms · Mini reviews in medicinal chemistry · 30 Sep 2026
4-octyl itaconate
upin mice1
1 study
4-octyl itaconate
upin mice1
4-octyl itaconate increases mitochondrial biogenesis (PGC-1α) in mice.
Animalsparotid gland25 mg/kg4 weeksmales
4-Octyl itaconate restores parotid gland function in aging mice · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 30 Sep 2026
Semaglutide
upin human cells1
1 study
Semaglutide
upin human cells1
Semaglutide activates mitochondrial biogenesis (PGC-1α) in human cells.
“suggesting activation of processes associated with mitochondrial biogenesis.”
Cellsmacrophage100 nM
Semaglutide Attenuates Inflammatory Macrophage Polarization and Promotes Changes Associated with Mitochondrial Biogenesis Through cAMP-Dependent Signaling · Biomedicines · 3 Sep 2026
Latest
29Inhibiting miR-128-3p restores muscle mass and function in aged mice
The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.
4-Octyl itaconate restores parotid gland function in aging mice
The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.
Parthenolide reduces senescence and skin fibrosis in scleroderma models
The compound targets Ero1L to stabilize contacts between mitochondria and the endoplasmic reticulum, mitigating tissue damage in cells and mice.