PINK1

GeneHomo sapiens6 papersHGNC 14581NCBI Gene 65018Taxon 9606

Humans1
Cells2

Latest

9

The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms

ReviewMini Reviews in Medicinal Chemistry

1 Oct

Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss

ReviewMolecular Neurobiology

1 Oct

HumansPreprintBrain aging29 Sep

Disrupted sphingolipid metabolism drives lysosomal and mitochondrial failure in Parkinson's disease

A preprint shows SMPD1 upregulation collapses a sphingolipid salvage pathway, causing mitophagy defects and marking aggressive motor phenotypes.

bioRxiv · Rai S et al.

Genetic architecture and molecular pathogenesis of Parkinson's disease: emerging mechanisms and therapeutic targets

ReviewMetabolic Brain Disease

29 Sep

Traditional Chinese medicine for Alzheimer's disease: pathological mechanisms and multi-target interventions

Review3 Biotech

28 Sep

CCN1 upregulation in diabetic wounds suppresses PINK1/Parkin-mediated mitophagy in dermal fibroblasts by regulating HIF-1α protein stability under decompensated hypoxic conditions

CellsCellular Signalling

28 Sep

Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential

ReviewReproductive Medicine and Biology

28 Sep

Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease: From Molecular Mechanisms to Biomarkers and Targeted Therapies

ReviewAntioxidants

26 Sep

CellsMitochondria26 Sep

Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models

The compound directly binds Prohibitin-2 to activate PINK1-PRKN-dependent clearance of damaged mitochondria, easing motor deficits in transgenic mice.

Biochemical Pharmacology · Ding XS et al.