AMPK signalling

Pathway23 papers5 findings

Studies in mice and Dictyostelium discoideum show that pharmacological agents activate AMPK signalling. Reviews also link berberine and intermittent fasting to activation of this pathway.

Animals5
Model organisms1
Cells4
In silico1

Interventions

MK-8722

upin mice1

1 study

MK-8722 activates AMPK signalling in mice.
Animalsin APP/PS1 miceliver
Pan-AMPK activator MK-8722 improves spatial memory in Alzheimer's model mice · Journal of neurochemistry · 1 Oct 2026

MK-8722 →

4-octyl itaconate

upin mice1

1 study

4-octyl itaconate activates AMPK signalling in mice.
Animalsparotid gland25 mg/kg4 weeksmales
4-Octyl itaconate restores parotid gland function in aging mice · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 30 Sep 2026

4-octyl itaconate →

Berberine

upin reviews1

1 study

Berberine activates AMPK signalling.
Review
Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP · Fitoterapia · 28 Sep 2026

Berberine →

Intermittent fasting

upin reviews1

1 study

Intermittent fasting activates AMPK signalling.
Review
Intermittent and periodic fasting: molecular mechanisms, health benefits and research challenges · Frontiers in nutrition · 15 Sep 2026

Intermittent fasting →

Metformin

upin D. discoideum1

1 study

Metformin activates AMPK signalling in D. discoideum.
“Gene-expression analysis revealed the upregulation of AMP-activated protein kinase (AMPK) and core autophagy genes, indicating activation of an AMPK-linked pro-autophagy pathway involved in aggregate clearance.”
Model organisms
Drug-Induced Reduction in 80Q Aggregates in a Dictyostelium discoideum Model of PolyQ Disease · Biomedicines · 28 Aug 2026

Metformin →

Latest

AnimalsBrain aging5 h

Pan-AMPK activator MK-8722 improves spatial memory in Alzheimer's model mice

Systemic treatment activated liver AMPK, restored plasma metabolites, and enhanced dendritic spine maturation without altering hippocampal long-term potentiation.

Journal of Neurochemistry · Nicol NI et al.

From seven combination hypotheses to one testable interaction: a gated agentic AI QSP workflow applied to healthy ageing interventions

In silicoPreprintbioRxiv

Yesterday

Chronic Inflammation as an Underlying Pathogenetic Mechanism of Chronic Non-Communicable Diseases: Molecular, Cellular, and Therapeutic Dimensions

ReviewPreprintPreprints.org

Yesterday

CellsPreprintNAD+ & sirtuins1 Oct

AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1

Experiments in human cells and computational modeling show that fasting sensor AMPK requires NAD+ and PGC-1-alpha to modulate cellular circadian rhythms.

bioRxiv · Vandenberghe A et al.