NRF2–KEAP1 antioxidant response
Pathway23 papers5 findings
Studies in mice, flies, and human cells demonstrate activation of the NRF2–KEAP1 antioxidant response by diverse interventions, including SIRT1 overexpression and specific natural polysaccharides. Reviews also describe melatonin activating this response in the kidney.
- Animals5
- Model organisms6
Interventions
5Gastrodia elata polysaccharides
upin mice1
1 study
Gastrodia elata polysaccharides
upin mice1
Gastrodia elata polysaccharides activate NRF2–KEAP1 antioxidant response in mice.
Animals
Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice · Food science & nutrition · 30 Sep 2026
4-octyl itaconate
upin mice1
1 study
4-octyl itaconate
upin mice1
4-octyl itaconate activates NRF2–KEAP1 antioxidant response in mice.
Animalsparotid gland25 mg/kg4 weeksmales
4-Octyl itaconate restores parotid gland function in aging mice · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 30 Sep 2026
Melatonin
upin reviews1
1 study
Melatonin
upin reviews1
Melatonin activates NRF2–KEAP1 antioxidant response.
Reviewkidney
Melatonin and Diabetic Nephropathy: From Mechanistic Pathways to Translational Opportunities in Clinical Management · Current medicinal chemistry · 25 Sep 2026
SIRT1 overexpression
upin human cells1
1 study
SIRT1 overexpression
upin human cells1
SIRT1 overexpression activates NRF2–KEAP1 antioxidant response in human cells.
Cellsosteogenic inductionpcDNA3.1-Sirt1 transfectionaortic valve interstitial cell
Activating Sirt1 reduces aortic valve calcification in mice and human cells · International journal of molecular medicine · 25 Sep 2026
Physalis pubescens polysaccharides
upin flies1
1 study
Physalis pubescens polysaccharides
upin flies1
Physalis pubescens polysaccharides activate NRF2–KEAP1 antioxidant response in flies.
Model organismsselenylated fruit polysaccharide derivativefemales
Selenylated Physalis pubescens polysaccharide extends lifespan and activates Nrf2/HO-1-mediated antioxidant defense: structural elucidation and multi-target mechanism · Bioorganic chemistry · 23 Sep 2026
Latest
23Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.
4-Octyl itaconate restores parotid gland function in aging mice
The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.
Krüppel-like factors modulate SKN-1 activity and lipid balance to control worm lifespan
KLF-1 drives SKN-1 activation through lipophagy-linked pathways to promote oxidative stress resistance and extend lifespan in germline-deficient Caenorhabditis elegans.