PPARGC1A
GeneHomo sapiens7 papers2 findingsHGNC 9237NCBI Gene 10891Taxon 9606
- Cells3
Interventions
2Exercise
upin humans1
1 study
Exercise
upin humans1
Exercise activates PPARGC1A in humans.
“Exercise opposes this cascade through the AMPK-PGC-1α axis, which coordinately activates four mitochondrial quality control (MQC) modules: biogenesis, antioxidant defense, dynamics, and mitophagy.”
Reviewvia AMPK-PGC-1α axisrepeated training
Mitochondrial Quality Control Links Exercise to Sterile Inflammation in the Cardiovascular System: A Narrative Review · Antioxidants (Basel, Switzerland) · 7 Sep 2026
Semaglutide
upin human cells1
1 study
Semaglutide
upin human cells1
Semaglutide increases PPARGC1A in human cells.
“Semaglutide also increased SIRT1 and PGC-1α expression, the COX-1/SDH-A ratio, and the mtDNA/nDNA ratio”
Cellsmacrophage100 nM
Semaglutide Attenuates Inflammatory Macrophage Polarization and Promotes Changes Associated with Mitochondrial Biogenesis Through cAMP-Dependent Signaling · Biomedicines · 3 Sep 2026
Latest
10AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1
Experiments in human cells and computational modeling show that fasting sensor AMPK requires NAD+ and PGC-1-alpha to modulate cellular circadian rhythms.
Senescent human astrocytes impair neuronal mitochondrial function through released factors
Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons.