Review30 Sep 2026

Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation

Aging and Disease

The paper

Qin N, Fan X, Tan Y et al.

Aging and Disease · 23 Sep 2026

doi.org/10.14336/ad.2026.0752 PubMed

AnimalsmTOR & rapamycin2 h

Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice

The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient mice.

International Immunopharmacology · Wang Y et al.

AnimalsCellular senescence2 h

Jianwei Shoutai Pills reduce uterine aging and pregnancy loss in aged mice

The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic signaling in aging female mice.

Phytomedicine · Guan F et al.

Cells2 h

Loss of lncRNA H19 suppresses osteoblast differentiation under oxidative stress

Overexpressing the noncoding RNA restored bone healing in mice, separating impaired osteogenesis from the onset of cellular senescence.

Bone · Shin HR et al.

CellsPreprint4 h

Aged human muscle secretes an enzyme that impairs stem cell maintenance

Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.

bioRxiv · Crisol B et al.

Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation

The paper

Latest stories

Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice

Jianwei Shoutai Pills reduce uterine aging and pregnancy loss in aged mice

Loss of lncRNA H19 suppresses osteoblast differentiation under oxidative stress

Aged human muscle secretes an enzyme that impairs stem cell maintenance