SIRT1
GeneHomo sapiens8 papers2 findingsHGNC 14929NCBI Gene 23411Taxon 9606
- Animals1
- Cells1
Effects
2Mitochondrial dysfunction
downin reviews1
1 study
Mitochondrial dysfunction
downin reviews1
SIRT1 protects against mitochondrial dysfunction.
“SIRT1 maintains mitochondrial function through three interconnected pathways: PGC-1α-driven mitochondria biogenesis, FOXO-dependent antioxidant defense, and mitophagic clearance of damaged organelles.”
Review
SIRT1 in Senescence: Mitochondria and Immune Crosstalk · Biology · 8 Sep 2026
Cellular senescence
downin reviews1
1 study
Cellular senescence
downin reviews1
SIRT1 decreases cellular senescence.
“SIRT1 levels and activity fall with age, and this decline directly promotes senescence.”
Review
SIRT1 in Senescence: Mitochondria and Immune Crosstalk · Biology · 8 Sep 2026
Latest
10AnimalsNAD+ & sirtuins
Activating Sirt1 reduces aortic valve calcification in mice and human cells
The sirtuin protects valves by activating the Nrf2 pathway, preserving mitochondrial function, and preventing iron-driven ferroptosis.