Insulin/IGF-1 signalling

Pathway10 papersGO 0008286

Animals1
Model organisms2

Latest

10

Muscle-brain crosstalk in sarcopenia and cognitive impairment: endocrine signaling, metabolic regulation, and exercise modulation

ReviewFrontiers in Endocrinology

Yesterday

Model organismsMitochondria1 Oct

USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms

A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.

Cell Reports · Gordillo-García S et al.

Intermittent and periodic fasting: molecular mechanisms, health benefits and research challenges

ReviewFrontiers in Nutrition

1 Oct

The IGF/IGFR System During Chronic Liver Disease: Role in Neurocognitive Complications and Aging

ReviewAging and Disease

30 Sep

Animals30 Sep

IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice

Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.

Aging Cell · Xu R et al.

Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies

ReviewDiabetes, Metabolic Syndrome and Obesity

30 Sep

Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway

Model organismsBiogerontology

28 Sep

Reframing Alzheimer's Disease Through a Redox-Metabolic Framework

ReviewInternational Journal of Molecular Sciences

28 Sep

Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective

ReviewBiomedicines

26 Sep

The Interplay of Metabolic Dysfunction, Neuroinflammation, and Mitochondrial Dysfunction in Balance Impairment: Insights from Type 2 Diabetes Mellitus and Alzheimer's Disease

ReviewMolecular Neurobiology

26 Sep