MitochondriaReview30 Sep 2026

Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies

Diabetes, Metabolic Syndrome and Obesity

The paper

Alghzawi HM, Younas S, Sahu S et al.

Diabetes, Metabolic Syndrome and Obesity · 23 Sep 2026

doi.org/10.2147/dmso.s627029 PubMed

See all

Animals30 Sep

Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor

Restoring cardiolipin synthesis in knockout mice reversed muscle atrophy and prevented premature death.

Nature Aging · Finger F et al.

AnimalsPreprint28 Sep

Early-life mitochondrial DNA mutations drive age-related pathology in mice

Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.

bioRxiv · Shemtov SJ et al.

AnimalsPreprintYesterday

Inhibiting miR-128-3p restores muscle mass and function in aged mice

The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.

bioRxiv · Boldridge MA et al.

AnimalsYesterday

Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice

TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.

Aging Cell · Chen G et al.

AnimalsPreprint29 Sep

Depp1 drives muscle loss under fasting and low oxygen in mice

The study reveals that the protein localizes to mitochondria to regulate autophagy and mitochondrial degradation during nutrient and oxygen limitation.

bioRxiv · Qayyum S et al.

Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies

The paper

More on Mitochondria

Cardiolipin loss drives muscle fiber shifts during aging via a nuclear receptor

Early-life mitochondrial DNA mutations drive age-related pathology in mice

Inhibiting miR-128-3p restores muscle mass and function in aged mice

Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice

Depp1 drives muscle loss under fasting and low oxygen in mice